Vitamin D deficiency is associated with increased disease activity in patients with inflammatory bowel disease
- Background and Aims: Vitamin D has an inhibitory role in the inflammatory signaling pathways and supports the integrity of the intestinal barrier. Due to its immunomodulatory effect, vitamin D plays a role in chronic inflammatory bowel disease (IBD) and a deficiency is associated with an increased risk for a flare. We aimed to investigate to what extent the 25-hydroxyvitamin D (25(OH)D3) level correlates with disease activity and whether a cut-off value can be defined that discriminates between active disease and remission. Methods: Patients with IBD, treated at the University Hospital Frankfurt were analyzed retrospectively. The 25(OH)D3 levels were correlated with clinical activity indices and laboratory chemical activity parameters. A deficiency was defined as 25(OH)D3 levels <30 ng/mL. Results: A total of 470 (257 female) patients with IBD were included, 272 (57.9%) with Crohn’s disease (CD), 198 (42.1%) with ulcerative colitis (UC). The median age of the patients was 41 (18–84). In 283 patients (60.2%), a vitamin D deficiency was detected. 245 (53.6%) patients received oral vitamin D supplementation, and supplemented patients had significantly higher vitamin D levels (p < 0.0001). Remission, vitamin D substitution, and male gender were independently associated with the 25(OH)D3 serum concentration in our cohort in regression analysis. A 25(OH)D3 serum concentration of 27.5 ng/mL was the optimal cut-off value. Conclusion: Vitamin D deficiency is common in IBD patients and appears to be associated with increased disease activity. In our study, vitamin D levels were inversely associated with disease activity. Thus, close monitoring should be established, and optimized supplementation should take place.
Verfasserangaben: | Johannes HausmannORCiDGND, Alica KubeschORCiDGND, Mana Amiri, Natalie FilmannORCiDGND, Irina Ursula BlumensteinORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-512800 |
DOI: | https://doi.org/10.3390/jcm8091319 |
ISSN: | 2077-0383 |
Pubmed-Id: | https://pubmed.ncbi.nlm.nih.gov/31461996 |
Titel des übergeordneten Werkes (Englisch): | Journal of Clinical Medicine |
Verlag: | MDPI |
Verlagsort: | Basel |
Dokumentart: | Wissenschaftlicher Artikel |
Sprache: | Englisch |
Jahr der Fertigstellung: | 2019 |
Datum der Erstveröffentlichung: | 27.08.2019 |
Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Datum der Freischaltung: | 10.10.2019 |
Freies Schlagwort / Tag: | Crohn’s disease; IBD; Ulcerative colitis; calcitriol; intestinal barrier; mucosal inflammation; vitamin D |
Jahrgang: | 8 |
Ausgabe / Heft: | 9, Art. 1319 |
Seitenzahl: | 9 |
Erste Seite: | 1 |
Letzte Seite: | 9 |
Bemerkung: | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
HeBIS-PPN: | 455370664 |
Institute: | Medizin / Medizin |
DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Open-Access-Publikationsfonds: | Medizin |
Lizenz (Deutsch): | Creative Commons - Namensnennung 4.0 |