Impact of scaffold granule size use in Masquelet technique on periosteal reaction: a study in rat femur critical size bone defect model

  • Purpose: The Masquelet technique for the treatment of large bone defects is a two-stage procedure based on an induced membrane. Compared to mature periosteum, the induced membrane differs significantly. However, both play a crucial role in bone regeneration. As part of a histological and radiological post-evaluation of an earlier project, we analyzed the influence of the granule size of the bone void filler Herafill® on development of periosteum regrowth in a critical size defect. Methods: We compared three different sizes of Herafill® granules (Heraeus Medical GmbH, Wehrheim) in vivo in a rat femoral critical size defect (10 mm) treated with the induced membrane technique. After 8 weeks healing time, femurs were harvested and taken for histological and radiological analysis. Results: A significantly increased regrowth of periosteum into the defect was found when small granules were used. Large granules showed significantly increased occurrence of bone capping. Small granules lead to significant increase in callus formation in the vicinity to the membrane. Conclusion: The size of Herafill® granules has significant impact on the development of periosteal-like structures around the defect using Masquelet’s induced membrane technique. Small granules show significantly increased regrowth of periosteum and improved bone formation adjacent to the induced membrane.

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Author:Maximilian LeibleinORCiDGND, Andreas Thomas WinkenbachGND, Elias KochGND, Alexander Schaible, Hubert BüchnerORCiD, Ingo MarziORCiDGND, Dirk HenrichORCiDGND, Christoph Nau
URN:urn:nbn:de:hebis:30:3-744992
DOI:https://doi.org/10.1007/s00068-020-01516-9
ISSN:1863-9941
Parent Title (English):European journal of trauma and emergency surgery
Publisher:Springer Medizin
Place of publication:Heidelberg
Document Type:Article
Language:English
Date of Publication (online):2020/10/06
Date of first Publication:2020/10/06
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/08/03
Volume:48
Issue:1
Page Number:9
First Page:679
Last Page:687
Note:
Open Access funding enabled and organized by Projekt DEAL. This project was funded in part by Heraeus Medical GmbH, Wehrheim, Germany.
HeBIS-PPN:512742669
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International