Is there an association between the H1N1 influenza pandemic vaccination and the manifestation of narcolepsy?

  • After the mass-vaccination campaign during the influenza A (H1N1) 2009 pandemic, a significant increase in narcolepsy incidence was observed initially in Scandinavia, later in other European countries and recently also in Canada. Narcolepsy is a sleep disease caused by the loss of hypocretin-producing cells in the hypothalamus. Almost all narcolepsy patients carry the HLA-DQB1*0602 allele, giving a link to an autoimmune-mediated process. Most of the observed narcolepsy cases were correlated to the vaccination with Pandemrix, the most frequently used vaccine in the EU, and a slight connection to Arepanrix was also detected, which was distributed in Canada. Both vaccines were adjuvanted with AS03, suggesting a possible link between AS03 and narcolepsy. No narcolepsy cases were detected with MF59-adjuvanted or non-adjuvanted influenza vaccines. Recent studies reported differences between Pandemrix and Arepanrix and suggested the vaccine rather than the adjuvant as a suspect for narcolepsy development following vaccination. In addition, in China an increase of narcolepsy cases was reported to occur in absence of vaccination. Possible factors and potential additive effects that may have triggered narcolepsy after the pandemic vaccination are being reviewed in this paper.
Author:Sanita Masoudi, Daniela Ploen, Eberhard HildtORCiDGND
Parent Title (German):Journal of vaccines & vaccination, volume 6.2015, issue 3, 1000280
Publisher:OMICS Publishing Group
Place of publication:Sofia
Document Type:Article
Date of Publication (online):2015/04/04
Date of first Publication:2015/04/04
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Granting Institution:Johann Wolfgang Goethe-Universität
Date of final exam:2014/02/12
Release Date:2016/02/09
Issue:3, 1000280
Page Number:10
Copyright: © 2015 Masoudi S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestrictedv use, distribution, and reproduction in any medium, provided the original author and source are credited.
Institutes:Biochemie, Chemie und Pharmazie / Pharmazie
Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0