Why is endothelial resilience key to maintain cardiac health?
- Myocardial injury as induced by myocardial infarction results in tissue ischemia, which critically incepts cardiomyocyte death. Endothelial cells play a crucial role in restoring oxygen and nutrient supply to the heart. Latest advances in single-cell multi-omics, together with genetic lineage tracing, reveal a transcriptional and phenotypical adaptation to the injured microenvironment, which includes alterations in metabolic, mesenchymal, hematopoietic and pro-inflammatory signatures. The extent of transition in mesenchymal or hematopoietic cell lineages is still debated, but it is clear that several of the adaptive phenotypical changes are transient and endothelial cells revert back to a naïve cell state after resolution of injury responses. This resilience of endothelial cells to acute stress responses is important for preventing chronic dysfunction. Here, we summarize how endothelial cells adjust to injury and how this dynamic response contributes to repair and regeneration. We will highlight intrinsic and microenvironmental factors that contribute to endothelial cell resilience and may be targetable to maintain a functionally active, healthy microcirculation.
Author: | Lukas TomborORCiDGND, Stefanie DimmelerORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-694735 |
DOI: | https://doi.org/10.1007/s00395-022-00941-8 |
ISSN: | 1435-1803 |
Parent Title (English): | Basic research in cardiology |
Publisher: | Steinkopff , Springer |
Place of publication: | [Darmstadt u.a.] , Heidelberg |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2022/07/14 |
Date of first Publication: | 2022/07/14 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2023/04/27 |
Tag: | Cardiac remodeling; Endothelial; Endothelial-to-mesenchymal transition; Microenvironment; Myocardial infarction; Plasticity; Resilience |
Volume: | 117 |
Issue: | 1, art. 35 |
Article Number: | 35 |
Page Number: | 15 |
First Page: | 1 |
Last Page: | 15 |
Note: | The authors thank the German Research Foundation (DFG) for support (SFB1366 Project B4 and EXC 2026-1). |
Note: | Open Access funding enabled and organized by Projekt DEAL. |
HeBIS-PPN: | 508544548 |
Institutes: | Biowissenschaften |
Medizin | |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |