Accuracy of cardiovascular magnetic resonance in myocarditis : comparison of MR and histological findings in an animal model

  • Background: Because Endomyocardial Biopsy has low sensitivity of about 20%, it can be performed near to myocardium that presented as Late Gadolinium Enhancement (LGE) in cardiovascular magnetic resonance (CMR). However the important issue of comparing topography of CMR and histological findings has not yet been investigated. Thus the current study was performed using an animal model of myocarditis. Results: In 10 male Lewis rats Experimental Autoimmune myocarditis was induced, 10 rats served as control. On day 21 animals were examined by CMR to compare topographic distribution of LGE to histological inflammation. Sensitivity, specificity, positive and negative predictive values for LGE in diagnosing myocarditis were determined for each segment of myocardium. Latter diagnostic values varied widely depending on topographic distribution of LGE and inflammation as well as on the used CMR sequence. Sensitivity of LGE was up to 76% (left lateral myocardium) and positive predictive values were up to 85% (left lateral myocardium), whereas sensitivity and positive predictive value dropped to 0 - 33% (left inferior myocardium). Conclusions: Topographic distribution of LGE and histological inflammation seem to influence sensitivity, specifity, positive and negative predictive values. Nevertheless, positive predictive value for LGE of up to 85% indicates that Endomyocardial Biopsy should be performed "MR-guided". LGE seems to have greater sensitivity than Endomyocardial Biopsy for the diagnosis of myocarditis.

Download full text files

Export metadata

Author:Hüdayi KorkusuzGND, Philip Esters, Frank Huebner, Reinhold Bug, Hanns AckermannGND, Thomas J. VoglORCiDGND
Pubmed Id:
Parent Title (German):Journal of cardiovascular magnetic resonance
Publisher:Taylor & Francis
Place of publication:Philadelphia, Pa.
Document Type:Article
Date of Publication (online):2010/09/16
Date of first Publication:2010/08/26
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2010/09/16
Issue:Art. 49
Page Number:10
First Page:1
Last Page:10
© 2010 Korkusuz et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Source:Journal of Cardiovascular Magnetic Resonance 2010, 12:49 ; doi:10.1186/1532-429X-12-49 ;
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 2.0