Prevalence of sleep disordered breathing in patients with primary mitral regurgitation undergoing mitral valve surgery

  • Sleep disordered breathing (SDB) is a frequent comorbidity in cardiac disease patients. Nevertheless, the prevalence and relationship between SDB and severe primary mitral regurgitation (PMR) has not been well investigated to date. Methods: A cohort of 121 patients with significant PMR undergoing mitral valve surgery were prospectively enrolled and received a cardiorespiratory single night polygraphy screening using ApneaLink before surgery. Eighty-two of them underwent a follow-up examination including a follow-up single-night sleep study 3 months after surgery. Results: The mean age of patients was 65.3 ± 12.0 years. Sixty patients (49.6%) were female. The mean EuroSCORE II was 2.5 ± 2.4%. Initially, 91 (75.2%) patients presented with SDB, among whom 50.4% (46 patients, 38.0% of total cohort) were classified as moderate to severe. These patients tended to require significantly longer postoperative intensive care and mechanical ventilation. Among the 82 patients who completed follow-up exams, mitral valve surgery led to a significant reduction in relevant SDB (20.7%). The apnea-hypopnea index (from 11/h [4;18] to 4/h [3;14] (p = 0.04)), the oxygenation-desaturation index (from 8/h [3;18] to 5/h [3;12] (p = 0.008)) as well as the saturation time below 90% (from 32 min [13;86] to 18 min [5;36] (p = 0.005)), were all shown to be improved significantly. Conclusion: The prevalence of SDB is very high in patients with severe primary mitral regurgitation and may contribute to postoperative complications and prolonged intensive care. A significantly reduced but still high prevalence of SDB was observed 3 months after mitral valve surgery, highlighting the bidirectional relationship between SDB and heart failure.

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Author:Muhammed GerçekORCiDGND, Olaf Oldenburg, Mustafa Gerçek, Henrik FoxORCiDGND, Volker Rudolph, Thomas Pühler, Hazem Omran, Lisa Katharina Wolf, Kavous Hakim-Meibodi, Andreas M. ZeiherORCiDGND, Jan Gummert, Zisis DimitriadisORCiDGND
Parent Title (English):Journal of clinical medicine
Place of publication:Basel
Document Type:Article
Date of Publication (online):2021/05/10
Date of first Publication:2021/05/10
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/08/11
Tag:mitral regurgitation; mitral valve surgery; sleep disordered breathing
Issue:9, art. 2039
Page Number:9
First Page:1
Last Page:9
The study was supported by the Medical Faculty, Ruhr-Universität Bochum, Germany(FoRUM programme F811-14).
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0