Mitochondrial functions in infection and immunity
- Mitochondria have a central role in regulating a range of cellular activities and host responses upon bacterial infection. Multiple pathogens affect mitochondria dynamics and functions to influence their intracellular survival or evade host immunity. On the other side, major host responses elicited against infections are directly dependent on mitochondrial functions, thus placing mitochondria centrally in maintaining homeostasis upon infection. In this review, we summarize how different bacteria and viruses impact morphological and functional changes in host mitochondria and how this manipulation can influence microbial pathogenesis as well as the host cell metabolism and immune responses.
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| Author: | Varnesh TikuORCiDGND, Man-Wah TanORCiD, Ivan ĐikićORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-777419 |
| DOI: | https://doi.org/10.1016/j.tcb.2020.01.006 |
| ISSN: | 0962-8924 |
| Parent Title (English): | Trends in Cell Biology |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2020/09/09 |
| Date of first Publication: | 2020/02/11 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2023/10/16 |
| Tag: | bacteria; cell death; innate immunity; mitochondrial metabolism; mitochondrial morphology; viruses |
| Volume: | 30 |
| Issue: | 4 |
| Page Number: | 15 |
| First Page: | 263 |
| Last Page: | 275 |
| HeBIS-PPN: | 515679356 |
| Institutes: | Medizin |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - CC BY - Namensnennung 4.0 International |
