Christian Lange, Stephanie Bibert, Zoltán Kutalik, Philippe Burgisser, Andreas Cerny, Jean-Francois Dufour, Andreas Geier, Tilman J. Gerlach, Markus H. Heim, Raffaele Malinverni, Francesco Negro, Stephan Regenass, Klaus Badenhoop, Jörg Bojunga, Christoph Sarrazin, Stefan Zeuzem, Tobias Müller, Thomas Berg, Pierre-Yves Bochud, Darius Moradpour
- Background: To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C.
Methodology/Principal Findings: Associations between a functionally relevant polymorphism in the gene encoding the vitamin D 1α-hydroxylase (CYP27B1-1260 rs10877012) and the response to treatment with pegylated interferon-α (PEG-IFN-α) and ribavirin were determined in 701 patients with chronic hepatitis C. In addition, associations between serum concentrations of 25-hydroxyvitamin D3 (25[OH]D3) and treatment outcome were analysed. CYP27B1-1260 rs10877012 was found to be an independent predictor of sustained virologic response (SVR) in patients with poor-response IL28B genotypes (15% difference in SVR for rs10877012 genotype AA vs. CC, p = 0.02, OR = 1.52, 95% CI = 1.061–2.188), but not in patients with favourable IL28B genotype. Patients with chronic hepatitis C showed a high prevalence of vitamin D insufficiency (25[OH]D3<20 ng/mL) during all seasons, but 25(OH)D3 serum levels were not associated with treatment outcome.
Conclusions/Significance: Our study suggests a role of bioactive vitamin D (1,25[OH]2D3, calcitriol) in the response to treatment of chronic hepatitis C. However, serum concentration of the calcitriol precursor 25(OH)D3 is not a suitable predictor of treatment outcome.
MetadatenVerfasserangaben: | Christian LangeGND, Stephanie Bibert, Zoltán Kutalik, Philippe Burgisser, Andreas Cerny, Jean-Francois Dufour, Andreas Geier, Tilman J. Gerlach, Markus H. Heim, Raffaele Malinverni, Francesco Negro, Stephan Regenass, Klaus BadenhoopORCiDGND, Jörg BojungaGND, Christoph SarrazinGND, Stefan ZeuzemORCiDGND, Tobias Müller, Thomas BergORCiDGND, Pierre-Yves Bochud, Darius Moradpour |
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URN: | urn:nbn:de:hebis:30:3-257656 |
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DOI: | https://doi.org/10.1371/journal.pone.0040159 |
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ISSN: | 1932-6203 |
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Pubmed-Id: | https://pubmed.ncbi.nlm.nih.gov/22808108 |
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Titel des übergeordneten Werkes (Englisch): | PLoS One |
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Verlag: | PLoS |
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Verlagsort: | Lawrence, Kan. |
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Dokumentart: | Wissenschaftlicher Artikel |
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Sprache: | Englisch |
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Datum der Veröffentlichung (online): | 12.07.2012 |
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Datum der Erstveröffentlichung: | 12.07.2012 |
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Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Urhebende Körperschaft: | Swiss Hepatitis C Cohort Study Group |
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Datum der Freischaltung: | 15.08.2012 |
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Jahrgang: | 7 |
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Ausgabe / Heft: | (7):e40159 |
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Seitenzahl: | 8 |
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HeBIS-PPN: | 357941403 |
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Institute: | Medizin / Medizin |
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DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Lizenz (Deutsch): | Creative Commons - Namensnennung 3.0 |
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