Refine
Author
- Cavalleri, Gianpiero L. (2)
- Cendes, Fernando (2)
- Doherty, Colin P. (2)
- Ishikawa, Akari (2)
- Jahanshad, Neda (2)
- Moreira, José Carlos Vasques (2)
- Thompson, Paul M. (2)
- Yasuda, Clarissa L. (2)
- Abela, Eugenio Cecilio (1)
- Abé, Christoph (1)
- Agartz, Ingrid (1)
- Akudjedu, Theophilus N. (1)
- Alhusaini, Saud (1)
- Allen, Nicholas B. (1)
- Altmann, André (1)
- Alvim, Marina K. M. (1)
- Ames, David (1)
- Andre, Aleman (1)
- Andreassen, Ole A. (1)
- Arias Vásquez, Alejandro (1)
- Armstrong, Nicola J. (1)
- Balachandra, Akshara R. (1)
- Bargallo, Núria (1)
- Bartolini, Emanuele (1)
- Bastin, Mark E. (1)
- Batalla, Albert (1)
- Bauer, Jochen (1)
- Baune, Bernhard T. (1)
- Baur, Ramona (1)
- Bender, Benjamin (1)
- Bergo, Felipe (1)
- Bernasconi, Andrea (1)
- Bernasconi, Neda (1)
- Bernhardt, Boris (1)
- Biederman, Joseph (1)
- Blaine, Sara K. (1)
- Boedhoe, Premika (1)
- Bonilha, Leonardo (1)
- Bose, Anushree (1)
- Bralten, Janita (1)
- Brandeis, Daniel (1)
- Brem, Silvia (1)
- Brodaty, Henry (1)
- Brooks, Samantha J. (1)
- Bröhl, Henrieke (1)
- Buitelaar, Jan K. (1)
- Busatto Filho, Geraldo (1)
- Bøen, Erlend (1)
- Bülow, Robin (1)
- Bürger, Christian (1)
- Caldairou, Benoit (1)
- Calhoun, Vince D. (1)
- Caligiuri, Maria Eugenia (1)
- Calvo, Anna (1)
- Canales-Rodrı́guez, Erick Jorge (1)
- Canive, Jose M. (1)
- Cannon, Dara M. (1)
- Caparelli, Elisabeth C. (1)
- Carr, Sarah J. A. (1)
- Castellanos, Francisco X. (1)
- Cervenka, Simon (1)
- Chaim-Avancini, Tiffany Moukbel (1)
- Chantiluke, Kaylita (1)
- Chen, Qun-lin (1)
- Chen, Xiayu (1)
- Cheng, Yuqi (1)
- Christakou, Anastasia (1)
- Clark, Vincent P. (1)
- Coghill, David (1)
- Collste, Karin (1)
- Concha, Luis (1)
- Connolly, Colm G. (1)
- Conzelmann, Annette (1)
- Cousijn, Janna (1)
- Crivello, Fabrice (1)
- Crow, Tim (1)
- Cubillo, Ana (1)
- Cόrdova-Palomera, Aldo (1)
- Dannlowski, Udo (1)
- Davoodi-Bojd, Esmaeil (1)
- De Zubicaray, Greig (1)
- Deary, Ian J. (1)
- Delanty, Norman (1)
- Demeter, Damion V. (1)
- Desmond, Patricia M. (1)
- Devinsky, Orrin (1)
- Di Martino, Adriana (1)
- Dickie, Erin W (1)
- Dietsche, Bruno (1)
- Doan, N. Trung (1)
- Domin, Martin (1)
- Doyle, Alysa (1)
- Duncan, John S. (1)
- Durston, Sarah (1)
- Earl, Eric (1)
- Ehrlich, Stefan (1)
- Eijk, Liza van (1)
- Ekman, Carl Johan (1)
- Elvsåshagen, Torbjørn (1)
- Engberg, Goran (1)
- Epstein, Jeffery N. (1)
- Erhardt, Sophie (1)
- Fair, Damien A. (1)
- Faraone, Stephen V. (1)
- Farde, Lars (1)
- Fatouros-Bergman, Helena (1)
- Fernndez, Guillen (1)
- Fisher, Simon E. (1)
- Flyckt, Lena (1)
- Focke, Niels K. (1)
- Foley, Sonya F. (1)
- Forster, Katharina (1)
- Foxe, John J. (1)
- Francks, Clyde (1)
- Franke, Barbara (1)
- Fuentes-Claramonte, Paola (1)
- Fullerton, Janice M. (1)
- Gambardella, Antonio (1)
- Garavan, Hugh (1)
- Garcia, Danielle do Santos (1)
- Glahn, David C. (1)
- Gleichgerrcht, Ezequiel (1)
- Gotlib, Ian H. (1)
- Goudriaan, Anna E. (1)
- Grabe, Hans Jörgen (1)
- Groenewold, Nynke A. (1)
- Grotegerd, Dominik (1)
- Gruber, Oliver (1)
- Guadalupe, Tulio (1)
- Guerrini, Renzo (1)
- Gurholt, Tiril (1)
- Haavik, Jan (1)
- Hahn, Tim (1)
- Hamandi, Khalid (1)
- Hansell, Narelle K. (1)
- Harris, Mathew A. (1)
- Hartman, Catharina (1)
- Hatton, Sean N. (1)
- Hedberg, Mikael (1)
- Hernandez, Maria del Carmen Valdes (1)
- Heslenfeld, Dirk (1)
- Hester, Robert (1)
- Hibar, Derrek Paul (1)
- Ho, Beng-Choon (1)
- Ho, Tiffany C. (1)
- Hoekstra, Pieter J. (1)
- Hoogman, Martine (1)
- Hovik, Marie F. (1)
- Howells, Fleur M. (1)
- Hugdahl, Kenneth (1)
- Huynh, Khoa H. (1)
- Huyser, Chaim (1)
- Ingvar, Martind (1)
- Irwin, Lourdes (1)
- James, Anthony (1)
- Jean-Paul, Fouche (1)
- Jernigan, Terry L. (1)
- Jönsson, Erik G. (1)
- Kahler, Claas (1)
- Kaleda, Vasily (1)
- Keller, Simon S. (1)
- Kelly, Clare (1)
- Kerich, Michael (1)
- Keshavan, Matcheri S (1)
- Khadka, Sabin (1)
- Kircher, Tilo (1)
- Kochunov, Peter V. (1)
- Kohls, Gregor (1)
- Kong, Xiang-Zhen (1)
- Konrad, Kerstin (1)
- Korucuoglu, Ozlem (1)
- Kotikalapudi, Raviteja (1)
- Kreilkamp, Barbara A. K. (1)
- Krug, Axel (1)
- Krämer, Bernd (1)
- Kwan, Patrick (1)
- Kwon, Jun Soo (1)
- Labate, Angelo (1)
- Lambregts-Rommelse, Nanda (1)
- Landén, Mikael (1)
- Langner, Sönke (1)
- Lebedeva, Irina (1)
- Lenge, Matteo (1)
- Lenroot, Rhoshel (1)
- Lesch, Klaus-Peter J. (1)
- Li, Qinqin (1)
- Lim, Kelvin O. (1)
- Liu, Jia (1)
- Liu, Min (1)
- Lochner, Christine (1)
- London, Edythe D. (1)
- Lonning, Vera (1)
- Lorenzetti, Valentina (1)
- Luciano, Michelle (1)
- Lui, Elaine (1)
- Luijten, Maartje (1)
- Lundervold, Astri J. (1)
- Lázaro, Luisa (1)
- MacMaster, Frank P. (1)
- Mackey, Scott (1)
- Maingault, Sophie (1)
- Malmqvist, Anna (1)
- Malpas, Charles B. (1)
- Malt, Ulrik F. (1)
- Maniega, Susana Munoz (1)
- Martin, Pascal (1)
- Martin-Santos, Rocio (1)
- Mascalchi, Mario (1)
- Mataix-Cols, David (1)
- Mathias, Samuel R. (1)
- Mayer, Andrew R. (1)
- Mazoyer, Bernard (1)
- McCarthy, Hazel (1)
- McDonald, Carrie R. (1)
- McDonald, Colm (1)
- McLellan, Quinn (1)
- McMahon, Katie L. (1)
- McPhilemy, Genevieve (1)
- Meer, Dennis van der (1)
- Mitchell, Philip B. (1)
- Momenan, Reza (1)
- Morales, Angelica M. (1)
- Morita-Sherman, Marcia Elisabete (1)
- Mueller, Bryon A. (1)
- Narayanaswamy, Janardhanan C. (1)
- Nerland, Stener (1)
- Nestor, Liam (1)
- Nigg, Joel T. (1)
- Nordvik, Jan-Egil (1)
- Novotny, Stephanie (1)
- Oberwelland, Eileen (1)
- Oosterlaan, Jaap (1)
- Oranje, Bob (1)
- Orhan, Funda (1)
- Orr, Catherine (1)
- Overs, Bronwyn (1)
- O’Brien, Terence J. (1)
- O’Gorman, Ruth L. (1)
- Pardoe, Heath R. (1)
- Pariente Zorrilla, José Carlos (1)
- Pauli, Paul (1)
- Paulus, Martin (1)
- Piehl, Fredrik (1)
- Plessen, Kerstin (1)
- Podewils, Felix von (1)
- Polier, Georg von (1)
- Pomarol-Clotet, Edith (1)
- Qiu, Jiang (1)
- Radua, Joaquim (1)
- Ramos-Quiroga, J. Antoni (1)
- Reddy, Y.C. Janardhan (1)
- Reif, Andreas (1)
- Ribeiro, Letı́cia F. (1)
- Richardson, Mark Philip (1)
- Roberts, Gloria (1)
- Rocha, Cristiane S. (1)
- Rodrı́guez-Cruces, Raúl (1)
- Rosa, Pedro (1)
- Rosenow, Felix (1)
- Rubia, Katya (1)
- Sacchet, Matthew D. (1)
- Sachdev, Perminder S. (1)
- Salvador, Raymond (1)
- Saud, Alhusaini (1)
- Schmaal, Lianne (1)
- Schweren, Lisanne (1)
- Schwieler, Lilly (1)
- Seidman, Larry J. (1)
- Seitz, Jochen (1)
- Serpa, Mauricio Henriques (1)
- Severino, Mariasavina (1)
- Shaw, Philip (1)
- Shumskaya, Elena (1)
- Silk, Timothy J. (1)
- Simmons, Alan N. (1)
- Simulionyte, Egle (1)
- Sinclair, Benjamin (1)
- Sinha, Rajita (1)
- Sisodiya, Sanjay M. (1)
- Sjoerds, Zsuzsika (1)
- Smelror, Runar Elle (1)
- Soliva, Joan Carlos (1)
- Solowij, Nadia (1)
- Soltanian-Zadeh, Hamid (1)
- Sponheim, Scott R. (1)
- Stein, Dan J. (1)
- Stein, Elliot A. (1)
- Stevens, Michael (1)
- Striano, Pasquale (1)
- Strike, Lachlan T. (1)
- Sudre, Gustavo (1)
- Sui, Jing (1)
- Tamm, Leanne (1)
- Taylor, Peter N. (1)
- Temmingh, Hendrik S. (1)
- Thoma, Robert J. (1)
- Thomas, Rhys H. (1)
- Tomyshev, Alexander S. (1)
- Tortora, Domenico (1)
- Tronchin, Giulia (1)
- Turner, Jessica A. (1)
- Tzourio-Mazoyer, Nathalie (1)
- Uhlmann, Anne (1)
- Vance, Alasdair (1)
- Veer, Ilya M. (1)
- Velakoulis, Dennis (1)
- Veltman, Dick J. (1)
- Venkatasubramanian, Ganesan (1)
- Vezzani, Annamaria (1)
- Victorsson, Pauliina (1)
- Vilarroya, Oscar (1)
- Vivash, Lucy (1)
- Vives-Gilabert, Yolanda (1)
- Voineskos, Aristotle N. (1)
- Vos, Sjoerd B. (1)
- Vuletic, Daniella (1)
- Völzke, Henry (1)
- Walitza, Susanne (1)
- Walter, Henrik (1)
- Walton, Esther (1)
- Wardlaw, Joanna M. (1)
- Weber, Bernd (1)
- Wen, Wei (1)
- Westlye, Lars T. (1)
- Whelan, Christopher D. (1)
- White, Tonya (1)
- Wiers, Reinout W. (1)
- Winston, Gavin P. (1)
- Wittfeld, Katharina (1)
- Wright, Margaret J. (1)
- Yang, Tony T. (1)
- Yoncheva, Yuliya (1)
- Yucel, Murat (1)
- Yun, Je-Yeon (1)
- Zanetti, Marcus Vinicius (1)
- Zeeuw, Patrick de (1)
- Zhen, Zonglei (1)
- Zhu, Xing-xing (1)
- Ziegler, Georg Christoph (1)
- Zierhut, Kathrin (1)
- Zwiers, Marcel P. (1)
- de Bruttopilo, Sara Ambrosino (1)
- van Erp, Theo G.M. (1)
- van Holst, Ruth J. (1)
- van den Heuvel, Odile (1)
Document Type
- Preprint (2)
Language
- English (2)
Has Fulltext
- yes (2)
Is part of the Bibliography
- no (2)
Institute
- Medizin (2)
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
(2017)
Kong, Xiang-Zhen ; Mathias, Samuel R. ; Guadalupe, Tulio ; Abé, Christoph ; Agartz, Ingrid ; Akudjedu, Theophilus N. ; Andre, Aleman ; Saud, Alhusaini ; Allen, Nicholas B. ; Ames, David ; Andreassen, Ole A. ; Arias Vásquez, Alejandro ; Armstrong, Nicola J. ; Bergo, Felipe ; Bastin, Mark E. ; Batalla, Albert ; Bauer, Jochen ; Baune, Bernhard T. ; Baur, Ramona ; Biederman, Joseph ; Blaine, Sara K. ; Boedhoe, Premika ; Bøen, Erlend ; Bose, Anushree ; Bralten, Janita ; Brandeis, Daniel ; Brem, Silvia ; Brodaty, Henry ; Bröhl, Henrieke ; Brooks, Samantha J. ; Buitelaar, Jan K. ; Bürger, Christian ; Bülow, Robin ; Calhoun, Vince D. ; Calvo, Anna ; Canales-Rodrı́guez, Erick Jorge ; Canive, Jose M. ; Cannon, Dara M. ; Caparelli, Elisabeth C. ; Castellanos, Francisco X. ; Cavalleri, Gianpiero L. ; Cendes, Fernando ; Chaim-Avancini, Tiffany Moukbel ; Chantiluke, Kaylita ; Chen, Qun-lin ; Chen, Xiayu ; Cheng, Yuqi ; Christakou, Anastasia ; Clark, Vincent P. ; Coghill, David ; Connolly, Colm G. ; Conzelmann, Annette ; Cόrdova-Palomera, Aldo ; Cousijn, Janna ; Crow, Tim ; Cubillo, Ana ; Dannlowski, Udo ; de Bruttopilo, Sara Ambrosino ; Zeeuw, Patrick de ; Deary, Ian J. ; Delanty, Norman ; Demeter, Damion V. ; Di Martino, Adriana ; Dickie, Erin W ; Dietsche, Bruno ; Doan, N. Trung ; Doherty, Colin P. ; Doyle, Alysa ; Durston, Sarah ; Earl, Eric ; Ehrlich, Stefan ; Ekman, Carl Johan ; Elvsåshagen, Torbjørn ; Epstein, Jeffery N. ; Fair, Damien A. ; Faraone, Stephen V. ; Fatouros-Bergman, Helena ; Fernndez, Guillen ; Busatto Filho, Geraldo ; Flyckt, Lena ; Forster, Katharina ; Jean-Paul, Fouche ; Foxe, John J. ; Fuentes-Claramonte, Paola ; Fullerton, Janice M. ; Garavan, Hugh ; Garcia, Danielle do Santos ; Gotlib, Ian H. ; Goudriaan, Anna E. ; Grabe, Hans Jörgen ; Groenewold, Nynke A. ; Grotegerd, Dominik ; Gruber, Oliver ; Gurholt, Tiril ; Haavik, Jan ; Hahn, Tim ; Hansell, Narelle K. ; Harris, Mathew A. ; Hartman, Catharina ; Hernandez, Maria del Carmen Valdes ; Heslenfeld, Dirk ; Hester, Robert ; Hibar, Derrek Paul ; Ho, Beng-Choon ; Ho, Tiffany C. ; Hoekstra, Pieter J. ; van Holst, Ruth J. ; Hoogman, Martine ; Hovik, Marie F. ; Howells, Fleur M. ; Hugdahl, Kenneth ; Huyser, Chaim ; Ingvar, Martind ; Irwin, Lourdes ; Ishikawa, Akari ; James, Anthony ; Jahanshad, Neda ; Jernigan, Terry L. ; Jönsson, Erik G. ; Kahler, Claas ; Kaleda, Vasily ; Kelly, Clare ; Kerich, Michael ; Keshavan, Matcheri S ; Khadka, Sabin ; Kircher, Tilo ; Kohls, Gregor ; Konrad, Kerstin ; Korucuoglu, Ozlem ; Krämer, Bernd ; Krug, Axel ; Kwon, Jun Soo ; Lambregts-Rommelse, Nanda ; Landén, Mikael ; Lázaro, Luisa ; Lebedeva, Irina ; Lenroot, Rhoshel ; Lesch, Klaus-Peter J. ; Li, Qinqin ; Lim, Kelvin O. ; Liu, Jia ; Lochner, Christine ; London, Edythe D. ; Lonning, Vera ; Lorenzetti, Valentina ; Luciano, Michelle ; Luijten, Maartje ; Lundervold, Astri J. ; Mackey, Scott ; MacMaster, Frank P. ; Maingault, Sophie ; Malpas, Charles B. ; Malt, Ulrik F. ; Mataix-Cols, David ; Martin-Santos, Rocio ; Mayer, Andrew R. ; McCarthy, Hazel ; Mitchell, Philip B. ; Mueller, Bryon A. ; Maniega, Susana Munoz ; Mazoyer, Bernard ; McDonald, Colm ; McLellan, Quinn ; McMahon, Katie L. ; McPhilemy, Genevieve ; Momenan, Reza ; Morales, Angelica M. ; Narayanaswamy, Janardhanan C. ; Moreira, José Carlos Vasques ; Nerland, Stener ; Nestor, Liam ; Nigg, Joel T. ; Nordvik, Jan-Egil ; Novotny, Stephanie ; Oberwelland, Eileen ; O’Gorman, Ruth L. ; Oosterlaan, Jaap ; Oranje, Bob ; Orr, Catherine ; Overs, Bronwyn ; Pauli, Paul ; Paulus, Martin ; Plessen, Kerstin ; Polier, Georg von ; Pomarol-Clotet, Edith ; Qiu, Jiang ; Radua, Joaquim ; Ramos-Quiroga, J. Antoni ; Reddy, Y.C. Janardhan ; Reif, Andreas ; Roberts, Gloria ; Rosa, Pedro ; Rubia, Katya ; Sacchet, Matthew D. ; Sachdev, Perminder S. ; Salvador, Raymond ; Schmaal, Lianne ; Schweren, Lisanne ; Seidman, Larry J. ; Seitz, Jochen ; Serpa, Mauricio Henriques ; Shaw, Philip ; Shumskaya, Elena ; Silk, Timothy J. ; Simmons, Alan N. ; Simulionyte, Egle ; Sinha, Rajita ; Sjoerds, Zsuzsika ; Smelror, Runar Elle ; Soliva, Joan Carlos ; Solowij, Nadia ; Sponheim, Scott R. ; Stein, Dan J. ; Stein, Elliot A. ; Stevens, Michael ; Strike, Lachlan T. ; Sudre, Gustavo ; Sui, Jing ; Tamm, Leanne ; Temmingh, Hendrik S. ; Thoma, Robert J. ; Tomyshev, Alexander S. ; Tronchin, Giulia ; Turner, Jessica A. ; Uhlmann, Anne ; van Erp, Theo G.M. ; van den Heuvel, Odile ; Meer, Dennis van der ; Eijk, Liza van ; Vance, Alasdair ; Veer, Ilya M. ; Veltman, Dick J. ; Venkatasubramanian, Ganesan ; Vilarroya, Oscar ; Vives-Gilabert, Yolanda ; Voineskos, Aristotle N. ; Völzke, Henry ; Vuletic, Daniella ; Walitza, Susanne ; Walter, Henrik ; Walton, Esther ; Wardlaw, Joanna M. ; Wen, Wei ; Westlye, Lars T. ; Whelan, Christopher D. ; White, Tonya ; Wiers, Reinout W. ; Wright, Margaret J. ; Wittfeld, Katharina ; Yang, Tony T. ; Yasuda, Clarissa L. ; Yoncheva, Yuliya ; Yucel, Murat ; Yun, Je-Yeon ; Zanetti, Marcus Vinicius ; Zhen, Zonglei ; Zhu, Xing-xing ; Ziegler, Georg Christoph ; Zierhut, Kathrin ; De Zubicaray, Greig ; Zwiers, Marcel P. ; Glahn, David C. ; Franke, Barbara ; Crivello, Fabrice ; Tzourio-Mazoyer, Nathalie ; Fisher, Simon E. ; Thompson, Paul M. ; Francks, Clyde ; Farde, Lars ; Engberg, Goran ; Erhardt, Sophie ; Cervenka, Simon ; Schwieler, Lilly ; Piehl, Fredrik ; Collste, Karin ; Victorsson, Pauliina ; Malmqvist, Anna ; Hedberg, Mikael ; Orhan, Funda
White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA Epilepsy study
(2019)
Hatton, Sean N. ; Huynh, Khoa H. ; Bonilha, Leonardo ; Abela, Eugenio Cecilio ; Alhusaini, Saud ; Altmann, André ; Alvim, Marina K. M. ; Balachandra, Akshara R. ; Bartolini, Emanuele ; Bender, Benjamin ; Bernasconi, Neda ; Bernasconi, Andrea ; Bernhardt, Boris ; Bargallo, Núria ; Caldairou, Benoit ; Caligiuri, Maria Eugenia ; Carr, Sarah J. A. ; Cavalleri, Gianpiero L. ; Cendes, Fernando ; Concha, Luis ; Davoodi-Bojd, Esmaeil ; Desmond, Patricia M. ; Devinsky, Orrin ; Doherty, Colin P. ; Domin, Martin ; Duncan, John S. ; Focke, Niels K. ; Foley, Sonya F. ; Gambardella, Antonio ; Gleichgerrcht, Ezequiel ; Guerrini, Renzo ; Hamandi, Khalid ; Ishikawa, Akari ; Keller, Simon S. ; Kochunov, Peter V. ; Kotikalapudi, Raviteja ; Kreilkamp, Barbara A. K. ; Kwan, Patrick ; Labate, Angelo ; Langner, Sönke ; Lenge, Matteo ; Liu, Min ; Lui, Elaine ; Martin, Pascal ; Mascalchi, Mario ; Moreira, José Carlos Vasques ; Morita-Sherman, Marcia Elisabete ; O’Brien, Terence J. ; Pardoe, Heath R. ; Pariente Zorrilla, José Carlos ; Ribeiro, Letı́cia F. ; Richardson, Mark Philip ; Rocha, Cristiane S. ; Rodrı́guez-Cruces, Raúl ; Rosenow, Felix ; Severino, Mariasavina ; Sinclair, Benjamin ; Soltanian-Zadeh, Hamid ; Striano, Pasquale ; Taylor, Peter N. ; Thomas, Rhys H. ; Tortora, Domenico ; Velakoulis, Dennis ; Vezzani, Annamaria ; Vivash, Lucy ; Podewils, Felix von ; Vos, Sjoerd B. ; Weber, Bernd ; Winston, Gavin P. ; Yasuda, Clarissa L. ; Thompson, Paul M. ; Jahanshad, Neda ; Sisodiya, Sanjay M. ; McDonald, Carrie R.
The epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging abnormalities in common epilepsy syndromes, including temporal lobe epilepsy, extratemporal epilepsy, and genetic generalized epilepsy. Our goal was to rank the most robust white matter microstructural differences across and within syndromes in a multicentre sample of adult epilepsy patients. Diffusion-weighted MRI data were analyzed from 1,069 non-epileptic controls and 1,249 patients: temporal lobe epilepsy with hippocampal sclerosis (N=599), temporal lobe epilepsy with normal MRI (N=275), genetic generalized epilepsy (N=182) and nonlesional extratemporal epilepsy (N=193). A harmonized protocol using tract-based spatial statistics was used to derive skeletonized maps of fractional anisotropy and mean diffusivity for each participant, and fiber tracts were segmented using a diffusion MRI atlas. Data were harmonized to correct for scanner-specific variations in diffusion measures using a batch-effect correction tool (ComBat). Analyses of covariance, adjusting for age and sex, examined differences between each epilepsy syndrome and controls for each white matter tract (Bonferroni corrected at p<0.001). Across “all epilepsies” lower fractional anisotropy was observed in most fiber tracts with small to medium effect sizes, especially in the corpus callosum, cingulum and external capsule. Less robust effects were seen with mean diffusivity. Syndrome-specific fractional anisotropy and mean diffusivity differences were most pronounced in patients with hippocampal sclerosis in the ipsilateral parahippocampal cingulum and external capsule, with smaller effects across most other tracts. Those with temporal lobe epilepsy and normal MRI showed a similar pattern of greater ipsilateral than contralateral abnormalities, but less marked than those in patients with hippocampal sclerosis. Patients with generalized and extratemporal epilepsies had pronounced differences in fractional anisotropy in the corpus callosum, corona radiata and external capsule, and in mean diffusivity of the anterior corona radiata. Earlier age of seizure onset and longer disease duration were associated with a greater extent of microstructural abnormalities in patients with hippocampal sclerosis. We demonstrate microstructural abnormalities across major association, commissural, and projection fibers in a large multicentre study of epilepsy. Overall, epilepsy patients showed white matter abnormalities in the corpus callosum, cingulum and external capsule, with differing severity across epilepsy syndromes. These data further define the spectrum of white matter abnormalities in common epilepsy syndromes, yielding new insights into pathological substrates that may be used to guide future therapeutic and genetic studies.
- 1 to 2