Low but recoverable markers of humoral immune response to BNT162b2 in elderly LTCF residents five to seven months after two-dose vaccination
- The immune response is known to wane after vaccination with BNT162b2, but the role of age, morbidity and body composition is not well understood. We conducted a cross-sectional study in long-term care facilities (LTCFs) for the elderly. All study participants had completed two-dose vaccination with BNT162b2 five to 7 months before sample collection. In 298 residents (median age 86 years, range 75–101), anti-SARS-CoV-2 rector binding IgG antibody (anti-RBD-IgG) concentrations were low and inversely correlated with age (mean 51.60 BAU/ml). We compared the results to Health Care Workers (HCW) aged 18–70 years (n = 114, median age: 53 years), who had a higher mean anti-RBD-IgG concentration of 156.99 BAU/ml. Neutralization against the Delta variant was low in both groups (9.5% in LTCF residents and 31.6% in HCWs). The Charlson Comorbidity Index was inversely correlated with anti-RBD-IgG, but not the body mass index (BMI). A control group of 14 LTCF residents with known breakthrough infection had significant higher antibody concentrations (mean 3,199.65 BAU/ml), and 85.7% had detectable neutralization against the Delta variant. Our results demonstrate low but recoverable markers of immunity in LTCF residents five to 7 months after vaccination.
Author: | Marla DelbrückORCiD, Sebastian HoehlORCiDGND, Tuna ToptanORCiDGND, Barbara SchenkGND, Katharina GrikscheitORCiD, Melinda MetzlerORCiD, Eva HerrmannORCiDGND, Sandra CiesekORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-813976 |
DOI: | https://doi.org/10.3389/fragi.2022.883724 |
ISSN: | 2673-6217 |
Parent Title (English): | Frontiers in aging |
Publisher: | Frontiers Media S.A. |
Place of publication: | Lausanne |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2022/04/25 |
Date of first Publication: | 2022/04/25 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2024/02/05 |
Tag: | COVID-19; SARS-CoV-2; elderly; immunity; immunosenescence; multimorbidity; vaccination |
Volume: | 3 |
Issue: | art. 883724 |
Article Number: | 883724 |
Page Number: | 7 |
First Page: | 1 |
Last Page: | 7 |
Note: | This study was funded by the Hessian Ministry of Social Issues and Integration. |
HeBIS-PPN: | 519209451 |
Institutes: | Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |