Patient-guided modifications of oral anticoagulant drug intake during Ramadan fasting: a multicenter cross-sectional study

  • Fasting Ramadan is known to influence patients’ medication adherence. Data on patients’ behavior to oral anticoagulant (OAC) drug intake during Ramadan is missing. We aimed to determine patient-guided modifications of OAC medication regimen during Ramadan and to evaluate its consequences. A multicenter cross-sectional study conducted in Saudi Arabia. Data were collected shortly after Ramadan 2019. Participants were patients who fasted Ramadan and who were on long-term anticoagulation. Patient-guided medication changes during Ramadan in comparison to the regular intake schedule before Ramadan were recorded. Modification behavior was compared between twice daily (BID) and once daily (QD) treatment regimens. Rates of hospital admission during Ramadan were determined. We included 808 patients. During Ramadan, 53.1% modified their intake schedule (31.1% adjusted intake time, 13.2% skipped intakes, 2.2% took double dosing). A higher frequency of patient-guided modification was observed in patients on BID regimen compared to QD regimen. During Ramadan, 11.3% of patients were admitted to hospital. Patient-guided modification was a strong predictor for hospital admission. Patient-guided modification of OAC intake during Ramadan is common, particularly in patients on BID regimen. It increases the risk of hospital admission during Ramadan. Planning of OAC intake during Ramadan and patient education on the risk of low adherence are advisable.
Author:AbdulAziz BatarfiORCiD, Haitham AleneziGND, Abdulrahman Alshehri, Saud Balelah, Hameedullah Kazim, Mohammed Algthami, Mariam M. Hussain, Nada Alshehri, Rahaf Alsharif, Hadeel Ashour, Mutaz Althobaiti, Shomokh Alotaibi, Helmuth SteinmetzORCiDGND, Christian FörchORCiDGND
Parent Title (English):Journal of thrombosis and thrombolysis
Publisher:Springer Science + Business Media B.V
Place of publication:Dordrecht [u.a.]
Document Type:Article
Date of Publication (online):2020/07/14
Date of first Publication:2020/07/14
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/01/05
Tag:Adherence; Education; Fasting; Oral anticoagulation; Ramadan; Saudi Arabia
Page Number:9
First Page:485
Last Page:493
Open Access funding provided by Projekt DEAL.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0