Aberrant epigenetic regulators control expansion of human CD34+ hematopoietic stem/progenitor cells
- Transcription is a tightly regulated process ensuring the proper expression of numerous genes regulating all aspects of cellular behavior. Transcription factors regulate multiple genes including other transcription factors that together control a highly complex gene network. The transcriptional machinery can be “hijacked” by oncogenic transcription factors, thereby leading to malignant cell transformation. Oncogenic transcription factors manipulate a variety of epigenetic control mechanisms to fulfill gene regulatory and cell transforming functions. These factors assemble epigenetic regulators at target gene promoter sequences, thereby disturbing physiological gene expression patterns. Retroviral vector technology and the availability of “healthy” human hematopoietic CD34+ progenitor cells enable the generation of pre-leukemic cell models for the analysis of aberrant human hematopoietic progenitor cell expansion mediated by leukemogenic transcription factors. This review summarizes recent findings regarding the mechanism by which leukemogenic gene products control human hematopoietic CD34+ progenitor cell expansion by disrupting the normal epigenetic program.
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| Author: | Farnaz Faridi, Kanagaraju Ponnusamy, Isabell Quagliano-Lo Coco, Linping Chen-Wichmann, Manuel GrezGND, Reinhard HenschlerGND, Christian WichmannGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-520383 |
| DOI: | https://doi.org/10.3389/fgene.2013.00254 |
| ISSN: | 1664-8021 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/24348510 |
| Parent Title (English): | Frontiers in genetics |
| Publisher: | Frontiers Media |
| Place of publication: | Lausanne |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2013 |
| Date of first Publication: | 2013/11/28 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2020/01/15 |
| Tag: | HSPC; RUNX1/ETO; epigenetics; leukemia; stem/progenitor cell expansion |
| Volume: | 4 |
| Issue: | Art. 254 |
| Page Number: | 7 |
| First Page: | 1 |
| Last Page: | 7 |
| Note: | Copyright © 2013 Faridi, Ponnusamy, Quagliano-Lo Coco, Chen-Wichmann, Grez, Henschler and Wichmann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| HeBIS-PPN: | 459324896 |
| Institutes: | Medizin / Medizin |
| Angeschlossene und kooperierende Institutionen / Georg-Speyer-Haus | |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 3.0 |
