Endothelial cell metabolism in Atherosclerosis
- Atherosclerosis and its sequelae, such as myocardial infarction and stroke, are the leading cause of death worldwide. Vascular endothelial cells (EC) play a critical role in vascular homeostasis and disease. Atherosclerosis as well as its independent risk factors including diabetes, obesity, and aging, are hallmarked by endothelial activation and dysfunction. Metabolic pathways have emerged as key regulators of many EC functions, including angiogenesis, inflammation, and barrier function, processes which are deregulated during atherogenesis. In this review, we highlight the role of glucose, fatty acid, and amino acid metabolism in EC functions during physiological and pathological states, specifically atherosclerosis, diabetes, obesity and aging.
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| Verfasserangaben: | Kosta Theodorou, Reinier BoonORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-473624 |
| DOI: | https://doi.org/10.3389/fcell.2018.00082 |
| ISSN: | 2296-634X |
| Pubmed-Id: | https://pubmed.ncbi.nlm.nih.gov/30131957 |
| Titel des übergeordneten Werkes (Englisch): | Frontiers in cell and developmental biology |
| Verlag: | Frontiers Media |
| Verlagsort: | Lausanne |
| Sonstige beteiligte Person(en): | Salvatore Papa |
| Dokumentart: | Wissenschaftlicher Artikel |
| Sprache: | Englisch |
| Jahr der Fertigstellung: | 2018 |
| Datum der Erstveröffentlichung: | 07.08.2018 |
| Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Datum der Freischaltung: | 30.10.2018 |
| Freies Schlagwort / Tag: | aging; atherosclerosis; endothelial cells; hyperglycemia; hyperlipidemia; inflammation; metabolism |
| Jahrgang: | 6 |
| Ausgabe / Heft: | Art. 82 |
| Seitenzahl: | 9 |
| Erste Seite: | 1 |
| Letzte Seite: | 9 |
| Bemerkung: | Copyright © 2018 Theodorou and Boon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| HeBIS-PPN: | 440663628 |
| Institute: | Medizin / Medizin |
| DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Open-Access-Publikationsfonds: | Medizin |
| Lizenz (Deutsch): |  Creative Commons - Namensnennung 4.0 |
