Filtern
Erscheinungsjahr
Dokumenttyp
- Wissenschaftlicher Artikel (402) (entfernen)
Volltext vorhanden
- ja (402)
Gehört zur Bibliographie
- nein (402)
Schlagworte
- Heavy Ion Experiments (20)
- Hadron-Hadron Scattering (11)
- Hadron-Hadron scattering (experiments) (11)
- LHC (9)
- Heavy-ion collision (6)
- ALICE experiment (4)
- Collective Flow (4)
- Jets (4)
- Quark-Gluon Plasma (4)
- ALICE (3)
- Heavy Ions (3)
- Jets and Jet Substructure (3)
- pp collisions (3)
- Beauty production (2)
- Charm physics (2)
- Experimental nuclear physics (2)
- Experimental particle physics (2)
- Heavy Quark Production (2)
- Lepton-Nucleon Scattering (experiments) (2)
- Particle Correlations and Fluctuations (2)
- Particle and resonance production (2)
- Particle correlations and fluctuations (2)
- Pb–Pb collisions (2)
- QCD (2)
- Single electrons (2)
- 900 GeV (1)
- ALICE detector (1)
- Anti-nuclei (1)
- Bacteraemia (1)
- Berufliche Gesundheit (1)
- Berufszufriedenheit (1)
- Betriebliche Gesundheitsförderung (1)
- Bloodstream infections (1)
- Boosted Jets (1)
- Büroarbeit (1)
- CVID (1)
- Cancer models (1)
- Centrality Class (1)
- Centrality Selection (1)
- Cognitive impairment (1)
- Collective Flow, (1)
- Comparison with QCD (1)
- Dance (1)
- Dehntraining (1)
- Electron-pion identification (1)
- Electroweak interaction (1)
- Elliptic flow (1)
- European Society for Immunodeficiencies (ESID) (1)
- Extracorporeal devices (1)
- Femtoscopy (1)
- Fibre/foam sandwich radiator (1)
- First-line regimen (1)
- Five-Konzept (1)
- Genetic engineering (1)
- German PID-NET registry (1)
- HBT (1)
- HIV (1)
- Hadron production (1)
- Hadron-Hadron Scattering Heavy (1)
- Hadron-hadron interactions (1)
- Haemodialysis (1)
- Hard Scattering (1)
- Heavy Ion Experiment (1)
- Heavy flavor production (1)
- Heavy flavour production (1)
- Heavy ions (1)
- Heavy-flavour decay muons (1)
- Heavy-flavour production (1)
- Heavy-ion collisions (1)
- Hyperons (1)
- IgG substitution therapy (1)
- Inclusive spectra (1)
- Intensity interferometry (1)
- Invariant Mass Distribution (1)
- Ionisation energy loss (1)
- Jet Physics (1)
- Jet Substructure (1)
- Job satisfaction (1)
- Lebensqualität (1)
- Leukaemia (1)
- Mid-rapidity (1)
- Minimum Bias (1)
- Monte Carlo (1)
- Multi-Parton Interactions (1)
- Multi-strange baryons (1)
- Multi-wire proportional drift chamber (1)
- Musculoskeletal diseases (1)
- Muskuloskeletale Erkrankungen (1)
- NMDA IgA/IgM antibodies (1)
- NMDA antibody (1)
- Neural network (1)
- Nuclear modification factor (1)
- Nucleus (1)
- Occupational health (1)
- Office work (1)
- PID prevalence (1)
- PYTHIA (1)
- Parkinson disease (1)
- Particle and Resonance Production (1)
- Pb–Pb (1)
- Pedagogue (1)
- Pharmacodynamics (1)
- Production Cross Section (1)
- Properties of Hadrons (1)
- Proton (1)
- Proton–proton (1)
- Pädagoge/in (1)
- Quality of life (1)
- Quark Deconfinement (1)
- Quark Gluon Plasma (1)
- Quark Production (1)
- Quark gluon plasma (1)
- Quarkonium (1)
- Rapidity Range (1)
- Relativistic heavy ion physics (1)
- Relativistic heavy-ion collisions (1)
- Resolution Parameter (1)
- SF-36 (1)
- Single muons (1)
- Strangeness (1)
- Stretch training (1)
- Subjective health status (1)
- Subjektiver Gesundheitszustand (1)
- Systematic Uncertainty (1)
- TR (1)
- Tanz (1)
- Target validation (1)
- Time Projection Chamber (1)
- Tracking (1)
- Transition radiation detector (1)
- Transverse momentum (1)
- Treatment modification (1)
- Trigger (1)
- Vector Boson Production (1)
- Work health promotion (1)
- Xenon-based gas mixture (1)
- amplicon sequencing (1)
- anticoagulation (1)
- atrial fibrillation (1)
- bacteria (1)
- biogeographic legaciese (1)
- cART (1)
- dE/dx (1)
- decomposition (1)
- forest classification (1)
- forest functional similarity (1)
- heavy ion experiments (1)
- left atrial appendage occlusion (1)
- metabarcoding (1)
- musculoskeletal disorders (1)
- nematode diversity (1)
- occupational health (1)
- phylogenetic community distance (1)
- primary immunodeficiency (PID) (1)
- quality of life (1)
- quark gluon plasma (1)
- registry for primary immunodeficiency (1)
- spectra (1)
- stretching (1)
- stroke (1)
- temperate forest (1)
- trophic interactions (1)
- tropical forests (1)
- workplace health promotion (1)
- √sN N = 2.76 TeV (1)
Institut
Background: Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic asthma. Leukotriene receptor antagonists are recommended as add-on therapy for this disease. The cys-leukotriene-1 receptor antagonist montelukast has been used in clinical asthma therapy during the last years. Besides its inhibitory action on bronchoconstriction, only little is known about its effects on airway secretions. Therefore, the aim of this study was to evaluate the effects of montelukast on platelet activating factor- and tachykinin induced tracheal secretory activity.
Methods: The effects of montelukast on platelet activating factor- and tachykinin induced tracheal secretory activity in the rat were assessed by quantification of secreted 35SO4 labelled mucus macromolecules using the modified Ussing chamber technique.
Results: Platelet activating factor potently stimulated airway secretion, which was completely inhibited by the platelet activating factor receptor antagonist WEB 2086 and montelukast. In contrast, montelukast had no effect on tachykinin induced tracheal secretory activity.
Conclusion: Cys-leukotriene-1 receptor antagonism by montelukast reverses the secretagogue properties of platelet activating factor to the same degree as the specific platelet activating factor antagonist WEB 2086 but has no influence on treacheal secretion elicited by tachykinins. These results suggest a role of montelukast in the signal transduction pathway of platelet activating factor induced secretory activity of the airways and may further explain the beneficial properties of cys-leukotriene-1 receptor antagonists.
Only 3 of the 13 species so far comprised in Amphidium were retained in the genus: A lapponicum (Hedw.) Schimp., A. mougeotii (B.S.G.) Schimp. and A. tortuosum (Hornschuch) Cufodontis. Amphidium. sublapponicum (C. Müll.) Broth. is conspecific with A. lapponicum, A. cyathicarpum (Mont.) Broth., A. curvipes (C. Müll.) Broth. and A. californicum (C. Müll.) Broth. are synoymous with A. tortuosum. Amphidium brevifolium Broth., A. clastophyllum Broth. and A. papillosum Broth., all known only from the type locality, are sterile and differ vegetatively from all other species of the genus. They belong probably not to Amphidium. The types of Amphidium letestui Thér. & P. Varde, A. aloysii-sabaudiae Negri and A. remotidens (C. Müll.) Broth. could not be located.