The LiverTox paradox-gaps between promised data and reality check

  • The LiverTox database compiles cases of idiosyncratic drug-induced liver injury (iDILI) with the promised aims to help identify hepatotoxicants and provide evidence-based information on iDILI. Weaknesses of this approach include case selection merely based on published case number and not on a strong causality assessment method such as the Roussel Uclaf Causality Assessment Method (RUCAM). The aim of this analysis was to find out whether the promised aims have been achieved by comparison of current iDILI case data with those promised in 2012 in LiverTox. First, the LiverTox criteria of likelihood categories applied to iDILI cases were analyzed regarding robustness. Second, the quality was analyzed in LiverTox cases caused by 46 selected drugs implicated in iDILI. LiverTox included iDILI cases of insufficient quality because most promised details were not fulfilled: (1) Standard liver injury definition; (2) incomplete narratives or inaccurate for alternative causes; and (3) not a single case was assessed for causality with RUCAM, as promised. Instead, causality was arbitrarily judged on the iDILI case number presented in published reports with the same drug. All of these issues characterize the paradox of LiverTox, requiring changes in the method to improve data quality and database reliability. In conclusion, establishing LiverTox is recognized as a valuable effort, but the paradox due to weaknesses between promised data quality and actual data must be settled by substantial improvements, including, for instance, clear definition and identification of iDILI cases after evaluation with RUCAM to establish a robust causality grading.

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Metadaten
Author:Rolf TeschkeORCiDGND, Gaby DananORCiD
URN:urn:nbn:de:hebis:30:3-692555
DOI:https://doi.org/10.3390/diagnostics11101754
ISSN:2075-4418
Parent Title (English):Diagnostics
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2021/09/24
Date of first Publication:2021/09/24
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2023/07/05
Tag:DILI database case quality; LiverTox; Roussel Uclaf Causality Assessment Method (RUCAM); iDILI; idiosyncratic drug-induced liver injury
Volume:11
Issue:10, art. 1754
Article Number:1754
Page Number:12
First Page:1
Last Page:12
Note:
Data supporting the results of the analysis can be retrived from the following sources: LiverTox. Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. LiverTox Database. Updated: 9 February 2021. Available at: https://www.ncbi.nlm.nih.gov/books/NBK547852/ accessed on 19 May 2021; Hoofnagle JH. Relaunched LiverTox remains important resource to diagnosis DILI. Available at: https://www.aasldnews.org/relaunched-livertox-remains-important-resource-to-diagnosis-dili/ accessed on 19 May 2021.
HeBIS-PPN:512234876
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universit├Ątspublikationen
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International