Vanessa Brinkmann, Margherita Romeo, Lucie Larigot, Anne Hemmers, Lisa Tschage, Jennifer Kleinjohann, Alfonso Schiavi, Swantje Steinwachs, Charlotte Esser, Ralph Menzel, Sara Giani Tagliabue, Laura Bonati, Fiona Cox, Niloofar Ale-Agha, Philipp Jakobs, Joachim Altschmied, Judith Haendeler, Xavier Coumoul, Natascia Ventura
- The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose activity can be modulated by polyphenols, such as curcumin. AhR and curcumin have evolutionarily conserved effects on aging. Here, we investigated whether and how the AhR mediates the anti-aging effects of curcumin across species. Using a combination of in vivo, in vitro, and in silico analyses, we demonstrated that curcumin has AhR-dependent or -independent effects in a context-specific manner. We found that in Caenorhabditis elegans, AhR mediates curcumin-induced lifespan extension, most likely through a ligand-independent inhibitory mechanism related to its antioxidant activity. Curcumin also showed AhR-independent anti-aging activities, such as protection against aggregation-prone proteins and oxidative stress in C. elegans and promotion of the migratory capacity of human primary endothelial cells. These AhR-independent effects are largely mediated by the Nrf2/SKN-1 pathway.
MetadatenAuthor: | Vanessa BrinkmannORCiDGND, Margherita RomeoORCiD, Lucie LarigotORCiD, Anne HemmersGND, Lisa TschageORCiD, Jennifer Kleinjohann, Alfonso SchiaviORCiDGND, Swantje Steinwachs, Charlotte EsserORCiDGND, Ralph MenzelGND, Sara Giani TagliabueORCiD, Laura BonatiORCiD, Fiona Cox, Niloofar Ale-Agha, Philipp JakobsORCiDGND, Joachim AltschmiedGND, Judith HaendelerORCiDGND, Xavier CoumoulORCiD, Natascia VenturaORCiDGND |
---|
URN: | urn:nbn:de:hebis:30:3-844258 |
---|
DOI: | https://doi.org/10.3390/antiox11040613 |
---|
ISSN: | 2076-3921 |
---|
Parent Title (English): | Antioxidants |
---|
Publisher: | MDPI |
---|
Place of publication: | Basel |
---|
Document Type: | Article |
---|
Language: | English |
---|
Date of Publication (online): | 2022/03/23 |
---|
Date of first Publication: | 2022/03/23 |
---|
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
---|
Release Date: | 2024/06/26 |
---|
Tag: | Caenorhabditis elegans; aryl hydrocarbon receptor; curcumin; endothelial cells; in silico; in vitro; in vivo; mice; oxidative stress |
---|
Volume: | 11 |
---|
Issue: | 4, art. 613 |
---|
Article Number: | 613 |
---|
Page Number: | 30 |
---|
First Page: | 1 |
---|
Last Page: | 30 |
---|
Note: | Funding:
DFG ; VE366/6-1
DFG ; VE366/8-1
DFG ; IRTG1902-P1
DFG ; IRTG1902-P2
Jürgen Manchot Foundation
Caenorhabditis Genetics Center
NIH Office of Research Infrastructure Programs ; P40 OD010440 |
---|
HeBIS-PPN: | 520821254 |
---|
Institutes: | Medizin |
---|
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
---|
| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
---|
Sammlungen: | Universitätspublikationen |
---|
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
---|