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Adams, John ; Adler, Clemens ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Amonett, John ; Anderson, Bryon D. ; Arkhipkin, Dmitry A. ; Averichev, Georgy S. ; Bai, Yu ; Balewski, Jan ; Barannikova, Olga ; Barnby, Lee Stuart ; Baudot, Jérome ; Bekele, Selemon ; Belaga, Victoria Vladimirovna ; Bellwied, Rene ; Berger, Jens ; Bezverkhny, B. I. ; Bharadwaj, Somnath ; Bhatia, V. S. ; Bichsel, Hans ; Bland, Leslie C. ; Blyth, Charles O. ; Bonner, Billy E. ; Botje, Michiel ; Boucham, Abdelkrim ; Brandin, Andrei V. ; Bravar, Alessandro ; Cadman, Robert V. ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Carroll, J. ; Castillo Castellanos, Javier Ernesto ; Cebra, Daniel A. ; Chaloupka, Petr ; Chattopdhyay, S. ; Chen, H. F. ; Chen, Y. ; Cheng, J. ; Cherney, Michael Gerard ; Chikanian, Alexei ; Christie, William ; Coffin, Jean Pierre ; Cormier, Thomas Michael ; Cramer, John G. ; Crawford, Henry J. ; Das, Debasish ; Das, Supriya ; de Moura, M. M. ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dietel, Thomas ; Dong, W. J. ; Dong, X. ; Draper, James E. ; Du, F. ; Dubey, Anand Kumar ; Dunin, V. B. ; Dunlop, James C. ; Dutta Mazumdar, M. R. ; Eckardt, Volker ; Efimov, Leonid G. ; Emelianov, V. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Erazmus, Barbara Ewa ; Estienne, Magali Danielle ; Fachini, Patricia ; Faivre, Julien ; Fatemi, Renee H. ; Fedorišin, Jan ; Filimonov, Kirill ; Filip, Peter ; Finch, Evan ; Fine, Valeri ; Fisyak, Yuri V. ; Flierl, Dominik Bernhard ; Foley, K. J. ; Fomenko, K. ; Fu, J. ; Gagliardi, Carl A. ; Gans, J. ; Ganti, Murthy S. ; Gaudichet, Ludovic ; Geurts, Frank ; Ghazikhanian, Vahe ; Ghosh, Premomoy ; Gonzalez, Johan Enmanuel ; Grachov, Oleg A. ; Grebenyuk, Oleksandr ; Gronstal, S. ; Grosnick, David P. ; Guertin, Steven M. ; Gupta, Anik ; Gutierrez, Thomas Dominic ; Hallman, Timothy J. ; Hamed, Ahmed M. ; Hardtke, David H. ; Harris, John W. ; Heinz, Mark Thomas ; Henry, Thomas W. ; Hepplemann, Steven Francis ; Hippolyte, Boris ; Hirsch, Andrew S. ; Hjort, Eric ; Hoffmann, Gerald W. ; Huang, Huan Zhong ; Huang, Shengli ; Hughes, Emlyn Willard ; Humanic, Thomas J. ; Igo, George J. ; Ishihara, A. ; Jacobs, Peter Martin ; Jacobs, William W. ; Janik, Michał ; Jiang, H. ; Jones, Peter Graham ; Judd, Eleanor G. ; Kabana, Sonia ; Kang, K. ; Kaplan, Morton ; Keane, Declan ; Khodyrev, V. Yu. ; Kiryluk, Joanna ; Kisiel, Adam Ryszard ; Kislov, E. M. ; Klay, Jennifer Lynn ; Klein, Spencer Robert ; Klyachko, A. ; Koetke, Donald D. ; Kollegger, Thorsten ; Kopytine, Mikhail L. ; Kotchenda, L. ; Kramer, Michael ; Kravtsov, Peter ; Kravtsov, Vladimir I. ; Krueger, Keith William ; Kuhn, Christian Claude ; Kulikov, Anatoly I. ; Kumar, Ajay ; Kunz, Christopher Lee ; Kutuev, R. Kh. ; Kuznetsov, A. A. ; Lamont, Matthew A. C. ; Landgraf, Jeffery M. ; Lange, S. ; Lansdell, C. L. ; Laue, Frank ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lehocka, S. ; LeVine, Micheal J. ; Li, C. ; Li, Q. ; LI, Y. ; Lindenbaum, Sam J. ; Lisa, Michael A. ; Liu, F. ; Liu, L. ; Liu, Q. J. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Long, H. ; Longacre, Ronald S. ; Lopez-Noriega, M. ; Love, William A. ; Ludlam, Thomas ; Lynn, David ; Ma, G. L. ; Ma, Jing-guo ; Ma, Yu-Gang ; Magestro, Daniel ; Mahajan, Sanjay ; Mahapatra, Durga Prasad ; Majka, Richard Daniel ; Mangotra, Lalit K. ; Manweiler, Robert W. ; Margetis, Spyridon ; Markert, Christina ; Martin, Lilian ; Marx, Jay N. ; Matis, Howard S. ; Matulenko, Yuri A. ; McClain, C. J. ; McShane, Tom S. ; Meißner, Falk ; Melnick, Yu. ; Meščanin, Aleksei P. ; Miller, Michael L. ; Milosevich, Z. ; Minaev, Nikolai G. ; Mironov, Camelia ; Mischke, André ; Mishra, Debadeepti ; Mitchell, J. ; Mohanty, Bedangadas ; Molnar, Levente ; Moore, C. F. ; Mora-Corral, M. J. ; Morozov, Dmitry A. ; Morozov, V. ; Munhoz, Marcelo Gameiro ; Nandi, Basanta Kumar ; Nayak, Tapan Kumar ; Nelson, John M. ; Netrakanti, Pawan Kumar ; Nikitin, Vladimir A. ; Nogach, Larisa V. ; Norman, Benjamin Edward ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Okorokov, Vitaly A. ; Oldenburg, Markus D. ; Olson, Douglas L. ; Pal, Susanta Kumar ; Panebratsev, Yuri ; Panitkin, Sergei Yurievich ; Pavlinov, Alexei I. ; Pawlak, Tomasz Jan ; Peitzmann, Thomas ; Perevoztchikov, V. ; Perkins, Chris ; Peryt, Wiktor Stanislaw ; Petrov, Vladimir A. ; Phatak, Shashikant C. ; Picha, R. ; Planinic, Mirko ; Pluta, Jan Marian ; Porile, Norbert T. ; Porter, Jeffrey Brent ; Poskanzer, Arthur M. ; Potekhin, Maxim ; Potrebenikova, E. ; Potukuchi, B. V. K. S. ; Prindle, Duncan J. ; Pruneau, Claude A. ; Putschke, Jörn H. ; Rai, Gulshan ; Rakness, Gregory L. ; Raniwala, Rashmi ; Raniwala, Sudhir ; Ravel, Olivier ; Ray, Robert L. ; Razin, Sergej V. ; Reichhold, Dennis Michael ; Reid, Jeffrey G. ; Renault, Gael ; Retiere, Fabrice ; Ridiger, Alexey ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Rose, Andrew Allen ; Ruan, Lijuan ; Sakrejda, Iwona ; Salur, Sevil ; Sandweiss, Jack H. ; Savin, Igor A. ; Sazhin, P. S. ; Schambach, Joachim ; Scharenberg, Rolf Paul ; Schmitz, Norbert ; Schroeder, Lee S. ; Schweda, Kai ; Seger, Janet Elizabeth ; Seyboth, Peter ; Shahaliev, Ehtiram ; Shao, M. ; Shao, W. ; Sharma, M. ; Shen, W. Q. ; Shestermanov, Konstantin E. ; Shimanskiy, Stepan S. ; Simon, F. ; Singaraju, Rama Narayana ; Skoro, Goran P. ; Smirnov, Nikolai ; Snellings, Raimond ; Sood, Gopika ; Sorensen, Paul Richard ; Sowinski, James ; Speltz, Jeff ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; St. Claire, L. ; Stadnik, A. ; Stock, Reinhard ; Stolpovsky, Alexander ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Struck, Christof ; Suaide, Alexandre Alarcon do Passo ; Sugarbaker, Evan R. ; Suire, Christophe Pierre ; Šumbera, Michal ; Surrow, Bernd ; Symons, Timothy James MacNeil ; Toledo, Alejandro Szanto de ; Szarwas, Piotr ; Tai, An ; Takahashi, Jun ; Tang, Aihong ; Thein, Dylan ; Thomas, James H. ; Timoshenko, Sergei ; Tokarev, Mikhail V. ; Trainor, Thomas A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tsai, Oleg D. ; Ullrich, Thomas ; Underwood, David G. ; Urkinbaev, Anarbay ; Van Buren, Gene ; Vander Molen, A. M. ; Varma, Raghava ; Vasilevski, I. M. ; Vasiliev, Alexander Nikolaevich ; Vernet, Renaud ; Vigdor, Steven E. ; Viyogi, V. P. ; Vokal, Stanislav ; Vznuzdaev, Marat ; Waggoner, William T. ; Wang, F. ; Wang, G. ; Wang, G. ; Wang, X. L. ; Wang, Y. ; Wang, Y. ; Wang, Z. M. ; Ward, H. ; Webb, Jason C. ; Wells, R. ; Westfall, Gary D. ; Wetzler, Alexander Albert ; Whitten, Charles A. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wood, John P. ; Wu, J. ; Xu, N. ; Xu, Z. ; Xu, Z. ; Yamamoto, E. ; Yepes, Pablo P. ; Yurevich, Vladimir Yurevich ; Zanevsky, Yuri V. ; Zhang, Haitao ; Zhang, Z. P. ; Zolnierczuk, Piotr Adam ; Zoulkarneev, Rafael ; Zoulkarneeva, Youlia ; Zubarev, A. N.
The transverse mass spectra and midrapidity yields for Xi s and Omega s are presented. For the 10% most central collisions, the Xi -bar+/h- ratio increases from the Super Proton Synchrotron to the Relativistic Heavy Ion Collider energies while the Xi -/h- stays approximately constant. A hydrodynamically inspired model fit to the Xi spectra, which assumes a thermalized source, seems to indicate that these multistrange particles experience a significant transverse flow effect, but are emitted when the system is hotter and the flow is smaller than values obtained from a combined fit to pi , K, p, and Lambda s.
Flinn, Laura J. ; Keatinge, Marcus ; Bretaud, Sandrine ; Mortiboys, Heather ; Matsui, Hideaki ; De Felice, Elena ; Woodroof, Helen I. ; Brown, Lucy ; McTighe, Aimee ; Söllner, Rosemarie Waltraud ; Allen, Claire E. ; Heath, Paul Roy ; Milo, Marta ; Muqit, Miratul M. K. ; Reichert, Andreas ; Köster, Reinhard W. ; Ingham, Philip W. ; Bandmann, Oliver
Objective: Loss of function mutations in PINK1 typically lead to early onset Parkinson disease (PD). Zebrafish (Danio rerio) are emerging as a powerful new vertebrate model to study neurodegenerative diseases. We used a pink1 mutant (pink−/−) zebrafish line with a premature stop mutation (Y431*) in the PINK1 kinase domain to identify molecular mechanisms leading to mitochondrial dysfunction and loss of dopaminergic neurons in PINK1 deficiency.
Methods: The effect of PINK1 deficiency on the number of dopaminergic neurons, mitochondrial function, and morphology was assessed in both zebrafish embryos and adults. Genome-wide gene expression studies were undertaken to identify novel pathogenic mechanisms. Functional experiments were carried out to further investigate the effect of PINK1 deficiency on early neurodevelopmental mechanisms and microglial activation.
Results: PINK1 deficiency results in loss of dopaminergic neurons as well as early impairment of mitochondrial function and morphology in Danio rerio. Expression of TigarB, the zebrafish orthologue of the human, TP53-induced glycolysis and apoptosis regulator TIGAR, was markedly increased in pink−/− larvae. Antisense-mediated inactivation of TigarB gave rise to complete normalization of mitochondrial function, with resulting rescue of dopaminergic neurons in pink−/− larvae. There was also marked microglial activation in pink−/− larvae, but depletion of microglia failed to rescue the dopaminergic neuron loss, arguing against microglial activation being a key factor in the pathogenesis.
Interpretation: Pink1−/− zebrafish are the first vertebrate model of PINK1 deficiency with loss of dopaminergic neurons. Our study also identifies TIGAR as a promising novel target for disease-modifying therapy in PINK1-related PD. Ann Neurol 2013;74:837–847
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