Metabolism of acids, lactones and esters acids

  • Compounds containing a carboxylic acid group may be metabolized along several routes. However, the most common pathways involve conjugation reactions with amino acids or glucuronic acid. Also, chain shortening due to beta-oxidation occurs when the carboxylic acid group is attached to a suitable aliphatic moiety. The various metabolic reactions of compounds containing the carboxylic acid group were reviewed by Caldwell. I Additional reactions of the carboxy group have been discovered which reveal that numerous I ipophilic conjugates may be formed. This subject was reviewed by CaldweW3 and Quistad and Hutson4 and the findings demonstrate that the acids may undergo chain extension or incorporation into triglycerides, cholesterol esters, and fatty acid derivatives. In addition to these reactions which occur in the tissues, the metabolism (e.g., decarboxylation or reduction) of some carboxylic acids may be carried out by the intestinal microflora.

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Author:Ronald R. Scheline
Parent Title (German):Scheline, Ronald R. : CRC handbook of mammalian metabolism of plant compounds
Publisher:CRC Press
Place of publication:Boca Raton
Document Type:Part of a Book
Date of Publication (online):2010/05/06
Year of first Publication:1991
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2010/05/06
First Page:139
Last Page:196
Signatur: Sq 91/374
Source:In: Scheline, Ronald R. : CRC handbook of mammalian metabolism of plant compounds, Boca Raton : CRC Press, 1991, S. 139-196
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Sammlungen:Sammlung Biologie / Weitere biologische Literatur (eingeschränkter Zugriff)
Licence (German):License LogoArchivex. zur Lesesaalplatznutzung § 52b UrhG