Mitochondrial functions in infection and immunity

  • Mitochondria have a central role in regulating a range of cellular activities and host responses upon bacterial infection. Multiple pathogens affect mitochondria dynamics and functions to influence their intracellular survival or evade host immunity. On the other side, major host responses elicited against infections are directly dependent on mitochondrial functions, thus placing mitochondria centrally in maintaining homeostasis upon infection. In this review, we summarize how different bacteria and viruses impact morphological and functional changes in host mitochondria and how this manipulation can influence microbial pathogenesis as well as the host cell metabolism and immune responses.

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Metadaten
Author:Varnesh TikuORCiDGND, Man-Wah TanORCiD, Ivan ĐikićORCiDGND
URN:urn:nbn:de:hebis:30:3-777419
DOI:https://doi.org/10.1016/j.tcb.2020.01.006
ISSN:0962-8924
Parent Title (English):Trends in Cell Biology
Publisher:Elsevier
Place of publication:Amsterdam
Document Type:Article
Language:English
Date of Publication (online):2020/09/09
Date of first Publication:2020/02/11
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/10/16
Tag:bacteria; cell death; innate immunity; mitochondrial metabolism; mitochondrial morphology; viruses
Volume:30
Issue:4
Page Number:15
First Page:263
Last Page:275
HeBIS-PPN:515679356
Institutes:Medizin
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International