Effects of comorbid disorders on reward processing and connectivity in adults with ADHD
- ADHD is a neurodevelopmental disorder with a long trajectory into adulthood where it is often comorbid with depression, substance use disorder (SUD) or obesity. Previous studies described a dysregulated dopaminergic system, reflected by abnormal reward processing, both in ADHD as well as in depression, SUD or obesity. No study so far however tested systematically whether pathologies in the brain’s reward system explain the frequent comorbidity in adult ADHD. To test this, we acquired MRI scans from 137 participants probing the reward system by a monetary incentive delay task (MIDT) as well as assessing resting-state connectivity with ventral striatum as a seed mask. No differences were found between comorbid disorders, but a significant linear effect pointed toward less left intrastriatal connectivity in patients depending on the number of comorbidities. This points towards a neurobiologically impaired reward- and decision-making ability in patients with more comorbid disorders. This suggests that less intrastriatal connectivity parallels disorder severity but not disorder specificity, while MIDT abnormalities seem mainly to be driven by ADHD.
Author: | Oliver GrimmORCiDGND, Daan van RooijORCiD, Asya Tshagharyan, Dilek Yildiz, Jan Leonards, Ahmed Elgohary, Jan K. BuitelaarORCiDGND, Andreas ReifORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-695431 |
DOI: | https://doi.org/10.1038/s41398-021-01758-0 |
ISSN: | 2158-3188 |
Parent Title (English): | Translational Psychiatry |
Publisher: | Nature Publishing Group |
Place of publication: | London |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2021/12/16 |
Date of first Publication: | 2021/12/16 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2023/08/17 |
Tag: | ADHD; Diagnostic markers; Human behaviour; Neuroscience |
Volume: | 11 |
Issue: | art. 636 |
Article Number: | 636 |
Page Number: | 7 |
First Page: | 1 |
Last Page: | 7 |
Note: | Financial support for this study was received from the European Union’s Horizon 2020 research and innovation program under grant agreement 667302: Comorbid Conditions of ADHD (CoCA). |
Note: | Open Access funding enabled and organized by Projekt DEAL. |
HeBIS-PPN: | 51261394X |
Institutes: | Medizin |
Dewey Decimal Classification: | 1 Philosophie und Psychologie / 15 Psychologie / 150 Psychologie |
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |