Ubiquinone binding and reduction by complex I : open questions and mechanistic implications
- NADH: ubiquinone oxidoreductase (complex I) is the first enzyme complex of the respiratory chain. Complex I is a redox-driven proton pump that contributes to the proton motive force that drives ATP synthase. The structure of complex I has been analyzed by x-ray crystallography and electron cryo-microscopy and is now well-described. The ubiquinone (Q) reduction site of complex I is buried in the peripheral arm and a tunnel-like structure is thought to provide access for the hydrophobic substrate from the membrane. Several intermediate binding positions for Q in the tunnel were identified in molecular simulations. Structural data showed the binding of native Q molecules and short chain analogs and inhibitors in the access pathway and in the Q reduction site, respectively. We here review the current knowledge on the interaction of complex I with Q and discuss recent hypothetical models for the coupling mechanism.
Download full text files
Additional Services
| Author: | Etienne Galemou YogaGND, Jonathan Schiller, Volker ZickermannORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-612487 |
| DOI: | https://doi.org/10.3389/fchem.2021.672851 |
| ISSN: | 2296-2646 |
| Parent Title (English): | Frontiers in Chemistry |
| Publisher: | Frontiers Media |
| Place of publication: | Lausanne |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2021/04/30 |
| Date of first Publication: | 2021/04/30 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2021/06/30 |
| Tag: | NADH dehydrogenase; electron transfer; inhibitor; oxidative phosphorylation; proton pumping; respiratory chain; semiquinone |
| Volume: | 9 |
| Issue: | art. 672851 |
| Page Number: | 9 |
| First Page: | 1 |
| Last Page: | 9 |
| HeBIS-PPN: | 484658832 |
| Institutes: | Medizin |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
| Sammlungen: | Universitätspublikationen |
| Open-Access-Publikationsfonds: | Medizin |
| Licence (German): |  Creative Commons - Namensnennung 4.0 |
