Gold nanoparticles : recent aspects for human toxicology

  • Nanoparticles (particles sized between 1 and 100 nanometers) are more and more used in all fields of science and medicine for their physicochemical properties. As gold has traditionally been considered as chemically inert and biocompatible, in particular, gold nanoparticles have been established as valuable tools in several areas of biomedical research. But in contrast to the multitude of studies that addressed the clinical use of gold nanoparticles, only little is known about potential toxicological effects such as induction of inflammatory immune responses, possible apoptotic cell death or developmental growth inhibition in embryos. Therefore the present study performed a systematic review of toxicological data, especially experimentally acquired data concerning in-vivo-toxicity, published in the PubMed. It can be stated that the data in this area of research is still largely limited. Especially, knowledge about size-, charge- and surface-chemistry dependent in-vivo-toxicity is needed to predict the hazard potential of auric nanoparticles (AuNPs) for humans.

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Author:Alexander Gerber, Matthias Bundschuh, Doris KlingelhöferORCiD, Jan David Alexander GronebergORCiDGND
Parent Title (English):Journal of occupational medicine and toxicology
Publisher:BioMed Central
Place of publication:London
Document Type:Article
Date of Publication (online):2013/12/11
Date of first Publication:2013/12/11
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2014/04/08
Tag:Auric nanoparticles; Gold; In-vivo; Toxicology
Page Number:6
© 2013 Gerber et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 2.0