Autophagy in cancer therapy

  • Autophagy represents a catabolic program involved in the degradation of cellular components via lysosomes. It serves to mitigate cellular stress and to provide metabolic precursors especially upon starvation. Thereby, autophagy can support the survival of cancer cells. In addition, there is now convincing evidence showing that under certain conditions autophagy can also foster cell death. This dual function of autophagy is also relevant upon anticancer treatment, as many chemotherapeutic agents engage autophagy. A better understanding of the molecular mechanisms that are critical for mediating autophagic cell death in cancer cells will be instrumental to selectively interfere with this cellular program in order to increase the cancer cell’s response to cytotoxic drugs. This review illustrates how anticancer drug-induced autophagy is involved in mediating cell death.

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Author:Simone FuldaORCiDGND
Parent Title (English):Frontiers in oncology
Publisher:Frontiers Research Foundation
Place of publication:Lausanne
Document Type:Article
Date of Publication (online):2017/06/15
Date of first Publication:2017/06/15
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/05/19
Tag:autophagic cell death; autophagy; cancer; cancer therapy; cell death
Issue:article 128
First Page:1
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0