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Nintedanib plus docetaxel after progression on immune checkpoint inhibitor therapy: insights from VARGADO, a prospective study in patients with lung adenocarcinoma
- Aim: To assess outcomes in patients with advanced adenocarcinoma non-small-cell lung cancer who received nintedanib plus docetaxel after progression on prior chemotherapy followed by immune checkpoint inhibitor (ICI) therapy. Patients & methods: VARGADO is a prospective, noninterventional study. We describe initial data from a cohort of 22 patients who received nintedanib plus docetaxel after chemotherapy and ICI therapy. Results: Median progression-free survival with nintedanib plus docetaxel was 5.5 months (95% CI: 1.9–8.7 months). The objective response rate was 7/12 (58%) and the disease control rate was 10/12 (83%). Data for overall survival rate 12 months after the start of treatment (primary end point) are not yet mature and are not reported. Of 22 patients, 73% experienced drug-related adverse events; adverse events led to treatment discontinuation in 32% of patients. Conclusion: These data highlight the potential clinical benefit of nintedanib plus docetaxel in patients who failed prior ICI therapy. Trial registration number: NCT02392455
Author: | Christian Grohe, Wolfgang Gleiber, Siegfried Haas, Christoph LosemGND, Harald Mueller-Huesmann, Mathias Schulze, Christian Franke, Nadezda Basara, Judith Atz, Rolf Kaiser |
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URN: | urn:nbn:de:hebis:30:3-475281 |
DOI: | https://doi.org/10.2217/fon-2019-0262 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/31282758 |
Parent Title (English): | Future oncology |
Publisher: | London |
Place of publication: | Future Medicine Ltd |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2019/07/08 |
Date of first Publication: | 2019/07/08 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2020/01/29 |
Tag: | VARGADO; angio-immunogenic switch; docetaxel; nintedanib; non-small-cell lung cancer; tumor microenvironment |
Volume: | 15 |
Issue: | 23 |
Page Number: | 8 |
First Page: | 2699 |
Last Page: | 2706 |
Note: | This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ |
HeBIS-PPN: | 459825410 |
Institutes: | Medizin / Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0 |