Christiana Graf, Antonia Maria Mondorf, Viola Knop, Kai-Henrik Peiffer, Julia Dietz, Julia Friess, Heiner Wedemeyer, Peter Buggisch, Stefan Mauß, Thomas Berg, Michael Rausch, Martin F. Sprinzl, Hartwig Klinker, Holger Hinrichsen, Jean-Pierre Bronowicki, Sebastian Haag, Dietrich Hüppe, Thomas Lutz, Thierry Poynard, Stefan Zeuzem, Mireen Friedrich-Rust, Christoph Sarrazin, Johannes Vermehren
- Background: Accurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of point shear wave elastography (pSWE) for longitudinal non-invasive fibrosis assessment in a large cohort of untreated patients with chronic HBeAg-negative hepatitis B virus (HBV) infection.
Methods: 407 consecutive patients with HBeAg-negative HBV infection who underwent pSWE, transient elastography (TE) as well as laboratory fibrosis markers, including fibrosis index based on four factors (FIB-4), aspartate to platelet ratio index (APRI) and FibroTest, on the same day were prospectively followed up for six years. Patients were classified into one of the three groups: inactive carriers (IC; HBV-DNA <2000 IU/mL and ALT <40 U/L); grey zone group 1 (GZ-1; HBV DNA <2000 IU/mL and ALT >40 U/L); grey zone group 2 (GZ-2; HBV-DNA >2000 IU/mL and ALT <40 U/L).
Results: pSWE results were significantly correlated with TE (r = 0.29, p < 0.001) and APRI (r = 0.17; p = 0.005). Median pSWE values did not differ between IC, GZ-1 and GZ-2 patients (p = 0.82, p = 0.17, p = 0.34). During six years of follow-up, median pSWE and TE values did not differ significantly over time (TE: p = 0.27; pSWE: p = 0.05).
Conclusion: Our data indicate that pSWE could be useful for non-invasive fibrosis assessment and follow-up in patients with HBeAg-negative chronic HBV infection.
MetadatenAuthor: | Christiana GrafORCiDGND, Antonia Maria MondorfORCiDGND, Viola Knop, Kai-Henrik PeifferORCiDGND, Julia DietzORCiDGND, Julia Friess, Heiner WedemeyerORCiDGND, Peter BuggischORCiDGND, Stefan Mauß, Thomas BergORCiDGND, Michael Rausch, Martin F. SprinzlORCiDGND, Hartwig KlinkerORCiD, Holger HinrichsenGND, Jean-Pierre Bronowicki, Sebastian Haag, Dietrich Hüppe, Thomas Lutz, Thierry PoynardORCiDGND, Stefan ZeuzemORCiDGND, Mireen Friedrich-RustORCiDGND, Christoph SarrazinGND, Johannes VermehrenGND |
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URN: | urn:nbn:de:hebis:30:3-527450 |
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DOI: | https://doi.org/10.3390/jcm8122101 |
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ISSN: | 2077-0383 |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/31810183 |
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Parent Title (English): | Journal of Clinical Medicine |
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Publisher: | MDPI |
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Place of publication: | Basel |
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Document Type: | Article |
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Language: | English |
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Year of Completion: | 2019 |
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Date of first Publication: | 2019/12/02 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2020/02/17 |
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Tag: | APRI; FIB-4; HBV; acoustic radiation force impulse imaging; fibrotest; non-invasive fibrosis assessment; point shear wave elastography; transient elastography |
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Volume: | 8 |
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Issue: | 12, Art. 2101 |
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Page Number: | 11 |
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First Page: | 1 |
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Last Page: | 11 |
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Note: | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
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HeBIS-PPN: | 460971603 |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Open-Access-Publikationsfonds: | Medizin |
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Licence (German): | Creative Commons - Namensnennung 4.0 |
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