Long non-coding RNA aerrie controls DNA damage repair via YBX1 to maintain endothelial cell function

  • Aging is accompanied by many physiological changes. These changes can progressively lead to many types of cardiovascular diseases. During this process blood vessels lose their ability to maintain vascular homeostasis, ultimately resulting in hypertension, stroke, or myocardial infarction. Increase in DNA damage is one of the hallmarks of aging and can be repaired by the DNA signaling and repair system. In our study we show that long non-coding RNA Aerrie (linc01013) contributes to the DNA signaling and repair mechanism. Silencing of Aerrie in endothelial cells impairs angiogenesis, migration, and barrier function. Aerrie associates with YBX1 and together they act as important factors in DNA damage signaling and repair. This study identifies Aerrie as a novel factor in genomic stability and as a binding partner of YBX1 in responding to DNA damage.

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Author:Tan Phát PhamORCiD, Diewertje I. BinkORCiD, Laura StanicekGND, Anke van BergenORCiD, Esmee van Leeuwen, Yvonne Tran, Ljubica Matic, Ulf Hedin, Ilka WittigORCiD, Stefanie DimmelerORCiDGND, Reinier BoonORCiDGND
Parent Title (English):Frontiers in cell and developmental biology
Publisher:Frontiers Media
Place of publication:Lausanne
Document Type:Article
Date of Publication (online):2021/01/11
Date of first Publication:2021/01/11
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/01/12
Tag:Aging; DNA Damage; Endothelial cell (EC); LncRNA - long noncoding RNA; cardiovascular disease
Issue:Article 619079
Page Number:16
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0