Elsa Solà, Elisa Pose Mendez, Daniela Campion, Salvatore Piano, Olivier Roux, Macarena Simon-Talero, Frank Erhard Uschner, Koos de Wit, Giacomo Zaccherini, Carlo Alessandria, Ulrich Beuers, Paolo Caraceni, Claire Francoz, Rajeshwar Prosad Mookerjee, Jonel Trebicka, Victor Manuel Vargas Blasco, Miquel Serra, Ferran Torres, Sara Montagnese, Aleksander Krag, Ruben Hernaez, Marko Korenjak, Hugh Watson, Juan G. Abraldes, Patrick S. Kamath, Pere Ginès
- Management of decompensated cirrhosis is currently geared towards the treatment of complications once they occur. To date there is no established disease-modifying therapy aimed at halting progression of the disease and preventing the development of complications in patients with decompensated cirrhosis. The design of clinical trials to investigate new therapies for patients with decompensated cirrhosis is complex. The population of patients with decompensated cirrhosis is heterogeneous (i.e., different etiologies, comorbidities and disease severity), leading to the inclusion of diverse populations in clinical trials. In addition, primary endpoints selected for trials that include patients with decompensated cirrhosis are not homogeneous and at times may not be appropriate. This leads to difficulties in comparing results obtained from different trials. Against this background, the LiverHope Consortium organized a meeting of experts, the goal of which was to develop recommendations for the design of clinical trials and to define appropriate endpoints, both for trials aimed at modifying the natural history and preventing progression of decompensated cirrhosis, as well as for trials aimed at managing the individual complications of cirrhosis.
MetadatenAuthor: | Elsa SolàORCiD, Elisa Pose MendezORCiD, Daniela CampionORCiD, Salvatore PianoORCiD, Olivier RouxORCiD, Macarena Simon-TaleroORCiD, Frank Erhard UschnerORCiDGND, Koos de WitORCiD, Giacomo ZaccheriniORCiD, Carlo AlessandriaORCiD, Ulrich BeuersORCiD, Paolo CaraceniORCiD, Claire FrancozORCiD, Rajeshwar Prosad MookerjeeORCiD, Jonel TrebickaORCiDGND, Victor Manuel Vargas BlascoORCiD, Miquel Serra, Ferran TorresORCiD, Sara MontagneseORCiD, Aleksander KragORCiDGND, Ruben HernaezORCiD, Marko KorenjakORCiD, Hugh WatsonORCiD, Juan G. AbraldesORCiD, Patrick S. KamathORCiD, Pere GinèsORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-631225 |
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DOI: | https://doi.org/10.1016/j.jhep.2020.08.009 |
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ISSN: | 1600-0641 |
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Parent Title (English): | Journal of hepatology |
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Publisher: | Elsevier Science |
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Place of publication: | Amsterdam [u.a.] |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2020/09/05 |
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Date of first Publication: | 2020/09/05 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Contributing Corporation: | LiverHope Consortium Investigators |
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Release Date: | 2023/07/19 |
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Tag: | ACLF; AKI; Ascites; Cirrhosis; Clinical trials; Endpoints; Hepatic encephalopathy; Hyponatremia; Infections; Liver transplant; Quality of life |
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Volume: | 74 |
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Issue: | 1 |
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Page Number: | 20 |
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First Page: | 200 |
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Last Page: | 219 |
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Note: | The work described has been funded by a H2020 Grant – LIVERHOPE – Project number: 731875. |
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HeBIS-PPN: | 512573115 |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |
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