Metabolic profiling in rheumatoid arthritis, psoriatic arthritis, and psoriasis: elucidating pathogenesis, improving diagnosis, and monitoring disease activity

  • Immune-mediated inflammatory diseases (IMIDs), such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), and psoriasis (Ps), represent autoinflammatory and autoimmune disorders, as well as conditions that have an overlap of both categories. Understanding the underlying pathogeneses, making diagnoses, and choosing individualized treatments remain challenging due to heterogeneous disease phenotypes and the lack of reliable biomarkers that drive the treatment choice. In this review, we provide an overview of the low-molecular-weight metabolites that might be employed as biomarkers for various applications, e.g., early diagnosis, disease activity monitoring, and treatment-response prediction, in RA, PsA, and Ps. The literature was evaluated, and putative biomarkers in different matrices were identified, categorized, and summarized. While some of these candidate biomarkers appeared to be disease-specific, others were shared across multiple IMIDs, indicating common underlying disease mechanisms. However, there is still a long way to go for their application in a routine clinical setting. We propose that studies integrating omics analyses of large patient cohorts from different IMIDs should be performed to further elucidate their pathomechanisms and treatment options. This could lead to the identification and validation of biomarkers that might be applied in the context of precision medicine to improve the clinical outcomes of these IMID patients.

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Author:Erika DorochowORCiD, Michaela KöhmORCiDGND, Lisa Katharina HahnefeldORCiDGND, Robert GurkeORCiDGND
Parent Title (English):Journal of Personalized Medicine
Place of publication:Basel
Document Type:Article
Date of Publication (online):2022/06/02
Date of first Publication:2022/06/02
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/02/14
Tag:arthritis; biomarkers; immune-mediated inflammatory diseases; lipidomics; metabolomics; precision medicine; psoriasis; psoriatic; rheumatoid
Issue:6, art. 924
Article Number:924
Page Number:23
First Page:1
Last Page:23
This work was supported by the Deutsche Forschungsgemeinschaft Sonderforschungsbereich SFB 1039/Z01 “Krankheitsrelevante Signaltransduktion durch Fettsäurederivate und Sphingolipide” and by the Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD).
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International