Selective progesterone receptor modulators for the medical treatment of uterine fibroids with a focus on ulipristal acetate

  • Uterine fibroids are the most frequent benign tumours in women of child-bearing age. Their symptoms are diverse and the quality of life of the women affected can be significantly impaired. While treatment to date has been primarily by means of surgical intervention, selective progesterone receptor modulators (SPRMs) open up new medication-based treatment options. EMA’s Pharmacovigilance Risk Assessment Committee (PRAC) has recently completed its review of ESMYA® (ulipristal acetate, 5 mg), following reports of serious liver injury, including liver failure leading to transplantation in postmarketing settings. We will provide some information on the PRAC’s recommendations to minimize this risk. Nevertheless, the effectiveness and safety of the SPRM ulipristal acetate (UPA), both with regard to preoperative administration and with regard to an intermittent administration as long-term treatment for patients with symptomatic uterine fibroids, have been shown in several clinical studies (PEARL I–IV).

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Author:Thomas Rabe, Nicole Sänger, Andreas D. Ebert, Thomas Römer, Hans-Rudolf Tinneberg, Rudy Leon de Wilde, Markus Wallwiener
Pubmed Id:
Parent Title (English):BioMed research international
Place of publication:New York [u. a.]
Contributor(s):Peter J. Oefner
Document Type:Article
Year of Completion:2018
Date of first Publication:2018/06/24
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/05/27
Issue:Art. 1374821
Page Number:13
First Page:1
Last Page:12
Corrigendum erschienen in: BioMed research international, 2018, Art. 6124628, doi:10.1155/2018/6124628
Copyright © 2018 Tomas Rabe et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0