Open Access

Nicola Scichilone, John Barnes, Salvatore Battaglia, Alida Benfante, Robert Brown, Giorgio Walter Canonica, Gaetano Caramori, Mario Cazzola, Stefano Centanni, Antonella Cianferoni, Angelo Corsico, Giuseppe De Carlo, Fabiano Di Marco, Mina Gaga, Catherine Hawrylowicz, Enrico Heffler, Maria Gabriella Matera, Andrea Matucci, Pierluigi Paggiaro, Alberto Papi, Todor Popov, Paola Rogliani, Pierachille Santus, Paolo Solidoro, Alkis Togias, Louis-Philippe Boulet

• Severe asthma is an important topic in respiratory diseases, due to its high impact on morbidity and mortality as well as on health-care resources. The many challenges that still exist in the management of the most difficult-to-treat forms of the disease, and the acknowledgement of the existence of unexplored areas in the pathophysiological mechanisms and the therapeutic targets represent an opportunity to gather experts in the field with the immediate goals to summarize current understanding about the natural history of severe asthma and to identify gaps in knowledge and research opportunities, with the aim to contribute to improved medical care and health outcomes. This article is a consensus document from the “International Course on Severe Asthma” that took place in Palermo, Italy, on May 10–11, 2019. Emerging topics in severe asthma were addressed and discussed among experts, with special focus on patient’s needs and research opportunities, with the aim to highlight the unanswered questions in the diagnostic process and therapeutic approach.