Redox regulation of Smac mimetic-induced cell death
- Cell death and survival programs are controlled by the cellular redox state, which is typically dysregulated during oncogenesis. A recent study reports that the inhibition of antioxidant defenses resulting from glutathione depletion can prime acute lymphoblastic leukemia cells for death induced by Smac mimetics.
Author: | Simone FuldaORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-506739 |
DOI: | https://doi.org/10.1080/23723556.2014.1000697 |
ISSN: | 2372-3556 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/27308489 |
Parent Title (English): | Molecular & cellular oncology |
Publisher: | Taylor & Francis |
Place of publication: | London |
Document Type: | Article |
Language: | English |
Year of Completion: | 2015 |
Date of first Publication: | 2015/01/23 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2019/07/11 |
Tag: | Smac; apoptosis; cell death; leukemia; redox |
Volume: | 2 |
Issue: | 4 |
Page Number: | 3 |
First Page: | e1000697-1 |
Last Page: | e1000697-2 |
Note: | This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
HeBIS-PPN: | 452969212 |
Institutes: | Medizin / Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell 3.0 |