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Antitumor effect of MAb EMD 55900 depends on EGF-R expression and histopathology
- The proliferative stimulus of the epidermal growth factor (EGF) in human epithelial cells is mediated by its binding to the external domain of the EGF receptor (EGF-R). The purpose of this study was to investigate whether growth arrest of tumors treated with anti-EGFR MAb (EMD 55900) was dependent on EGF-R expression and distinct histopathologic criteria of those neoplasms. Nine different adenocarcinomas, squamous cell carcinomas and two neoplastic epithelial cell lines (A431 and Detroit 562), which were characterized by high EGF-R expression, were xenotransplanted onto NMRI-nu/nu mice and treated with an anti-EGF-R antibody (EMD 55900). Results revealed that EGF-R expression and distinct histopathologic growth patterns play an important role for the therapeutic effect of the EGF-R antibody treatment. Tumors with high epithelial cellularity and little connective tissue responded to EMD 55900 treatment to a greater degree of growth reduction than tumors with lower cellularity. These results will be helpful for evaluation of patients who would benefit from tumor therapy with anti-EGF-R antibody.
Author: | Christine SolbachORCiDGND, Anja Sterner-Kock, Marc Roller, Hans-Georg Schnürch, Manfred Stegmüller, Gudrun Caspar-Bell, Petra-Maria Schumm-DraegerGND, Manfred KaufmannGND, Rainald KnechtGND |
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URN: | urn:nbn:de:hebis:30:3-456163 |
DOI: | https://doi.org/10.1038/sj.neo.7900236 |
ISSN: | 1476-5586 |
ISSN: | 1522-8002 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/11988843 |
Parent Title (English): | Neoplasia |
Publisher: | Stockton Press |
Place of publication: | Basingstoke |
Document Type: | Article |
Language: | English |
Year of Completion: | 2002 |
Year of first Publication: | 2002 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2018/02/06 |
Tag: | EGFR; EMD 55900; EMD 72000; antibody; histology |
Volume: | 4 |
Issue: | 3 |
Page Number: | 6 |
First Page: | 237 |
Last Page: | 242 |
Note: | User License: Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0) |
HeBIS-PPN: | 426736397 |
Institutes: | Medizin / Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |