Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

  • Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families as well as 438 subjects from an independent, sporadic BD case-control cohort were analysed. Polygenic risk scores (PRS) for BD, schizophrenia, and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had significantly higher PRS for all three psychiatric disorders than the independent controls, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and sporadic BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses, therefore, demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. The PRS explained only part of the observed phenotypic variance and rare variants might have also contributed to disease development.

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Author:Till AndlauerORCiDGND, José Guzman-ParraORCiDGND, Fabian StreitORCiDGND, Jana StrohmaierORCiDGND, Maria José González, Susana Gil Flores, Francisco J. Cabaleiro Fabeiro, Francisco del Rı́o NoriegaORCiD, Fermin Perez Perez, Jesus Haro González, Guillermo Orozco Diaz, Yolanda de Diego-OteroORCiD, Berta Moreno-KuestnerORCiDGND, Georg AuburgerORCiDGND, Franziska DegenhardtORCiDGND, Stefanie Heilmann-HeimbachORCiDGND, Stefan HermsORCiD, Per HoffmannORCiDGND, Josef FrankORCiDGND, Jerome Clifford FooORCiDGND, Jens TreutleinORCiDGND, Stephanie H. WittORCiDGND, Sven CichonORCiDGND, Manolis KogevinasORCiD, Fabio RivasORCiD, Fermı́n MayoralORCiD, Bertram Müller-MyhsokORCiD, Andreas Josef ForstnerORCiDGND, Markus Maria NöthenORCiDGND, Marcella RietschelORCiDGND
Parent Title (English):bioRxiv
Document Type:Preprint
Date of Publication (online):2018/12/20
Date of first Publication:2018/12/20
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Contributing Corporation:Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Release Date:2023/03/17
Page Number:16
Preprint, später in Molecular Psychiatry doi: 10.1038/s41380-019-0558-2
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0