A decade of organs-on-a-chip emulating human physiology at the microscale: a critical status report on progress in toxicology and pharmacology

  • Organ-on-a-chip technology has the potential to accelerate pharmaceutical drug development, improve the clinical translation of basic research, and provide personalized intervention strategies. In the last decade, big pharma has engaged in many academic research cooperations to develop organ-on-a-chip systems for future drug discoveries. Although most organ-on-a-chip systems present proof-of-concept studies, miniaturized organ systems still need to demonstrate translational relevance and predictive power in clinical and pharmaceutical settings. This review explores whether microfluidic technology succeeded in paving the way for developing physiologically relevant human in vitro models for pharmacology and toxicology in biomedical research within the last decade. Individual organ-on-a-chip systems are discussed, focusing on relevant applications and highlighting their ability to tackle current challenges in pharmacological research.

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Author:Mario Rothbauer, Barbara E. M. Bachmann, Christoph Eilenberger, Sebastian R. A. Kratz, Sarah Spitz, Gregor Höll, Peter Ertl
Parent Title (English):Micromachines
Place of publication:Basel
Document Type:Article
Date of Publication (online):2021/04/21
Date of first Publication:2021/04/21
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/10/06
Tag:bioprinting; body-on-a-chip; heart-on-a-chip; kidney-on-a-chip; liver-on-a-chip; lung-on-a-chip; micro-physiological systems; organs-on-a-chip; skin-on-a-chip
Issue:5, art. 470
Page Number:54
First Page:1
Last Page:54
The APC was funded by TU Wien University Library for financial support through its Open Access Funding Program.
Institutes:Biochemie, Chemie und Pharmazie
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
6 Technik, Medizin, angewandte Wissenschaften / 62 Ingenieurwissenschaften / 620 Ingenieurwissenschaften und zugeordnete Tätigkeiten
Licence (German):License LogoCreative Commons - Namensnennung 4.0