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Background: Risk stratification, detection of minimal residual disease (MRD), and implementation of novel therapeutic agents have improved outcome in acute lymphoblastic leukemia (ALL), but survival of adult patients with T-cell acute lymphoblastic leukemia (T-ALL) remains unsatisfactory. Thus, novel molecular insights and therapeutic approaches are urgently needed.
Methods: We studied the impact of B-cell CLL/lymphoma 11b (BCL11b), a key regulator in normal T-cell development, in T-ALL patients enrolled into the German Multicenter Acute Lymphoblastic Leukemia Study Group trials (GMALL; n = 169). The mutational status (exon 4) of BCL11b was analyzed by Sanger sequencing and mRNA expression levels were determined by quantitative real-time PCR. In addition gene expression profiles generated on the Human Genome U133 Plus 2.0 Array (affymetrix) were used to investigate BCL11b low and high expressing T-ALL patients.
Results: We demonstrate that BCL11b is aberrantly expressed in T-ALL and gene expression profiles reveal an association of low BCL11b expression with up-regulation of immature markers. T-ALL patients characterized by low BCL11b expression exhibit an adverse prognosis [5-year overall survival (OS): low 35% (n = 40) vs. high 53% (n = 129), P = 0.02]. Within the standard risk group of thymic T-ALL (n = 102), low BCL11b expression identified patients with an unexpected poor outcome compared to those with high expression (5-year OS: 20%, n = 18 versus 62%, n = 84, P < 0.01). In addition, sequencing of exon 4 revealed a high mutation rate (14%) of BCL11b.
Conclusions: In summary, our data of a large adult T-ALL patient cohort show that low BCL11b expression was associated with poor prognosis; particularly in the standard risk group of thymic T-ALL. These findings can be utilized for improved risk prediction in a significant proportion of adult T-ALL patients, which carry a high risk of standard therapy failure despite a favorable immunophenotype.
Background: To assess the potential of radiomic features to quantify components of blood in intraaortic vessels to non-invasively predict moderate-to-severe anemia in non-contrast enhanced CT scans. Methods: One hundred patients (median age, 69 years; range, 19–94 years) who received CT scans of the thoracolumbar spine and blood-testing for hemoglobin and hematocrit levels ± 24 h between 08/2018 and 11/2019 were retrospectively included. Intraaortic blood was segmented using a spherical volume of interest of 1 cm diameter with consecutive radiomic analysis applying PyRadiomics software. Feature selection was performed applying analysis of correlation and collinearity. The final feature set was obtained to differentiate moderate-to-severe anemia. Random forest machine learning was applied and predictive performance was assessed. A decision-tree was obtained to propose a cut-off value of CT Hounsfield units (HU). Results: High correlation with hemoglobin and hematocrit levels was shown for first-order radiomic features (p < 0.001 to p = 0.032). The top 3 features showed high correlation to hemoglobin values (p) and minimal collinearity (r) to the top ranked feature Median (p < 0.001), Energy (p = 0.002, r = 0.387), Minimum (p = 0.032, r = 0.437). Median (p < 0.001) and Minimum (p = 0.003) differed in moderate-to-severe anemia compared to non-anemic state. Median yielded superiority to the combination of Median and Minimum (p(AUC) = 0.015, p(precision) = 0.017, p(accuracy) = 0.612) in the predictive performance employing random forest analysis. A Median HU value ≤ 36.5 indicated moderate-to-severe anemia (accuracy = 0.90, precision = 0.80). Conclusions: First-order radiomic features correlate with hemoglobin levels and may be feasible for the prediction of moderate-to-severe anemia. High dimensional radiomic features did not aid augmenting the data in our exemplary use case of intraluminal blood component assessment.
Using 9.9 fb−1 of e+e− collision data collected by the BESIII detector at center-of-mass energies between 4.15 and 4.30 GeV, we search for the processes e+e−→γX(3872) with X(3872)→π0χc0 and X(3872)→ππχc0. Depending on the fitting model, the statistical significance for X(3872)→π0χc0 ranges from 1.3σ to 2.8σ. We set upper limits (at 90\% C.L.) of B(X(3872)→π0χc0)B(X(3872)→π+π−J/ψ)<3.6, B(X(3872)→π+π−χc0)B(X(3872)→π+π−J/ψ)<0.68, and B(X(3872)→π0π0χc0)B(X(3872)→π+π−J/ψ)<1.7. Combined with the BESIII measurement of X(3872)→π0χc1, we also set an upper limit of B(X(3872)→π0χc0)B(X(3872)→π0χc1)<4.4.
Using 9.9 fb−1 of e+e− collision data collected by the BESIII detector at center-of-mass energies between 4.15 and 4.30 GeV, we search for the processes e+e−→γX(3872) with X(3872)→π0χc0 and X(3872)→ππχc0. Depending on the fitting model, the statistical significance for X(3872)→π0χc0 ranges from 1.3σ to 2.8σ. We set upper limits (at 90\% C.L.) of B(X(3872)→π0χc0)B(X(3872)→π+π−J/ψ)<3.6, B(X(3872)→π+π−χc0)B(X(3872)→π+π−J/ψ)<0.68, and B(X(3872)→π0π0χc0)B(X(3872)→π+π−J/ψ)<1.7. Combined with the BESIII measurement of X(3872)→π0χc1, we also set an upper limit of B(X(3872)→π0χc0)B(X(3872)→π0χc1)<4.4.
Using 9.9 fb−1 of e+e− collision data collected by the BESIII detector at center-of-mass energies between 4.15 and 4.30 GeV, we search for the processes e+e−→γX(3872) with X(3872)→π0χc0 and X(3872)→ππχc0. Depending on the fitting model, the statistical significance for X(3872)→π0χc0 ranges from 1.3σ to 2.8σ. We set upper limits (at 90\% C.L.) of B(X(3872)→π0χc0)B(X(3872)→π+π−J/ψ)<3.6, B(X(3872)→π+π−χc0)B(X(3872)→π+π−J/ψ)<0.68, and B(X(3872)→π0π0χc0)B(X(3872)→π+π−J/ψ)<1.7. Combined with the BESIII measurement of X(3872)→π0χc1, we also set an upper limit of B(X(3872)→π0χc0)B(X(3872)→π0χc1)<4.4.
Objectives: To assess the impact of noise-optimised virtual monoenergetic imaging (VMI+) on image quality and diagnostic evaluation in abdominal dual-energy CT scans with impaired portal-venous contrast.
Methods: We screened 11,746 patients who underwent portal-venous abdominal dual-energy CT for cancer staging between 08/2014 and 11/2019 and identified those with poor portal-venous contrast.
Standard linearly-blended image series and VMI+ image series at 40, 50, and 60 keV were reconstructed. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of abdominal organs and vascular structures were calculated. Image noise, image contrast and overall image quality were rated by three radiologists using 5-point Likert scale.
Results: 452 of 11,746 (4%) exams were poorly opacified. We excluded 190 cases due to incomplete datasets or multiple exams of the same patient with a final study group of 262. Highest CNR values in all abdominal organs (liver, 6.4 ± 3.0; kidney, 17.4 ± 7.5; spleen, 8.0 ± 3.5) and vascular structures (aorta, 16.0 ± 7.3; intrahepatic vein, 11.3 ± 4.7; portal vein, 15.5 ± 6.7) were measured at 40 keV VMI+ with significantly superior values compared to all other series. In subjective analysis, highest image contrast was seen at 40 keV VMI+ (4.8 ± 0.4), whereas overall image quality peaked at 50 keV VMI+ (4.2 ± 0.5) with significantly superior results compared to all other series (p < 0.001).
Conclusions: Image reconstruction using VMI+ algorithm at 50 keV significantly improves image contrast and image quality of originally poorly opacified abdominal CT scans and reduces the number of non-diagnostic scans.
Advances in knowledge: We validated the impact of VMI+ reconstructions in poorly attenuated DECT studies of the abdomen in a big data cohort.
Using 7.33 fb−1 of e+e− collision data collected by the BESIII detector at center-of-mass energies between 4.128 and 4.226~GeV, we observe for the first time the decay D±s→ωπ±η with a statistical significance of 7.6σ. The measured branching fraction of this decay is (0.54±0.12±0.04)%, where the first uncertainty is statistical and the second is systematic.
Highlights
• Assessment of coronary artery plaque burden according to the CAC-DRS Score correlated well with pulmonary involvement of SARS-CoV-2 pneumonia (min. r=0.81, 95% CI 0.76 to 0.86).
• Visual and quantitative CAC-DRS Score of coronary artery plaque burden provided independent prognostic information on all-cause mortality in patients with SARS-CoV-2 pneumonia (p=0.0016 and p<0.0001, respectively).
• Incorporating CAC-DRS Score and pulmonary involvement into clinical decision making revealed great potential to discriminate patients with fatal outcomes from a mild course of disease (AUC 0.938, 95% CI 0.89 to 0.97) and the need for intensive care treatment (AUC 0.801, 95% CI 0.77 to 0.83).
Purpose: To assess and correlate pulmonary involvement and outcome of SARS-CoV-2 pneumonia with the degree of coronary plaque burden based on the CAC-DRS classification (Coronary Artery Calcium Data and Reporting System).
Methods: This retrospective study included 142 patients with confirmed SARS-CoV-2 pneumonia (58 ± 16 years; 57 women) who underwent non-contrast CT between January 2020 and August 2021 and were followed up for 129 ± 72 days. One experienced blinded radiologist analyzed CT series for the presence and extent of calcified plaque burden according to the visual and quantitative HU-based CAC-DRS Score. Pulmonary involvement was automatically evaluated with a dedicated software prototype by another two experienced radiologists and expressed as Opacity Score.
Results: CAC-DRS Scores derived from visual and quantitative image evaluation correlated well with the Opacity Score (r=0.81, 95% CI 0.76-0.86, and r=0.83, 95% CI 0.77-0.89, respectively; p<0.0001) with higher correlation in severe than in mild stage SARS-CoV-2 pneumonia (p<0.0001). Combined, CAC-DRS and Opacity Scores revealed great potential to discriminate fatal outcomes from a mild course of disease (AUC 0.938, 95% CI 0.89-0.97), and the need for intensive care treatment (AUC 0.801, 95% CI 0.77-0.83). Visual and quantitative CAC-DRS Scores provided independent prognostic information on all-cause mortality (p=0.0016 and p<0.0001, respectively), both in univariate and multivariate analysis.
Conclusions: Coronary plaque burden is strongly correlated to pulmonary involvement, adverse outcome, and death due to respiratory failure in patients with SARS-CoV-2 pneumonia, offering great potential to identify individuals at high risk.
Highlights
• MRI and ultrasound provided significant correlations between findings suggestive of vasculitis and the final diagnosis.
• Careful selection of available imaging techniques is warranted considering the time course, location, and clinical history.
• Considering its moderate diagnostic power to distinguish tracer uptake, a holistic view of PET/CT findings is essential.
Abstract
Purpose: To assess the diagnostic value of different imaging modalities in distinguishing systemic vasculitis from other internal and immunological diseases.
Methods: This retrospective study included 134 patients with suspected vasculitis who underwent ultrasound, magnetic resonance imaging (MRI), or 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) between 01/2010 and 01/2019, finally consisting of 70 individuals with vasculitis. The main study parameter was the confirmation of the diagnosis using one of the three different imaging modalities, with the adjudicated clinical and histopathological diagnosis as the gold standard. A secondary parameter was the morphological appearance of the vessel affected by vasculitis.
Results: Patients with systemic vasculitis had myriad clinical manifestations with joint pain as the most common symptom. We found significant correlations between different imaging findings suggestive of vasculitis and the final adjudicated clinical diagnosis. In this context, on MRI, vessel wall thickening, edema, and diameter differed significantly between vasculitis and non-vasculitis groups (p < 0.05). Ultrasound revealed different findings that may serve as red flags in identifying patients with vasculitis, such as vascular occlusion or halo sign (p = 0.02 vs. non-vasculitis group). Interestingly, comparing maximal standardized uptake values from PET/CT examinations with vessel wall thickening or vessel diameter did not result in significant differences (p > 0.05).
Conclusions: We observed significant correlations between different imaging findings suggestive of vasculitis on ultrasound or MRI and the final adjudicated diagnosis. While ultrasound and MRI were considered suitable imaging methods for detecting and discriminating typical vascular changes, 18F-FDG PET/CT requires careful timing and patient selection given its moderate diagnostic accuracy.
Purpose: To assess the diagnostic precision of three different workstations for measuring thoracic aortic aneurysms (TAAs) in vivo and ex vivo using either pre-interventional computed tomography angiography scans (CTA) or a specifically designed phantom model.
Methods: This retrospective study included 23 patients with confirmed TAA on routinely performed CTAs. In addition to phantom tube diameters, one experienced blinded radiologist evaluated the dimensions of TAAs on three different workstations in two separate rounds. Precision was assessed by calculating measurement errors. In addition, correlation analysis was performed using Pearson correlation.
Results: Measurements acquired at the Siemens workstation deviated by 3.54% (range, 2.78–4.03%; p = 0.14) from the true size, those at General Electric by 4.05% (range, 1.46–7.09%; p < 0.0001), and at TeraRecon by 4.86% (range, 3.22–6.45%; p < 0.0001). Accordingly, Siemens provided the most precise workstation at simultaneously most fluctuating values (scattering of 4.46%). TeraRecon had the smallest fluctuation (scattering of 2.83%), but the largest deviation from the true size of the phantom. The workstation from General Electric showed a scattering of 2.94%. The highest overall correlation between the 1st and 2nd rounds was observed with measurements from Siemens (r = 0.898), followed by TeraRecon (r = 0.799), and General Electric (r = 0.703). Repetition of measurements reduced processing times by 40% when using General Electric, by 20% with Siemens, and by 18% with TeraRecon.
Conclusions: In conclusion, all three workstations facilitated precise assessment of dimensions in the majority of cases at simultaneously high reproducibility, ensuring accurate pre-interventional planning of thoracic endovascular aortic repair.
Purpose: To identify transjugular intrahepatic portosystemic shunt (TIPS) thrombosis in abdominal CT scans applying quantitative image analysis.
Materials and methods: We retrospectively screened 184 patients to include 20 patients (male, 8; female, 12; mean age, 60.7 ± 8.87 years) with (case, n = 10) and without (control, n = 10) in-TIPS thrombosis who underwent clinically indicated contrast-enhanced and unenhanced abdominal CT followed by conventional TIPS-angiography between 08/2014 and 06/2020. First, images were scored visually. Second, region of interest (ROI) based quantitative measurements of CT attenuation were performed in the inferior vena cava (IVC), portal vein and in four TIPS locations. Minimum, maximum and average Hounsfield unit (HU) values were used as absolute and relative quantitative features. We analyzed the features with univariate testing.
Results: Subjective scores identified in-TIPS thrombosis in contrast-enhanced scans with an accuracy of 0.667 – 0.833. Patients with in-TIPS thrombosis had significantly lower average (p < 0.001), minimum (p < 0.001) and maximum HU (p = 0.043) in contrast-enhanced images. The in-TIPS / IVC ratio in contrast-enhanced images was significantly lower in patients with in-TIPS thrombosis (p < 0.001). No significant differences were found for unenhanced images. Analyzing the visually most suspicious ROI with consecutive calculation of its ratio to the IVC, all patients with a ratio < 1 suffered from in-TIPS thrombosis (p < 0.001, sensitivity and specificity = 100%).
Conclusion: Quantitative analysis of abdominal CT scans facilitates the stratification of in-TIPS thrombosis. In contrast-enhanced scans, an in-TIPS / IVC ratio < 1 could non-invasively stratify all patients with in-TIPS thrombosis.
This prospective study sought to evaluate potential savings of radiation dose to medical staff using real-time dosimetry coupled with visual radiation dose feedback during angiographic interventions. For this purpose, we analyzed a total of 214 angiographic examinations that consisted of chemoembolizations and several other types of therapeutic interventions. The Unfors RaySafe i2 dosimeter was worn by the interventionalist at chest height over the lead protection. A total of 110 interventions were performed with real-time radiation dosimetry allowing the interventionalist to react upon higher x-ray exposure and 104 examinations served as the comparative group without real-time radiation monitoring. By using the real-time display during interventions, the overall mean operator radiation dose decreased from 3.67 (IQR, 0.95–23.01) to 2.36 μSv (IQR, 0.52–12.66) (−36%; p = 0.032) at simultaneously reduced operator exposure time by 4.5 min (p = 0.071). Dividing interventions into chemoembolizations and other types of therapeutic interventions, radiation dose decreased from 1.31 (IQR, 0.46-3.62) to 0.95 μSv (IQR, 0.53-3.11) and from 24.39 (IQR, 12.14-63.0) to 10.37 μSv (IQR, 0.85-36.84), respectively, using live-screen dosimetry (p ≤ 0.005). Radiation dose reductions were also observed for the participating assistants, indicating that they could also benefit from real-time visual feedback dosimetry during interventions (−30%; p = 0.039). Integration of real-time dosimetry into clinical processes might be useful in reducing occupational radiation exposure time during angiographic interventions. The real-time visual feedback raised the awareness of interventionalists and their assistants to the potential danger of prolonged radiation exposure leading to the adoption of radiation-sparing practices. Therefore, it might create a safer environment for the medical staff by keeping the applied radiation exposure as low as possible.
The nuclear factor kappa beta (NFκB) signaling pathway plays an important role in liver homeostasis and cancer development. Tax1-binding protein 1 (Tax1BP1) is a regulator of the NFκB signaling pathway, but its role in the liver and hepatocellular carcinoma (HCC) is presently unknown. Here we investigated the role of Tax1BP1 in liver cells and murine models of HCC and liver fibrosis. We applied the diethylnitrosamine (DEN) model of experimental hepatocarcinogenesis in Tax1BP1+/+ and Tax1BP1−/− mice. The amount and subsets of non-parenchymal liver cells in in Tax1BP1+/+ and Tax1BP1−/− mice were determined and activation of NFκB and stress induced signaling pathways were assessed. Differential expression of mRNA and miRNA was determined. Tax1BP1−/− mice showed increased numbers of inflammatory cells in the liver. Furthermore, a sustained activation of the NFκB signaling pathway was found in hepatocytes as well as increased transcription of proinflammatory cytokines in isolated Kupffer cells from Tax1BP1−/− mice. Several differentially expressed mRNAs and miRNAs in livers of Tax1BP1−/− mice were found, which are regulators of inflammation or are involved in cancer development or progression. Furthermore, Tax1BP1−/− mice developed more HCCs than their Tax1BP1+/+ littermates. We conclude that Tax1BP1 protects from liver cancer development by limiting proinflammatory signaling.
Several microRNAs (miRNAs) are associated with the molecular pathogenesis of hepatocellular carcinoma (HCC). However, previous studies analyzing the dysregulation of miRNAs in HCC show heterogeneous results. We hypothesized that part of this heterogeneity might be attributable to variations of miRNA expression deriving from the HCC capsule or the fibrotic septa within the peritumoral tissue used as controls. Tissue from surgically resected hepatitis C–associated HCC from six well-matched patients was microdissected using laser microdissection and pressure catapulting technique. Four distinct histologic compartments were isolated: tumor parenchyma (TP), fibrous capsule of the tumor (TC), tumor-adjacent liver parenchyma (LP), and cirrhotic septa of the tumor-adjacent liver (LC). MiRNA expression profiling analysis of 1105 mature miRNAs and precursors was performed using miRNA microarray. Principal component analysis and consecutive pairwise supervised comparisons demonstrated distinct patterns of expressed miRNAs not only for TP versus LP (e.g., intratumoral down-regulation of miR-214, miR-199a, miR-146a, and miR-125a; P< .05) but also for TC versus LC (including down-regulation within TC of miR-126, miR-99a/100, miR-26a, and miR-125b; P< .05). The tumor capsule therefore demonstrates a tumor-like phenotype with down-regulation of well-known tumor-suppressive miRNAs. Variations of co-analyzed fibrotic tissue within the tumor or in controls may have profound influence on miRNA expression analyses in HCC. Several miRNAs, which are proposed to be HCC specific, may indeed be rather associated to the tumor capsule. As miRNAs evolve to be important biomarkers in liver tumors, the presented data have important translational implications on diagnostics and treatment in patients with HCC.
Measurement of e⁺e⁻ → π⁺π⁻D⁺D⁻ cross sections at center-of-mass energies from 4.190 to 4.946 GeV
(2022)
Using data samples collected with the BESIII detector operating at the BEPCII storage ring, we measure the cross sections of the e+e−→π+π−D+D− process at center-of-mass energies from 4.190 to 4.946 GeV with a partial reconstruction method. Two resonance structures are seen and the resonance parameters are determined from a fit to the cross section line shape. The first resonance we observe has a mass of (4373.1 ± 4.0 ± 2.2) MeV/c2 and a width of (146.5 ± 7.4 ± 1.3) MeV, in agreement with those of the Y(4390) state; the other resonance has a mass of (4706 ± 11 ± 4) MeV/c2, a width of (45 ± 28 ± 9) MeV, and a statistical significance of 4.1 standard deviations (σ). This is the first evidence for a vector state at this mass value. The spin-3 D-wave charmonium state X(3842) is searched for through the e+e−→π+π−X(3842)→π+π−D+D− process, and evidence with a significance of 4.2σ is found in the data samples with center-of-mass energies from 4.600 to 4.700 GeV.
The decays J/ψ→ηΣ+Σ¯− and ψ(3686)→ηΣ+Σ¯− are observed for the first time, using (10087±44)×106 J/ψ and (448.1±2.9)×106 ψ(3686) events collected with the BESIII detector at the BEPCII collider. We determine the branching fractions of these two decays to be B(J/ψ→ηΣ+Σ¯−)=(6.34±0.21±0.37)×10−5 and B(ψ(3686)→ηΣ+Σ¯−)=(9.59±2.37±0.61)×10−6, where the first uncertainties are statistical and the second are systematic. The ratio of these two branching fractions is determined to be B(ψ(3686)→ηΣ+Σ¯−)B(J/ψ→ηΣ+Σ¯−)=(15.1±3.8)%, which is in agreement with the "12\% rule."
Dendritic spines are crucial for excitatory synaptic transmission as the size of a spine head correlates with the strength of its synapse. The distribution of spine head sizes follows a lognormal-like distribution with more small spines than large ones. We analysed the impact of synaptic activity and plasticity on the spine size distribution in adult-born hippocampal granule cells from rats with induced homo- and heterosynaptic long-term plasticity in vivo and CA1 pyramidal cells from Munc-13-1-Munc13-2 knockout mice with completely blocked synaptic transmission. Neither induction of extrinsic synaptic plasticity nor the blockage of presynaptic activity degrades the lognormal-like distribution but changes its mean, variance and skewness. The skewed distribution develops early in the life of the neuron. Our findings and their computational modelling support the idea that intrinsic synaptic plasticity is sufficient for the generation, while a combination of intrinsic and extrinsic synaptic plasticity maintains lognormal like distribution of spines.
he decay D→K−π+ is studied in a sample of quantum-correlated DD¯ pairs, based on a data set corresponding to an integrated luminosity of 2.93\,fb−1 collected at the ψ(3770) resonance by the BESIII experiment. The asymmetry between CP-odd and CP-even eigenstate decays into K−π+ is determined to be AKπ=0.132±0.011±0.007, where the first uncertainty is statistical and the second is systematic. This measurement is an update of an earlier study exploiting additional tagging modes, including several decay modes involving a K0L meson. The branching fractions of the K0L modes are determined as input to the analysis in a manner that is independent of any strong phase uncertainty. Using the predominantly CP-even tag D→π+π−π0 and the ensemble of CP-odd eigenstate tags, the observable Aπππ0Kπ is measured to be 0.130±0.012±0.008. The two asymmetries are sensitive to rKπDcosδKπD, where rKπD and δKπD are the ratio of amplitudes and phase difference, respectively, between the doubly Cabibbo-suppressed and Cabibbo-favoured decays. In addition, events containing D→K−π+ tagged by D→K0S,Lπ+π− are studied in bins of phase space of the three-body decays. This analysis has sensitivity to both rKπDcosδKπD and rKπDsinδKπD. A fit to AKπ, Aπππ0Kπ and the phase-space distribution of the D→K0S,Lπ+π− tags yields δKπD=(187.5+8.9−9.7+5.4−6.4) degrees, where external constraints are applied for rKπD and other relevant parameters. This is the most precise measurement of δKπD in quantum-correlated DD¯ decays.
The decay D→K−π+ is studied in a sample of quantum-correlated DD¯ pairs, based on a data set corresponding to an integrated luminosity of 2.93\,fb−1 collected at the ψ(3770) resonance by the BESIII experiment. The asymmetry between CP-odd and CP-even eigenstate decays into K−π+ is determined to be AKπ=0.132±0.011±0.007, where the first uncertainty is statistical and the second is systematic. This measurement is an update of an earlier study exploiting additional tagging modes, including several decay modes involving a K0L meson. The branching fractions of the K0L modes are determined as input to the analysis in a manner that is independent of any strong phase uncertainty. Using the predominantly CP-even tag D→π+π−π0 and the ensemble of CP-odd eigenstate tags, the observable Aπππ0Kπ is measured to be 0.130±0.012±0.008. The two asymmetries are sensitive to rKπDcosδKπD, where rKπD and δKπD are the ratio of amplitudes and phase difference, respectively, between the doubly Cabibbo-suppressed and Cabibbo-favoured decays. In addition, events containing D→K−π+ tagged by D→K0S,Lπ+π− are studied in bins of phase space of the three-body decays. This analysis has sensitivity to both rKπDcosδKπD and rKπDsinδKπD. A fit to AKπ, Aπππ0Kπ and the phase-space distribution of the D→K0S,Lπ+π− tags yields δKπD=(187.6+8.9−9.7+5.4−6.4) degrees, where external constraints are applied for rKπD and other relevant parameters. This is the most precise measurement of δKπD in quantum-correlated DD¯ decays.
Based on a sample of 448.1×106 ψ(3686) events collected with the BESIII detector, a study of ψ(3686)→ΛΛ¯π0 and ψ(3686)→ΛΛ¯η is performed. Evidence of the isospin-violating decay ψ(3686)→ΛΛ¯π0 is found for the first time with a statistical significance of 3.7σ, the branching fraction B(ψ(3686)→ΛΛ¯π0) is measured to be (1.42±0.39±0.59)×10−6, and its corresponding upper limit is determined to be 2.47×10−6 at 90\% confidence level. A partial wave analysis of ψ(3686)→ΛΛ¯η shows that the peak around Λη invariant mass threshold favors a Λ∗ resonance with mass and width in agreement with the Λ(1670). The branching fraction of the ψ(3686)→ΛΛ¯η is measured to be (2.34±0.18±0.52)×10−5. The first uncertainties are statistical and the second are systematic.
Based on e+e− collision data corresponding to an integrated luminosity of 4.5 fb−1 collected at the center-of-mass energies between 4.600 and 4.699 GeV with the BESIII detector at BEPCII, the absolute branching fraction of the inclusive decay Λ+c→n+X, where X refers to any possible final state particles, is measured. The absolute branching fraction is determined to be B(Λ+c→n+X)=(32.4±0.7±1.5)%, where the first uncertainty is statistical and the second systematic. Assuming CP symmetry, the measurement indicates that about one-fourth of Λ+c (Λ¯−c) decay modes with a neutron (an anti-neutron) in the final state have not been observed.
Based on e+e− collision data corresponding to an integrated luminosity of 4.5 fb−1 collected at the center-of-mass energies between 4.600 and 4.699 Gev with the BESIII detector at BEPCII, the absolute branching fraction of the inclusive decay Λ¯−c→n¯+X, where X refers to any possible final state particles, is measured. The absolute branching fraction is determined to be B(Λ¯−c→n¯+X)=(33.5±0.7±1.2)%, where the first uncertainty is statistical and the second systematic. Neglecting the effect of CP violation, the measurement indicates that about one-fourth of Λ+c decay modes with a neutron in the final state have not been observed.
The radiative hyperon decay Λ→𝑛𝛾 is studied using (10087±44)×106 𝐽/𝜓 events collected with the BESIII detector operating at BEPCII. The absolute branching fraction of the decay Λ→𝑛𝛾 is determined to be (0.832±0.038stat±0.054syst)×10−3, which is a factor of 2.1 lower and 5.6 standard deviations different than the previous measurement. By analyzing the joint angular distribution of the decay products, the first determination of the decay asymmetry 𝛼𝛾 is reported with a value of −0.16±0.10stat±0.05syst.
Measurement of e⁺e⁻ → π⁺π⁻D⁺D⁻ cross sections at center-of-mass energies from 4.190 to 4.946 GeV
(2022)
Using data samples collected with the BESIII detector operating at the BEPCII storage ring, we measure the cross sections of the e+e−→π+π−D+D− process at center-of-mass energies from 4.190 to 4.946 GeV with a partial reconstruction method. Two resonance structures are seen and the resonance parameters are determined from a fit to the cross section line shape. The first resonance we observe has a mass of (4373.1 ± 4.0 ± 2.2) MeV/c2 and a width of (146.5 ± 7.4 ± 1.3) MeV, in agreement with those of the Y(4390) state; the other resonance has a mass of (4706 ± 11 ± 4) MeV/c2, a width of (45 ± 28 ± 9) MeV, and a statistical significance of 4.1 standard deviations (σ). This is the first evidence for a vector state at this mass value. The spin-3 D-wave charmonium state X(3842) is searched for through the e+e−→π+π−X(3842)→π+π−D+D− process, and evidence with a significance of 4.2σ is found in the data samples with center-of-mass energies from 4.600 to 4.700 GeV.
Cross sections for the process e+e−→K0SK0SJ/ψ at center-of-mass energies from 4.128 to 4.950 GeV are measured using data samples with a total integrated luminosity of 21.2 fb−1 collected by the BESIII detector operating at the BEPCII storage ring. The Y(4230) state is observed in the energy dependence of the e+e−→K0SK0SJ/ψ cross section for the first time with a statistical significance of 26.0σ. In addition, an enhancement around 4.710 GeV, called the Y(4710), is seen with a statistical significance of 4.2σ. There is no clear structure around 4.484 GeV. Using a fit with a coherent sum of three Breit-Wigner functions, we determine the mass and width of the Y(4230) state to be 4226.9±6.6±21.9 MeV/c2 and 71.7±16.2±31.4 MeV, respectively, and the mass and width of the Y(4710) state to be 4704.0±52.3±69.5 MeV/c2 and 183.2±114.0±90.8 MeV, respectively, where the first uncertainties are statistical and the second are systematic. In addition, the average Born cross section ratio of e+e−→K0SK0SJ/ψ to e+e−→K+K−J/ψ is measured to be 0.388+0.035−0.028±0.016, or 0.426+0.038−0.031±0.018 if three-body phase space is considered.
Using 4.5fb−1 of e+e− annihilation data samples collected at center-of-mass energies ranging from 4.600 to 4.698 GeV with the BESIII detector at the BEPCII collider, we measured the absolute branching fraction for the inclusive semileptonic decay Λ+c→Xe+νe, where X refers to any possible particle system. The branching fraction of the decay is determined to be B(Λ+c→Xe+νe)=(4.06±0.10stat.±0.09syst.)%. Our result improves the precision of previous measurement of B(Λ+c→Xe+νe) by more than threefold. Using the known Λ+c lifetime and the charge-averaged semileptonic decay width of nonstrange charmed mesons, we measure the ratio of inclusive semileptonic decay widths Γ(Λ+c→Xe+νe)/Γ¯(D→Xe+νe)=1.28±0.05, where statistical and systematic uncertainties are combined.
Based on 7.33 fb−1 of e+e− collision data taken at center-of-mass energies between 4.128 and 4.226 GeV with the BESIII detector, we measure the branching fraction of D∗+s→D+sπ0 relative to that of D∗+s→D+sγ to be (6.16±0.43±0.19)%. The first uncertainty is statistical and the second one is systematic. By using the world average value of the branching fraction of D∗+s→D+se+e−, we determine the branching fractions of D∗+s→D+sγ and D∗+s→D+sπ0 to be (93.57±0.44±0.19)% and (5.76±0.44±0.19)%, respectively.
Cross sections for the process e+e−→K0SK0SJ/ψ at center-of-mass energies from 4.128 to 4.950 GeV are measured using data samples with a total integrated luminosity of 21.2 fb−1 collected by the BESIII detector operating at the BEPCII storage ring. The Y(4230) state is observed in the energy dependence of the e+e−→K0SK0SJ/ψ cross section for the first time with a statistical significance of 26.0σ. In addition, an enhancement around 4.710 GeV, called the Y(4710), is seen with a statistical significance of 4.2σ. There is no clear structure around 4.484 GeV. Using a fit with a coherent sum of three Breit-Wigner functions, we determine the mass and width of the Y(4230) state to be 4226.9±6.6±21.9 MeV/c2 and 71.7±16.2±31.4 MeV, respectively, and the mass and width of the Y(4710) state to be 4704.0±52.3±69.5 MeV/c2 and 183.2±114.0±90.8 MeV, respectively, where the first uncertainties are statistical and the second are systematic. In addition, the average Born cross section ratio of e+e−→K0SK0SJ/ψ to e+e−→K+K−J/ψ is measured to be 0.388+0.035−0.028±0.016, or 0.426+0.038−0.031±0.018 if three-body phase space is considered.
Using 7.33 fb−1 of e+e− collision data collected by the BESIII detector at center-of-mass energies between 4.128 and 4.226~GeV, we observe for the first time the decay D±s→ωπ±η with a statistical significance of 7.6σ. The measured branching fraction of this decay is (0.54±0.12±0.04)%, where the first uncertainty is statistical and the second is systematic.
Using data samples of e+e− collisions collected with the BESIII detector at eight center-of-mass energy points between 3.49 and 3.67 GeV, corresponding to an integrated luminosity of 670 pb−1, we present the upper limits of Born cross sections and the effective form factor for the process e+e−→Ω−Ω¯+. A fit to the cross sections using a pQCD-derived energy dependent function shows no significant threshold effect. The upper limit on the measured effective form factor is consistent with a theoretical prediction within the uncertainty of 1σ. These results provide new experimental information on the production mechanism of Ω.
A determination of the CP-even fraction F+ in the decay D0→K+K−π+π− is presented. Using 2.93 fb−1 of e+e−→ψ(3770)→DD¯ data collected by the BESIII detector, one charm meson is reconstructed in the signal mode and the other in a CP eigenstate or the decay D→K0S,Lπ+π−. Analysis of the relative rates of these double-tagged events yields the result F+=0.730±0.037±0.021, where the first uncertainty is statistical and the second is systematic. This is the first model-independent measurement of F+ in D0→K+K−π+π− decays.
The Cabibbo-allowed weak radiative decay Λ+c→Σ+γ has been searched for in a sample of Λ+cΛ¯−c pairs produced in e+e− annihilations, corresponding to an integrated luminosity of 4.5fb−1 collected with the BESIII detector at center-of-mass energies between 4.60 and 4.70 GeV. No excess of signal above background is observed, and we set an upper limit on the branching fraction of this decay to be B(Λ+c→Σ+γ)<4.4×10−4 at a confidence level of 90\%, which is in agreement with Standard Model expectations.
A determination of the CP-even fraction F+ in the decay D0→K+K−π+π− is presented. Using 2.93 fb−1 of e+e−→ψ(3770)→DD¯ data collected by the BESIII detector, one charm meson is reconstructed in the signal mode and the other in a CP eigenstate or the decay D→K0S,Lπ+π−. Analysis of the relative rates of these double-tagged events yields the result F+=0.730±0.037±0.021, where the first uncertainty is statistical and the second is systematic. This is the first model-independent measurement of F+ in D0→K+K−π+π− decays.
Using 4.7 fb−1 of e+e− collision data at center-of-mass energies from 4.661 to 4.951 GeV collected by the BESIII detector at the BEPCII collider, we observe the X(3872) production process e+e−→ωX(3872) for the first time. The significance is 7.8σ, including both the statistical and systematic uncertainties. The e+e−→ωX(3872) Born cross section and the corresponding upper limit at 90\% confidence level at each energy point are reported. The line shape of the cross section indicates that the ωX(3872) signals may be from the decays of some non-trivial structures.
The Cabibbo-allowed weak radiative decay Λ+c→Σ+γ has been searched for in a sample of Λ+cΛ¯−c pairs produced in e+e− annihilations, corresponding to an integrated luminosity of 4.5fb−1 collected with the BESIII detector at center-of-mass energies between 4.60 and 4.70 GeV. No excess of signal above background is observed, and we set an upper limit on the branching fraction of this decay to be B(Λ+c→Σ+γ)<4.4×10−4 at a confidence level of 90\%, which is in agreement with Standard Model expectations.
Using 4.7fb−1 of e+e− collision data at center-of-mass energies from 4.661 to 4.951 GeV collected by the BESIII detector at the BEPCII collider, we observe the X(3872) production process e+e−→ωX(3872) for the first time. The significance is 7.5σ, including both the statistical and systematic uncertainties. The e+e−→ωX(3872) Born cross section and the corresponding upper limit at 90\% confidence level at each energy point are reported. The line shape of the cross section indicates that the ωX(3872) signals may be from the decays of some non-trivial structures.
Cross sections for the process e+e−→K0SK0SJ/ψ at center-of-mass energies from 4.128 to 4.950 GeV are measured using data samples with a total integrated luminosity of 21.2 fb−1 collected by the BESIII detector operating at the BEPCII storage ring. The Y(4230) state is observed in the energy dependence of the e+e−→K0SK0SJ/ψ cross section for the first time with a statistical significance of 26.0σ. In addition, an enhancement around 4.710 GeV, called the Y(4710), is seen with a statistical significance of 4.2σ. There is no clear structure around 4.484 GeV. Using a fit with a coherent sum of three Breit-Wigner functions, we determine the mass and width of the Y(4230) state to be 4226.9±6.6±21.9 MeV/c2 and 71.7±16.2±31.4 MeV, respectively, and the mass and width of the Y(4710) state to be 4704.0±52.3±69.5 MeV/c2 and 183.2±114.0±90.8 MeV, respectively, where the first uncertainties are statistical and the second are systematic. In addition, the average Born cross section ratio of e+e−→K0SK0SJ/ψ to e+e−→K+K−J/ψ is measured to be 0.388+0.035−0.028±0.016, or 0.426+0.038−0.031±0.018 if three-body phase space is considered.
Cross sections for the process e+e−→K0SK0SJ/ψ at center-of-mass energies from 4.128 to 4.950 GeV are measured using data samples with a total integrated luminosity of 21.2 fb−1 collected by the BESIII detector operating at the BEPCII storage ring. The Y(4230) state is observed in the energy dependence of the e+e−→K0SK0SJ/ψ cross section for the first time with a statistical significance of 26.0σ. In addition, an enhancement around 4.710 GeV, called the Y(4710), is seen with a statistical significance of 4.2σ. There is no clear structure around 4.484 GeV. Using a fit with a coherent sum of three Breit-Wigner functions, we determine the mass and width of the Y(4230) state to be 4226.9±6.6±21.9 MeV/c2 and 71.7±16.2±31.4 MeV, respectively, and the mass and width of the Y(4710) state to be 4704.0±52.3±69.5 MeV/c2 and 183.2±114.0±90.8 MeV, respectively, where the first uncertainties are statistical and the second are systematic. In addition, the average Born cross section ratio of e+e−→K0SK0SJ/ψ to e+e−→K+K−J/ψ is measured to be 0.388+0.035−0.028±0.016, or 0.426+0.038−0.031±0.018 if three-body phase space is considered.
Based on 7.33 fb−1 of e+e− collision data taken at center-of-mass energies between 4.128 and 4.226 GeV with the BESIII detector, we measure the branching fraction of D∗+s→D+sπ0 relative to that of D∗+s→D+sγ to be (6.16±0.43±0.19)%. The first uncertainty is statistical and the second one is systematic. By using the world average value of the branching fraction of D∗+s→D+se+e−, we determine the branching fractions of D∗+s→D+sγ and D∗+s→D+sπ0 to be (93.57±0.44±0.19)% and (5.76±0.44±0.19)%, respectively.
Cross sections for the process e+e−→K0SK0SJ/ψ at center-of-mass energies from 4.128 to 4.950 GeV are measured using data samples with a total integrated luminosity of 21.2 fb−1 collected by the BESIII detector operating at the BEPCII storage ring. The Y(4230) state is observed in the energy dependence of the e+e−→K0SK0SJ/ψ cross section for the first time with a statistical significance of 26.0σ. In addition, an enhancement around 4.710~GeV, called the Y(4710), is seen with a statistical significance of 4.2σ. There is no clear structure around 4.484 GeV. Using a fit with a coherent sum of three Breit-Wigner functions, we determine the mass and width of the Y(4230) state to be 4226.9±6.6±21.9 MeV/c2 and 71.7±16.2±31.4 MeV, respectively, and the mass and width of the Y(4710) state to be 4704.0±52.3±69.5 MeV/c2 and 183.2±114.0±90.8 MeV, respectively, where the first uncertainties are statistical and the second are systematic. In addition, the average Born cross section ratio of e+e−→K0SK0SJ/ψ to e+e−→K+K−J/ψ is measured to be 0.415+0.032−0.026±0.017, or 0.449+0.034−0.028±0.019 if three-body phase space is considered.
We present the first search for the leptonic decays D∗+→e+νe and D∗+→μ+νμ by analyzing a data sample of electron-positron collisions recorded with the BESIII detector at center-of-mass energies between 4.178 and 4.226 GeV, corresponding to an integrated luminosity of 6.32~fb−1. No significant signal is observed. The upper limits on the branching fractions for D∗+→e+νe and D∗+→μ+νμ are set to be 1.1×10−5 and 4.3×10−6 at 90\% confidence level, respectively.
Based on 7.33 fb−1 of e+e− collision data taken at center-of-mass energies between 4.128 and 4.226 GeV with the BESIII detector, we measure the branching fraction of D∗+s→D+sπ0 relative to that of D∗+s→D+sγ to be (6.16±0.43±0.19)%. The first uncertainty is statistical and the second one is systematic. By using the world average value of the branching fraction of D∗+s→D+se+e−, we determine the branching fractions of D∗+s→D+sγ and D∗+s→D+sπ0 to be (93.57±0.44±0.19)% and (5.76±0.44±0.19)%, respectively.
Using 4.7 fb−1 of e+e− collision data at center-of-mass energies from 4.661 to 4.951 GeV collected by the BESIII detector at the BEPCII collider, we observe the X(3872) production process e+e−→ωX(3872) for the first time. The significance is 7.8σ, including both the statistical and systematic uncertainties. The e+e−→ωX(3872) Born cross section and the corresponding upper limit at 90\% confidence level at each energy point are reported. The line shape of the cross section indicates that the ωX(3872) signals may be from the decays of some non-trivial structures.
We present the first search for the semileptonic decay D+s→π0e+νe using a data sample of electron-positron collisions recorded with the BESIII detector at center-of-mass energies between 4.178 and 4.226~GeV, corresponding to an integrated luminosity of 6.32~fb−1. This decay is expected to be sensitive to π0--η mixing. No significant signal is observed. We set an upper limit of 6.4×10−5 on the branching fraction at the 90% confidence level.
The Cabibbo-allowed weak radiative decay Λ+c→Σ+γ has been searched for in a sample of Λ+cΛ¯−c pairs produced in e+e− annihilations, corresponding to an integrated luminosity of 4.5fb−1 collected with the BESIII detector at center-of-mass energies between 4.60 and 4.70 GeV. No excess of signal above background is observed, and we set an upper limit on the branching fraction of this decay to be B(Λ+c→Σ+γ)<4.4×10−4 at a confidence level of 90\%, which is in agreement with Standard Model expectations.
Measurement of the e⁺e⁻ → ωπ⁰π⁰ cross section at center-of-mass energies from 2.0 to 3.08 GeV
(2022)
The cross section of the process e+e−→ωπ0π0 is measured at nineteen center-of-mass energies from 2.0 to 3.08 GeV using data collected with the BESIII detector at the BEPCII storage ring. A resonant structure around 2.20 GeV is observed with statistical significance larger than 5σ. Using a coherent fit to the cross section line shape, the mass and width are determined to be M=2222±7±2 MeV/c2 and Γ=59±30±6 MeV, respectively, where the first uncertainties are statistical and the second ones are systematic.
A determination of the CP-even fraction F+ in the decay D0→K+K−π+π− is presented. Using 2.93 fb−1 of e+e−→ψ(3770)→DD¯ data collected by the BESIII detector, one charm meson is reconstructed in the signal mode and the other in a CP eigenstate or the decay D→K0S,Lπ+π−. Analysis of the relative rates of these double-tagged events yields the result F+=0.730±0.037±0.021, where the first uncertainty is statistical and the second is systematic. This is the first model-independent measurement of F+ in D0→K+K−π+π− decays.
Measurement of the absolute branching fraction of the singly Cabibbo suppressed decay Λc⁺ → pη′
(2022)
The singly Cabibbo suppressed decay Λ+c→pη′ is measured using 4.5 fb−1 of e+e− collision data collected at center-of-mass energies between 4.600 and 4.699 GeV with the BESIII detector at BEPCII. Evidence for Λ+c→pη′ with a statistical significance of 3.6σ is reported with a double-tag approach. The Λ+c→pη′ absolute branching fraction is determined to be (5.62+2.46−2.04±0.26)×10−4, where the first and second uncertainties are statistical and systematic, respectively. Our result is consistent with the branching fraction obtained by the Belle collaboration within the uncertainty of 1σ.
Measurement of e⁺e⁻ → ΛΛ¯η from 3.5106 to 4.6988 GeV and study of ΛΛ¯ mass threshold enhancement
(2023)
Using data samples with a total integrated luminosity of approximately 18 fb−1 collected by the BESIII detector operating at the BEPCII, the process e+e−→ΛΛ¯η is studied at center-of-mass energies between 3.5106 and 4.6988 GeV. The Born cross section for the process e+e−→ΛΛ¯η is measured. No significant structure is observed in the Born cross section line shape. An enhancement near the ΛΛ¯ mass threshold is observed for the first time in the process. The structure can be described by an S-wave Breit-Wigner function. Neglecting contribution of excited Λ states and potential interferences, the mass and width are determined to be (2356±7±17) MeV/c2 and (304±28±54) MeV, respectively, where the first uncertainties are statistical and the second are systematic.
Based on e+e− collision data corresponding to an integrated luminosity of 4.5 fb−1 collected at the center-of-mass energies between 4.600 and 4.699 GeV with the BESIII detector at BEPCII, the absolute branching fraction of the inclusive decay Λ+c→n+X, where X refers to any possible final state particles, is measured. The absolute branching fraction is determined to be B(Λ+c→n+X)=(32.4±0.7±1.5)%, where the first uncertainty is statistical and the second systematic. Assuming CP symmetry, the measurement indicates that about one-fourth of Λ+c (Λ¯−c) decay modes with a neutron (an anti-neutron) in the final state have not been observed.