Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis

  • The re-emergence of tuberculosis in its present-day manifestations - single, multiple and extensive drug-resistant forms and as HIV-TB coinfections - has resulted in renewed research on fundamental questions such as the nature of the organism itself, Mycobacterium tuberculosis, the molecular basis of its pathogenesis, definition of the immunological response in animal models and humans, and development of new intervention strategies such as vaccines and drugs. Foremost among these developments has been the precise chemical definition of the complex and distinctive cell wall of M. tuberculosis, elucidation of the relevant pathways and underlying genetics responsible for the synthesis of the hallmark moieties of the tubercle bacillus such as the mycolic acid-arabinogalactan-peptidoglycan complex, the phthiocerol- and trehalose-containing effector lipids, the phosphatidylinositol-containing mannosides, lipomannosides and lipoarabinomannosides, major immunomodulators, and others. In this review, the laboratory personnel who have been the focal point of some to these developments review recent progress towards a comprehensive understanding of the basic physiology and functions of the cell wall of M. tuberculosis.

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Author:Devinder Kaur, Marcelo E. Guerin, Henrieta Škovierová, Patrick J. Brennan, Mary Jackson
Parent Title (English):Advances in applied microbiology
Document Type:Article
Date of Publication (online):2010/11/10
Year of first Publication:2009
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2010/11/10
Page Number:56
First Page:23
Last Page:78
Institutes:keine Angabe Fachbereich / Extern
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Sammlungen:Sammlung Biologie / Weitere biologische Literatur (eingeschränkter Zugriff)
Licence (German):License LogoArchivex. zur Lesesaalplatznutzung § 52b UrhG