Joana Lérias, Georgia Paraschoudi, Ines Silva, João Martins, Eric de Sousa, Carolina Condeço, Nuno Figueiredo, Carlos Carvalho, Ernest Dodoo, Elke Jäger, Martin Rao, Markus Maeurer
- Immune responses to human cytomegalovirus (CMV) can be used to assess immune fitness in an individual. Further to its clinical significance in posttransplantation settings, emerging clinical and translational studies provide examples of immune correlates of protection pertaining to anti-CMV immune responses in the context of cancer or infectious diseases, e.g., tuberculosis. In this viewpoint, we provide a brief overview about CMV-directed immune reactivity and immune fitness in a clinical context and incorporate some of our own findings obtained from peripheral blood or tumour-infiltrating lymphocytes (TIL) from patients with advanced cancer. Observations in patients with solid cancers whose lesions contain both CMV and tumour antigen-specific T-cell subsets are highlighted, due to a possible CMV-associated "bystander" effect in amplifying local inflammation and subsequent tumour rejection. The role of tumour-associated antibodies recognising diverse CMV-derived epitopes is also discussed in light of anti-cancer immune responses. We discuss here the use of anti-CMV immune responses as a theranostic tool—combining immunodiagnostics with a personalised therapeutic potential—to improve treatment outcomes in oncological indications.
MetadatenAuthor: | Joana Lérias, Georgia Paraschoudi, Ines Silva, João Martins, Eric de Sousa, Carolina Condeço, Nuno Figueiredo, Carlos Carvalho, Ernest Dodoo, Elke Jäger, Martin Rao, Markus Maeurer |
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URN: | urn:nbn:de:hebis:30:3-501257 |
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DOI: | https://doi.org/10.3390/ijms20081986 |
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ISSN: | 1422-0067 |
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ISSN: | 1661-6596 |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/31018546 |
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Parent Title (English): | International journal of molecular sciences |
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Publisher: | Molecular Diversity Preservation International |
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Place of publication: | Basel |
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Document Type: | Article |
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Language: | English |
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Year of Completion: | 2019 |
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Date of first Publication: | 2019/04/23 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2019/04/29 |
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Tag: | T cells; antibodies; cancer; cytomegalovirus; immune responses; immunotherapy; interferon gamma |
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Volume: | 20 |
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Issue: | 8, Art. 1986 |
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Page Number: | 13 |
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First Page: | 1 |
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Last Page: | 13 |
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Note: | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). |
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HeBIS-PPN: | 450779661 |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung 4.0 |
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