Hubert Scharnagl, Marcus E. Kleber, Bernd Genser, Sandra Kickmaier, Wilfried Renner, Gisela Weihrauch, Tanja B. Grammer, Christine Rossmann, Bernhard R. Winkelmann, Bernhard O. Böhm, Wolfgang Sattler, Winfried März, Ernst Malle
- Background: The phagocytic enzyme myeloperoxidase (MPO) acts as a front-line defender against microorganisms. However, increased MPO levels have been found to be associated with complex and calcified atherosclerotic lesions and incident cardiovascular disease. Therefore, this study aimed to investigate a predictive role of MPO, a biomarker of inflammation and oxidative stress, for total and cardiovascular mortality in patients referred to coronary angiography.
Methods and results: MPO plasma concentrations along with eight MPO polymorphisms were determined in 3036 participants of the Ludwigshafen Risk and Cardiovascular Health study (median follow-up 7.75 years). MPO concentrations were positively associated with age, diabetes, smoking, markers of systemic inflammation (interleukin-6, fibrinogen, C-reactive protein, serum amyloid A) and vascular damage (vascular cellular adhesion molecule-1 and intercellular adhesion molecule-1) but negatively associated with HDL-cholesterol and apolipoprotein A-I. After adjustment for cardiovascular risk factors MPO concentrations in the highest versus the lowest quartile were associated with a 1.34-fold risk (95% CI: 1.09–1.67) for total mortality. In the adjusted model the hazard ratio for cardiovascular mortality in the highest MPO quartile was 1.42 (95% CI: 1.07–1.88). Five MPO polymorphisms were positively associated with MPO concentrations but not with mortality. Using Mendelian randomization, we did not obtain evidence for a causal association of MPO with either total or cardiovascular mortality.
Conclusions: MPO concentrations but not genetic variants at the MPO locus are independently associated with risk for total and cardiovascular mortality in coronary artery disease patients.
MetadatenAuthor: | Hubert ScharnaglORCiDGND, Marcus E. Kleber, Bernd Genser, Sandra Kickmaier, Wilfried RennerORCiD, Gisela Weihrauch, Tanja B. GrammerGND, Christine Rossmann, Bernhard R. WinkelmannGND, Bernhard O. BöhmGND, Wolfgang Sattler, Winfried MärzORCiDGND, Ernst Malle |
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URN: | urn:nbn:de:hebis:30:3-364760 |
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DOI: | https://doi.org/10.1016/j.ijcard.2014.03.168 |
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ISSN: | 0167-5273 |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/24746542 |
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Parent Title (English): | International journal of cardiology |
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Publisher: | Elsevier Science |
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Place of publication: | Amsterdam [u.a.] |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2015/01/16 |
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Date of first Publication: | 2014/04/03 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2015/01/16 |
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Tag: | Cardiovascular mortality; High-density lipoprotein; Inflammation; Myeloperoxidase; Risk factor |
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Volume: | 174 |
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Issue: | 1 |
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Page Number: | 10 |
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First Page: | 96 |
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Last Page: | 105 |
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Note: | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
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HeBIS-PPN: | 367498901 |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0 |
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