Patterns of care, toxicity and outcome in the treatment of salivary gland carcinomas: long-term experience from a tertiary cancer center

  • Background; Salivary gland carcinomas (SGC) cover a heterogeneous group of malignancies with a lack of data of high-level evidence. Methods; Clinical data of 127 patients treated for SGC at a university cancer center between 2002 and 2017 were analyzed retrospectively. The association of clinicopathological characteristics, treatment modalities, adverse events, and outcome was assessed. Results: Patients received surgery (n = 65), surgery followed by (chemo-)radiotherapy (n = 56), or primary (chemo-)radiotherapy (n = 6). Injury to the cranial nerves or their branches was the most frequent surgical complication affecting 40 patients (33.1%). Ten year overall and progression-free survival rates were 73.2% and 65.4%, respectively. Parotid tumor site, advanced tumor, and positive nodal stage remained independent negative prognostic factors for overall survival, loco-regional and distant tumor control in multivariate analysis. Conclusions: Optimizing treatment strategies for SGC, depending on distinct clinicopathological factors, remains challenging due to the low incidence rates of the disease.

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Author:Jens Müller-von der GrünORCiDGND, Anne Ria WinkelmannGND, Franz RödelORCiDGND, Sven BalsterGND, Thomas Peter Michael NeumayerGND, Shahram Michael GhanaatiORCiDGND, Christian Hubertus BrandtsORCiDGND, Iris BurckORCiDGND, Daniel MartinGND, Claus RödelORCiDGND, Nikolina KesarGND, Panagiotis BalermpasORCiDGND
Parent Title (English):European archives of oto-rhino-laryngology and head & neck
Place of publication:Berlin ; Heidelberg
Document Type:Article
Date of Publication (online):2021/03/24
Date of first Publication:2021/03/24
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/01/31
Tag:Head and neck cancer; Patterns of care; Radiotherapy; Salivary gland carcinoma; Surgery
Page Number:11
First Page:4411
Last Page:4421
This work was supported by grants from the Else Kröner-Fresenius-Stiftung to Jens von der Grün. Open Access funding enabled and organized by Projekt DEAL.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0