Left ventricular hypertrabeculation is not associated with cardiovascular morbity or mortality: insights from the Eurocmr registry

  • Aim: Left ventricular non-compaction (LVNC) is perceived as a rare high-risk cardiomyopathy characterized by excess left ventricular (LV) trabeculation. However, there is increasing evidence contesting the clinical significance of LV hyper-trabeculation and the existence of LVNC as a distinct cardiomyopathy. The aim of this study is to assess the association of LV trabeculation extent with cardiovascular morbidity and all-cause mortality in patients undergoing clinical cardiac magnetic resonance (CMR) scans across 57 European centers from the EuroCMR registry. Methods and Results: We studied 822 randomly selected cases from the EuroCMR registry. Image acquisition was according to international guidelines. We manually segmented images for LV chamber quantification and measurement of LV trabeculation (as per Petersen criteria). We report the association between LV trabeculation extent and important cardiovascular morbidities (stroke, atrial fibrillation, heart failure) and all-cause mortality prospectively recorded over 404 ± 82 days of follow-up. Maximal non-compaction to compaction ratio (NC/C) was mean (standard deviation) 1.81 ± 0.67, from these, 17% were above the threshold for hyper-trabeculation (NC/C > 2.3). LV trabeculation extent was not associated with increased risk of the defined outcomes (morbidities, mortality, LV CMR indices) in the whole cohort, or in sub-analyses of individuals without ischaemic heart disease, or those with NC/C > 2.3. Conclusion: Among 882 patients undergoing clinical CMR, excess LV trabeculation was not associated with a range of important cardiovascular morbidities or all-cause mortality over ~12 months of prospective follow-up. These findings suggest that LV hyper-trabeculation alone is not an indicator for worse cardiovascular prognosis.

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Author:Filip Zemrak, Zahra Raisi-Estabragh, Mohammed Y. Khanji, Saidi A. Mohiddin, Oliver Bruder, Anja Wagner, Massimo Lombardi, Juerg Schwitter, Albert C. van RossumORCiD, Günter Pilz, Detlev Nothnagel, Henning Steen, Eike NagelORCiDGND, Sanjay K. Prasad, Christina Christina Deluigi, Thorsten Dill, Herbert Frank, Steffen Schneider, Heiko Mahrholdt, Steffen Erhard Petersen
Parent Title (English):Frontiers in Cardiovascular Medicine
Publisher:Frontiers Media
Place of publication:Lausanne
Document Type:Article
Date of Publication (online):2020/09/22
Date of first Publication:2020/09/22
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/12/11
Tag:cardiac magnetic; cardiomyopathy; left ventricular non-compaction; left ventricular trabeculation; mortality; resonance
Issue:Article 158
Page Number:11
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0