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Concordance between preoperative mpMRI and pathological stage and its influence on nerve-sparing surgery in patients with high-risk prostate cancer

  • Background: We aimed to determine the concordance between the radiologic stage (rT), using multiparametric magnetic resonance imaging (mpMRI), and pathologic stage (pT) in patients with high-risk prostate cancer and its influence on nerve-sparing surgery compared to the use of the intraoperative frozen section technique (IFST). Methods: The concordance between rT and pT and the rates of nerve-sparing surgery and positive surgical margin were assessed for patients with high-risk prostate cancer who underwent radical prostatectomy. Results: The concordance between the rT and pT stages was shown in 66.4% (n = 77) of patients with clinical high-risk prostate cancer. The detection of patients with extraprostatic disease (≥pT3) by preoperative mpMRI showed a sensitivity, negative predictive value and accuracy of 65.1%, 51.7% and 67.5%. In addition to the suspicion of extraprostatic disease in mpMRI (≥rT3), 84.5% (n = 56) of patients with ≥rT3 underwent primary nerve-sparing surgery with IFST, resulting in 94.7% (n = 54) of men with at least unilateral nerve-sparing surgery after secondary resection with a positive surgical margin rate related to an IFST of 1.8% (n = 1). Conclusion: Patients with rT3 should not be immediately excluded from nerve-sparing surgery, as by using IFST some of these patients can safely undergo nerve-sparing surgery.

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Verfasserangaben:Clara Julia HumkeGND, Robert Benedikt HöhORCiDGND, Felix PreißerORCiDGND, Mike WenzelORCiDGND, Maria-Noemi WelteGND, Lena Hermine TheißenGND, Boris BodelleGND, Jens KöllermannORCiDGND, Thomas SteuberGND, Alexander HaeseGND, Frederik RoosGND, Luis KluthORCiDGND, Andreas BeckerGND, Felix ChunORCiDGND, Philipp MandelORCiDGND
URN:urn:nbn:de:hebis:30:3-818051
DOI:https://doi.org/10.3390/curroncol29040193
ISSN:1718-7729
Titel des übergeordneten Werkes (Englisch):Current oncology
Verlag:Multimed
Verlagsort:Toronto, Ontario
Dokumentart:Wissenschaftlicher Artikel
Sprache:Englisch
Datum der Veröffentlichung (online):28.03.2022
Datum der Erstveröffentlichung:28.03.2022
Veröffentlichende Institution:Universitätsbibliothek Johann Christian Senckenberg
Datum der Freischaltung:31.01.2024
Freies Schlagwort / Tag:multiparametric magnetic resonance imaging; nerve-sparing surgery; prostate cancer; radical prostatectomy
Jahrgang:29
Ausgabe / Heft:4
Seitenzahl:10
Erste Seite:2385
Letzte Seite:2394
Institute:Medizin
DDC-Klassifikation:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Lizenz (Deutsch):License LogoCreative Commons - CC BY - Namensnennung 4.0 International