Practical guidelines: lung transplantation in patients with cystic fibrosis

  • There are no European recommendations on issues specifically related to lung transplantation (LTX) in cystic fibrosis (CF). The main goal of this paper is to provide CF care team members with clinically relevant CF-specific information on all aspects of LTX, highlighting areas of consensus and controversy throughout Europe. Bilateral lung transplantation has been shown to be an important therapeutic option for end-stage CF pulmonary disease. Transplant function and patient survival after transplantation are better than in most other indications for this procedure. Attention though has to be paid to pretransplant morbidity, time for referral, evaluation, indication, and contraindication in children and in adults. This review makes extensive use of specific evidence in the field of lung transplantation in CF patients and addresses all issues of practical importance. The requirements of pre-, peri-, and postoperative management are discussed in detail including bridging to transplant and postoperative complications, immune suppression, chronic allograft dysfunction, infection, and malignancies being the most important. Among the contributors to this guiding information are 19 members of the ECORN-CF project and other experts. The document is endorsed by the European Cystic Fibrosis Society and sponsored by the Christiane Herzog Foundation.

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Author:Tim Oliver HircheGND, Christiane Knoop, Helge Uwe HebestreitORCiDGND, Dee Shimmin, Amparo Solé, Joseph Stuart Elborn, Helmut Ellemunter, Paul Aurora, Michael HogardtORCiDGND, Thomas O. F. WagnerORCiDGND
Pubmed Id:
Parent Title (English):Pulmonary medicine
Place of publication:New York, NY [u.a.]
Document Type:Article
Date of Publication (online):2014/03/30
Date of first Publication:2014/03/30
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Contributing Corporation:ECORN-CF Study Group
Release Date:2014/06/02
Issue:Article ID 621342
Page Number:23
First Page:1
Last Page:22
Copyright © 2014 T. O. Hirche et al. This is an open access article distributed under the   Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 3.0