Jasmin Quandt, Alexander Muik, Nadine Christina Salisch, Bonny Gaby Lui, Sebastian Lutz, Kimberly Krüger, Ann-Kathrin Wallisch, Petra Adams-Quack, Maren Bacher, Andrew Finlayson, Orkun Ozhelvaci, Isabel Vogler, Katharina Grikscheit, Sebastian Hoehl, Udo Götsch, Sandra Ciesek, Özlem Türeci, Ugur Sahin
- Omicron is the evolutionarily most distinct severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VOC) to date. We report that Omicron BA.1 breakthrough infection in BNT162b2-vaccinated individuals resulted in strong neutralizing activity against Omicron BA.1, BA.2, and previous SARS-CoV-2 VOCs but not against the Omicron sublineages BA.4 and BA.5. BA.1 breakthrough infection induced a robust recall response, primarily expanding memory B (BMEM) cells against epitopes shared broadly among variants, rather than inducing BA.1-specific B cells. The vaccination-imprinted BMEM cell pool had sufficient plasticity to be remodeled by heterologous SARS-CoV-2 spike glycoprotein exposure. Whereas selective amplification of BMEM cells recognizing shared epitopes allows for effective neutralization of most variants that evade previously established immunity, susceptibility to escape by variants that acquire alterations at hitherto conserved sites may be heightened.
MetadatenAuthor: | Jasmin QuandtORCiDGND, Alexander MuikORCiDGND, Nadine Christina SalischGND, Bonny Gaby LuiORCiDGND, Sebastian LutzORCiD, Kimberly Krüger, Ann-Kathrin WallischORCiD, Petra Adams-QuackORCiD, Maren Bacher, Andrew FinlaysonORCiD, Orkun OzhelvaciORCiD, Isabel VoglerORCiDGND, Katharina GrikscheitORCiD, Sebastian HoehlORCiDGND, Udo GötschGND, Sandra CiesekORCiDGND, Özlem TüreciGND, Ugur SahinORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-704777 |
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DOI: | https://doi.org/10.1126/sciimmunol.abq2427 |
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ISSN: | 2470-9468 |
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Parent Title (English): | Science Immunology |
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Publisher: | American Association for the Advancement of Science |
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Place of publication: | Washington, DC |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2022/06/02 |
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Date of first Publication: | 2022/06/02 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2022/10/07 |
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Volume: | 7 |
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Issue: | 75, eabq2427 |
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Article Number: | eabq2427 |
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Page Number: | 12 |
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HeBIS-PPN: | 502473797 |
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Institutes: | Medizin / Medizin |
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| Forschungscluster / EMTHERA |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung 4.0 |
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