Distinct feedforward and feedback pathways for cell-type specific attention effects

  • Spatial attention increases both inter-areal synchronization and spike rates across the visual hierarchy. To investigate whether these attentional changes reflect distinct or common mechanisms, we performed simultaneous laminar recordings of identified cell classes in macaque V1 and V4. Enhanced V4 spike rates were expressed by both excitatory neurons and fast-spiking interneurons, and were most prominent and arose earliest in time in superficial layers, consistent with a feedback modulation. By contrast, V1-V4 gamma-synchronization reflected feedforward communication and surprisingly engaged only fast-spiking interneurons in the V4 input layer. In mouse visual cortex, we found a similar motif for optogenetically identified inhibitory-interneuron classes. Population decoding analyses further indicate that feedback-related increases in spikes rates encoded attention more reliably than feedforward-related increases in synchronization. These findings reveal distinct, cell-type-specific feedforward and feedback pathways for the attentional modulation of inter-areal synchronization and spike rates, respectively.

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Author:Georgios Spyropoulos, Marius SchneiderORCiD, Jochem van KempenORCiD, Marc Alwin GieselmannORCiDGND, Alexander ThieleORCiDGND, Martin VinckORCiD
Parent Title (English):bioRxiv
Document Type:Preprint
Date of Publication (online):2022/11/30
Date of first Publication:2022/11/30
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2023/03/22
Page Number:22
Dewey Decimal Classification:1 Philosophie und Psychologie / 15 Psychologie / 150 Psychologie
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International