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Guerrero Sánchez, Carlos ; Lerendegui-Marco, Jorge ; Domingo-Pardo, César ; Casanovas Hoste, Adrià ; Dressler, Rugard ; Halfon, Shlomi ; Heinitz, Stephan ; Kivel, Nikolay ; Köster, Ulrich ; Paul, Michael ; Quesada Molina, José Manuel ; Schumann, Dorothea ; Tarifeño-Saldivia, Ariel ; Tessler, Moshe ; Weissman, Leo ; Aberle, Oliver ; Andrzejewski, Józef ; Audouin, Laurent ; Bacak, Michael ; Balibrea Correa, Javier ; Barbagallo, Massimo ; Bečvář, František ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brown, Adam ; Caamaño, Manuel ; Calviño Tavares, Francisco ; Calviani, Marco ; Cano-Ott, Daniel ; Cardella, Roberto ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Colonna, Nicola ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Cosentino, Luigi ; Damone, Lucia Anna ; Diakaki, Maria ; Dupont, Emmeric ; Durán, Ignacio ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Ferreira, Pedro G. ; Finocchiaro, Paolo ; Göbel, Kathrin ; García Ríos, Aczel Regino ; Gawlik, Aleksandra ; Gilardoni, Simone ; Glodariu, Tudor ; Gonçalves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Griesmayer, Erich ; Gunsing, Frank ; Harada, Hideo ; Heyse, Jan ; Jenkins, David ; Jericha, Erwin ; Käppeler, Franz ; Kadi, Yacine ; Kalamara, Antigoni ; Kavrigin, Pavel ; Kimura, Atsushi ; Kivel, Nikolay ; Kokkoris, Michael ; Krtička, Milan ; Kurtulgil, Cem Deniz ; Leal Cidoncha, Esther ; Lederer, Claudia ; Leeb, Helmut ; Lo Meo, Sergio ; Lonsdale, Sarah Jane ; Macina, Daniela ; Marganiec, Justyna ; Martı́nez, Trinitario ; Masi, Alessandro ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Maugeri, Emilio Andrea ; Mazzone, Annamaria ; Mendoza Cembranos, Emilio ; Mengoni, Alberto ; Milazzo, Paolo Maria ; Mingrone, Federica ; Musumarra, Agatino ; Negret, Alexandru ; Nolte, Ralf ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Porras Sánchez, José Ignacio ; Praena, Javier ; Radeck, Désirée ; Rauscher, Thomas ; Reifarth, René ; Rout, Prakash Chandra ; Rubbia, Carlo ; Ryan, James ; Sabaté-Gilarte, Marta ; Saxena, Alok ; Schillebeeckx, Peter ; Smith, Alastair Gavin ; Sosnin, Nikolay V. ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Tassan-Got, Laurent ; Tsinganis, Andrea ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vlachoudis, Vasilis ; Vlastou, Rosa ; Wallner, Anton ; Warren, Stephen J. ; Weiß, Christina ; Woods, Philip John ; Wright, Tobias ; Žugec, Petar
The neutron capture cross section of several key unstable isotopes acting as branching points in the s-process are crucial for stellar nucleosynthesis studies, but they are very challenging to measure due to the difficult production of sufficient sample material, the high activity of the resulting samples, and the actual (n,γ) measurement, for which high neutron fluxes and effective background rejection capabilities are required. As part of a new program to measure some of these important branching points, radioactive targets of 147Pm and 171Tm have been produced by irradiation of stable isotopes at the ILL high flux reactor. Neutron capture on 146Nd and 170Er at the reactor was followed by beta decay and the resulting matrix was purified via radiochemical separation at PSI. The radioactive targets have been used for time-of-flight measurements at the CERN n_TOF facility using the 19 and 185 m beam lines during 2014 and 2015. The capture cascades were detected using a set of four C6D6 scintillators, allowing to observe the associated neutron capture resonances. The results presented in this work are the first ever determination of the resonance capture cross section of 147Pm and 171Tm. Activation experiments on the same 147Pm and 171Tm targets with a high-intensity 30 keV quasi-Maxwellian flux of neutrons will be performed using the SARAF accelerator and the Liquid-Lithium Target (LiLiT) in order to extract the corresponding Maxwellian Average Cross Section (MACS). The status of these experiments and preliminary results will be presented and discussed as well.
Mingrone, Federica ; Aberle, Oliver ; Andrzejewski, Józef ; Audouin, Laurent ; Bécares, Vicente ; Bacak, Michael ; Balibrea Correa, Javier ; Barbagallo, Massimo ; Barros, Susana C.C. ; Bečvář, František ; Beinrucker, Clemens ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brugger, Markus ; Caamaño, Manuel ; Calviño Tavares, Francisco ; Calviani, Marco ; Cano-Ott, Daniel ; Cardella, Roberto ; Casanovas Hoste, Adrià ; Castelluccio, Donato Maurizio ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Colonna, Nicola ; Cortés-Giraldo, Miguel Antonio ; Cortés Rossell, Guillem Pere ; Cosentino, Luigi ; Damone, Lucia Anna ; Diakaki, Maria ; Domingo-Pardo, César ; Dressler, Rugard ; Dupont, Emmeric ; Durán, Ignacio ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Ferreira, Pedro G. ; Finocchiaro, Paolo ; Furman, Valter ; Ganesan, Srinivasan ; García Ríos, Aczel Regino ; Gawlik, Aleksandra ; Gheorghe, Ioana ; Glodariu, Tudor ; Gonçalves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Goverdovski, Andrey ; Griesmayer, Erich ; Guerrero Sánchez, Carlos ; Gunsing, Frank ; Göbel, Kathrin ; Harada, Hideo ; Heftrich, Tanja ; Heinitz, Stephan ; Heyse, Jan ; Jenkins, David ; Jericha, Erwin ; Käppeler, Franz ; Kadi, Yacine ; Katabuchi, Tatsuya ; Kavrigin, Pavel ; Ketlerov, Vladimir ; Khryachkov, Vitaly ; Kimura, Atsushi ; Kivel, Nikolay ; Kokkoris, Michael ; Krtička, Milan ; Leal Cidoncha, Esther ; Lederer, Claudia ; Leeb, Helmut ; Lerendegui, Jorge ; Lo Meo, Sergio ; Lonsdale, Sarah Jane ; Losito, Roberto ; Macina, Daniela ; Marganiec, Justyna ; Martínez, Trinitario ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Matteucci, Francesca ; Maugeri, Emilio Andrea ; Mendoza Cembranos, Emilio ; Mengoni, Alberto ; Milazzo, Paolo Maria ; Mirea, Mihail ; Montesano, Simone ; Musumarra, Agatino ; Nolte, Ralf ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Praena, Javier ; Quesada Molina, José Manuel ; Rajeev, K. ; Rauscher, Thomas ; Reifarth, René ; Riego Pérez, Albert ; Rout, Prakash Chandra ; Rubbia, Carlo ; Ryan, James A. ; Sabaté-Gilarte, Marta ; Saxena, Alok ; Schillebeeckx, Peter ; Schmidt, Stefan ; Schumann, Dorothea ; Sedyshev, Pavel V. ; Smith, Alastair Gavin ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Tarifeño-Saldivia, Ariel ; Tassan-Got, Laurent ; Tsinganis, Andrea ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vlachoudis, Vasilis ; Vlastou, Rosa ; Wallner, Anton ; Warren, Stephen J. ; Weigand, Mario ; Weiß, Christina ; Wolf, Clemens ; Woods, Philip John ; Wright, Tobias ; Žugec, Petar
he study of the resonant structures in neutron-nucleus cross-sections, and therefore of the compound-nucleus reaction mechanism, requires spectroscopic measurements to determine with high accuracy the energy of the neutron interacting with the material under study.
To this purpose, the neutron time-of-flight facility n_TOF has been operating since 2001 at CERN. Its characteristics, such as the high intensity instantaneous neutron flux, the wide energy range from thermal to few GeV, and the very good energy resolution, are perfectly suited to perform high-quality measurements of neutron-induced reaction cross sections. The precise and accurate knowledge of these cross sections plays a fundamental role in nuclear technologies, nuclear astrophysics and nuclear physics.
Two different measuring stations are available at the n_TOF facility, called EAR1 and EAR2, with different characteristics of intensity of the neutron flux and energy resolution. These experimental areas, combined with advanced detection systems lead to a great flexibility in performing challenging measurement of high precision and accuracy, and allow the investigation isotopes with very low cross sections, or available only in small quantities, or with very high specific activity.
The characteristics and performances of the two experimental areas of the n_TOF facility will be presented, together with the most important measurements performed to date and their physics case. In addition, the significant upcoming measurements will be introduced.
Gunsing, Frank ; Aberle, Oliver ; Andrzejewski, Józef ; Audouin, Laurent ; Bécares, Vicente ; Bacak, Michael ; Balibrea Correa, Javier ; Barbagallo, Massimo ; Barros, Susana C.C. ; Bečvář, František ; Beinrucker, Clemens ; Belloni, Fabio ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brown, Adam ; Brugger, Markus ; Caamaño, Manuel ; Calviño Tavares, Francisco ; Calviani, Marco ; Cano-Ott, Daniel ; Cardella, Roberto ; Casanovas Hoste, Adrià ; Castelluccio, Donato Maurizio ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Colonna, Nicola ; Cortés-Giraldo, Miguel Antonio ; Cortés Rossell, Guillem Pere ; Cosentino, Luigi ; Damone, Lucia Anna ; Deo, Kapil ; Diakaki, Maria ; Domingo-Pardo, César ; Dressler, Rugard ; Dupont, Emmeric ; Durán, Ignacio ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Ferreira, Pedro G. ; Finocchiaro, Paolo ; Frost, Robert J. W. ; Furman, Valter ; Ganesan, Srinivasan ; García Ríos, Aczel Regino ; Gawlik, Aleksandra ; Gheorghe, Ioana ; Gilardoni, Simone ; Glodariu, Tudor ; Gonçalves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Goverdovski, Andrey ; Griesmayer, Erich ; Guerrero Sánchez, Carlos ; Göbel, Kathrin ; Harada, Hideo ; Heftrich, Tanja ; Heinitz, Stephan ; Hernández Prieto, Álvaro ; Heyse, Jan ; Jenkins, David ; Jericha, Erwin ; Käppeler, Franz ; Kadi, Yacine ; Kalamara, Antigoni ; Katabuchi, Tatsuya ; Kavrigin, Pavel ; Ketlerov, Vladimir ; Khryachkov, Vitaly ; Kimura, Atsushi ; Kivel, Nikolay ; Kokkoris, Michael ; Krtička, Milan ; Kurtulgil, Cem Deniz ; Leal Cidoncha, Esther ; Lederer, Claudia ; Leeb, Helmut ; Lerendegui, Jorge ; Licata, Mauro ; Lo Meo, Sergio ; Lonsdale, Sarah Jane ; Losito, Roberto ; Macina, Daniela ; Marganiec, Justyna ; Martı́nez, Trinitario ; Masi, Alessandro ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Matteucci, Francesca ; Maugeri, Emilio Andrea ; Mazzone, Annamaria ; Mendoza Cembranos, Emilio ; Mengoni, Alberto ; Milazzo, Paolo Maria ; Mingrone, Federica ; Mirea, Mihail ; Montesano, Simone ; Musumarra, Agatino ; Nolte, Ralf ; Negret, Alexandru ; Oprea, Andreea ; Palomo Pinto, Francisco Rogelio ; Paradela Dobarro, Carlos ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Porras Sánchez, José Ignacio ; Praena, Javier ; Quesada Molina, José Manuel ; Radeck, Désirée ; Rajeev, K. ; Rauscher, Thomas ; Reifarth, René ; Riego Pérez, Albert ; Robles Manzano, Maria Soledad ; Rout, Prakash Chandra ; Rubbia, Carlo ; Ryan, James ; Sabaté-Gilarte, Marta ; Saxena, Alok ; Schillebeeckx, Peter ; Schmidt, Stefan ; Schumann, Dorothea ; Sedyshev, Pavel V. ; Smith, Alastair Gavin ; Sosnin, Nikolay V. ; Stamatopoulos, Athanasios ; Suryanarayana, Saraswatula Venkata ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Tarifeño-Saldivia, Ariel ; Tarrío Vilas, Diego ; Tassan-Got, Laurent ; Tsinganis, Andrea ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vlachoudis, Vasilis ; Vlastou, Rosa ; Wallner, Anton ; Warren, Stephen J. ; Weigand, Mario ; Weiß, Christina ; Wolf, Clemens ; Woods, Philip John ; Wright, Tobias ; Žugec, Petar
Neutron-induced reaction cross sections are important for a wide variety of research fields ranging from the study of nuclear level densities, nucleosynthesis to applications of nuclear technology like design, and criticality and safety assessment of existing and future nuclear reactors, radiation dosimetry, medical applications, nuclear waste transmutation, accelerator-driven systems and fuel cycle investigations. Simulations and calculations of nuclear technology applications largely rely on evaluated nuclear data libraries. The evaluations in these libraries are based both on experimental data and theoretical models. CERN’s neutron time-of-flight facility n_TOF has produced a considerable amount of experimental data since it has become fully operational with the start of its scientific measurement programme in 2001. While for a long period a single measurement station (EAR1) located at 185 m from the neutron production target was available, the construction of a second beam line at 20 m (EAR2) in 2014 has substantially increased the measurement capabilities of the facility. An outline of the experimental nuclear data activities at n_TOF will be presented.
Cosentino, Luigi ; Musumarra, Agatino ; Barbagallo, Massimo ; Pappalardo, Alessandro ; Colonna, Nicola ; Damone, Lucia Anna ; Piscopo, Massimo ; Finocchiaro, Paolo ; Maugeri, Emilio Andrea ; Heinitz, Stephan ; Schumann, Dorothea ; Dressler, Rugard ; Kivel, Nikolay ; Aberle, Oliver ; Andrzejewski, Józef ; Audouin, Laurent ; Ayranov, Marin ; Bacak, Michael ; Barros, Susana C.C. ; Balibrea Correa, Javier ; Bécares, Vicente ; Bečvář, František ; Beinrucker, Clemens ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brugger, Markus ; Caamaño, Manuel ; Calviani, Marco ; Calviño Tavares, Francisco ; Cano-Ott, Daniel ; Cardella, Roberto ; Casanovas Hoste, Adrià ; Castelluccio, Donato Maurizio ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Diakaki, Maria ; Domingo-Pardo, César ; Dupont, Emmeric ; Durán, Ignacio ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Ferreira, Pedro G. ; Furman, Valter ; Ganesan, Srinivasan ; García Ríos, Aczel Regino ; Gawlik, Aleksandra ; Gheorghe, Ioana ; Glodariu, Tudor ; Göbel, Kathrin ; Gonc̗alves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Griesmayer, Erich ; Guerrero Sánchez, Carlos ; Gunsing, Frank ; Harada, Hideo ; Heftrich, Tanja ; Heyse, Jan ; Jenkins, David ; Jericha, Erwin ; Käppeler, Franz ; Katabuchi, Tatsuya ; Kavrigin, Pavel ; Kimura, Atsushi ; Kokkoris, Michael ; Krtička, Milan ; Leal Cidoncha, Esther ; Lerendegui, Jorge ; Lederer, Claudia ; Leeb, Helmut ; Lo Meo, Sergio ; Lonsdale, Sarah Jane ; Losito, Roberto ; Macina, Daniela ; Marganiec, Justyna ; Martínez, Trinitario ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Matteucci, Francesca ; Mazzone, Annamaria ; Mendoza Cembranos, Emilio ; Mengoni, Alberto ; Milazzo, Paolo Maria ; Mingrone, Federica ; Mirea, Mihail ; Montesano, Simone ; Nolte, Ralf ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Praena, Javier ; Quesada Molina, José Manuel ; Kumar, Rajeev ; Rauscher, Thomas ; Reifarth, René ; Riego Pérez, Albert ; Rout, Prakash Chandra ; Rubbia, Carlo ; Ryan, James A. ; Sabate-Gilarte, Marta ; Saxena, Alok ; Schillebeeckx, Peter ; Schmidt, Stefan ; Sedyshev, Pavel V. ; Smith, Alastair Gavin ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Tarifeño-Saldivia, Ariel ; Tassan-Got, Laurent ; Tsinganis, Andrea ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vlachoudis, Vasilis ; Vlastou, Rosa ; Vollaire, Joachim ; Wallner, Anton ; Warren, Stephen J. ; Weigand, Mario ; Weiß, Christina ; Wolf, Clemens ; Woods, Philip John ; Wright, Tobias ; Žugec, Petar
Kische, Hanna ; Hoyer, Jürgen ; Pieper, Lars ; Venz, John ; Klotsche, Jens ; März, Winfried ; Koch-Gromus, Uwe ; Pittrow, David ; Lehnert, Hendrik ; Silber, Sigmund ; Stalla, Günter K. ; Zeiher, Andreas M. ; Wittchen, Hans-Ulrich ; Haring, Robin
Background: Previous experimental research on testosterone (T) and psychological traits is inconclusive. Thus, we performed the first large-scale observational study of the association between T and dispositional optimism / pessimism.
Methods: We used prospective data from 6,493 primary-care patients (3,840 women) of the DETECT study (Diabetes Cardiovascular Risk-Evaluation: Targets and Essential Data for Commitment of Treatment), including repeated immunoassay-based measurement of serum T and optimism / pessimism assessed by the revised Life-Orientation Test (LOT-R). Cross-sectional and longitudinal associations of baseline T and one-year change in T with optimism and pessimism were investigated using age- and multivariable-adjusted regression models.
Results: Cross-sectional analyses showed no association of T with optimism or pessimism in both sexes. Longitudinal analyses also showed no association of baseline T with optimism or pessimism at four-year follow-up. Multivariable analyses of total LOT-R score yielded similarly non-significant results (β-coefficient per unit change in T for men: -0.01 (95% CI: -0.24–0.22), women: 0.08 (-0.03–0.20)). Furthermore, change in T was not related to optimism or pessimism at four-year follow-up.
Conclusions: The present observational study of a large-scale prospective sample showed no association of T with optimism or pessimism. Integrating further experimental and interventional evidence from alternative methodological approaches would strengthen this conclusion and establish stronger evidence about the potential hormonal basis of psychological traits.
Torres-Sánchez, Pablo ; Praena, Javier ; Porras Sánchez, José Ignacio ; Sabaté-Gilarte, Marta ; Lederer-Woods, Claudia ; Aberle, Oliver ; Alcayne, Victor ; Amaducci, Simone ; Andrzejewski, Józef ; Audouin, Laurent ; Bécares, Vicente ; Babiano Suarez, Victor ; Bacak, Michael ; Barbagallo, Massimo ; Bečvář, František ; Bellia, Giorgio ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brown, Adam ; Busso, Maurizio ; Caamaño, Manuel ; Caballero Ontanaya, Luis ; Calviño Tavares, Francisco ; Calviani, Marco ; Cano-Ott, Daniel ; Casanovas Hoste, Adrià ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Colonna, Nicola ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Cosentino, Luigi ; Cristallo, Sergio ; Damone, Lucia Anna ; Diakaki, Maria ; Dietz, Mirco ; Domingo-Pardo, César ; Dressler, Rugard ; Dupont, Emmeric ; Durán, Ignacio ; Eleme, Zinovia ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Ferrer, Francisco Javier ; Finocchiaro, Paolo ; Furman, Valter ; Göbel, Kathrin ; Garg, Ruchi ; Gawlik-Ramięga, Aleksandra ; Geslot, Benoit ; Gilardoni, Simone ; Glodariu, Tudor ; Gonçalves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Guerrero Sánchez, Carlos ; Gunsing, Frank ; Harada, Hideo ; Heinitz, Stephan ; Heyse, Jan ; Jenkins, David ; Jericha, Erwin ; Käppeler, Franz ; Kadi, Yacine ; Kimura, Atsushi ; Kivel, Nikolay ; Kokkoris, Michael ; Kopatch, Yuri N. ; Krtička, Milan ; Kurtulgil, Cem Deniz ; Ladarescu, Ion ; Leeb, Helmut ; Lerendegui-Marco, Jorge ; Lo Meo, Sergio ; Lonsdale, Sarah Jane ; Macina, Daniela ; Manna, Alice ; Martínez, Trinitario ; Masi, Alessandro ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Matteucci, Francesca ; Maugeri, Emilio Andrea ; Mazzone, Annamaria ; Mendoza Cembranos, Emilio ; Mengoni, Alberto ; Michalopoulou, Veatriki ; Milazzo, Paolo Maria ; Mingrone, Federica ; Musumarra, Agatino ; Negret, Alexandru ; Nolte, Ralf ; Ogállar Ruiz, Francisco ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Piersanti, Luciano ; Quesada Molina, José Manuel ; Radeck, Désirée ; Ramos Doval, Diego ; Rauscher, Thomas ; Reifarth, René ; Rochman, Dimitri ; Rubbia, Carlo ; Saxena, Alok ; Schillebeeckx, Peter ; Schumann, Dorothea ; Smith, Alastair Gavin ; Sosnin, Nikolay V. ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, Jose Luis ; Talip, Zeynep ; Tarifeño-Saldivia, Ariel ; Tassan-Got, Laurent ; Tsinganis, Andrea ; Ulrich, Jiri ; Urlaß, Sebastian ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vlachoudis, Vasilis ; Vlastou, Rosa ; Wallner, Anton ; Woods, Philip John ; Wright, Tobias ; Žugec, Petar
The 14N(n,p)14C reaction is of interest in neutron capture therapy, where nitrogen-related dose is the main component due to low-energy neutrons, and in astrophysics, where 14N acts as a neutron poison in the s-process. Several discrepancies remain between the existing data obtained in partial energy ranges: thermal energy, keV region and resonance region. Purpose: Measuring the 14N(n,p)14C cross section from thermal to the resonance region in a single measurement for the first time, including characterization of the first resonances, and providing calculations of Maxwellian averaged cross sections (MACS). Method: Time-of-flight technique. Experimental Area 2 (EAR-2) of the neutron time-of-flight (n_TOF) facility at CERN. 10B(n,α)7Li and 235U(n,f) reactions as references. Two detection systems running simultaneously, one on-beam and another off-beam. Description of the resonances with the R-matrix code sammy. Results: The cross section has been measured from sub-thermal energy to 800 keV resolving the two first resonances (at 492.7 and 644 keV). A thermal cross-section (1.809±0.045 b) lower than the two most recent measurements by slightly more than one standard deviation, but in line with the ENDF/B-VIII.0 and JEFF-3.3 evaluations has been obtained. A 1/v energy dependence of the cross section has been confirmed up to tens of keV neutron energy. The low energy tail of the first resonance at 492.7 keV is lower than suggested by evaluated values, while the overall resonance strength agrees with evaluations. Conclusions: Our measurement has allowed to determine the 14N(n,p) cross-section over a wide energy range for the first time. We have obtained cross-sections with high accuracy (2.5 %) from sub-thermal energy to 800 keV and used these data to calculate the MACS for kT = 5 to kT = 100 keV.
Stolzenburg, Dominik ; Fischer, Lukas ; Vogel, Alexander L. ; Heinritzi, Martin ; Schervish, Meredith ; Simon, Mario ; Wagner, Andrea Christine ; Dada, Lubna ; Ahonen, Lauri R. ; Amorim, Antonio ; Baccarini, Andrea ; Bauer, Paulus Salomon ; Baumgartner, Bernhard ; Bergen, Anton ; Bianchi, Federico ; Breitenlechner, Martin ; Brilke, Sophia ; Buenrostro Mazon, Stephany ; Chen, Dexian ; Dias, Antonio ; Draper, Danielle C. ; Duplissy, Jonathan ; El Haddad, Imad ; Finkenzeller, Henning ; Frege, Carla ; Fuchs, Claudia ; Garmash, Olga ; Gordon, Hamish ; He, Xucheng ; Helm, Johanna ; Hofbauer, Victoria ; Hoyle, Christopher Robert ; Kim, Changhyuk ; Kirkby, Jasper ; Kontkanen, Jenni ; Kürten, Christoph Andreas ; Lampilahti, Janne ; Lawler, Michael Joseph ; Lehtipalo, Katrianne ; Leiminger, Markus ; Mai, Huajun ; Mathot, Serge ; Mentler, Bernhard ; Molteni, Ugo ; Nie, Wei ; Nieminen, Tuomo ; Nowak, John B. ; Ojdanic, Andrea ; Onnela, Antti ; Passananti, Monica ; Petäjä, Tuukka ; Quéléver, Lauriane L. J. ; Rissanen, Matti P. ; Sarnela, Nina ; Schallhart, Simon ; Tauber, Christian ; Tomé, Antonio ; Wagner, Robert ; Wang, Mingyi ; Weitz, Lena ; Wimmer, Daniela ; Xiao, Mao ; Yan, Chao ; Ye, Penglin ; Zha, Qiaozhi ; Baltensperger, Urs ; Curtius, Joachim ; Dommen, Josef ; Flagan, Richard C. ; Kulmala, Markku ; Smith, James N. ; Worsnop, Douglas R. ; Hansel, Armin ; Donahue, Neil McPherson ; Winkler, Paul M.
Nucleation and growth of aerosol particles from atmospheric vapors constitutes a major source of global cloud condensation nuclei (CCN). The fraction of newly formed particles that reaches CCN sizes is highly sensitive to particle growth rates, especially for particle sizes <10 nm, where coagulation losses to larger aerosol particles are greatest. Recent results show that some oxidation products from biogenic volatile organic compounds are major contributors to particle formation and initial growth. However, whether oxidized organics contribute to particle growth over the broad span of tropospheric temperatures remains an open question, and quantitative mass balance for organic growth has yet to be demonstrated at any temperature. Here, in experiments performed under atmospheric conditions in the Cosmics Leaving Outdoor Droplets (CLOUD) chamber at the European Organization for Nuclear Research (CERN), we show that rapid growth of organic particles occurs over the range from −25 ∘C to 25 ∘C. The lower extent of autoxidation at reduced temperatures is compensated by the decreased volatility of all oxidized molecules. This is confirmed by particle-phase composition measurements, showing enhanced uptake of relatively less oxygenated products at cold temperatures. We can reproduce the measured growth rates using an aerosol growth model based entirely on the experimentally measured gas-phase spectra of oxidized organic molecules obtained from two complementary mass spectrometers. We show that the growth rates are sensitive to particle curvature, explaining widespread atmospheric observations that particle growth rates increase in the single-digit-nanometer size range. Our results demonstrate that organic vapors can contribute to particle growth over a wide range of tropospheric temperatures from molecular cluster sizes onward.
Eckert, Ellen ; Laeng, Alexandra ; Lossow, Stefan ; Kellmann, Sylvia ; Stiller, Gabriele ; Clarmann, Thomas von ; Glatthor, Norbert ; Höpfner, Michael ; Kiefer, Michael ; Oelhaf, Herman ; Orphal, Johannes ; Funke, Bernd ; Grabowski, Udo ; Haenel, Florian ; Linden, Andrea ; Wetzel, Gerald ; Woiwode, Wolfgang ; Bernath, Peter F. ; Boone, Christopher D. ; Dutton, Geoffrey S. ; Elkins, James W. ; Engel, Andreas ; Gille, John C. ; Kolonjari, Felicia ; Sugita, Takafumi ; Toon, Geoffrey C. ; Walker, Kaley A.
Profiles of CFC-11 (CCl3F) and CFC-12 (CCl2F2) of the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) aboard the European satellite Envisat have been retrieved from versions MIPAS/4.61 to MIPAS/4.62 and MIPAS/5.02 to MIPAS/5.06 level-1b data using the scientific level-2 processor run by Karlsruhe Institute of Technology (KIT), Institute of Meteorology and Climate Research (IMK) and Consejo Superior de Investigaciones Científicas (CSIC), Instituto de Astrofísica de Andalucía (IAA). These profiles have been compared to measurements taken by the balloon-borne cryosampler, Mark IV (MkIV) and MIPAS-Balloon (MIPAS-B), the airborne MIPAS-STRatospheric aircraft (MIPAS-STR), the satellite-borne Atmospheric Chemistry Experiment Fourier transform spectrometer (ACE-FTS) and the High Resolution Dynamic Limb Sounder (HIRDLS), as well as the ground-based Halocarbon and other Atmospheric Trace Species (HATS) network for the reduced spectral resolution period (RR: January 2005–April 2012) of MIPAS. ACE-FTS, MkIV and HATS also provide measurements during the high spectral resolution period (full resolution, FR: July 2002–March 2004) and were used to validate MIPAS CFC-11 and CFC-12 products during that time, as well as profiles from the Improved Limb Atmospheric Spectrometer, ILAS-II. In general, we find that MIPAS shows slightly higher values for CFC-11 at the lower end of the profiles (below ∼ 15 km) and in a comparison of HATS ground-based data and MIPAS measurements at 3 km below the tropopause. Differences range from approximately 10 to 50 pptv ( ∼ 5–20 %) during the RR period. In general, differences are slightly smaller for the FR period. An indication of a slight high bias at the lower end of the profile exists for CFC-12 as well, but this bias is far less pronounced than for CFC-11 and is not as obvious in the relative differences between MIPAS and any of the comparison instruments. Differences at the lower end of the profile (below ∼ 15 km) and in the comparison of HATS and MIPAS measurements taken at 3 km below the tropopause mainly stay within 10–50 pptv (corresponding to ∼ 2–10 % for CFC-12) for the RR and the FR period. Between ∼ 15 and 30 km, most comparisons agree within 10–20 pptv (10–20 %), apart from ILAS-II, which shows large differences above ∼ 17 km. Overall, relative differences are usually smaller for CFC-12 than for CFC-11. For both species – CFC-11 and CFC-12 – we find that differences at the lower end of the profile tend to be larger at higher latitudes than in tropical and subtropical regions. In addition, MIPAS profiles have a maximum in their mixing ratio around the tropopause, which is most obvious in tropical mean profiles. Comparisons of the standard deviation in a quiescent atmosphere (polar summer) show that only the CFC-12 FR error budget can fully explain the observed variability, while for the other products (CFC-11 FR and RR and CFC-12 RR) only two-thirds to three-quarters can be explained. Investigations regarding the temporal stability show very small negative drifts in MIPAS CFC-11 measurements. These instrument drifts vary between ∼ 1 and 3 % decade−1. For CFC-12, the drifts are also negative and close to zero up to ∼ 30 km. Above that altitude, larger drifts of up to ∼ 50 % decade−1 appear which are negative up to ∼ 35 km and positive, but of a similar magnitude, above.
Aamodt, Kenneth ; Abrahantes Quintana, A. ; Adamová, Dagmar ; Adare, A.M. ; Aggarwal, Madan Mohan ; Aglieri Rinella, Gianluca ; Agocs, A.G. ; Aguilar Salazar, S. ; Ahammed, Zubayer ; Ahmad, Nazeer ; Ahmad Masoodi, A. ; Ahn, Sang Un ; Akindinov, Alexander ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alfaro Molina, Jose Ruben ; Alici, Andrea ; Alkin, Anton ; Almaráz Aviña, E. ; Alt, Torsten ; Altini, V. ; Altinpinar, Sedat ; Altsybeev, Igor ; Andrei, Cristian ; Andronic, Anton ; Anguelov, Venelin ; Anson, Christopher Daniel ; Antičić, Tome ; Antinori, Federico ; Antonioli, Pietro ; Aphecetche, Laurent Bernard ; Appelshäuser, Harald ; Arbor, N. ; Arcelli, Silvia ; Arend, A. ; Armesto, Néstor ; Arnaldi, Roberta ; Aronsson, Tomas Robert ; Arsene, Ionut Cristian ; Asryan, A. ; Augustinus, Andre ; Averbeck, Ralf Peter ; Awes, T.C. ; Äystö, J. ; Azmi, Mohd Danish ; Bach, Matthias ; Badalà, Angela ; Baek, Yong Wook ; Bagnasco, Stefano ; Bailhache, Raphaëlle ; Bala, Remu ; Baldini Ferroli, Rinaldo ; Baldisseri, Alberto ; Baldit, A. ; Bán, J. ; Barbera, Roberto ; Barile, Francesco ; Barnaföldi, Gergely Gábor ; Barnby, Lee Stuart ; Barret, Valerie ; Bartke, Jerzy ; Basile, Maurizio ; Bastid, Nicole ; Bathen, Bastian ; Batigne, Guillaume ; Batyunya, Boris ; Baumann, C. ; Bearden, Ian Gardner ; Beck, Hans ; Belikov, Iouri ; Bellini, Francesca ; Bellwied, Rene ; Belmont-Moreno, Ernesto ; Beolè, Stefania ; Berceanu, Ionela ; Bercuci, Alexandru ; Berdermann, E. ; Berdnikov, Yaroslav ; Betev, Latchezar ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bianchi, Livio ; Bianchi, Nicola ; Bianchin, Chiara ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bilandzic, Ante ; Biolcati, E. ; Blanc, A. ; Blanco, Fernando ; Blanco, Fernando ; Blau, Dmitry S. ; Blume, Christoph ; Boccioli, M. ; Bock, N. ; Bogdanov, Alexey A. ; Bøggild, Hans ; Bogolyubsky, M. ; Boldizsár, László ; Bombara, Marek ; Bombonati, C. ; Book, Julian ; Borel, Hervé ; Bortolin, C. ; Bose, S. ; Bossú, Francesco ; Botje, Michiel ; Böttger, Stefan ; Boyer, B. ; Braun-Munzinger, Peter ; Bravina, L. ; Bregant, Marco ; Breitner, Timo ; Broz, Michal ; Brun, René ; Bruna, Elena ; Bruno, Giuseppe Eugenio ; Budnikov, Dmitry ; Büsching, Henner ; Busch, Oliver ; Buthelezi, Edith Zinhle ; Caffarri, Davide ; Cai, Xiao ; Caines, Helen Louise ; Calvo Villar, Ernesto ; Camerini, Paolo ; Canoa Roman, Veronica ; Cara Romeo, G. ; Carena, Francesco ; Carena, Wisla ; Carminati, F. ; Casanova Díaz, A. ; Caselle, M. ; Castillo Castellanos, Javier Ernesto ; Catanescu, V. ; Cavicchioli, Costanza ; Cerello, Piergiorgio ; Chang, B. ; Chapeland, Sylvain ; Charvet, Jean-Luc Fernand ; Chattopadhyay, S. ; Chattopadhyay, S. ; Cherney, Michael Gerard ; Cheshkov, Cvetan Valeriev ; Cheynis, Brigitte ; Chiavassa, E. ; Chibante Barroso, Vasco Miguel ; Chinellato, David Dobrigkeit ; Chochula, Peter ; Chojnacki, Marek ; Christakoglou, Panagiotis ; Christensen, Christian Holm ; Christiansen, Peter L. ; Chujo, Tatsuya ; Cicalò, Corrado ; Cifarelli, Luisa ; Cindolo, Federico ; Cleymans, Jean Willy Andre ; Coccetti, F. ; Coffin, J.-P. ; Coli, S. ; Conesa Balbastre, Gustavo ; Conesa del Valle, Zaida ; Constantin, P. ; Contin, Giacomo ; Contreras Nuno, Jesus Guillermo ; Cormier, Thomas Michael ; Corrales Morales, Yasser ; Cortés Maldonado, Ismael ; Cortese, Pietro ; Cosentino, Mauro Rogerio ; Costa, Filippo ; Cotallo, M.E. ; Crescio, E. ; Crochet, Philippe ; Cuautle Flores, Eleazar ; Cunqueiro Mendez, Leticia ; D’Erasmo, Ginevra ; Dainese, Andrea ; Dalsgaard, H.H. ; Danu, Andrea ; Das, Debasish ; Das, Indranil ; Dash, Ajay Kumar ; Dash, Sadhana ; De, Sudipan ; De Azevedo Moregula, A. ; de Barros, G.O.V. ; De Caro, Annalisa ; De Cataldo, Giacinto ; Cuveland, Jan de ; De Falco, Alessandro ; De Gruttola, Daniele ; De Marco, Nora ; De Pasquale, Salvatore ; De Remigis, R. ; de Rooij, R. ; Delagrange, H. ; Delgado Mercado, Y. ; Dellacasa, G. ; Deloff, Andrzej ; Demanov, V. ; Dénes, Ervin Sandor ; Deppman, A. ; Di Bari, Domenico ; Di Giglio, C. ; Di Liberto, S. ; Di Mauro, Antonio ; Di Nezza, Pasquale ; Dietel, Thomas ; Divià, Roberto ; Djuvsland, Øystein ; Dobrin, Alexandru Florin ; Dobrowolski, Tadeusz Antoni ; Domínguez, I. ; Dönigus, Benjamin ; Dordic, Olja ; Driga, O. ; Dubey, Anand Kumar ; Ducroux, Laurent ; Dupieux, Pascal ; Dutta Majumdar, A.K. ; Dutta Majumdar, M.R. ; Elia, Domenico ; Emschermann, D. ; Engel, Heiko ; Erdal, H.A. ; Espagnon, Bruno ; Estienne, Magali Danielle ; Esumi, ShinIchi ; Evans, David ; Evrard, S. ; Eyyubova, Gyulnara ; Fabjan, C.W. ; Fabris, Daniela ; Faivre, Julien ; Falchieri, D. ; Fantoni, Alessandra ; Fasel, Markus ; Fearick, R. ; Fedunov, A. ; Fehlker, D. ; Fekete, V. ; Felea, Daniel ; Feofilov, Grigori A. ; Fernández Téllez, Arturo ; Ferretti, Alessandro ; Ferretti, R. ; Figueredo, Marcel Araujo Silva ; Filchagin, Sergey ; Fini, R. ; Finogeev, Dmitry ; Fionda, Fiorella Maria Celeste ; Fiore, Enrichetta Maria ; Floris, Michele ; Foertsch, Siegfried Valentin ; Foka, Panagiota ; Fokin, Sergey ; Fragiacomo, Enrico ; Fragkiadakis, M. ; Frankenfeld, Ulrich ; Fuchs, Ulrich ; Furano, F. ; Furget, Christophe ; Fusco Girard, Mario ; Gaardhøje, Jens Jørgen ; Gadrat, S. ; Gagliardi, Martino ; Gago, A. ; Gallio, Mauro ; Ganoti, Paraskevi ; Garabatos, Chilo ; Gemme, R. ; Gerhard, J. ; Germain, Marie ; Geuna, C. ; Gheata, Andrei George ; Gheata, Mihaela ; Ghidini, B. ; Ghosh, Premomoy ; Girard, M.R. ; Giraudo, G. ; Giubellino, Paolo ; Gładysz-Dziaduś, Ewa ; Glässel, Peter ; Gomez, R. ; González Trueba, Laura Helena ; González Zamora, Pedro ; González Santos, H. ; Gorbunov, Sergey ; Gotovac, Sven ; Grabski, Varlen ; Grajcarek, R. ; Gramling, J.L. ; Grelli, Alessandro ; Grigoras, Alina Gabriela ; Grigoraș, Costin ; Grigoriev, Vladislav A. ; Grigoryan, Ara ; Grigoryan, Smbat ; Grinyov, Boris V. ; Grion, Nevio ; Gros, P. ; Große-Oetringhaus, Jan Fiete ; Grossiord, Jean-Yves ; Grosso, Raffaele ; Guber, Fedor ; Guernane, Rachid ; Guerra Gutierrez, C. ; Guerzoni, Barbara ; Gulbrandsen, Kristjan Herlache ; Gulkanyan, Hrant ; Gunji, Taku ; Gupta, Anik ; Gupta, Ramni ; Gutbrod, H. ; Haaland, Øystein Senneset ; Hadjidakis, Cynthia Marie ; Haiduc, Maria ; Hamagaki, Hideki ; Hamar, Gergö ; Harris, John W. ; Hartig, M. ; Hasch, D. ; Hasegan, D. ; Hatzifotiadou, Despina ; Hayrapetyan, A. ; Heide, Markus ; Heinz, Mark Thomas ; Helstrup, Håvard ; Herghelegiu, Andrei Ionut ; Hernández, C. ; Herrera Corral, Gerardo Antonio ; Herrmann, Norbert ; Hetland, Kristin Fanebust ; Hicks, B. ; Hille, P.T. ; Hippolyte, Boris ; Horaguchi, T. ; Hori, Y. ; Hristov, Peter ; Hřivnáčová, I. ; Huang, M. ; Huber, S. ; Humanic, Thomas J. ; Hwang, D.S. ; Ichou, R. ; Ilkaev, Radiy ; Ilkiv, Iryna ; Inaba, Motoi ; Incani, E. ; Innocenti, Gian Michele ; Innocenti, P.G. ; Ippolitov, Mikhail ; Irfan, M. ; Ivan, C. ; Ivanov, A. ; Ivanov, Marian ; Ivanov, V. ; Jacholkowski, Adam Wlodzimierz ; Jacobs, Peter Martin ; Jancurová, L. ; Jangal, S. ; Janik, R. ; Jayarathna, S.P. ; Jena, Satyajit ; Jirden, L. ; Jones, Goronwy Tudor ; Jones, Peter Graham ; Jovanović, P. ; Jung, H. ; Jung, W. ; Jusko, Anton ; Kalcher, S. ; Kaliňák, Peter ; Kalisky, M. ; Kalliokoski, T. ; Kalweit, Alexander Philipp ; Kamermans, R. ; Kanaki, K. ; Kang, E. ; Kang, Ju Hwan ; Kaplin, Vladimir ; Karavichev, Oleg V. ; Karavicheva, Tatiana L. ; Karpechev, Evgeny ; Kazantsev, Andrey ; Kebschull, Udo ; Keidel, Ralf ; Khan, M.M. ; Khanzadeev, Alexei ; Kharlov, Yury ; Kileng, Bjarte ; Kim, D.J. ; Kim, D.S. ; Kim, D.W. ; Kim, H.N. ; Kim, J.H. ; Kim, J.S. ; Kim, M. ; Kim, M. ; Kim, S. ; Kim, S.H. ; Kirsch, Stefan ; Kisel, Ivan ; Kiselev, Sergej N. ; Kisiel, Adam Ryszard ; Klay, Jennifer Lynn ; Klein, Jochen ; Klein-Bösing, Christian ; Kliemant, Michael ; Klovning, A. ; Kluge, Alexander ; Knichel, Michael Linus ; Koch, K. ; Köhler, Markus Konrad ; Kolevatov, R. ; Kolojvari, Anatoly ; Kondratiev, Valery P. ; Kondratyeva, Natalia ; Konevskih, A. ; Kornaś, Ewelina ; Kottachchi Kankanamge Don, C. ; Kour, R. ; Kowalski, Marek ; Kox, Serge ; Koyithatta Meethaleveedu, Greeshma ; Kozlov, K. ; Kral, Jiří ; Králik, Ivan ; Kramer, F. ; Kraus, Ingrid ; Krawutschke, T. ; Kretz, Matthias ; Krivda, Marian ; Krumbhorn, D. ; Krus, M. ; Kryshen, Evgeny ; Krzewicki, Mikolaj ; Kucheriaev, Yury ; Kuhn, Christian Claude ; Kuijer, Paulus Gerardus ; Kurashvili, Podist ; Kurepin, Alexander ; Kurepin, Alexey B. ; Kuryakin, Alexey ; Kushpil, Svetlana ; Kushpil, V. ; Kweon, Min Jung ; Kwon, Youngil ; La Rocca, Paola ; Ladron de Guevara, Pedro ; Lafage, V. ; Lara Martinez, Camilo Ernesto ; Larsen, D.T. ; Lazzeroni, C. ; Le Bornec, Y. ; Lea, Ramona ; Lee, K.S. ; Lee, S.C. ; Lefèvre, F. ; Lehnert, Jörg ; Leistam, L. ; Lenhardt, M. ; Lenti, Vito ; León Monzón, Ildefonso ; León Vargas, H. ; Lévai, Péter ; Li, X. ; Lietava, Roman ; Lindal, Svein ; Lindenstruth, Volker ; Lippmann, Christian ; Lisa, Michael A. ; Liu, L. ; Loggins, Vera Renee ; Loginov, Vitaly ; Lohn, S. ; Lohner, D. ; Loizides, Constantinos ; Lopez, Xavier Bernard ; López Noriega, M. ; López Torres, Ernesto ; Løvhøiden, G. ; Lu, X.-G. ; Lüttig, Philipp ; Lunardon, Marcello ; Luparello, Grazia ; Luquin, L. ; Luzzi, C. ; Ma, K. ; Ma, R. ; Madagodahettige-Don, D.M. ; Maevskaya, Alla ; Mager, Magnus ; Mahapatra, D.P. ; Maire, Antonin ; Malaev, Mikhail ; Maldonado Cervantes, Ivonne Alicia ; Malinina, Liudmila ; Mal’Kevich, Dmitry ; Malzacher, Peter ; Mamonov, Alexander ; Manceau, Loic Henri Antoine ; Mangotra, L. ; Manko, Vladislav ; Manso, Franck ; Manzari, Vito ; Mao, Yaxian ; Mareš, Jiří ; Margagliotti, Giacomo Vito ; Margotti, Anselmo ; Marín, Ana ; Martashvili, Irakli ; Martinengo, Paolo ; Martínez Hernández, Mario Iván ; Martínez Davalos, A. ; Martínez Garcia, Ginés ; Martynov, Yevgen ; Mas, Alexis Jean-Michel ; Masciocchi, Silvia ; Masera, Massimo ; Masoni, Alberto ; Massacrier, Laure Marie ; Mastromarco, Mario ; Mastroserio, Annalisa ; Matthews, Z.L. ; Matyja, Adam Tomasz ; Mayani, D. ; Mazza, G. ; Mazzoni, Alessandra Maria ; Meddi, Franco ; Menchaca-Rocha, Arturo Alejandro ; Mendez Lorenzo, P. ; Mercado Pérez, Jorge ; Mereu, P. ; Miake, Yasuo ; Midori, J. ; Milano, Leonardo ; Milošević, Jovan ; Mischke, André ; Miśkowiec, Dariusz Czesław ; Mitu, C. ; Mlynarz, J. ; Mohanty, Bedangadas ; Molnar, Levente ; Montaño Zetina, Luis Manuel ; Monteno, M. ; Montes Prado, Esther ; Morando, Maurizio ; Godoy, Denise Aparecida Moreira de ; Moretto, Sandra ; Morsch, Andreas ; Muccifora, Valeria ; Mudnic, Eugen ; Müller, H. ; Muhuri, Sanjib ; Munhoz, Marcelo Gameiro ; Munoz, J. ; Musa, Luciano ; Musso, A. ; Nandi, Basanta Kumar ; Nania, Rosario ; Nappi, Eugenio ; Nattrass, Christine ; Navach, F. ; Navin, S. ; Nayak, Tapan Kumar ; Nazarenko, Sergey ; Nazarov, G. ; Nedosekin, Alexander ; Nendaz, F. ; Newby, J. ; Nicassio, Maria ; Nielsen, Borge Svane ; Nikolaev, Sergey ; Nikolic, V. ; Nikulin, Sergey ; Nikulin, Vladimir ; Nilsen, B.S. ; Nilsson, M.S. ; Noferini, Francesco ; Nooren, Gerardus ; Novitzky, Norbert ; Nyanin, Alexander ; Nyatha, A. ; Nygaard, C. ; Nystrand, Joakim Ingemar ; Obayashi, H. ; Ochirov, A. ; Oeschler, Helmut ; Oh, Sun Kun ; Oleniacz, Janusz ; Oppedisano, Chiara ; Ortiz Velasquez, Antonio ; Ortona, G. ; Oskarsson, Anders Nils Erik ; Ostrowski, P. ; Otterlund, I. ; Otwinowski, Jacek Tomasz ; Ø, G. ; Oyama, Ken ; Ozawa, K. ; Pachmayer, Yvonne C. ; Pachr, Miloš ; Padilla, F. ; Pagano, Paola ; Paić, Guy ; Painke, F. ; Pajares Vales, Carlos ; Pal, S. ; Pal, Susanta Kumar ; Palaha, A. ; Palmeri, A. ; Pappalardo, Giuseppe Salvatore ; Park, WooJin ; Paticchio, Vincenzo ; Pavlinov, A. ; Pawlak, Tomasz Jan ; Peitzmann, Thomas ; Peresunko, Dmitry Yurevich ; Pérez Lara, Carlos Eugenio ; Perini, D. ; Perrino, D. ; Peryt, Wiktor Stanislaw ; Pesci, A. ; Peskov, Vladimir ; Pestov, Yury N. ; Peters, A.J. ; Petráček, Vojtech ; Petris, M. ; Petrov, P. ; Petrovici, Mihai A. ; Petta, Catia ; Piano, Stefano ; Piccotti, A. ; Pikna, Miroslav ; Pillot, Philippe ; Pinazza, Ombretta ; Pinsky, Lawrence ; Pitz, N. ; Piuz, F. ; Piyarathna, Danthasinghe B. ; Platt, R. ; Płoskoń, Mateusz ; Pluta, Jan Marian ; Pocheptsov, T. ; Pochybova, Sona ; Podesta Lerma, Pedro Luis Manuel ; Poghosyan, Martin G. ; Polák, K. ; Polichtchouk, Boris ; Pop, Amalia ; Pospíšil, V. ; Potukuchi, B. ; Prasad, Sidharth Kumar ; Preghenella, Roberto ; Prino, Francesco ; Pruneau, Claude A. ; Pshenichnov, Igor A. ; Puddu, Giovanna ; Pulvirenti, A. ; Punin, Valery ; Putiš, M. ; Putschke, Jörn H. ; Quercigh, E. ; Qvigstad, Henrik ; Rachevski, Alexandre ; Rademakers, A. ; Rademakers, O. ; Radomski, S. ; Räihä, T.S. ; Rak, Jan ; Rakotozafindrabe, Andry Malala ; Ramello, Luciano ; Ramírez Reyes, A. ; Rammler, M. ; Raniwala, Rashmi ; Raniwala, Sudhir ; Räsänen, Sami Sakari ; Read, Kenneth Francis ; Real, Jean-Sébastien ; Redlich, Krzysztof ; Renfordt, Rainer Arno Ernst ; Reolon, Anna Rita ; Reshetin, Andrey ; Rettig, Felix Vincenz ; Revol, Jean-Pierre ; Reygers, Klaus ; Ricaud, H. ; Riccati, L. ; Ricci, Renato Angelo ; Richter, Matthias Rudolph ; Riedler, Petra ; Riegler, Werner ; Riggi, Francesco ; Rivetti, Angelo ; Rodrı́guez Cahuantzi, Mario ; Rohr, David ; Röhrich, Dieter ; Romita, Rosa ; Ronchetti, Federico ; Rosinský, P. ; Rosnet, Philippe ; Rossegger, S. ; Rossi, Andrea ; Roukoutakis, Filimon ; Rousseau, S. ; Roy, Christelle Sophie ; Roy, Pradip Kumar ; Rubio Montero, Antonio Juan ; Rui, Rinaldo ; Rusanov, I. ; Ryabinkin, Evgeny ; Rybicki, Andrzej ; Sadovskiy, Sergey ; Šafařík, Karel ; Sahoo, Raghunath ; Sahu, Pradip Kumar ; Saiz, P. ; Sakai, Shingo ; Sakata, D. ; Salgado, Carlos A. ; Samanta, T. ; Sambyal, Sanjeev Singh ; Samsonov, Vladimir ; Šándor, Ladislav ; Sandoval, Andres ; Sano, Masato ; Sano, S. ; Santo, R. ; Santoro, R. ; Sarkamo, J. ; Saturnini, P. ; Scapparone, Eugenio ; Scarlassara, Fernando ; Scharenberg, Rolf Paul ; Schiaua, Claudiu Cornel ; Schicker, Rainer ; Schmidt, Christian Joachim ; Schmidt, Hans Rudolf ; Schreiner, S. ; Schuchmann, Simone ; Schukraft, Jürgen ; Schutz, Yves Roland ; Schwarz, Kilian ; Schweda, Kai ; Scioli, Gilda ; Scomparin, Enrico ; Scott, P.A. ; Scott, Rebecca Michelle ; Segato, G. ; Senyukov, Serhiy ; Seo, Jeewon ; Serci, S. ; Serradilla, Eulogio ; Sevcenco, Adrian ; Shabratova, G. ; Shahoyan, Ruben ; Sharma, Natasha ; Sharma, S. ; Shigaki, Kenta ; Shimomura, Maya ; Shtejer, Katherin ; Sibiriak, Yury ; Siciliano, M. ; Sicking, E. ; Siemiarczuk, Teodor ; Silenzi, A. ; Silvermyr, David Olle Rickard ; Simonetti, Giuseppe ; Singaraju, Rama Narayana ; Singh, R. ; Sinha, Bikash ; Sinha, Tinku ; Sitar, Branislav ; Sitta, Mario ; Skaali, Toralf Bernhard ; Skjerdal, K. ; Smakal, R. ; Smirnov, N. ; Snellings, Raimond ; Søgaard, C. ; Soloviev, A. ; Soltz, Ron ; Son, H. ; Song, M. ; Soos, C. ; Soramel, Francesca ; Spyropoulou-Stassinaki, Martha ; Srivastava, Brijesh Kumar ; Stachel, Johanna ; Stan, Ionel ; Stefanek, Grzegorz ; Stefanini, G. ; Steinbeck, T. ; Stenlund, Evert Anders ; Steyn, Gideon Francois ; Stocco, Diego ; Stock, Reinhard ; Stolpovskiy, M. ; Strmen, Peter ; Suaide, Alexandre Alarcon do Passo ; Subieta Vasquez, Martin Alfonso ; Sugitate, Toru ; Suire, Christophe Pierre ; Šumbera, Michal ; Šuša, Tatjana ; Swoboda, D. ; Symons, Timothy James MacNeil ; Toledo, Alejandro Szanto de ; Szarka, Imrich ; Szostak, A. ; Tagridis, C. ; Takahashi, Jun ; Tapia Takaki, Jesus Daniel ; Tauro, Arturo ; Tavlet, M. ; Tejeda Muñoz, Guillermo ; Telesca, Adriana ; Terrevoli, Cristina ; Thäder, Jochen ; Thomas, Deepa ; Thomas, James H. ; Tieulent, Raphael Noel ; Timmins, Anthony Robert ; Tlusty, David ; Toia, Alberica ; Torii, H. ; Toscano, L. ; Tosello, F. ; Traczyk, T. ; Truesdale, David Christopher ; Trzaska, Wladyslaw Henryk ; Tumkin, Alexandr ; Turrisi, Rosario ; Turvey, A.J. ; Tveter, Trine Spedstad ; Ulery, Jason Glyndwr ; Ullaland, Kjetil ; Uras, Antonio ; Urbán, J. ; Urciuoli, G.M. ; Usai, Gianluca ; Vacchi, A. ; Vala, Martin ; Valencia Palomo, Lizardo ; Vallero, Sara ; Kolk, Naomi van der ; Leeuwen, Marco van ; Vyvre, Pierre vande ; Vannucci, L. ; Vargas Treviño, Maria Aurora Diozcora ; Varma, Raghava ; Vasileiou, Maria ; Vasiliev, Andrey ; Vechernin, Vladimir ; Venaruzzo, Massimo ; Vercellin, Ermanno ; Vergara, S. ; Vernet, Renaud ; Verweij, Marta ; Vicković, Linda ; Viesti, Giuseppe ; Vikhlyantsev, O. ; Vilakazi, Zabulon ; Villalobos Baillie, Orlando ; Vinogradov, Alexander A. ; Vinogradov, Leonid ; Vinogradov, Yury I. ; Virgili, Tiziano ; Viyogi, Yogendra P. ; Vodopyanov, Alexander ; Voloshin, Kirill ; Voloshin, Sergei ; Volpe, Giacomo ; Haller, Barthélémy von ; Vranić, Danilo ; Vrláková, Janka ; Vulpescu, Bogdan ; Wagner, Boris ; Wagner, V. ; Wan, R. ; Wang, D. ; Wang, Y. ; Wang, Y. ; Watanabe, K. ; Wessels, Johannes P. ; Westerhoff, Uwe ; Wiechula, Jens ; Wikne, Jon ; Wilde, Martin ; Wilk, A. ; Wilk, Grzegorz Andrzej ; Williams, M. Crispin S. ; Windelband, Bernd ; Yang, H. ; Yasnopolskiy, S. ; Yi, J. ; Yin, Zhongbao ; Yokoyama, Hiroki ; Yoo, In-Kwon ; Yuan, X. ; Yushmanov, Igor E. ; Zabrodin, E. ; Zampolli, Chiara ; Zaporozhets, Sergey ; Zarochentsev, Andrey ; Závada, Petr ; Zbroszczyk, Hanna Paulina ; Zelnicek, P. ; Zenin, A. ; Zgura, I. ; Zhalov, Mikhail ; Zhang, X. ; Zhou, D. ; Zhu, X. ; Zichichi, Antonino ; Zinovjev, Gennady M. ; Zoccarato, Y. ; Zynovyev, M.
The first measurement of two-pion Bose–Einstein correlations in central Pb–Pb collisions at √sNN=2.76 TeV at the Large Hadron Collider is presented. We observe a growing trend with energy now not only for the longitudinal and the outward but also for the sideward pion source radius. The pion homogeneity volume and the decoupling time are significantly larger than those measured at RHIC.
Aamodt, Kenneth ; Abrahantes Quintana, A. ; Adamová, Dagmar ; Adare, A.M. ; Aggarwal, Madan Mohan ; Aglieri Rinella, Gianluca ; Agocs, A.G. ; Aguilar Salazar, S. ; Ahammed, Zubayer ; Ahmad, Nazeer ; Ahmad Masoodi, A. ; Ahn, Sang Un ; Akindinov, Alexander ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alfaro Molina, Jose Ruben ; Alici, Andrea ; Alkin, Anton ; Almaráz Aviña, E. ; Alt, Torsten ; Altini, V. ; Altinpinar, Sedat ; Altsybeev, Igor ; Andrei, Cristian ; Andronic, Anton ; Anguelov, Venelin ; Anson, Christopher Daniel ; Antičić, Tome ; Antinori, Federico ; Antonioli, Pietro ; Aphecetche, Laurent Bernard ; Appelshäuser, Harald ; Arbor, N. ; Arcelli, Silvia ; Arend, A. ; Armesto, Néstor ; Arnaldi, Roberta ; Aronsson, Tomas Robert ; Arsene, Ionut Cristian ; Asryan, A. ; Augustinus, Andre ; Averbeck, Ralf Peter ; Awes, T.C. ; Äystö, J. ; Azmi, Mohd Danish ; Bach, Matthias ; Badalà, Angela ; Baek, Yong Wook ; Bagnasco, Stefano ; Bailhache, Raphaëlle ; Bala, Remu ; Baldini Ferroli, Rinaldo ; Baldisseri, Alberto ; Baldit, A. ; Bán, J. ; Barbera, Roberto ; Barile, Francesco ; Barnaföldi, Gergely Gábor ; Barnby, Lee Stuart ; Barret, Valerie ; Bartke, Jerzy ; Basile, Maurizio ; Bastid, Nicole ; Bathen, Bastian ; Batigne, Guillaume ; Batyunya, Boris ; Baumann, C. ; Bearden, Ian Gardner ; Beck, Hans ; Belikov, Iouri ; Bellini, Francesca ; Bellwied, Rene ; Belmont-Moreno, Ernesto ; Beolè, Stefania ; Berceanu, Ionela ; Bercuci, Alexandru ; Berdermann, E. ; Berdnikov, Yaroslav ; Betev, Latchezar ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bianchi, Livio ; Bianchi, Nicola ; Bianchin, Chiara ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bilandzic, Ante ; Biolcati, E. ; Blanc, A. ; Blanco, Fernando ; Blanco, Fernando ; Blau, Dmitry S. ; Blume, Christoph ; Boccioli, M. ; Bock, N. ; Bogdanov, Alexey A. ; Bøggild, Hans ; Bogolyubsky, M. ; Boldizsár, László ; Bombara, Marek ; Bombonati, C. ; Book, Julian ; Borel, Hervé ; Bortolin, C. ; Bose, S. ; Bossú, Francesco ; Botje, Michiel ; Böttger, Stefan ; Boyer, B. ; Braun-Munzinger, Peter ; Bravina, L. ; Bregant, Marco ; Breitner, Timo ; Broz, Michal ; Brun, René ; Bruna, Elena ; Bruno, Giuseppe Eugenio ; Budnikov, Dmitry ; Büsching, Henner ; Busch, Oliver ; Buthelezi, Edith Zinhle ; Caffarri, Davide ; Cai, Xiao ; Caines, Helen Louise ; Calvo Villar, Ernesto ; Camerini, Paolo ; Canoa Roman, Veronica ; Cara Romeo, G. ; Carena, Francesco ; Carena, Wisla ; Carminati, F. ; Casanova Díaz, A. ; Caselle, M. ; Castillo Castellanos, Javier Ernesto ; Catanescu, V. ; Cavicchioli, Costanza ; Cerello, Piergiorgio ; Chang, B. ; Chapeland, Sylvain ; Charvet, Jean-Luc Fernand ; Chattopadhyay, S. ; Chattopadhyay, S. ; Cherney, Michael Gerard ; Cheshkov, Cvetan Valeriev ; Cheynis, Brigitte ; Chiavassa, E. ; Chibante Barroso, Vasco Miguel ; Chinellato, David Dobrigkeit ; Chochula, Peter ; Chojnacki, Marek ; Christakoglou, Panagiotis ; Christensen, Christian Holm ; Christiansen, Peter L. ; Chujo, Tatsuya ; Cicalò, Corrado ; Cifarelli, Luisa ; Cindolo, Federico ; Cleymans, Jean Willy Andre ; Coccetti, F. ; Coffin, J.-P. ; Coli, S. ; Conesa Balbastre, Gustavo ; Conesa del Valle, Zaida ; Constantin, P. ; Contin, Giacomo ; Contreras Nuno, Jesus Guillermo ; Cormier, Thomas Michael ; Corrales Morales, Yasser ; Cortés Maldonado, Ismael ; Cortese, Pietro ; Cosentino, Mauro Rogerio ; Costa, Filippo ; Cotallo, M.E. ; Crescio, E. ; Crochet, Philippe ; Cuautle Flores, Eleazar ; Cunqueiro Mendez, Leticia ; Erasmo, G.D. ; Dainese, Andrea ; Dalsgaard, H.H. ; Danu, Andrea ; Das, Debasish ; Das, Indranil ; Dash, Ajay Kumar ; Dash, Sadhana ; De, Sudipan ; De Azevedo Moregula, A. ; de Barros, G.O.V. ; De Caro, Annalisa ; De Cataldo, Giacinto ; Cuveland, Jan de ; De Falco, Alessandro ; De Gruttola, Daniele ; De Marco, Nora ; De Pasquale, Salvatore ; De Remigis, R. ; de Rooij, R. ; Delagrange, H. ; Delgado Mercado, Y. ; Dellacasa, G. ; Deloff, Andrzej ; Demanov, V. ; Dénes, Ervin Sandor ; Deppman, A. ; Di Bari, Domenico ; Di Giglio, C. ; Di Liberto, S. ; Di Mauro, Antonio ; Di Nezza, Pasquale ; Dietel, Thomas ; Divià, Roberto ; Djuvsland, Øystein ; Dobrin, Alexandru Florin ; Dobrowolski, Tadeusz Antoni ; Domínguez, I. ; Dönigus, Benjamin ; Dordic, Olja ; Driga, O. ; Dubey, Anand Kumar ; Dubuisson, J. ; Ducroux, Laurent ; Dupieux, Pascal ; Dutta Majumdar, A.K. ; Dutta Majumdar, M.R. ; Elia, Domenico ; Emschermann, D. ; Engel, Heiko ; Erdal, H.A. ; Espagnon, Bruno ; Estienne, Magali Danielle ; Esumi, ShinIchi ; Evans, David ; Evrard, S. ; Eyyubova, Gyulnara ; Fabjan, C.W. ; Fabris, Daniela ; Faivre, Julien ; Falchieri, D. ; Fantoni, Alessandra ; Fasel, Markus ; Fearick, R. ; Fedunov, A. ; Fehlker, D. ; Fekete, V. ; Felea, Daniel ; Feofilov, Grigori A. ; Fernández Téllez, Arturo ; Ferretti, Alessandro ; Ferretti, R. ; Figueredo, Marcel Araujo Silva ; Filchagin, Sergey ; Fini, R. ; Finogeev, Dmitry ; Fionda, Fiorella Maria Celeste ; Fiore, Enrichetta Maria ; Floris, Michele ; Foertsch, Siegfried Valentin ; Foka, Panagiota ; Fokin, Sergey ; Fragiacomo, Enrico ; Fragkiadakis, M. ; Frankenfeld, Ulrich ; Fuchs, Ulrich ; Furano, F. ; Furget, Christophe ; Fusco Girard, Mario ; Gaardhøje, Jens Jørgen ; Gadrat, S. ; Gagliardi, Martino ; Gago, A. ; Gallio, Mauro ; Ganoti, Paraskevi ; Garabatos, Chilo ; Gemme, R. ; Gerhard, J. ; Germain, Marie ; Geuna, C. ; Gheata, Andrei George ; Gheata, Mihaela ; Ghidini, B. ; Ghosh, Premomoy ; Girard, M.R. ; Giraudo, G. ; Giubellino, Paolo ; Gładysz-Dziaduś, Ewa ; Glässel, Peter ; Gomez, R. ; González Trueba, Laura Helena ; González Zamora, Pedro ; González Santos, H. ; Gorbunov, Sergey ; Gotovac, Sven ; Grabski, Varlen ; Grajcarek, R. ; Grelli, Alessandro ; Grigoras, Alina Gabriela ; Grigoraș, Costin ; Grigoriev, Vladislav A. ; Grigoryan, Ara ; Grigoryan, Smbat ; Grinyov, Boris V. ; Grion, Nevio ; Gros, P. ; Große-Oetringhaus, Jan Fiete ; Grossiord, Jean-Yves ; Grosso, Raffaele ; Guber, Fedor ; Guernane, Rachid ; Guerra Gutierrez, C. ; Guerzoni, Barbara ; Gulbrandsen, Kristjan Herlache ; Gunji, Taku ; Gupta, Anik ; Gupta, Ramni ; Gutbrod, H. ; Haaland, Øystein Senneset ; Hadjidakis, Cynthia Marie ; Haiduc, Maria ; Hamagaki, Hideki ; Hamar, Gergö ; Harris, John W. ; Hartig, M. ; Hasch, D. ; Hasegan, D. ; Hatzifotiadou, Despina ; Hayrapetyan, A. ; Heide, Markus ; Heinz, Mark Thomas ; Helstrup, Håvard ; Herghelegiu, Andrei Ionut ; Hernández, C. ; Herrera Corral, Gerardo Antonio ; Herrmann, Norbert ; Hetland, Kristin Fanebust ; Hicks, B. ; Hille, P.T. ; Hippolyte, Boris ; Horaguchi, T. ; Hori, Y. ; Hristov, Peter ; Hřivnáčová, I. ; Huang, M. ; Huber, S. ; Humanic, Thomas J. ; Hwang, D.S. ; Ichou, R. ; Ilkaev, Radiy ; Ilkiv, Iryna ; Inaba, Motoi ; Incani, E. ; Innocenti, Gian Michele ; Innocenti, P.G. ; Ippolitov, Mikhail ; Irfan, M. ; Ivan, C. ; Ivanov, A. ; Ivanov, Marian ; Ivanov, V. ; Jacholkowski, Adam Wlodzimierz ; Jacobs, Peter Martin ; Jancurová, L. ; Jangal, S. ; Janik, R. ; Jayarathna, S.P. ; Jena, Satyajit ; Jirden, L. ; Jones, Goronwy Tudor ; Jones, Peter Graham ; Jovanović, P. ; Jung, H. ; Jung, W. ; Jusko, Anton ; Kalcher, S. ; Kaliňák, Peter ; Kalisky, M. ; Kalliokoski, T. ; Kalweit, Alexander Philipp ; Kamermans, R. ; Kanaki, K. ; Kang, E. ; Kang, Ju Hwan ; Kaplin, Vladimir ; Karavichev, Oleg V. ; Karavicheva, Tatiana L. ; Karpechev, Evgeny ; Kazantsev, Andrey ; Kebschull, Udo ; Keidel, Ralf ; Khan, M.M. ; Khanzadeev, Alexei ; Kharlov, Yury ; Kileng, Bjarte ; Kim, D.J. ; Kim, D.S. ; Kim, D.W. ; Kim, H.N. ; Kim, J.H. ; Kim, J.S. ; Kim, M. ; Kim, M. ; Kim, S. ; Kim, S.H. ; Kirsch, Stefan ; Kisel, Ivan ; Kiselev, Sergej N. ; Kisiel, Adam Ryszard ; Klay, Jennifer Lynn ; Klein, Jochen ; Klein-Bösing, Christian ; Kliemant, Michael ; Klovning, A. ; Kluge, Alexander ; Knichel, Michael Linus ; Koch, K. ; Köhler, Markus Konrad ; Kolevatov, R. ; Kolojvari, Anatoly ; Kondratiev, Valery P. ; Kondratyeva, Natalia ; Konevskih, A. ; Kornaś, Ewelina ; Kottachchi Kankanamge Don, C. ; Kour, R. ; Kowalski, Marek ; Kox, Serge ; Kozlov, K. ; Kral, Jiří ; Králik, Ivan ; Kramer, F. ; Kraus, Ingrid ; Krawutschke, T. ; Kretz, Matthias ; Krivda, Marian ; Krumbhorn, D. ; Krus, M. ; Kryshen, Evgeny ; Krzewicki, Mikolaj ; Kucheriaev, Yury ; Kuhn, Christian Claude ; Kuijer, Paulus Gerardus ; Kurashvili, Podist ; Kurepin, Alexander ; Kurepin, Alexey B. ; Kuryakin, Alexey ; Kushpil, Svetlana ; Kushpil, V. ; Kweon, Min Jung ; Kwon, Youngil ; La Rocca, Paola ; Ladron de Guevara, Pedro ; Lafage, V. ; Lara Martinez, Camilo Ernesto ; Larsen, D.T. ; Lazzeroni, C. ; Le Bornec, Y. ; Lea, Ramona ; Lee, K.S. ; Lee, S.C. ; Lefèvre, F. ; Lehnert, Jörg ; Leistam, L. ; Lenhardt, M. ; Lenti, Vito ; León Monzón, Ildefonso ; León Vargas, H. ; Lévai, Péter ; Li, X. ; Lietava, Roman ; Lindal, Svein ; Lindenstruth, Volker ; Lippmann, Christian ; Lisa, Michael A. ; Liu, L. ; Loggins, Vera Renee ; Loginov, Vitaly ; Lohn, S. ; Lohner, D. ; Loizides, Constantinos ; Lopez, Xavier Bernard ; López Noriega, M. ; López Torres, Ernesto ; Løvhøiden, G. ; Lu, X.-G. ; Lüttig, Philipp ; Lunardon, Marcello ; Luparello, Grazia ; Luquin, L. ; Luzzi, C. ; Ma, K. ; Ma, R. ; Madagodahettige-Don, D.M. ; Maevskaya, Alla ; Mager, Magnus ; Mahapatra, D.P. ; Maire, Antonin ; Malaev, Mikhail ; Maldonado Cervantes, Ivonne Alicia ; Mal’Kevich, Dmitry ; Malzacher, Peter ; Mamonov, Alexander ; Manceau, Loic Henri Antoine ; Mangotra, L. ; Manko, Vladislav ; Manso, Franck ; Manzari, Vito ; Mao, Yaxian ; Mareš, Jiří ; Margagliotti, Giacomo Vito ; Margotti, Anselmo ; Marín, Ana ; Martashvili, Irakli ; Martinengo, Paolo ; Martínez Hernández, Mario Iván ; Martínez Davalos, A. ; Martínez Garcia, Ginés ; Martynov, Yevgen ; Mas, Alexis Jean-Michel ; Masciocchi, Silvia ; Masera, Massimo ; Masoni, Alberto ; Massacrier, Laure Marie ; Mastromarco, Mario ; Mastroserio, Annalisa ; Matthews, Z.L. ; Matyja, Adam Tomasz ; Mayani, D. ; Mazza, G. ; Mazzoni, Alessandra Maria ; Meddi, Franco ; Menchaca-Rocha, Arturo Alejandro ; Mendez Lorenzo, P. ; Mercado Pérez, Jorge ; Mereu, P. ; Miake, Yasuo ; Midori, J. ; Milano, Leonardo ; Milošević, Jovan ; Mischke, André ; Miśkowiec, Dariusz Czesław ; Mitu, C. ; Mlynarz, J. ; Mohanty, Bedangadas ; Molnar, Levente ; Montaño Zetina, Luis Manuel ; Monteno, M. ; Montes Prado, Esther ; Morando, Maurizio ; Godoy, Denise Aparecida Moreira de ; Moretto, Sandra ; Morsch, Andreas ; Muccifora, Valeria ; Mudnic, Eugen ; Müller, H. ; Muhuri, Sanjib ; Munhoz, Marcelo Gameiro ; Munoz, J. ; Musa, Luciano ; Musso, A. ; Nandi, Basanta Kumar ; Nania, Rosario ; Nappi, Eugenio ; Nattrass, Christine ; Navach, F. ; Navin, S. ; Nayak, Tapan Kumar ; Nazarenko, Sergey ; Nazarov, G. ; Nedosekin, Alexander ; Nendaz, F. ; Newby, J. ; Nicassio, Maria ; Nielsen, Borge Svane ; Nikolaev, Sergey ; Nikolic, V. ; Nikulin, Sergey ; Nikulin, Vladimir ; Nilsen, B.S. ; Nilsson, M.S. ; Noferini, Francesco ; Nooren, Gerardus ; Novitzky, Norbert ; Nyanin, Alexander ; Nyatha, A. ; Nygaard, C. ; Nystrand, Joakim Ingemar ; Obayashi, H. ; Ochirov, A. ; Oeschler, Helmut ; Oh, Sun Kun ; Oleniacz, Janusz ; Oppedisano, Chiara ; Ortiz Velasquez, Antonio ; Ortona, G. ; Oskarsson, Anders Nils Erik ; Ostrowski, P. ; Otterlund, I. ; Otwinowski, Jacek Tomasz ; Øvrebekk, G. ; Oyama, Ken ; Ozawa, K. ; Pachmayer, Yvonne C. ; Pachr, Miloš ; Padilla, F. ; Pagano, Paola ; Paić, Guy ; Painke, F. ; Pajares Vales, Carlos ; Pal, S. ; Pal, Susanta Kumar ; Palaha, A. ; Palmeri, A. ; Pappalardo, Giuseppe Salvatore ; Park, WooJin ; Paticchio, Vincenzo ; Pavlinov, A. ; Pawlak, Tomasz Jan ; Peitzmann, Thomas ; Peresunko, Dmitry Yurevich ; Pérez Lara, Carlos Eugenio ; Perini, D. ; Perrino, D. ; Peryt, Wiktor Stanislaw ; Pesci, A. ; Peskov, Vladimir ; Pestov, Yury N. ; Peters, A.J. ; Petráček, Vojtech ; Petris, M. ; Petrov, P. ; Petrovici, Mihai A. ; Petta, Catia ; Piano, Stefano ; Piccotti, A. ; Pikna, Miroslav ; Pillot, Philippe ; Pinazza, Ombretta ; Pinsky, Lawrence ; Pitz, N. ; Piuz, F. ; Piyarathna, Danthasinghe B. ; Platt, R. ; Płoskoń, Mateusz ; Pluta, Jan Marian ; Pocheptsov, T. ; Pochybova, Sona ; Podesta Lerma, Pedro Luis Manuel ; Poghosyan, Martin G. ; 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Inclusive transverse momentum spectra of primary charged particles in Pb–Pb collisions at √sNN=2.76 TeV have been measured by the ALICE Collaboration at the LHC. The data are presented for central and peripheral collisions, corresponding to 0–5% and 70–80% of the hadronic Pb–Pb cross section. The measured charged particle spectra in |η|<0.8 and 0.3<pT<20 GeV/c are compared to the expectation in pp collisions at the same sNN, scaled by the number of underlying nucleon–nucleon collisions. The comparison is expressed in terms of the nuclear modification factor RAA. The result indicates only weak medium effects (RAA≈0.7) in peripheral collisions. In central collisions, RAA reaches a minimum of about 0.14 at pT=6–7 GeV/c and increases significantly at larger pT. The measured suppression of high-pT particles is stronger than that observed at lower collision energies, indicating that a very dense medium is formed in central Pb–Pb collisions at the LHC.
Aamodt, Kenneth ; Abel, N. ; Abeysekara, U. ; Abrahantes Quintana, A. ; Abramyan, A. ; Adamová, Dagmar ; Aggarwal, Madan Mohan ; Aglieri Rinella, Gianluca ; Agocs, A.G. ; Aguilar Salazar, S. ; Ahammed, Zubayer ; Ahmad, A. ; Ahmad, Nazeer ; Ahn, Sang Un ; Akimoto, R. ; Akindinov, Alexander ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alfaro Molina, Jose Ruben ; Alici, Andrea ; Almaráz Aviña, E. ; Alme, Johan ; Alt, Torsten ; Altini, V. ; Altinpinar, Sedat ; Andrei, Cristian ; Andronic, Anton ; Anelli, G. ; Angelov, V. ; Anson, Christopher Daniel ; Antičić, Tome ; Antinori, Federico ; Antinori, S. ; Antipin, K. ; Antończyk, Dariusz ; Antonioli, Pietro ; Anzo, A. ; Aphecetche, Laurent Bernard ; Appelshäuser, Harald ; Arcelli, Silvia ; Arceo, R. ; Arend, A. ; Armesto, Néstor ; Arnaldi, Roberta ; Aronsson, Tomas Robert ; Arsene, Ionut Cristian ; Asryan, A. ; Augustinus, Andre ; Averbeck, Ralf Peter ; Awes, T.C. ; Äystö, J. ; Azmi, Mohd Danish ; Bablok, Sebastian ; Bach, Matthias ; Badalà, Angela ; 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The inclusive charged particle transverse momentum distribution is measured in proton–proton collisions at s=900 GeV at the LHC using the ALICE detector. The measurement is performed in the central pseudorapidity region (|η|<0.8) over the transverse momentum range 0.15<pT<10 GeV/c. The correlation between transverse momentum and particle multiplicity is also studied. Results are presented for inelastic (INEL) and non-single-diffractive (NSD) events. The average transverse momentum for |η|<0.8 is 〈pT〉INEL=0.483±0.001 (stat.)±0.007 (syst.) GeV/c and 〈pT〉NSD=0.489±0.001 (stat.)±0.007 (syst.) GeV/c, respectively. The data exhibit a slightly larger 〈pT〉 than measurements in wider pseudorapidity intervals. The results are compared to simulations with the Monte Carlo event generators PYTHIA and PHOJET.
Rapidity and transverse momentum dependence of inclusive J/ψ production in pp collisions at √s=7 TeV
(2011)
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Kozlov, K. ; Kral, Jiří ; Králik, Ivan ; Kramer, F. ; Kraus, Ingrid ; Krawutschke, T. ; Kretz, Matthias ; Krivda, Marian ; Krizek, Filip ; Krus, M. ; Kryshen, Evgeny ; Krzewicki, Mikolaj ; Kucheriaev, Yury ; Kuhn, Christian Claude ; Kuijer, Paulus Gerardus ; Kurashvili, Podist ; Kurepin, Alexander ; Kurepin, Alexey B. ; Kuryakin, Alexey ; Kushpil, Svetlana ; Kushpil, V. ; Kweon, Min Jung ; Kwon, Youngil ; La Rocca, Paola ; Ladron de Guevara, Pedro ; Lafage, V. ; Lakomov, Igor ; Lara Martinez, Camilo Ernesto ; Larsen, D.T. ; Lazzeroni, C. ; Le Bornec, Y. ; Lea, Ramona ; Lechman, M. ; Lee, K.S. ; Lee, S.C. ; Lefèvre, F. ; Lehnert, Jörg ; Leistam, L. ; Lenhardt, M. ; Lenti, Vito ; León Monzón, Ildefonso ; León Vargas, H. ; Lévai, Péter ; Li, X. ; Lietava, Roman ; Lindal, Svein ; Lindenstruth, Volker ; Lippmann, Christian ; Lisa, Michael A. ; Liu, L. ; Loggins, Vera Renee ; Loginov, Vitaly ; Lohn, S. ; Lohner, D. ; Loizides, Constantinos ; Loo, K.K. ; Lopez, Xavier Bernard ; López Noriega, M. ; López Torres, Ernesto ; Løvhøiden, G. ; Lu, X.-G. ; Lüttig, Philipp ; Lunardon, Marcello ; Luparello, Grazia ; Luquin, L. ; Luzzi, C. ; Ma, K. ; Ma, R. ; Madagodahettige-Don, D.M. ; Maevskaya, Alla ; Mager, Magnus ; Mahapatra, D.P. ; Maire, Antonin ; Malaev, Mikhail ; Maldonado Cervantes, Ivonne Alicia ; MalʼKevich, D. ; Malzacher, Peter ; Mamonov, Alexander ; Manceau, Loic Henri Antoine ; Manko, Vladislav ; Manso, Franck ; Manzari, Vito ; Mao, Yaxian ; Marchisone, Massimiliano ; Mareš, Jiří ; Margagliotti, Giacomo Vito ; Margotti, Anselmo ; Marín, Ana ; Markert, Christina ; Martashvili, Irakli ; Martinengo, Paolo ; Martínez Hernández, Mario Iván ; Martínez Davalos, A. ; Martínez Garcia, Ginés ; Martynov, Yevgen ; Mas, Alexis Jean-Michel ; Masciocchi, Silvia ; Masera, Massimo ; Masoni, Alberto ; Massacrier, Laure Marie ; Mastromarco, Mario ; Mastroserio, Annalisa ; Matthews, Z.L. ; Matyja, Adam Tomasz ; Mayani, D. ; Mazzoni, Alessandra Maria ; Meddi, Franco ; Menchaca-Rocha, Arturo Alejandro ; Mendez Lorenzo, P. ; Mercado Pérez, Jorge ; Meres, Michal ; Miake, Yasuo ; Midori, J. ; Milano, Leonardo ; Milošević, Jovan ; Mischke, André ; Miśkowiec, Dariusz Czesław ; Mitu, C. ; Mlynarz, J. ; Mohanty, Bedangadas ; Molnar, Levente ; Montaño Zetina, Luis Manuel ; Monteno, M. ; Montes Prado, Esther ; Morando, Maurizio ; Godoy, Denise Aparecida Moreira de ; Moretto, Sandra ; Morsch, Andreas ; Muccifora, Valeria ; Mudnic, Eugen ; Müller, H. ; Muhuri, Sanjib ; Munhoz, Marcelo Gameiro ; Musa, Luciano ; Musso, A. ; Nandi, Basanta Kumar ; Nania, Rosario ; Nappi, Eugenio ; Nattrass, Christine ; Navach, F. ; Navin, S. ; Nayak, Tapan Kumar ; Nazarenko, Sergey ; Nazarov, G. ; Nedosekin, Alexander ; Nendaz, F. ; Nicassio, Maria ; Nielsen, Borge Svane ; Nikolaev, Sergey ; Nikolic, V. ; Nikulin, Sergey ; Nikulin, Vladimir ; Nilsen, B.S. ; Nilsson, M.S. ; Noferini, Francesco ; Nooren, Gerardus ; Novitzky, Norbert ; Nyanin, Alexander ; Nyatha, A. ; Nygaard, C. ; Nystrand, Joakim Ingemar ; Obayashi, H. ; Ochirov, A. ; Oeschler, Helmut ; Oh, Sun Kun ; Oleniacz, Janusz ; Oppedisano, Chiara ; Ortiz Velasquez, Antonio ; Ortona, G. ; Oskarsson, Anders Nils Erik ; Ostrowski, P. ; Otterlund, I. ; Otwinowski, Jacek Tomasz ; Øvrebekk, G. ; Oyama, Ken ; Ozawa, K. ; Pachmayer, Yvonne C. ; Pachr, Miloš ; Padilla, F. ; Pagano, Paola ; Paić, Guy ; Painke, F. ; Pajares Vales, Carlos ; Pal, S. ; Pal, Susanta Kumar ; Palaha, A. ; Palmeri, A. ; Pappalardo, Giuseppe Salvatore ; Park, WooJin ; Paticchio, Vincenzo ; Pavlinov, A. ; Pawlak, Tomasz Jan ; Peitzmann, Thomas ; Peresunko, Dmitry Yurevich ; Pérez Lara, Carlos Eugenio ; Perini, D. ; Perrino, D. ; Peryt, Wiktor Stanislaw ; Pesci, A. ; Peskov, Vladimir ; Pestov, Yury N. ; Peters, A.J. ; Petráček, Vojtech ; Petran, M. ; Petris, M. ; Petrov, P. ; Petrovici, Mihai A. ; Petta, Catia ; Piano, Stefano ; Piccotti, A. ; Pikna, Miroslav ; Pillot, Philippe ; Pinazza, Ombretta ; Pinsky, Lawrence ; Pitz, N. ; Piuz, F. ; Piyarathna, Danthasinghe B. ; Platt, R. ; Płoskoń, Mateusz ; Pluta, Jan Marian ; Pocheptsov, T. ; Pochybova, Sona ; Podesta Lerma, Pedro Luis Manuel ; Poghosyan, Martin G. ; Polichtchouk, Boris ; Pop, Amalia ; Pospíšil, V. ; Potukuchi, B. ; Prasad, Sidharth Kumar ; Preghenella, Roberto ; Prino, Francesco ; Pruneau, Claude A. ; Pshenichnov, Igor A. ; Puddu, Giovanna ; Pulvirenti, A. ; Punin, Valery ; Putiš, M. ; Putschke, Jörn H. ; Quercigh, E. ; Qvigstad, Henrik ; Rachevski, Alexandre ; Rademakers, A. ; Radomski, S. ; Räihä, T.S. ; Rak, Jan ; Rakotozafindrabe, Andry Malala ; Ramello, Luciano ; Ramírez Reyes, A. ; Rammler, M. ; Raniwala, Rashmi ; Raniwala, Sudhir ; Räsänen, Sami Sakari ; Rathee, Deepika ; Read, Kenneth Francis ; Real, Jean-Sébastien ; Redlich, Krzysztof ; Renfordt, Rainer Arno Ernst ; Reolon, Anna Rita ; Reshetin, Andrey ; Rettig, Felix Vincenz ; Revol, Jean-Pierre ; Reygers, Klaus ; Ricaud, H. ; Riccati, L. ; Ricci, Renato Angelo ; Richter, Matthias Rudolph ; Riedler, Petra ; Riegler, Werner ; Riggi, Francesco ; Rodrı́guez Cahuantzi, Mario ; Rohr, David ; Röhrich, Dieter ; Romita, Rosa ; Ronchetti, Federico ; Rosinský, P. ; Rosnet, Philippe ; Rossegger, S. ; Rossi, Andrea ; Roukoutakis, Filimon ; Rousseau, S. ; Roy, Christelle Sophie ; Roy, Pradip Kumar ; Rubio Montero, Antonio Juan ; Rui, Rinaldo ; Ryabinkin, Evgeny ; Rybicki, Andrzej ; Sadovskiy, Sergey ; Šafařík, Karel ; Sahoo, Raghunath ; Sahu, Pradip Kumar ; Saiz, P. ; Sakai, Shingo ; Sakata, D. ; Salgado, Carlos A. ; Sambyal, Sanjeev Singh ; Samsonov, Vladimir ; Šándor, Ladislav ; Sandoval, Andres ; Sano, Masato ; Sano, S. ; Santo, R. ; Santoro, R. ; Sarkamo, J. ; Saturnini, P. ; Scapparone, Eugenio ; Scarlassara, Fernando ; Scharenberg, Rolf Paul ; Schiaua, Claudiu Cornel ; Schicker, Rainer ; Schmidt, Christian Joachim ; Schmidt, Hans Rudolf ; Schreiner, S. ; Schuchmann, Simone ; Schukraft, Jürgen ; Schutz, Yves Roland ; Schwarz, Kilian ; Schweda, Kai ; Scioli, Gilda ; Scomparin, Enrico ; Scott, P.A. ; Scott, Rebecca Michelle ; Segato, G. ; Senyukov, Serhiy ; Seo, Jeewon ; Serci, S. ; Serradilla, Eulogio ; Sevcenco, Adrian ; Sgura, I. ; Shabratova, G. ; Shahoyan, Ruben ; Sharma, Natasha ; Sharma, S. ; Shigaki, Kenta ; Shimomura, Maya ; Shtejer, Katherin ; Sibiriak, Yury ; Siciliano, M. ; Sicking, E. ; Siemiarczuk, Teodor ; Silvermyr, David Olle Rickard ; Simonetti, Giuseppe ; Singaraju, Rama Narayana ; Singh, R. ; Singha, Subhash ; Sinha, Bikash ; Sinha, Tinku ; Sitar, Branislav ; Sitta, Mario ; Skaali, Toralf Bernhard ; Skjerdal, K. ; Smakal, R. ; Smirnov, N. ; Snellings, Raimond ; Søgaard, C. ; Soltz, Ron ; Son, H. ; Song, J. ; Song, M. ; Soos, C. ; Soramel, Francesca ; Spyropoulou-Stassinaki, Martha ; Srivastava, Brijesh Kumar ; Stachel, Johanna ; Stan, Ionel ; Stefanek, Grzegorz ; Stefanini, G. ; Steinbeck, T. ; Steinpreis, M. ; Stenlund, Evert Anders ; Steyn, Gideon Francois ; Stocco, Diego ; Stock, Reinhard ; Stokkevag, C.H. ; Stolpovskiy, M. ; Strmen, Peter ; Suaide, Alexandre Alarcon do Passo ; Subieta Vasquez, Martin Alfonso ; Sugitate, Toru ; Suire, Christophe Pierre ; Sukhorukov, M. ; Šumbera, Michal ; Šuša, Tatjana ; Swoboda, D. ; Symons, Timothy James MacNeil ; Toledo, Alejandro Szanto de ; Szarka, Imrich ; Szostak, A. ; Tagridis, C. ; Takahashi, Jun ; Tapia Takaki, Jesus Daniel ; Tauro, Arturo ; Tejeda Muñoz, Guillermo ; Telesca, Adriana ; Terrevoli, Cristina ; Thäder, Jochen ; Thomas, Deepa ; Thomas, James H. ; Tieulent, Raphael Noel ; Timmins, Anthony Robert ; Tlusty, David ; Toia, Alberica ; Torii, H. ; Tosello, F. ; Traczyk, T. ; Truesdale, David Christopher ; Trzaska, Wladyslaw Henryk ; Tumkin, Alexandr ; Turrisi, Rosario ; Turvey, A.J. ; Tveter, Trine Spedstad ; Ulery, Jason Glyndwr ; Ullaland, Kjetil ; Uras, Antonio ; Urbán, J. ; Urciuoli, G.M. ; Usai, Gianluca ; Vajzer, Michal ; Vala, Martin ; Valencia Palomo, Lizardo ; Vallero, Sara ; Kolk, Naomi van der ; Leeuwen, Marco van ; Vyvre, Pierre vande ; Vannucci, L. ; Vargas Treviño, Maria Aurora Diozcora ; Varma, Raghava ; Vasileiou, Maria ; Vasiliev, Andrey ; Vechernin, Vladimir ; Veldhoen, Misha ; Venaruzzo, Massimo ; Vercellin, Ermanno ; Vergara, S. ; Vernekohl, D.C. ; Vernet, Renaud ; Verweij, Marta ; Vicković, Linda ; Viesti, Giuseppe ; Vikhlyantsev, O. ; Vilakazi, Zabulon ; Villalobos Baillie, Orlando ; Vinogradov, Alexander A. ; Vinogradov, Leonid ; Vinogradov, Yury I. ; Virgili, Tiziano ; Viyogi, Yogendra P. ; Vodopyanov, Alexander ; Voloshin, Kirill ; Voloshin, Sergei ; Volpe, Giacomo ; Haller, Barthélémy von ; Vranić, Danilo ; Vrláková, Janka ; Vulpescu, Bogdan ; Vyushin, Alexey ; Wagner, Boris ; Wagner, V. ; Wan, R. ; Wang, D. ; Wang, M. ; Wang, Y. ; Wang, Y. ; Watanabe, K. ; Wessels, Johannes P. ; Westerhoff, Uwe ; Wiechula, Jens ; Wikne, Jon ; Wilde, Martin ; Wilk, A. ; Wilk, Grzegorz Andrzej ; Williams, M. Crispin S. ; Windelband, Bernd ; Yang, H. ; Yasnopolskiy, S. ; Yi, J. ; Yin, Zhongbao ; Yokoyama, Hiroki ; Yoo, In-Kwon ; Yuan, X. ; Yushmanov, Igor E. ; Zabrodin, E. ; Zach, C. ; Zampolli, Chiara ; Zaporozhets, Sergey ; Zarochentsev, Andrey ; Závada, Petr ; Zaviyalov, Nikolaj ; Zbroszczyk, Hanna Paulina ; Zelnicek, P. ; Zenin, A. ; Zgura, I. ; Zhalov, Mikhail ; Zhang, X. ; Zhou, D. ; Zhou, F. ; Zhou, Y. ; Zhu, X. ; Zichichi, Antonino ; Zinovjev, Gennady M. ; Zoccarato, Y. ; Zynovyev, M.
The ALICE experiment at the LHC has studied inclusive J/ψ production at central and forward rapidities in pp collisions at √s=7 TeV. In this Letter, we report on the first results obtained detecting the J/ψ through the dilepton decay into e+e− and μ+μ− pairs in the rapidity ranges |y|<0.9 and 2.5<y<4, respectively, and with acceptance down to zero pT. In the dielectron channel the analysis was carried out on a data sample corresponding to an integrated luminosity Lint=5.6 nb−1 and the number of signal events is NJ/ψ=352±32(stat.)±28(syst.); the corresponding figures in the dimuon channel are Lint=15.6 nb−1 and NJ/ψ=1924±77(stat.)±144(syst.). The measured production cross sections are σJ/ψ(|y|<0.9)=10.7±1.0(stat.)±1.6(syst.)−2.3+1.6(syst.pol.)μb and σJ/ψ(2.5<y<4)=6.31±0.25(stat.)±0.76(syst.)−1.96+0.95(syst.pol.)μb. The differential cross sections, in transverse momentum and rapidity, of the J/ψ were also measured.
Hiranuma, Naruki ; Augustin-Bauditz, Stefanie ; Bingemer, Heinz ; Budke, Carsten ; Curtius, Joachim ; Danielczok, Anja ; Diehl, Karoline ; Dreischmeier, Katharina ; Ebert, Martin ; Frank, Fabian ; Hoffmann, Nadine ; Kandler, Konrad ; Kiselev, Alexei ; Koop, Thomas ; Leisner, Thomas ; Möhler, Ottmar ; Nillius, Björn ; Peckhaus, Andreas ; Rose, Diana ; Hader, John D. ; Hill, Thomas C. ; Kanji, Zamin A. ; Kulkarni, Gargi ; Levin, Ezra J. T. ; McCluskey, Christina S. ; Murakami, Masataka ; Murray, Benjamin J. ; Niedermeier, Dennis ; Petters, Markus D. ; O'Sullivan, Daniel ; Saito, Atsushi ; Schill, Gregory P. ; Tajiri, Takuya ; Tolbert, Margret A. ; Welti, André ; Whale, Thomas F. ; Wright, Timothy P. ; Yamashita, Katsuya
Immersion freezing is the most relevant heterogeneous ice nucleation mechanism through which ice crystals are formed in mixed-phase clouds. In recent years, an increasing number of laboratory experiments utilizing a variety of instruments have examined immersion freezing activity of atmospherically relevant ice-nucleating particles. However, an intercomparison of these laboratory results is a difficult task because investigators have used different ice nucleation (IN) measurement methods to produce these results. A remaining challenge is to explore the sensitivity and accuracy of these techniques and to understand how the IN results are potentially influenced or biased by experimental parameters associated with these techniques.
Within the framework of INUIT (Ice Nuclei Research Unit), we distributed an illite-rich sample (illite NX) as a representative surrogate for atmospheric mineral dust particles to investigators to perform immersion freezing experiments using different IN measurement methods and to obtain IN data as a function of particle concentration, temperature (T), cooling rate and nucleation time. A total of 17 measurement methods were involved in the data intercomparison. Experiments with seven instruments started with the test sample pre-suspended in water before cooling, while 10 other instruments employed water vapor condensation onto dry-dispersed particles followed by immersion freezing. The resulting comprehensive immersion freezing data set was evaluated using the ice nucleation active surface-site density, ns, to develop a representative ns(T) spectrum that spans a wide temperature range (−37 °C < T < −11 °C) and covers 9 orders of magnitude in ns.
In general, the 17 immersion freezing measurement techniques deviate, within a range of about 8 °C in terms of temperature, by 3 orders of magnitude with respect to ns. In addition, we show evidence that the immersion freezing efficiency expressed in ns of illite NX particles is relatively independent of droplet size, particle mass in suspension, particle size and cooling rate during freezing. A strong temperature dependence and weak time and size dependence of the immersion freezing efficiency of illite-rich clay mineral particles enabled the ns parameterization solely as a function of temperature. We also characterized the ns(T) spectra and identified a section with a steep slope between −20 and −27 °C, where a large fraction of active sites of our test dust may trigger immersion freezing. This slope was followed by a region with a gentler slope at temperatures below −27 °C. While the agreement between different instruments was reasonable below ~ −27 °C, there seemed to be a different trend in the temperature-dependent ice nucleation activity from the suspension and dry-dispersed particle measurements for this mineral dust, in particular at higher temperatures. For instance, the ice nucleation activity expressed in ns was smaller for the average of the wet suspended samples and higher for the average of the dry-dispersed aerosol samples between about −27 and −18 °C. Only instruments making measurements with wet suspended samples were able to measure ice nucleation above −18 °C. A possible explanation for the deviation between −27 and −18 °C is discussed. Multiple exponential distribution fits in both linear and log space for both specific surface area-based ns(T) and geometric surface area-based ns(T) are provided. These new fits, constrained by using identical reference samples, will help to compare IN measurement methods that are not included in the present study and IN data from future IN instruments.
Isaak, Johann ; Löher, Bastian ; Savran, Deniz ; Aumann, Thomas ; Beller, Jacob ; Cooper, Nathan ; Derya, Vera ; Duchêne, Marc ; Endres, Janis ; Fiori, Enrico ; Kelley, John H. ; Knörzer, Michael ; Pietralla, Norbert ; Ponomarev, V. Yu. ; Romig, Christopher ; Scheck, Marcus ; Scheit, Heiko ; Silva, Joel ; Tonchev, Anton P. ; Tornow, Werner ; Weller, Henry R. ; Werner, Volker ; Zilges, Andreas ; Zweidinger, Markus
The decay behavior of low-lying dipole states in 140Ce was investigated exploiting the γ3-setup at the HIγS facility using quasi-monochromatic photon beams. Branching ratios of individual excited states as well as average branching ratios to low-lying states have been extracted using γ – γ coincidence measurements. The comparison of the average branching ratios to QPM calculations shows a remarkable agreement between experiment and theory in the energy range from 5.0 to 8.5 MeV.
Mazzone, Annamaria ; Cristallo, Sergio ; Aberle, Oliver ; Alaerts, Gery ; Alcayne, Victor ; Amaducci, Simone ; Andrzejewski, Józef ; Audouin, Laurent ; Babiano Suarez, Victor ; Bacak, Michael ; Barbagallo, Massimo ; Bécares, Vicente ; Bečvář, František ; Bellia, Giorgio ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brown, Adam S. ; Busso, Maurizio ; Caamaño, Manuel ; Caballero Ontanaya, Luis ; Calviani, Marco ; Calviño Tavares, Francisco ; Cano-Ott, Daniel ; Casanovas Hoste, Adrià ; Castelluccio, Donato Maurizio ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Clai, Giulia ; Colonna, Nicola ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Cosentino, Luigi ; Damone, Lucia Anna ; Diakaki, Maria ; Dietz, Mirco ; Domingo-Pardo, César ; Dressler, Rugard ; Dupont, Emmeric ; Durán, Ignacio ; Eleme, Zinovia ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Gonçalves, Isabel Maria Ferro ; Finocchiaro, Paolo ; Furman, Valter ; Garg, Ruchi ; Gawlik, Aleksandra ; Gilardoni, Simone ; Glodariu, Tudor ; Göbel, Kathrin ; González Romero, Enrique Miguel ; Guerrero Sánchez, Carlos ; Gunsing, Frank ; Heinitz, Stephan ; Heyse, Jan ; Jenkins, David ; Jericha, Erwin ; Kadi, Yacine ; Käppeler, Franz ; Kimura, Atsushi ; Kivel, Nikolay ; Kokkoris, Michael ; Kopatch, Yuri N. ; Kopecky, Stefan ; Krtička, Milan ; Kurtulgil, Cem Deniz ; Ladarescu, Ion ; Lederer-Woods, Claudia ; Lerendegui-Marco, Jorge ; Lo Meo, Sergio ; Lonsdale, Sarah-Jane ; Macina, Daniela ; Manna, Alice ; Martínez, Trinitario ; Masi, Alessandro ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Matteucci, Francesca ; Maugeri, Emilio Andrea ; Mendoza Cembranos, Emilio ; Mengoni, Alberto ; Michalopoulou, Veatriki ; Milazzo, Paolo Maria ; Mingrone, Federica ; Mucciola, Riccardo ; Musumarra, Agatino ; Negret, Alexandru ; Nolte, Ralf ; Ogállar Ruiz, Francisco ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Piersanti, Luciano ; Porras Sánchez, José Ignacio ; Praena, Javier ; Quesada Molina, José Manuel ; Radeck, Désirée ; Ramos Doval, Diego ; Reifarth, René ; Rochman, Dimitri ; Rubbia, Carlo ; Sabaté-Gilarte, Marta ; Saxena, Alok ; Schillebeeckx, Peter ; Schumann, Dorothea ; Smith, Alastair Gavin ; Sosnin, Nikolay V. ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Talip, Zeynep ; Tarifeño-Saldivia, Ariel ; Tassan-Got, Laurent ; Torres-Sánchez, Pablo ; Tsinganis, Andrea ; Ulrich, Jiri ; Urlaß, Sebastian ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vescovi, Diego ; Vlachoudis, Vasilis ; Vlastou, Rosa ; Wallner, Anton ; Woods, Philip John ; Wynants, Ruud ; Wright, Tobias J. ; Žugec, Petar
The neutron capture cross section of 154Gd was measured from 1 eV to 300 keV in the experimental area located 185 m from the CERN n_TOF neutron spallation source, using a metallic sample of gadolinium, enriched to 67% in 154Gd. The capture measurement, performed with four C6D6 scintillation detectors, has been complemented by a transmission measurement performed at the GELINA time-of-flight facility (JRC-Geel), thus minimising the uncertainty related to sample composition. An accurate Maxwellian averaged capture cross section (MACS) was deduced over the temperature range of interest for s process nucleosynthesis modelling. We report a value of 880(50) mb for the MACS at kT = 30 keV, significantly lower compared to values available in literature. The new adopted 154Gd(n,γ) cross section reduces the discrepancy between observed and calculated solar s-only isotopic abundances predicted by s-process nucleosynthesis models.
Bauer, Matthias R. ; Jones, Rhiannon N. ; Baud, Matthias G. J. ; Wilcken, Rainer ; Böckler, Frank ; Fersht, Alan ; Jörger, Andreas C. ; Spencer, John
Many oncogenic mutants of the tumor suppressor p53 are conformationally unstable, including the frequently occurring Y220C mutant. We have previously developed several small-molecule stabilizers of this mutant. One of these molecules, PhiKan083, 1-(9-ethyl-9H-carbazole-3-yl)-N-methylmethanamine, binds to a mutation-induced surface crevice with a KD = 150 μM, thereby increasing the melting temperature of the protein and slowing its rate of aggregation. Incorporation of fluorine atoms into small molecule ligands can substantially improve binding affinity to their protein targets. We have, therefore, harnessed fluorine–protein interactions to improve the affinity of this ligand. Step-wise introduction of fluorines at the carbazole ethyl anchor, which is deeply buried within the binding site in the Y220C–PhiKan083 complex, led to a 5-fold increase in affinity for a 2,2,2-trifluoroethyl anchor (ligand efficiency of 0.3 kcal mol–1 atom–1). High-resolution crystal structures of the Y220C–ligand complexes combined with quantum chemical calculations revealed favorable interactions of the fluorines with protein backbone carbonyl groups (Leu145 and Trp146) and the sulfur of Cys220 at the mutation site. Affinity gains were, however, only achieved upon trifluorination, despite favorable interactions of the mono- and difluorinated anchors with the binding pocket, indicating a trade-off between energetically favorable protein–fluorine interactions and increased desolvation penalties. Taken together, the optimized carbazole scaffold provides a promising starting point for the development of high-affinity ligands to reactivate the tumor suppressor function of the p53 mutant Y220C in cancer cells.
Mathur, Anthony ; Fernández-Avilés, Francisco ; Dimmeler, Stefanie ; Hauskeller, Christine ; Janssens, Stefan ; Menasche, Philippe ; Wojakowski, Wojtek ; Martin, John F. ; Zeiher, Andreas M.
In 2006, the Task Force of the European Society of Cardiology published its consensus document on the use of autologous cell therapy for repair of the heart. Since then, there have been numerous clinical trials and analyses performed to establish the role of autologous cell therapy in the treatment of both acute and chronic cardiac disease. The majority of these studies have been Phase II clinical trials. Phase III clinical trials of autologous cell therapy have been launched (e.g. BAMI), which marks the successful progression of clinical investigation of autologous cell therapy in heart disease. The Task Force has reviewed its 2006 recommendations and the developments in this area of research and proposes updated recommendations for the future of autologous cell therapy in the heart. This article does not duplicate the many reviews on stem cells and the heart but gives considered recommendations based on the experience from the last 10 years.
Casanovas Hoste, Adrià ; Domingo-Pardo, César ; Guerrero Sánchez, Carlos ; Lerendegui-Marco, Jorge ; Calviño Tavares, Francisco ; Tarifeño-Saldivia, Ariel ; Dressler, Rugard ; Heinitz, Stephan ; Kivel, Nikolay ; Quesada Molina, José Manuel ; Schumann, Dorothea ; Aberle, Oliver ; Alcayne, Victor ; Andrzejewski, Józef ; Audouin, Laurent ; Bécares, Vicente ; Bacak, Michael ; Barbagallo, Massimo ; Bečvář, František ; Bellia, Giorgio ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brown, Adam ; Busso, Maurizio ; Caamaño, Manuel ; Caballero Ontanaya, Luis ; Calviani, Marco ; Cano-Ott, Daniel ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Colonna, Nicola ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Cosentino, Luigi ; Cristallo, Sergio ; Damone, Lucia Anna ; Diakaki, Maria ; Dietz, Mirco ; Dupont, Emmeric ; Durán, Ignacio ; Eleme, Zinovia ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Ferreira, Pedro G. ; Finocchiaro, Paolo ; Furman, Valter ; Göbel, Kathrin ; Gawlik, Aleksandra ; Gilardoni, Simone ; Glodariu, Tudor ; Gonçalves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Gunsing, Frank ; Heyse, Jan ; Jenkins, David ; Käppeler, Franz ; Kadi, Yacine ; Katabuchi, Tatsuya ; Kimura, Atsushi ; Kokkoris, Michael ; Kopatch, Yuri N. ; Krtička, Milan ; Kurtulgil, Cem Deniz ; Ladarescu, Ion ; Lederer-Woods, Claudia ; Lo Meo, Sergio ; Lonsdale, Sarah Jane ; Macina, Daniela ; Martı́nez, Trinitario ; Masi, Alessandro ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Matteucci, Francesca ; Maugeri, Emilio Andrea ; Mazzone, Annamaria ; Mendoza Cembranos, Emilio ; Mengoni, Alberto ; Michalopoulou, Veatriki ; Milazzo, Paolo Maria ; Mingrone, Federica ; Musumarra, Agatino ; Negret, Alexandru ; Nolte, Ralf ; Ogállar Ruiz, Francisco ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Piersanti, Luciano ; Porras Sánchez, José Ignacio ; Praena, Javier ; Radeck, Désirée ; Ramos Doval, Diego ; Rauscher, Thomas ; Reifarth, René ; Rochman, Dimitri ; Sabaté-Gilarte, Marta ; Saxena, Alok ; Schillebeeckx, Peter ; Simone, Saverio ; Smith, Alastair Gavin ; Sosnin, Nikolay V. ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Talip, T. ; Tassan-Got, Laurent ; Tsinganis, Andrea ; Ulrich, Jiri ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vlachoudis, Vasilis ; Vlastou, Rosa ; Wallner, Anton ; Woods, Philip John ; Wright, Tobias ; Žugec, Petar ; Köster, Ulrich
The neutron capture cross section of some unstable nuclei is especially relevant for s-process nucleosynthesis studies. This magnitude is crucial to determine the local abundance pattern, which can yield valuable information of the s-process stellar environment. In this work we describe the neutron capture (n,γ) measurement on two of these nuclei of interest, 204Tl and 171Tm, from target production to the final measurement, performed successfully at the n_TOF facility at CERN in 2014 and 2015. Preliminary results on the ongoing experimental data analysis will also be shown. These results include the first ever experimental observation of capture resonances for these two nuclei.
Dietz, Mirco ; Lederer-Woods, Claudia ; Aberle, Oliver ; Andrzejewski, Józef ; Audouin, Laurent ; Bacak, Michael ; Balibrea Correa, Javier ; Barbagallo, Massimo ; Bečvář, František ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brown, Adam ; Caamaño, Manuel ; Calviño Tavares, Francisco ; Calviani, Marco ; Cano-Ott, Daniel ; Cardella, Roberto ; Casanovas Hoste, Adrià ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Colonna, Nicola ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Cosentino, Luigi ; Damone, Lucia Anna ; Diakaki, Maria ; Domingo-Pardo, César ; Dressler, Rugard ; Dupont, Emmeric ; Durán, Ignacio ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Ferreira, Pedro G. ; Finocchiaro, Paolo ; Furman, Valter ; Göbel, Kathrin ; García Ríos, Aczel Regino ; Garg, Ruchi ; Gawlik, Aleksandra ; Gilardoni, Simone ; Glodariu, Tudor ; Gonçalves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Griesmayer, Erich ; Guerrero Sánchez, Carlos ; Gunsing, Frank ; Harada, Hideo ; Heinitz, Stephan ; Heyse, Jan ; Jenkins, David ; Jericha, Erwin ; Käppeler, Franz ; Kadi, Yacine ; Kahl, David ; Kalamara, Antigoni ; Kavrigin, Pavel ; Kimura, Atsushi ; Kivel, Nikolay ; Kokkoris, Michael ; Krtička, Milan ; Kurtulgil, Cem Deniz ; Leal Cidoncha, Esther ; Leeb, Helmut ; Lerendegui-Marco, Jorge ; Lo Meo, Sergio ; Lonsdale, Sarah Jane ; Macina, Daniela ; Marganiec, Justyna ; Martı́nez, Trinitario ; Masi, Alessandro ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Maugeri, Emilio Andrea ; Mazzone, Annamaria ; Mendoza Cembranos, Emilio ; Mengoni, Alberto ; Milazzo, Paolo Maria ; Mingrone, Federica ; Musumarra, Agatino ; Negret, Alexandru ; Nolte, Ralf ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Porras Sánchez, José Ignacio ; Praena, Javier ; Quesada Molina, José Manuel ; Radeck, Désirée ; Rauscher, Thomas ; Reifarth, René ; Rubbia, Carlo ; Ryan, James A. ; Sabateé-Gilarte, Marta ; Saxena, Alok ; Schillebeeckx, Peter ; Schumann, Dorothea ; Sedyshev, Pavel V. ; Smith, Alastair Gavin ; Sosnin, Nikolay V. ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, Jose Luis ; Tarifeño-Saldivia, Ariel ; Tassan-Got, Laurent ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vlachoudis, Vasilis ; Vlastou, Rosa ; Wallner, Anton ; Warren, Stephen J. ; Weiß, Christina ; Woods, Philip John ; Wright, Tobias ; Žugec, Petar
The slow neutron capture process (s-process) is responsible for producing about half of the elemental abundances heavier than iron in the universe. Neutron capture cross sections on stable isotopes are a key nuclear physics input for s-process studies. The 72Ge(n, γ) cross section has an important influence on production of isotopes between Ge and Zr during s-process in massive stars and therefore experimental data are urgently required. 72Ge(n, γ) was measured at the neutron time-of-flight facility n_TOF (CERN) for the first time at stellar energies. The measurement was performed using an enriched 72GeO2 sample at a flight path of 185m with a set of liquid scintillation detectors (C6D6). The motivation, experiment and current status of the data analysis are reported.
Semiquinone radical anions are prototype compounds for contact ion pair formation with metal counter cations. In order to investigate the still open question whether bulky alkyl groups can sterically interfere, diphenoquinone derivatives O=C(RC=CH)2C=C(HC=CR)2C=O with R = C(CH3)3, CH(CH3)2 and CH3 have been selected and the following ESR/ENDOR results are obtained for the alkaline metal cations: The tetrakis(tert-butyl)-substituted radical anion only adds Li⊕ and Na⊕, while K⊕ forms no ion pair. The 3,3ʹ,5,5ʹ-tetra(isopropyl)diphenoquinone radical anion is accessible to all cations Me⊕, although Rb⊕ and Cs⊕ seem to be present solvent-separated in solution. The tetramethyl-substituted radical anion unfortunately polymerizes rapidly. Additional information concerns the ESR/ENDOR proof for ion triple radical cation formation [Li⊕ M•⊖Li⊕]•⊕, or the difference in the coupling constants upon Me⊕ docking at one δ⊖O=C group, suggesting that about 87% of the spin density is located in the cation-free molecular half of the diphenoquinone radical anion. Based on the wealth of ESR/ENDOR information, crystallization of the contact ion pairs and their structural characterization should be attempted.
The one-electron transfer to large π-delocalized hydrocarbons provides an interesting possibility to crystallize solvent-separated ion-pair salts containing optimally solvated cations. Accordingly, the reduction of 9.9′-bianthryl in aprotic 1.2-dimethoxyethane (DME) solution at a sodium metal mirror allows to grow dark blue, brick-like crystals of its radical anion and threefold DME-solvated sodium cation. The structure of the radical anion is very similar to that recently published for the neutral molecule. According to AM 1 enthalpy hypersurface calculations based on the structural data, the torsion angle between 60° and 120° is determined by the lattice packing and the negative charge is -π-delocalized predominantly within only one anthracene subunit. The counter cation [Na⊕(DME)3], reported only three times so far, shows a sixfold propeller-like coordination of approximate D3 skeletal symmetry with contact distances Na⊕···O between 232 and 243 pm and angles ≮ONa⊕O varying between 69° and 159°. Due to the small repulsion between the chelating DME molecules, the isodesmically calculated Na⊕ solvation enthalpy is more negative than that of the analogous tetrahydrofuran complex [Na⊕(THF)6] - as confirmed by the laboratory experience that salts of less stable anions are preferentially crystallized from a strongly cation solvating DME solution.
Bauer, Michael ; Glenn, Tasha ; Achtyes, Eric D. ; Agaoglu, Esen ; Altınbaş, Kürşat ; Andreassen, Ole A. ; Angelopoulos, Elias ; Ardau, Raffaella ; Arrua Vares, Edgar ; Aydin, Memduha ; Ayhan, Yavuz ; Baethge, Christopher Jan ; Bauer, Rita ; Baune, Bernhard T. ; Balaban, Ceylan ; Becerra-Palars, Claudia ; Behere, Aniruddh P. ; Behere, Prakash B. ; Belete, Habte ; Belete, Tilahun ; Belizario, Gabriel Okawa ; Bellivier, Frank ; Belmaker, Robert H. ; Benedetti, Francesco ; Berk, Michael ; Bersudsky, Yuly ; Bicakci, Şule ; Birabwa-Oketcho, Harriet ; Bjella, Thomas D. ; Brady, Conan ; Cabrera, Jorge ; Cappucciati, Marco ; Castro, Angela Marianne Paredes ; Chen, Wei-Ling ; Cheung, Eric Y. Wo ; Chiesa, Silvia ; Crowe, Marie ; Cuomo, Alessandro ; Dallaspezia, Sara ; Del Zompo, Maria ; Desai, Pratikkumar ; Dodd, Seetal ; Donix, Markus ; Etain, Bruno ; Fagiolini, Andrea ; Fellendorf, Frederike Tabea ; Ferensztajn-Rochowiak, Ewa ; Fiedorowicz, Jess G. ; Fountoulakis, Kostas N. ; Frye, Mark A. ; Geoffroy, Pierre A. ; Gonzalez-Pinto, Ana ; Gottlieb, John F. ; Grof, Paul ; Haarman, Bartholomeus C. M. ; Harima, Hirohiko ; Hasse-Sousa, Mathias ; Henry, Chantal ; Høffding, Lone ; Houenou, Josselin ; Imbesi, Massimiliano ; Isometsä, Erkki T. ; Ivkovic, Maja ; Janno, Sven ; Johnsen, Simon ; Kapczinski, Flávio ; Karakatsoulis, Gregory N. ; Kardell, Mathias ; Kessing, Lars Vedel ; Kim, Seong Jae ; König, Barbara ; Kot, Timur L. ; Koval, Michael ; Kunz, Mauricio ; Lafer, Beny ; Landén, Mikael ; Larsen, Erik R. ; Lenger, Melanie ; Lewitzka, Ute ; Licht, Rasmus W. ; Lopez-Jaramillo, Carlos ; MacKenzie, Alan ; Madsen, Helle Østergaard ; Madsen, Simone Alberte Kongstad A. ; Mahadevan, Jayant ; Mahardika, Agustine ; Manchia, Mirko ; Marsh, Wendy ; Martinez-Cengotitabengoa, Monica ; Martiny, Klaus ; Mashima, Yuki ; McLoughlin, Declan M. ; Meesters, Ybe ; Melle, Ingrid ; Meza-Urzúa, Fátima ; Ming, Mok Yee ; Monteith, Scott ; Moorthy, Muthukumaran ; Morken, Gunnar ; Mosca, Enrica ; Mozzhegorov, Anton A. ; Munoz, Rodrigo ; Mythri, Starlin V. ; Nacef, Fethi ; Nadella, Ravi K. ; Nakanotani, Takako ; Nielsen, René Ernst ; O'Donovan, Claire ; Omrani, Adel ; Osher, Yamima ; Ouali, Uta ; Pantovic-Stefanovic, Maja ; Pariwatcharakul, Pornjira ; Petite, Joanne ; Pfennig, Andrea ; Pica Ruiz, Yolanda ; Pilhatsch, Maximilian ; Pinna, Marco ; Pompili, Maurizio ; Porter, Richard ; Quiroz, Danilo ; Rabelo-da-Ponte, Francisco Diego ; Ramesar, Raj ; Rasgon, Natalie ; Ratta-apha, Woraphat ; Ratzenhofer, Michaela ; Redahan, Maria ; Reddy, M. S. ; Reif, Andreas ; Reininghaus, Eva Z. ; Richards, Jenny Gringer ; Ritter, Philipp ; Rybakowski, Janusz K. ; Sathyaputri, Leela ; Scippa, Ângela M. ; Simhandl, Christian ; Severus, Emanuel ; Smith, Daniel ; Smith, José ; Stackhouse Jr., Paul W. ; Stein, Dan J. ; Stilwell, Kellen ; Strejilevich, Sergio ; Su, Kuan-Pin ; Subramaniam, Mythily ; Sulaiman, Ahmad Hatim ; Suominen, Kirsi ; Tanra, Andi J. ; Tatebayashi, Yoshitaka ; Teh, Wen Lin ; Tondo, Leonardo ; Torrent, Carla ; Tuinstra, Daniel ; Uchida, Takahito ; Vaaler, Arne E. ; Veeh, Julia ; Vieta, Eduard ; Viswanath, Biju ; Yoldi-Negrete, Maria ; Yalcinkaya, Oguz Kaan ; Young, Allan H. ; Zgueb, Yosra ; Whybrow, Peter C.
Background: Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods: Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun’s electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results: This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p < 0.01. Conclusion: A large change in solar insolation, both between winter and summer and between the minimum and maximum monthly values, may increase the risk of suicide attempts in bipolar I disorder. With frequent circadian rhythm dysfunction and suicidal behavior in bipolar disorder, greater understanding of the optimal roles of daylight and electric lighting in circadian entrainment is needed.
Pirkis, Jane ; Gunnell, David ; Shin, Sangsoo ; Del Pozo-Banos, Marcos ; Arya, Vikas ; Analuisa Aguilar, Pablo ; Appleby, Louis ; Yasir Arafat, S. M. ; Arensman, Ella ; Ayuso-Mateos, Jose Luis ; Pal Singh Balhara, Yatan ; Bantjes, Jason ; Baran, Anna ; Behera, Chittaranjan ; Bertolote, Jose ; Borges, Guilherme ; Bray, Michael ; Brečić, Petrana ; Caine, Eric ; Calati, Raffaella ; Carli, Vladimir ; Castelpietra, Giulio ; Fong Chan, Lai ; Chang, Shu-Sen ; Colchester, David ; Coss-Guzmán, Maria ; Crompton, David ; Ćurković, Marko ; Dandona, Rakhi ; De Jaegere, Eva ; De Leo, Diego ; Deisenhammer, Eberhard A. ; Dwyer, Jeremy ; Erlangsen, Annette ; Faust, Jeremy S. ; Fornaro, Michele ; Fortune, Sarah ; Garrett, Andrew ; Gentile, Guendalina ; Gerstner, Rebekka ; Gilissen, Renske ; Gould, Madelyn ; Kumar Gupta, Sudhir ; Hawton, Keith ; Holz, Franziska ; Kamenshchikov, Iurii ; Kapur, Navneet ; Kasal, Alexandr ; Khan, Murad ; Kirtley, Olivia J. ; Knipe, Duleeka ; Kõlves, Kairi ; Kölzer, Sarah C. ; Krivda, Hryhorii ; Leske, Stuart ; Madeddu, Fabio ; Marshall, Andrew ; Memon, Anjum ; Mittendorfer-Rutz, Ellenor ; Nestadt, Paul ; Neznanov, Nikolay ; Niederkrotenthaler, Thomas ; Nielsen, Emma ; Nordentoft, Merete ; Oberlerchner, Herwig ; O’Connor, Rory C. ; Papsdorf, Rainer ; Partonen, Timo ; Phillips, Michael R. ; Platt, Steve ; Portzky, Gwendolyn ; Psota, Georg ; Qin, Ping ; Radeloff, Daniel ; Reif, Andreas ; Reif-Leonhard, Christine ; Rezaeian, Mohsen ; Román-Vázquez, Nayda ; Roskar, Saska ; Rozanov, Vsevolod ; Sara, Grant ; Scavacini, Karen ; Schneider, Barbara ; Semenova, Natalia ; Sinyor, Mark ; Tambuzzi, Stefano ; Townsend, Ellen ; Ueda, Michiko ; Wasserman, Danuta ; Webb, Roger T. ; Winkler, Petr ; Yip, Paul S. F. ; Zalsman, Gil ; Zoja, Riccardo ; John, Ann ; Spittal, Matthew J.
Background: Predicted increases in suicide were not generally observed in the early months of the COVID-19 pandemic. However, the picture may be changing and patterns might vary across demographic groups. We aimed to provide a timely, granular picture of the pandemic's impact on suicides globally.
Methods: We identified suicide data from official public-sector sources for countries/areas-within-countries, searching websites and academic literature and contacting data custodians and authors as necessary. We sent our first data request on 22nd June 2021 and stopped collecting data on 31st October 2021. We used interrupted time series (ITS) analyses to model the association between the pandemic's emergence and total suicides and suicides by sex-, age- and sex-by-age in each country/area-within-country. We compared the observed and expected numbers of suicides in the pandemic's first nine and first 10-15 months and used meta-regression to explore sources of variation.
Findings: We sourced data from 33 countries (24 high-income, six upper-middle-income, three lower-middle-income; 25 with whole-country data, 12 with data for area(s)-within-the-country, four with both). There was no evidence of greater-than-expected numbers of suicides in the majority of countries/areas-within-countries in any analysis; more commonly, there was evidence of lower-than-expected numbers. Certain sex, age and sex-by-age groups stood out as potentially concerning, but these were not consistent across countries/areas-within-countries. In the meta-regression, different patterns were not explained by countries’ COVID-19 mortality rate, stringency of public health response, economic support level, or presence of a national suicide prevention strategy. Nor were they explained by countries’ income level, although the meta-regression only included data from high-income and upper-middle-income countries, and there were suggestions from the ITS analyses that lower-middle-income countries fared less well.
Interpretation: Although there are some countries/areas-within-countries where overall suicide numbers and numbers for certain sex- and age-based groups are greater-than-expected, these countries/areas-within-countries are in the minority. Any upward movement in suicide numbers in any place or group is concerning, and we need to remain alert to and respond to changes as the pandemic and its mental health and economic consequences continue.
Zink, Joana Miriam ; Frye, Maike ; Frömel, Timo ; Carlantoni, Claudia ; John, David ; Schreier, Danny ; Weigert, Andreas ; Laban, Hebatullah ; Salinas, Gabriela ; Stingl, Heike ; Günther, Lea ; Popp, Rüdiger ; Hu, Jiong ; Vanhollebeke, Benoit ; Schmidt, Hannes ; Acker-Palmer, Amparo ; Renné, Thomas ; Fleming, Ingrid ; Benz, Peter M.
Endothelial tip cells are essential for VEGF-induced angiogenesis, but underlying mechanisms are elusive. The Ena/VASP protein family, consisting of EVL, VASP, and Mena, plays a pivotal role in axon guidance. Given that axonal growth cones and endothelial tip cells share many common features, from the morphological to the molecular level, we investigated the role of Ena/VASP proteins in angiogenesis. EVL and VASP, but not Mena, are expressed in endothelial cells of the postnatal mouse retina. Global deletion of EVL (but not VASP) compromises the radial sprouting of the vascular plexus in mice. Similarly, endothelial-specific EVL deletion compromises the radial sprouting of the vascular plexus and reduces the endothelial tip cell density and filopodia formation. Gene sets involved in blood vessel development and angiogenesis are down-regulated in EVL-deficient P5-retinal endothelial cells. Consistently, EVL deletion impairs VEGF-induced endothelial cell proliferation and sprouting, and reduces the internalization and phosphorylation of VEGF receptor 2 and its downstream signaling via the MAPK/ERK pathway. Together, we show that endothelial EVL regulates sprouting angiogenesis via VEGF receptor-2 internalization and signaling.
Buchmann, Giulia Karolin ; Schürmann, Christoph ; Spaeth, Manuela ; Abplanalp, Wesley ; Tombor, Lukas ; John, David ; Warwick, Timothy ; Rezende Felipe, Flávia Figueiredo de ; Weigert, Andreas ; Shah, Ajay M. ; Hansmann, Martin-Leo ; Weißmann, Norbert ; Dimmeler, Stefanie ; Schröder, Katrin ; Brandes, Ralf
Objective: The NADPH oxidase Nox4 is an important source of H2O2. Nox4-derived H2O2 limits vascular inflammation and promotes smooth muscle differentiation. On this basis, the role of Nox4 for restenosis development was determined in the mouse carotid artery injury model. Methods and results: Genetic deletion of Nox4 by a tamoxifen-activated Cre-Lox-system did not impact on neointima formation in the carotid artery wire injury model. To understand this unexpected finding, time-resolved single-cell RNA-sequencing (scRNAseq) from injured carotid arteries of control mice and massive-analysis-of-cDNA-ends (MACE)-RNAseq from the neointima harvested by laser capture microdissection of control and Nox4 knockout mice was performed. This revealed that resting smooth muscle cells (SMCs) and fibroblasts exhibit high Nox4 expression, but that the proliferating de-differentiated SMCs, which give rise to the neointima, have low Nox4 expression. In line with this, the first weeks after injury, gene expression was unchanged between the carotid artery neointimas of control and Nox4 knockout mice. Conclusion: Upon vascular injury, Nox4 expression is transiently lost in the cells which comprise the neointima. NADPH oxidase 4 therefore does not interfere with restenosis development after wire-induced vascular injury.
Hoffmann, Jedrzej ; Luxán, Guillermo ; Abplanalp, Wesley Tyler ; Glaser, Simone F. ; Rasper, Tina ; Fischer, Ariane ; Muhly-Reinholz, Marion ; Potente, Michael ; Aßmus, Birgit ; John, David ; Zeiher, Andreas M. ; Dimmeler, Stefanie
The regulation of bone vasculature by chronic diseases, such as heart failure is unknown. Here, we describe the effects of myocardial infarction and post-infarction heart failure on the bone vascular cell composition. We demonstrate an age-independent loss of type H endothelium in heart failure after myocardial infarction in both mice and humans. Using single-cell RNA sequencing, we delineate the transcriptional heterogeneity of human bone marrow endothelium, showing increased expression of inflammatory genes, including IL1B and MYC, in ischemic heart failure. Endothelial-specific overexpression of MYC was sufficient to induce type H bone endothelial cells, whereas inhibition of NLRP3-dependent IL-1β production partially prevented the post-myocardial infarction loss of type H vasculature in mice. These results provide a rationale for using anti-inflammatory therapies to prevent or reverse the deterioration of bone vascular function in ischemic heart disease.
Robinson, Alan D. ; Millard, Genevieve A. ; Danis, François ; Guirlet, Marielle ; Harris, Neil R. P. ; Lee, Adrian M. ; McIntyre, J. D. ; Pyle, John A. ; Arvelius, Johan ; Dagnesjo, Saga ; Kirkwood, Sheila ; Nilsson, Hampus ; Toohey, Darin W. ; Deshler, Terry ; Goutail, Florence ; Pommereau, Jean-Pierre ; Elkins, James William ; Moore, Fred L. ; Ray, Eric ; Schmidt, Ulrich ; Engel, Andreas ; Müller, Melanie
Balloon-borne measurements of CFC11 (from the DIRAC in situ gas chromatograph and the DESCARTES grab sampler), ClO and O3 were made during the 1999/2000 Arctic winter as part of the SOLVE-THESEO 2000 campaign, based in Kiruna (Sweden). Here we present the CFC11 data from nine flights and compare them first with data from other instruments which flew during the campaign and then with the vertical distributions calculated by the SLIMCAT 3D CTM. We calculate ozone loss inside the Arctic vortex between late January and early March using the relation between CFC11 and O3 measured on the flights. The peak ozone loss (~1200ppbv) occurs in the 440-470K region in early March in reasonable agreement with other published empirical estimates. There is also a good agreement between ozone losses derived from three balloon tracer data sets used here. The magnitude and vertical distribution of the loss derived from the measurements is in good agreement with the loss calculated from SLIMCAT over Kiruna for the same days.
Chemotherapy and diffuse low-grade gliomas : a survey within the European Low-Grade Glioma Network
(2018)
Darlix, Amélie ; Mandonnet, Emmanuel ; Freyschlag, Christian Franz ; Pinggera, Daniel ; Forster, Marie-Thérèse ; Voß, Martin ; Steinbach, Joachim Peter ; Loughrey, Carmel ; Goodden, John ; Banna, Giuseppe ; Di Blasi, Concetta ; Foroglou, Nicolas ; Hottinger, Andreas F. ; Baron, Marie-Hélène ; Pallud, Johan ; Duffau, Hugues ; Rutten, Geert-Jan ; Almairac, Fabien ; Fontaine, Denys ; Taillandier, Luc ; Viegas, Catarina ; Albuquerque, Luisa ; Campe, Gord von ; Urbanic Purkart, Tadeja ; Blonski, Marie
Background: Diffuse low-grade gliomas (DLGGs) are rare and incurable tumors. Whereas maximal safe, functional-based surgical resection is the first-line treatment, the timing and choice of further treatments (chemotherapy, radiation therapy, or combined treatments) remain controversial.
Methods: An online survey on the management of DLGG patients was sent to 28 expert centers from the European Low-Grade Glioma Network (ELGGN) in May 2015. It contained 40 specific questions addressing the modalities of use of chemotherapy in these patients.
Results: The survey demonstrated a significant heterogeneity in practice regarding the initial management of DLGG patients and the use of chemotherapy. Interestingly, radiation therapy combined with the procarbazine, CCNU (lomustine), and vincristine regimen has not imposed itself as the gold-standard treatment after surgery, despite the results of the Radiation Therapy Oncology Group 9802 study. Temozolomide is largely used as first-line treatment after surgical resection for high-risk DLGG patients, or at progression.
Conclusions: The heterogeneity in the management of patients with DLGG demonstrates that many questions regarding the postoperative strategy and the use of chemotherapy remain unanswered. Our survey reveals a high recruitment potential within the ELGGN for retrospective or prospective studies to generate new data regarding these issues.
Théry, Clotilde ; Witwer, Kenneth W. ; Aikawa, Elena ; Alcaraz, Maria Jose ; Anderson, Johnathon D. ; Andriantsitohaina, Ramaroson ; Antoniou, Anna ; Arab, Tanina ; Archer, Fabienne ; Atkin-Smith, Georgia K. ; Ayre, D. Craig ; Bach, Jean-Marie ; Bachurski, Daniel ; Baharvand, Hossein ; Balaj, Leonora ; Baldacchino, Shawn ; Bauer, Natalie N. ; Baxter, Amy A. ; Bebawy, Mary ; Beckham, Carla ; Zavec, Apolonija Bedina ; Benmoussa, Abderrahim ; Berardi, Anna C. ; Bergese, Paolo ; Bielska, Ewa ; Blenkiron, Cherie ; Bobis-Wozowicz, Sylwia ; Boilard, Eric ; Boireau, Wilfrid ; Bongiovanni, Antonella ; Borràs, Francesc E. ; Bosch, Steffi ; Boulanger, Chantal M. ; Breakefield, Xandra ; Breglio, Andrew M. ; Brennan, Meadhbh Aín ; Brigstock, David R. ; Brisson, Alain ; Broekman, Marike L. D. ; Bromberg, Jacqueline F. ; Bryl-Gorecka, Paulina ; Buch, Shilpa ; Buck, Amy H. ; Burger, Dylan ; Busatto, Sara ; Buschmann, Dominik ; Bussolati, Benedetta ; Buzás, Edit I. ; Byrd, James Bryan ; Camussi, Giovanni ; Carter, David R. F. ; Caruso, Sarah ; Chamley, Lawrence W. ; Chang, Yu-Ting ; Chen, Chihchen ; Chen, Shuai ; Cheng, Lesley ; Chin, Andrew R. ; Clayton, Aled ; Clerici, Stefano P. ; Cocks, Alex ; Cocucci, Emanuele ; Coffey, Robert J. ; Cordeiro-da-Silva, Anabela ; Couch, Yvonne ; Coumans, Frank A. W. ; Coyle, Beth ; Crescitelli, Rossella ; Criado, Miria Ferreira ; D’Souza-Schorey, Crislyn ; Das, Saumya ; Chaudhuri, Amrita Datta ; de-Candia, Paola ; De Santana, Eliezer F. ; De Wever, Olivier ; del Portillo, Hernando A. ; Demaret, Tanguy ; Deville, Sarah ; Devitt, Andrew ; Dhondt, Bert ; Di Vizio, Dolores ; Dieterich, Lothar C. ; Dolo, Vincenza ; Dominguez Rubio, Ana Paula ; Dominici, Massimo ; Dourado, Mauricio R. ; Driedonks, Tom A. P. ; Duarte, Filipe V. ; Duncan, Heather M. ; Eichenberger, Ramon Marc ; Ekström, Karin ; El Andaloussi, Samir ; Elie-Caille, Celine ; Erdbrügger, Uta ; Falcón-Pérez, Juan M. ; Fatima, Farah ; Fish, Jason E. ; Flores-Bellver, Miguel ; Försönits, András ; Frelet-Barrand, Annie ; Fricke, Fabia ; Fuhrmann, Gregor ; Gabrielsson, Susanne ; Gámez-Valero, Ana ; Gardiner, Chris ; Gärtner, Kathrin ; Gaudin, Raphael ; Gho, Yong Song ; Giebel, Bernd ; Gilbert, Caroline ; Gimona, Mario ; Giusti, Ilaria ; Goberdhan, Deborah C. I. ; Görgens, André ; Gorski, Sharon M. ; Greening, David W. ; Groß, Julia Christina ; Gualerzi, Alice ; Gupta, Gopal N. ; Gustafson, Dakota ; Handberg, Aase ; Haraszti, Réka Ágnes ; Harrison, Paul ; Hegyesi, Hargita ; Hendrix, An ; Hill, Andrew F. ; Hochberg, Fred H. ; Hoffmann, Karl F. ; Holder, Beth ; Holthofer, Harry ; Hosseinkhani, Baharak ; Hu, Guoku ; Huang, Yiyao ; Huber, Veronica ; Hunt, Stuart ; Ibrahim, Ahmed Gamal-Eldin ; Ikezu, Tsuneya ; Inal, Jameel M. ; Isin, Mustafa ; Ivanova, Alena ; Jackson, Hannah K. ; Jacobsen, Soren ; Jay, Steven M. ; Jayachandran, Muthuvel ; Jenster, Guido ; Jiang, Lanzhou ; Johnson, Suzanne M. ; Jones, Jennifer C. ; Jong, Ambrose ; Jovanovic-Talisman, Tijana ; Jung, Stephanie ; Kalluri, Raghu ; Kano, Shin-ichi ; Kaur, Sukhbir ; Kawamura, Yumi ; Keller, Evan T. ; Khamari, Delaram ; Khomyakova, Elena ; Khvorova, Anastasia ; Kierulf, Peter ; Kim, Kwang Pyo ; Kislinger, Thomas ; Klingeborn, Mikael ; Klinke, David J. ; Kornek, Miroslaw ; Kosanović, Maja M. ; Kovács, Árpád Ferenc ; Krämer-Albers, Eva-Maria ; Krasemann, Susanne ; Krause, Mirja ; Kurochkin, Igor V. ; Kusuma, Gina D. ; Kuypers, Sören ; Laitinen, Saara ; Langevin, Scott M. ; Languino, Lucia R. ; Lannigan, Joanne ; Lässer, Cecilia ; Laurent, Louise C. ; Lavieu, Gregory ; Lázaro-Ibáñez, Elisa ; Le Lay, Soazig ; Lee, Myung-Shin ; Lee, Yi Xin Fiona ; Lemos, Debora S. ; Lenassi, Metka ; Leszczynska, Aleksandra ; Li, Isaac T. S. ; Liao, Ke ; Libregts, Sten F. ; Ligeti, Erzsebet ; Lim, Rebecca ; Lim, Sai Kiang ; Linē, Aija ; Linnemannstöns, Karen ; Llorente, Alicia ; Lombard, Catherine Ann ; Lorenowicz, Magdalena J. ; Lörincz, Ákos M. ; Lötvall, Jan ; Lovett, Jason ; Lowry, Michelle C. ; Loyer, Xavier ; Lu, Quan ; Lukomska, Barbara ; Lunavat, Taral Rameshchand ; Maas, Sybren L. N. ; Malhi, Harmeet ; Marcilla, Antonio ; Mariani, Jacopo ; Mariscal, Javier ; Martens-Uzunova, Elena S. ; Martin-Jaular, Lorena ; Martinez, M. Carmen ; Martins, Vilma Regina ; Mathieu, Mathilde ; Mathivanan, Suresh ; Maugeri, Marco ; McGinnis, Lynda K. ; McVey, Mark J. ; Meckes, David G. ; Meehan, Katie ; Mertens, Inge ; Minciacchi, Valentina R. ; Möller, Andreas ; Møller Jørgensen, Malene ; Morales-Kastresana, Aizea ; Morhayim, Jess ; Mullier, François ; Muraca, Maurizio ; Musante, Luca ; Mussack, Veronika ; Muth, Dillon C. ; Myburgh, Kathryn H. ; Najrana, Tanbir ; Nawaz, Muhammad ; Nazarenko, Irina ; Nejsum, Peter ; Neri, Christian ; Neri, Tommaso ; Nieuwland, Rienk ; Nimrichter, Leonardo ; Nolan, John P. ; Nolte-’t Hoen, Esther N. M. ; Hooten, Nicole Noren ; O’Driscoll, Lorraine ; O’Grady, Tina ; O’Loghlen, Ana ; Ochiya, Takahiro ; Olivier, Martin ; Ortiz, Alberto ; Ortiz, Luis A. ; Osteikoetxea, Xabier ; Østergaard, Ole ; Ostrowski, Matias ; Park, Jaesung ; Pegtel, Dirk Michiel ; Peinado, Hector ; Perut, Francesca ; Pfaffl, Michael ; Phinney, Donald G. ; Pieters, Bartijn C. H. ; Pink, Ryan Charles ; Pisetsky, David S. ; Pogge von Strandmann, Elke ; Polakovicova, Iva ; Poon, Ivan K. H. ; Powell, Bonita H. ; Prada, Ilaria ; Pulliam, Lynn ; Quesenberry, Peter ; Radeghieri, Annalisa ; Raffai, Robert L. ; Raimondo, Stefania ; Rak, Janusz ; Ramirez, Marcel I. ; Raposo, Graça ; Rayyan, Morsi S. ; Regev-Rudzki, Neta ; Ricklefs, Franz Lennard ; Robbins, Paul D. ; Roberts, David D. ; Rodrigues, Silvia C. ; Rohde, Eva ; Rome, Sophie ; Rouschop, Kasper M. ; Rughetti, Aurelia ; Russell, Ashley E. ; Saá, Paula ; Sahoo, Susmita ; Salas-Huenuleo, Edison ; Sánchez, Catherine ; Saugstad, Julie A. ; Saul, Meike J. ; Schiffelers, Raymond M. ; Schneider, Raphael ; Schøyen, Tine Hiorth ; Scott, Aaron ; Shahaj, Eriomina ; Sharma, Shivani ; Shatnyeva, Olga ; Shekari, Faezeh ; Shelke, Ganesh Vilas ; Shetty, Ashok K. ; Shiba, Kiyotaka ; Siljander, Pia R.-M. ; Silva, Andreia M. ; Skowronek, Agata ; Snyder, Orman L. ; Soares, Rodrigo Pedro ; Sódar, Barbara W. ; Soekmadji, Carolina ; Sotillo, Javier ; Stahl, Philip D. ; Stoorvogel, Willem ; Stott, Shannon L. ; Strasser, Erwin F. ; Swift, Simon ; Tahara, Hidetoshi ; Tewari, Muneesh ; Timms, Kate ; Tiwari, Swasti ; Tixeira, Rochelle ; Tkach, Mercedes ; Toh, Wei Seong ; Tomasini, Richard ; Torrecilhas, Ana Claudia ; Tosar, Juan Pablo ; Toxavidis, Vasilis ; Urbanelli, Lorena ; Vader, Pieter ; Balkom, Bastiaan Wilhelmus Maria van ; Grein, Susanne G. van der ; Van Deun, Jan ; Herwijnen, Martijn J. C. van ; Van Keuren-Jensen, Kendall R. ; Niel, Guillaume van ; Royen, Martin E. van ; Wijnen, Andre J. van ; Vasconcelos, M. Helena ; Vechetti, Ivan J. ; Veit, Tiago D. ; Vella, Laura J. ; Velot, Émilie ; Verweij, Frederik ; Vestad, Beate ; Viñas, Jose Luis ; Visnovitz, Tamás ; Vukman, Krisztina V. ; Wahlgren, Jessica ; Watson, Dionysios C. ; Wauben, Marca H. M. ; Weaver, Alissa ; Webber, Jason P. ; Weber, Viktoria ; Wehman, Ann M. ; Weiss, Daniel J. ; Welsh, Joshua A. ; Wendt, Sebastian ; Wheelock, Åsa M. ; Wiener, Zoltán ; Witte, Leonie ; Wolfram, Joy ; Xagorari, Angeliki ; Xander, Patricia ; Xu, Jing ; Yan, Xiaomei ; Yáñez-Mó, María ; Yin, Hang ; Yuana, Yuana ; Zappulli, Valentina ; Zarubova, Jana ; Žėkas, Vytautas ; Zhang, Jian-ye ; Zhao, Zezhou ; Zheng, Lei ; Zheutlin, Alexander R. ; Zickler, Antje Maria ; Zimmermann, Pascale ; Zivkovic, Angela M. ; Zocco, Davide ; Zuba-Surma, Ewa K.
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
Dropmann, Anne ; Dooley, Steven ; Dewidar, Bedair ; Hammad, Seddik ; Dediulia, Tatjana ; Werle, Julia ; Hartwig, Vanessa ; Ghafoory, Shahrouz ; Wölfl, Stefan ; Korhonen, Hanna ; Janicot, Michel ; Wosikowski, Katja ; Itzel, Timo ; Teufel, Andreas ; Schuppan, Detlef ; Stojanovic, Ana ; Cerwenka, Adelheid ; Nittka, Stefanie ; Piiper, Albrecht ; Gaiser, Timo ; Beraza, Naiara ; Milkiewicz, Malgorzata ; Milkiewicz, Piotr ; Brain, John G. ; Jones, David E. J. ; Weiß, Thomas S. ; Zanger, Ulrich M. ; Ebert, Matthias ; Meindl-Beinker, Nadja M.
Objective: TGF-β2 (TGF-β, transforming growth factor beta), the less-investigated sibling of TGF-β1, is deregulated in rodent and human liver diseases. Former data from bile duct ligated and MDR2 knockout (KO) mouse models for human cholestatic liver disease suggested an involvement of TGF-β2 in biliary-derived liver diseases.
Design: As we also found upregulated TGFB2 in liver tissue of patients with primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), we now fathomed the positive prospects of targeting TGF-β2 in early stage biliary liver disease using the MDR2-KO mice. Specifically, the influence of TgfB2 silencing on the fibrotic and inflammatory niche was analysed on molecular, cellular and tissue levels.
Results: TgfB2-induced expression of fibrotic genes in cholangiocytes and hepatic stellate cellswas detected. TgfB2 expression in MDR2-KO mice was blunted using TgfB2-directed antisense oligonucleotides (AON). Upon AON treatment, reduced collagen deposition, hydroxyproline content and αSMA expression as well as induced PparG expression reflected a significant reduction of fibrogenesis without adverse effects on healthy livers. Expression analyses of fibrotic and inflammatory genes revealed AON-specific regulatory effects on Ccl3, Ccl4, Ccl5, Mki67 and Notch3 expression. Further, AON treatment of MDR2-KO mice increased tissue infiltration by F4/80-positive cells including eosinophils, whereas the number of CD45-positive inflammatory cells decreased. In line, TGFB2 and CD45 expression correlated positively in PSC/PBC patients and localised in similar areas of the diseased liver tissue.
Conclusions: Taken together, our data suggest a new mechanistic explanation for amelioration of fibrogenesis by TGF-β2 silencing and provide a direct rationale for TGF-β2-directed drug development.
The two-electron reduction of tetraphenyl-p-quinodimethane M via its radical anion M⊖ to its dianion M⊖⊖ is explored both by cyclovoltammetry and ESR/ENDOR spectroscopy. Contact of the diglyme solution with added 15-crown-5 under aprotic conditions with a sodium metal mirror yields black crystals of a solvent-separated contact ion triple [M⊖⊖][Na⊕(OCH2CH2)5(H3CO(CH2CH2O)2CH3)]2. The two-electron-insertion into the pquinodimethane derivative R2C⊖=C(HC=CH)2C=CR2 changes its structure drastically to that of a twofold carbanion substituted benzene, R2C⊖ -(C6H4)- ⊖CR2. MNDO calculations provide a rationale for both the tremendous solvation of a Na⊕ center coordinated to seven oxygen centers of 15-crown-5 and of one diglyme molecule and the structural changes as well as the charge distribution in the unique Tetraphenyl-p-quinodimethane dianion (H5C6)2C⊖-(C6H4)- ⊖C(C6H5)2, in which the two negative charges are largely localized at the carbanion center of the benzene -substituents.
Kirkby, Jasper ; Duplissy, Jonathan ; Sengupta, Kamalika ; Frege, Carla ; Gordon, Hamish ; Williamson, Christina ; Heinritzi, Martin ; Simon, Mario ; Yan, Chao ; Almeida, Joao ; Tröstl, Jasmin ; Nieminen, Tuomo ; Ortega, Ismael K. ; Wagner, Robert ; Adamov, Alexey ; Amorim, Antonio ; Bernhammer, Anne-Kathrin ; Bianchi, Federico ; Breitenlechner, Martin ; Brilke, Sophia ; Chen, Xuemeng ; Craven, Jill ; Dias, Antonio ; Ehrhart, Sebastian ; Flagan, Richard C. ; Franchin, Alessandro ; Fuchs, Claudia ; Guida, Roberto ; Hakala, Jani ; Hoyle, Christopher Robert ; Jokinen, Tuija ; Junninen, Heikki ; Kangasluoma, Juha ; Kim, Jaeseok ; Krapf, Manuel ; Kürten, Christoph Andreas ; Laaksonen, Ari ; Lehtipalo, Katrianne ; Makhmutov, Vladimir ; Mathot, Serge ; Molteni, Ugo ; Onnela, Antti ; Peräkylä, Otso ; Piel, Felix ; Petäjä, Tuukka ; Praplan, Arnaud Patrick ; Pringle, Kirsty ; Rap, Alexandru ; Richards, Nigel A. D. ; Riipinen, Ilona ; Rissanen, Matti P. ; Rondo, Linda ; Sarnela, Nina ; Schobesberger, Siegfried ; Scott, Catherine E. ; Seinfeld, John H. ; Sipilä, Mikko ; Steiner, Gerhard ; Stozhkov, Yuri ; Stratmann, Frank ; Tomé, Antonio ; Virtanen, Annele ; Vogel, Alexander L. ; Wagner, Andrea Christine ; Wagner, Paul E. ; Weingartner, Ernest ; Wimmer, Daniela ; Winkler, Paul M. ; Ye, Penglin ; Zhang, Xuan ; Hansel, Armin ; Dommen, Josef ; Donahue, Neil McPherson ; Worsnop, Douglas R. ; Baltensperger, Urs ; Kulmala, Markku ; Carslaw, Kenneth S. ; Curtius, Joachim
Atmospheric aerosols and their effect on clouds are thought to be important for anthropogenic radiative forcing of the climate, yet remain poorly understood1. Globally, around half of cloud condensation nuclei originate from nucleation of atmospheric vapours2. It is thought that sulfuric acid is essential to initiate most particle formation in the atmosphere3,4, and that ions have a relatively minor role5. Some laboratory studies, however, have reported organic particle formation without the intentional addition of sulfuric acid, although contamination could not be excluded6,7. Here we present evidence for the formation of aerosol particles from highly oxidized biogenic vapours in the absence of sulfuric acid in a large chamber under atmospheric conditions. The highly oxygenated molecules (HOMs) are produced by ozonolysis of α-pinene. We find that ions from Galactic cosmic rays increase the nucleation rate by one to two orders of magnitude compared with neutral nucleation. Our experimental findings are supported by quantum chemical calculations of the cluster binding energies of representative HOMs. Ion-induced nucleation of pure organic particles constitutes a potentially widespread source of aerosol particles in terrestrial environments with low sulfuric acid pollution.
Almeida, Joao ; Schobesberger, Siegfried ; Kürten, Christoph Andreas ; Ortega, Ismael K. ; Kupiainen-Määttä, Oona ; Praplan, Arnaud Patrick ; Adamov, Alexey ; Amorim, Antonio ; Bianchi, Federico ; Breitenlechner, Martin ; David, André ; Dommen, Josef ; Donahue, Neil McPherson ; Downard, Andrew ; Dunne, Eimear M. ; Duplissy, Jonathan ; Ehrhart, Sebastian ; Flagan, Richard C. ; Franchin, Alessandro ; Guida, Roberto ; Hakala, Jani ; Hansel, Armin ; Heinritzi, Martin ; Henschel, Henning ; Jokinen, Tuija ; Junninen, Heikki ; Kajos, Maija ; Kangasluoma, Juha ; Keskinen, Helmi ; Kupc, Agnieszka ; Kurtén, Theo ; Kvashin, Alexander N. ; Laaksonen, Ari ; Lehtipalo, Katrianne ; Leiminger, Markus ; Leppä, Johannes ; Loukonen, Ville ; Makhmutov, Vladimir ; Mathot, Serge ; McGrath, Matthew J. ; Nieminen, Tuomo ; Olenius, Tinja ; Onnela, Antti ; Petäjä, Tuukka ; Riccobono, Francesco ; Riipinen, Ilona ; Rissanen, Matti P. ; Rondo, Linda ; Ruuskanen, Taina ; Santos, Filipe Duarte ; Sarnela, Nina ; Schallhart, Simon ; Schnitzhofer, Ralf ; Seinfeld, John H. ; Simon, Mario ; Sipilä, Mikko ; Stozhkov, Yuri ; Stratmann, Frank ; Tomé, Antonio ; Tröstl, Jasmin ; Tsagkogeorgas, Georgios ; Vaattovaara, Petri ; Viisanen, Yrjo ; Virtanen, Annele ; Vrtala, Aron ; Wagner, Paul E. ; Weingartner, Ernest ; Wex, Heike ; Williamson, Christina ; Wimmer, Daniela ; Ye, Penglin ; Yli-Juuti, Taina ; Carslaw, Kenneth S. ; Kulmala, Markku ; Curtius, Joachim ; Baltensperger, Urs ; Worsnop, Douglas R. ; Vehkamäki, Hanna ; Kirkby, Jasper
Nucleation of aerosol particles from trace atmospheric vapours is thought to provide up to half of global cloud condensation nuclei. Aerosols can cause a net cooling of climate by scattering sunlight and by leading to smaller but more numerous cloud droplets, which makes clouds brighter and extends their lifetimes. Atmospheric aerosols derived from human activities are thought to have compensated for a large fraction of the warming caused by greenhouse gases. However, despite its importance for climate, atmospheric nucleation is poorly understood. Recently, it has been shown that sulphuric acid and ammonia cannot explain particle formation rates observed in the lower atmosphere. It is thought that amines may enhance nucleation, but until now there has been no direct evidence for amine ternary nucleation under atmospheric conditions. Here we use the CLOUD (Cosmics Leaving Outdoor Droplets) chamber at CERN and find that dimethylamine above three parts per trillion by volume can enhance particle formation rates more than 1,000-fold compared with ammonia, sufficient to account for the particle formation rates observed in the atmosphere. Molecular analysis of the clusters reveals that the faster nucleation is explained by a base-stabilization mechanism involving acid–amine pairs, which strongly decrease evaporation. The ion-induced contribution is generally small, reflecting the high stability of sulphuric acid–dimethylamine clusters and indicating that galactic cosmic rays exert only a small influence on their formation, except at low overall formation rates. Our experimental measurements are well reproduced by a dynamical model based on quantum chemical calculations of binding energies of molecular clusters, without any fitted parameters. These results show that, in regions of the atmosphere near amine sources, both amines and sulphur dioxide should be considered when assessing the impact of anthropogenic activities on particle formation.
Accurate measurement of the standard 235U(n,f) cross section from thermal to 170 keV neutron energy
(2020)
Amaducci, Simone ; Aberle, Oliver ; Andrzejewski, Józef ; Audouin, Laurent ; Bacak, Michael ; Balibrea Correa, Javier ; Barbagallo, Massimo ; Bečvář, František ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brown, Adam ; Caamaño, Manuel ; Calviño Tavares, Francisco ; Calviani, Marco ; Cano-Ott, Daniel ; Cardella, Roberto ; Casanovas Hoste, Adrià ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Colonna, Nicola ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Cosentino, Luigi ; Damone, Lucia Anna ; Diakaki, Maria ; Domingo-Pardo, César ; Dressler, Rugard ; Dupont, Emmeric ; Durán, Ignacio ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Ferreira, Pedro G. ; Finocchiaro, Paolo ; Furman, Valter ; Göbel, Kathrin ; García Ríos, Aczel Regino ; Gawlik, Aleksandra ; Gilardoni, Simone ; Glodariu, Tudor ; Gonçalves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Griesmayer, Erich ; Guerrero Sánchez, Carlos ; Gunsing, Frank ; Harada, Hideo ; Heinitz, Stephan ; Heyse, Jan ; Jenkins, David ; Jericha, Erwin ; Käppeler, Franz ; Kadi, Yacine ; Kalamara, Antigoni ; Kavrigin, Pavel ; Kimura, Atsushi ; Kivel, Nikolay ; Knapová, Ingrid ; Kokkoris, Michael ; Krtička, Milan ; Kurtulgil, Cem Deniz ; Leal Cidoncha, Esther ; Lederer, Claudia ; Leeb, Helmut ; Lerendegui-Marco, Jorge ; Lo Meo, Sergio ; Lonsdale, Sarah Jane ; Macina, Daniela ; Manna, Alice ; Marganiec, Justyna ; Martı́nez, Trinitario ; Masi, Alessandro ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Maugeri, Emilio Andrea ; Mazzone, Annamaria ; Mendoza Cembranos, Emilio ; Mengoni, Alberto ; Milazzo, Paolo Maria ; Mingrone, Federica ; Musumarra, Agatino ; Negret, Alexandru ; Nolte, Ralf ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Porras Sánchez, José Ignacio ; Praena, Javier ; Quesada Molina, José Manuel ; Radeck, Désirée ; Rauscher, Thomas ; Reifarth, René ; Rubbia, Carlo ; Ryan, James A. ; Sabaté-Gilarte, Marta ; Saxena, Alok ; Schillebeeckx, Peter ; Schumann, Dorothea ; Sedyshev, Pavel V. ; Smith, Alastair Gavin ; Sosnin, Nikolay V. ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Tarifeño-Saldivia, Ariel ; Tassan-Got, Laurent ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vlachoudis, Vasilis ; Vlastou, Rosa ; Wallner, Anton ; Warren, Stephen J. ; Weiß, Christina ; Woods, Philip John ; Wright, Tobias ; Žugec, Petar
An accurate measurement of the 235U(n,f) cross section from thermal to 170 keV of neutron energy has recently been performed at n_TOF facility at CERN using 6Li(n,t)4He and 10B(n,α)7Li as references. This measurement has been carried out in order to investigate a possible overestimation of the 235U fission cross section evaluation provided by most recent libraries between 10 and 30 keV. A custom experimental apparatus based on in-beam silicon detectors has been used, and a Monte Carlo simulation in GEANT4 has been employed to characterize the setup and calculate detectors efficiency. The results evidenced the presence of an overestimation in the interval between 9 and 18 keV and the new data may be used to decrease the uncertainty of 235U(n,f) cross section in the keV region.
Alcayne, Victor ; Mendoza Cembranos, Emilio ; Cano-Ott, Daniel ; Kimura, Atsushi ; Aberle, Oliver ; Amaducci, Simone ; Andrzejewski, Józef ; Audouin, Laurent ; Babiano Suarez, Victor ; Bacak, Michael ; Barbagallo, Massimo ; Bécares, Vicente ; Bečvář, František ; Bellia, Giorgio ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brown, Adam S. ; Busso, Maurizio ; Caamaño, Manuel ; Caballero Ontanaya, Luis ; Calviani, Marco ; Calviño Tavares, Francisco ; Casanovas Hoste, Adrià ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Colonna, Nicola ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Cosentino, Luigi ; Cristallo, Sergio ; Damone, Lucia Anna ; Diakaki, Maria ; Dietz, Mirco ; Domingo-Pardo, César ; Dressler, Rugard ; Dupont, Emmeric ; Durán, Ignacio ; Eleme, Zinovia ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Gonçalves, Isabel Maria Ferro ; Finocchiaro, Paolo ; Furman, Valter ; Garg, Ruchi ; Gawlik, Aleksandra ; Gilardoni, Simone ; Glodariu, Tudor ; Göbel, Kathrin ; González Romero, Enrique Miguel ; Guerrero Sánchez, Carlos ; Gunsing, Frank ; Heinitz, Stephan ; Heyse, Jan ; Jenkins, David ; Jericha, Erwin ; Kadi, Yacine ; Käppeler, Franz ; Kivel, Nikolay ; Kokkoris, Michael ; Kopatch, Yuri N. ; Krtička, Milan ; Kurtulgil, Cem Deniz ; Ladarescu, Ion ; Lederer-Woods, Claudia ; Lerendegui-Marco, Jorge ; Lo Meo, Sergio ; Lonsdale, Sarah-Jane ; Macina, Daniela ; Manna, Alice ; Martı́nez, Trinitario ; Masi, Alessandro ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Matteucci, Francesca ; Maugeri, Emilio Andrea ; Mazzone, Annamaria ; Mengoni, Alberto ; Michalopoulou, Veatriki ; Milazzo, Paolo Maria ; Mingrone, Federica ; Musumarra, Agatino ; Negret, Alexandru ; Nolte, Ralf ; Ogállar Ruiz, Francisco ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Piersanti, Luciano ; Porras Sánchez, José Ignacio ; Praena, Javier ; Quesada Molina, José Manuel ; Radeck, Désirée ; Ramos Doval, Diego ; Reifarth, René ; Rochman, Dimitri ; Rubbia, Carlo ; Sabaté-Gilarte, Marta ; Saxena, Alok ; Schillebeeckx, Peter ; Schumann, Dorothea ; Smith, Alastair Gavin ; Sosnin, Nikolay V. ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Talip, Zeynep ; Tarifeño-Saldivia, Ariel ; Tassan-Got, Laurent ; Torres-Sánchez, Pablo ; Tsinganis, Andrea ; Ulrich, Jiri ; Urlaß, Sebastian ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vlachoudis, Vasilis ; Vlastou, Rosa ; Wallner, Anton ; Woods, Philip John ; Wright, Tobias J. ; Žugec, Petar
Accurate neutron capture cross section data for minor actinides (MAs) are required to estimate the production and transmutation rates of MAs in light water reactors with a high burnup, critical fast reactors like Gen-IV systems and other innovative reactor systems such as accelerator driven systems (ADS). Capture reactions of 244Cm open the path for the formation of heavier Cm isotopes and of heavier elements such as Bk and Cf. In addition, 244Cm shares nearly 50% of the total actinide decay heat in irradiated reactor fuels with a high burnup, even after three years of cooling.
Experimental data for this isotope are very scarce due to the difficulties of providing isotopically enriched samples and because the high intrinsic activity of the samples requires the use of neutron facilities with high instantaneous flux. The only two previous experimental data sets for this neutron capture cross section have been obtained in 1969 using a nuclear explosion and, more recently, at J-PARC in 2010. The neutron capture cross sections have been measured at n_TOF with the same samples that the previous experiments in J-PARC. The samples were measured at n_TOF Experimental Area 2 (EAR-2) with three C6D6 detectors and also in Experimental Area 1 (EAR-1) with the Total Absorption Calorimeter (TAC). Preliminary results assessing the quality and limitations of these new experimental datasets are presented for the experiments in both areas. Preliminary yields of both measurements will be compared with evaluated libraries for the first time.
Bacak, Michael ; Aïche, Mourad ; Bélier, Gilbert ; Berthoumieux, Eric ; Diakaki, Maria ; Dupont, Emmeric ; Gunsing, Frank ; Heyse, Jan ; Kopecky, Stefan ; Krtička, Milan ; Laurent, Benoit ; Leeb, Helmut ; Mathieu, Ludovic ; Schillebeeckx, Peter ; Serot, Olivier ; Taieb, Julien ; Valenta, Stanislav ; Vlachoudis, Vasilis ; Aberle, Oliver ; Andrzejewski, Józef ; Audouin, Laurent ; Balibrea Correa, Javier ; Barbagallo, Massimo ; Bečvář, František ; Billowes, Jonathan ; Bosnar, Damir ; Brown, Adam ; Caamaño, Manuel ; Calviño Tavares, Francisco ; Calviani, Marco ; Cano-Ott, Daniel ; Cardella, Roberto ; Casanovas Hoste, Adrià ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Colonna, Nicola ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Cosentino, Luigi ; Damone, Lucia Anna ; Domingo-Pardo, César ; Dressler, Rugard ; Durán, Ignacio ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Ferreira, Pedro G. ; Finocchiaro, Paolo ; Furman, Valter ; Göbel, Kathrin ; García Ríos, Aczel Regino ; Gawlik, Aleksandra ; Gilardoni, Simone ; Glodariu, Tudor ; Gonçalves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Griesmayer, Erich ; Guerrero Sánchez, Carlos ; Harada, Hideo ; Heinitz, Stephan ; Jenkins, David ; Jericha, Erwin ; Käppeler, Franz ; Kadi, Yacine ; Kalamara, Antigoni ; Kavrigin, Pavel ; Kimura, Atsushi ; Kivel, Nikolay ; Knapová, Ingrid ; Kokkoris, Michael ; Kurtulgil, Cem Deniz ; Leal Cidoncha, Esther ; Lederer, Claudia ; Lerendegui-Marco, Jorge ; Lo Meo, Sergio ; Lonsdale, Sarah Jane ; Macina, Daniela ; Manna, Alice ; Marganiec, Justyna ; Martı́nez, Trinitario ; Masi, Alessandro ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Maugeri, Emilio Andrea ; Mazzone, Annamaria ; Mendoza Cembranos, Emilio ; Mengoni, Alberto ; Milazzo, Paolo Maria ; Mingrone, Federica ; Musumarra, Agatino ; Negret, Alexandru ; Nolte, Ralf ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Porras Sánchez, José Ignacio ; Praena, Javier ; Quesada Molina, José Manuel ; Radeck, Désirée ; Rauscher, Thomas ; Reifarth, René ; Rubbia, Carlo ; Ryan, James A. ; Sabaté-Gilarte, Marta ; Saxena, Alok ; Schumann, Dorothea ; Sedyshev, Pavel V. ; Smith, Alastair Gavin ; Sosnin, Nikolay V. ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Tarifeño-Saldivia, Ariel ; Tassan-Got, Laurent ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vlastou, Rosa ; Wallner, Anton ; Warren, Stephen J. ; Weiß, Christina ; Woods, Philip John ; Wright, Tobias ; Žugec, Petar
233U is the fissile nuclei in the Th-U fuel cycle with a particularily small neutron capture cross setion which is on average about one order of magnitude lower than its fission cross section. Hence, the measurement of the 233U(n, γ) cross section relies on a method to accurately distinguish between capture and fission γ-rays. A measurement of the 233U α-ratio has been performed at the n_TOF facility at CERN using a so-called fission tagging setup, coupling n_TOF 's Total Absorption Calorimeter with a novel fission chamber to tag the fission γ-rays. The experimental setup is described and essential parts of the analysis are discussed. Finally, a preliminary 233U α-ratio is presented.
Massimi, Cristian ; Aberle, Oliver ; Andrzejewski, Józef ; Audouin, Laurent ; Bacak, Michael ; Balibrea Correa, Javier ; Barbagallo, Massimo ; Bečvář, František ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brown, Adam ; Caamaño, Manuel ; Calviño Tavares, Francisco ; Calviani, Marco ; Cano-Ott, Daniel ; Cardella, Roberto ; Casanovas Hoste, Adrià ; Castelluccio, Donato Maurizio ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Clai, Giulia ; Colonna, Nicola ; Console Camprini, P. ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Cosentino, Luigi ; Damone, Lucia Anna ; Diakaki, Maria ; Domingo-Pardo, César ; Dressler, Rugard ; Dupont, Emmeric ; Durán, Ignacio ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Ferreira, Pedro G. ; Finocchiaro, Paolo ; Furman, Valter ; Göbel, Kathrin ; García Ríos, Aczel Regino ; Gawlik, Aleksandra ; Gilardoni, Simone ; Glodariu, Tudor ; Gonçalves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Griesmayer, Erich ; Guerrero Sánchez, Carlos ; Guglielmelli, A. ; Gunsing, Frank ; Harada, Hideo ; Heinitz, Stephan ; Heyse, Jan ; Jenkins, David ; Jericha, Erwin ; Käppeler, Franz ; Kadi, Yacine ; Kalamara, Antigoni ; Kavrigin, Pavel ; Kimura, Atsushi ; Kivel, Nikolay ; Knapová, Ingrid ; Kokkoris, Michael ; Krtička, Milan ; Kurtulgil, Cem Deniz ; Leal Cidoncha, Esther ; Lederer, Claudia ; Leeb, Helmut ; Lerendegui-Marco, Jorge ; Lonsdale, Sarah Jane ; Macina, Daniela ; Manna, Alice ; Marganiec, Justyna ; Martı́nez, Trinitario ; Masi, Alessandro ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Maugeri, Emilio Andrea ; Mazzone, Annamaria ; Mendoza Cembranos, Emilio ; Mengoni, Alberto ; Milazzo, Paolo Maria ; Mingrone, Federica ; Mucciola, Riccardo ; Musumarra, Agatino ; Negret, Alexandru ; Nolte, Ralf ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Porras Sánchez, José Ignacio ; Praena, Javier ; Quesada Molina, José Manuel ; Radeck, Désirée ; Rauscher, Thomas ; Reifarth, René ; Rocchi, F. ; Rubbia, Carlo ; Ryan, James A. ; Sabaté-Gilarte, Marta ; Saxena, Alok ; Schillebeeckx, Peter ; Schumann, Dorothea ; Sedyshev, Pavel V. ; Smith, Alastair Gavin ; Sosnin, Nikolay V. ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Tarifeño-Saldivia, Ariel ; Tassan-Got, Laurent ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vlachoudis, Vasilis ; Vlastou, Rosa ; Wallner, Anton ; Warren, Stephen J. ; Weiss, Christian ; Woods, Philip John ; Wright, Tobias ; Žugec, Petar
We have measured the capture cross section of the 155Gd and 157Gd isotopes between 0.025 eV and 1 keV. The capture events were recorded by an array of 4 C6D6 detectors, and the capture yield was deduced exploiting the total energy detection system in combination with the Pulse Height Weighting Techniques. Because of the large cross section around thermal neutron energy, 4 metallic samples of different thickness were used to prevent problems related to self-shielding. The samples were isotopically enriched, with a cross contamination of the other isotope of less than 1.14%. The capture yield was analyzed with an R-Matrix code to describe the cross section in terms of resonance parameters. Near thermal energies, the results are significantly different from evaluations and from previous time-of-flight experiments. The data from the present measurement at n_TOF are publicly available in the experimental nuclear reaction database EXFOR.
Measurement of the 244Cm and 246Cm neutron-induced capture cross sections at the n_TOF facility
(2019)
Alcayne, Victor ; Kimura, Atsushi ; Mendoza Cembranos, Emilio ; Cano-Ott, Daniel ; Martı́nez, Trinitario ; Aberle, Oliver ; Andrzejewski, Józef ; Audouin, Laurent ; Bécares, Vicente ; Bacak, Michael ; Barbagallo, Massimo ; Bečvář, František ; Bellia, Giorgio ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brown, Adam ; Busso, Maurizio ; Caamaño, Manuel ; Caballero Ontanaya, Luis ; Calviño Tavares, Francisco ; Calviani, Marco ; Casanovas Hoste, Adrià ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Colonna, Nicola ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Cosentino, Luigi ; Cristallo, Sergio ; Damone, Lucia Anna ; Diakaki, Maria ; Dietz, Mirco ; Domingo-Pardo, César ; Dressler, Rugard ; Dupont, Emmeric ; Durán, Ignacio ; Eleme, Zinovia ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Finocchiaro, Paolo ; Furman, Valter ; Göbel, Kathrin ; Gawlik, Aleksandra ; Gilardoni, Simone ; Glodariu, Tudor ; Gonçalves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Guerrero Sánchez, Carlos ; Gunsing, Frank ; Harada, Hideo ; Heinitz, Stephan ; Heyse, Jan ; Jenkins, David ; Käppeler, Franz ; Kadi, Yacine ; Katabuchi, Tatsuya ; Kivel, Nikolay ; Knapová, Ingrid ; Kokkoris, Michael ; Kopatch, Yuri N. ; Krtička, Milan ; Kurtulgil, Cem Deniz ; Ladarescu, Ion ; Lederer-Woods, Claudia ; Lerendegui-Marco, Jorge ; Lo Meo, Sergio ; Lonsdale, Sarah Jane ; Macina, Daniela ; Manna, Alice ; Masi, Alessandro ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Matteucci, Francesca ; Maugeri, Emilio Andrea ; Mazzone, Annamaria ; Mengoni, Alberto ; Michalopoulou, Veatriki ; Milazzo, Paolo Maria ; Mingrone, Federica ; Musumarra, Agatino ; Negret, Alexandru ; Nolte, Ralf ; Ogállar Ruiz, Francisco ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Piersanti, Luciano ; Porras Sánchez, José Ignacio ; Praena, Javier ; Quesada Molina, José Manuel ; Radeck, Désirée ; Ramos Doval, Diego ; Rauscher, Thomas ; Reifarth, René ; Rochman, Dimitri ; Sabaté-Gilarte, Marta ; Saxena, Alok ; Schillebeeckx, Peter ; Schumann, Dorothea ; Simone, S. ; Smith, Alastair Gavin ; Sosnin, Nikolay V. ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Talip, T. ; Tarifeño-Saldivia, Ariel ; Tassan-Got, Laurent ; Tsinganis, Andrea ; Ulrich, Jiri ; Urlaß, Sebastian ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vescovi, Diego ; Vlachoudis, Vasilis ; Vlastou, Rosa ; Wallner, Anton ; Woods, Philip John ; Wright, Tobias ; Žugec, Petar
The neutron capture reactions of the 244Cm and 246Cm isotopes open the path for the formation of heavier Cm isotopes and heavier elements such as Bk and Cf in a nuclear reactor. In addition, both isotopes belong to the minor actinides with a large contribution to the decay heat and to the neutron emission in irradiated fuels. There are only two previous 244Cm and 246Cm capture cross section measurements: one in 1969 using a nuclear explosion [1] and the most recent data measured at J-PARC in 2010 [2]. The data for both isotopes are very scarce due to the difficulties in performing the measurements: high intrinsic activity of the samples and limited facilities capable of providing isotopically enriched samples.
We have measured both neutron capture cross sections at the n_TOF Experimental Area 2 (EAR-2) with three C6 D6 detectors and also at Area 1 (EAR-1) with the TAC. Preliminary results assessing the quality and limitations (back-ground subtraction, measurement technique and counting statistics) of this new experimental datasets are presented and discussed.
Bacak, Michael ; Aïche, Mourad ; Bélier, Gilbert ; Berthoumieux, Eric ; Diakaki, Maria ; Dupont, Emmeric ; Gunsing, Frank ; Heyse, Jan ; Kopecky, Stefan ; Laurent, Benoit ; Leeb, Helmut ; Mathieu, Ludovic ; Schillebeeckx, Peter ; Serot, Olivier ; Taieb, Julien ; Vlachoudis, Vasilis ; Aberle, Oliver ; Andrzejewski, Józef ; Audouin, Laurent ; Balibrea Correa, Javier ; Barbagallo, Massimo ; Bečvář, František ; Billowes, Jonathan ; Bosnar, Damir ; Brown, Adam ; Caamaño, Manuel ; Calviño Tavares, Francisco ; Calviani, Marco ; Cano-Ott, Daniel ; Cardella, Roberto ; Casanovas Hoste, Adrià ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Colonna, Nicola ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Cosentino, Luigi ; Damone, Lucia Anna ; Domingo-Pardo, César ; Dressler, Rugard ; Durán, Ignacio ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Ferreira, Pedro G. ; Finocchiaro, Paolo ; Furman, Valter ; Göbel, Kathrin ; García Ríos, Aczel Regino ; Gawlik, Aleksandra ; Gilardoni, Simone ; Glodariu, Tudor ; Gonçalves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Griesmayer, Erich ; Guerrero Sánchez, Carlos ; Harada, Hideo ; Heinitz, Stephan ; Jenkins, David ; Jericha, Erwin ; Käppeler, Franz ; Kadi, Yacine ; Kalamara, Antigoni ; Kavrigin, Pavel ; Kimura, Atsushi ; Kivel, Nikolay ; Knapová, Ingrid ; Kokkoris, Michael ; Krtička, Milan ; Kurtulgil, Cem Deniz ; Leal Cidoncha, Esther ; Lederer, Claudia ; Lerendegui-Marco, Jorge ; Lo Meo, Sergio ; Lonsdale, Sarah Jane ; Macina, Daniela ; Manna, Alice ; Marganiec, Justyna ; Martı́nez, Trinitario ; Masi, Alessandro ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Maugeri, Emilio Andrea ; Mazzone, Annamaria ; Mendoza Cembranos, Emilio ; Mengoni, Alberto ; Milazzo, Paolo Maria ; Mingrone, Federica ; Musumarra, Agatino ; Negret, Alexandru ; Nolte, Ralf ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Porras Sánchez, José Ignacio ; Praena, Javier ; Quesada Molina, José Manuel ; Radeck, Désirée ; Rauscher, Thomas ; Reifarth, René ; Rubbia, Carlo ; Ryan, James A. ; Sabaté-Gilarte, Marta ; Saxena, Alok ; Schumann, Dorothea ; Sedyshev, Pavel V. ; Smith, Alastair Gavin ; Sosnin, Nikolay V. ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Tarifeño-Saldivia, Ariel ; Tassan-Got, Laurent ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vlastou, Rosa ; Wallner, Anton ; Warren, Stephen J. ; Weiß, Christina ; Woods, Philip John ; Wright, Tobias ; Žugec, Petar
233U is of key importance among the fissile nuclei in the Th-U fuel cycle. A particularity of 233U is its small neutron capture cross-section, which is on average about one order of magnitude lower than the fission cross-section. The accuracy in the measurement of the 233U capture cross-section depends crucially on an efficient capture-fission discrimination, thus a combined set-up of fission and γ-detectors is needed. A measurement of the 233U capture cross-section and capture-to-fission ratio was performed at the CERN n_TOF facility. The Total Absorption Calorimeter (TAC) of n_TOF was employed as γ-detector coupled with a novel compact ionization chamber as fission detector. A brief description of the experimental set-up will be given, and essential parts of the analysis procedure as well as the preliminary response of the set-up to capture are presented and discussed.
Stamatopoulos, Athanasios ; Tsinganis, Andrea ; Diakaki, Maria ; Colonna, Nicola ; Kokkoris, Michael ; Vlastou, Rosa ; Kalamara, Antigoni ; Schillebeeckx, Peter ; Tassan-Got, Laurent ; Žugec, Petar ; Sabaté-Gilarte, Marta ; Patronis, Nikolas ; Eleme, Zinovia ; Heyse, Jan ; Aberle, Oliver ; Andrzejewski, Józef ; Audouin, Laurent ; Bacak, Michael ; Balibrea Correa, Javier ; Barbagallo, Massimo ; Bečvář, František ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brown, Adam ; Caamaño, Manuel ; Calviño Tavares, Francisco ; Calviani, Marco ; Cano-Ott, Daniel ; Cardella, Roberto ; Casanovas Hoste, Adrià ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Cosentino, Luigi ; Damone, Lucia Anna ; Domingo-Pardo, César ; Dressler, Rugard ; Dupont, Emmeric ; Durán, Ignacio ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Ferreira, Pedro G. ; Finocchiaro, Paolo ; Furman, Valter ; Göbel, Kathrin ; García Ríos, Aczel Regino ; Gawlik, Aleksandra ; Gilardoni, Simone ; Glodariu, Tudor ; Gonçalves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Griesmayer, Erich ; Guerrero Sánchez, Carlos ; Gunsing, Frank ; Harada, Hideo ; Heinitz, Stephan ; Jenkins, David ; Jericha, Erwin ; Käppeler, Franz ; Kadi, Yacine ; Kavrigin, Pavel ; Kimura, Atsushi ; Kivel, Nikolay ; Knapová, Ingrid ; Krtička, Milan ; Kurtulgil, Cem Deniz ; Leal Cidoncha, Esther ; Lederer, Claudia ; Leeb, Helmut ; Lerendegui-Marco, Jorge ; Lo Meo, Sergio ; Lonsdale, Sarah Jane ; Macina, Daniela ; Manna, Alice ; Marganiec, Justyna ; Martı́nez, Trinitario ; Masi, Alessandro ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Maugeri, Emilio Andrea ; Mazzone, Annamaria ; Mendoza Cembranos, Emilio ; Mengoni, Alberto ; Milazzo, Paolo Maria ; Mingrone, Federica ; Musumarra, Agatino ; Negret, Alexandru ; Nolte, Ralf ; Oprea, Andreea ; Pavlik, Andreas ; Perkowski, Jarosław ; Porras Sánchez, José Ignacio ; Praena, Javier ; Quesada Molina, José Manuel ; Radeck, Désirée ; Rauscher, Thomas ; Reifarth, René ; Rubbia, Carlo ; Ryan, James A. ; Saxena, Alok ; Schumann, Dorothea ; Sedyshev, Pavel V. ; Smith, Alastair Gavin ; Sosnin, Nikolay V. ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Tarifeño-Saldivia, Ariel ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vescovi, Diego ; Vlachoudis, Vasilis ; Wallner, Anton ; Warren, Stephen J. ; Weiß, Christina ; Woods, Philip John ; Wright, Tobias
Neutron-induced fission cross sections of isotopes involved in the nuclear fuel cycle are vital for the design and safe operation of advanced nuclear systems. Such experimental data can also provide additional constraints for the adjustment of nuclear model parameters used in the evaluation process, resulting in the further development of fission models. In the present work, the 237Np(n,f) cross section was studied at the EAR2 vertical beam-line at CERN's n_TOF facility, over a wide range of neutron energies, from meV to MeV, using the time-of-flight technique and a set-up based on Micromegas detectors, in an attempt to provide accurate experimental data. Preliminary results in the 200 keV – 14 MeV neutron energy range as well as the experimental procedure, including a description of the facility and the data handling and analysis, will be presented.
Mendoza Cembranos, Emilio ; Alcayne, Victor ; Cano-Ott, Daniel ; Kimura, Atsushi ; Skarbeli, A. V. ; Aberle, Oliver ; Amaducci, Simone ; Andrzejewski, Józef ; Audouin, Laurent ; Babiano Suarez, Victor ; Bacak, Michael ; Barbagallo, Massimo ; Bécares, Vicente ; Bečvář, František ; Bellia, Giorgio ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brown, Adam S. ; Busso, Maurizio ; Caamaño, Manuel ; Caballero Ontanaya, Luis ; Calviani, Marco ; Calviño Tavares, Francisco ; Casanovas Hoste, Adrià ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Colonna, Nicola ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Cosentino, Luigi ; Cristallo, Sergio ; Damone, Lucia Anna ; Diakaki, Maria ; Dietz, Mirco ; Domingo-Pardo, César ; Dressler, Rugard ; Dupont, Emmeric ; Durán, Ignacio ; Eleme, Zinovia ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Gonçalves, Isabel Maria Ferro ; Finocchiaro, Paolo ; Furman, Valter ; Garg, Ruchi ; Gawlik, Aleksandra ; Gilardoni, Simone ; Glodariu, Tudor ; Göbel, Kathrin ; González Romero, Enrique Miguel ; Guerrero Sánchez, Carlos ; Gunsing, Frank ; Heinitz, Stephan ; Heyse, Jan ; Jenkins, David ; Jericha, Erwin ; Kadi, Yacine ; Käppeler, Franz ; Kivel, Nikolay ; Kokkoris, Michael ; Kopatch, Yuri N. ; Krtička, Milan ; Kurtulgil, Cem Deniz ; Ladarescu, Ion ; Lederer-Woods, Claudia ; Lerendegui-Marco, Jorge ; Lo Meo, Sergio ; Lonsdale, Sarah-Jane ; Macina, Daniela ; Manna, Alice ; Martı́nez, Trinitario ; Masi, Alessandro ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Matteucci, Francesca ; Maugeri, Emilio Andrea ; Mazzone, Annamaria ; Mengoni, Alberto ; Michalopoulou, Veatriki ; Milazzo, Paolo Maria ; Mingrone, Federica ; Musumarra, Agatino ; Negret, Alexandru ; Nolte, Ralf ; Ogállar Ruiz, Francisco ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Piersanti, Luciano ; Porras Sánchez, José Ignacio ; Praena, Javier ; Quesada Molina, José Manuel ; Radeck, Désirée ; Ramos Doval, Diego ; Reifarth, René ; Rochman, Dimitri ; Rubbia, Carlo ; Sabaté-Gilarte, Marta ; Saxena, Alok ; Schillebeeckx, Peter ; Schumann, Dorothea ; Smith, Alastair Gavin ; Sosnin, Nikolay V. ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Talip, Zeynep ; Tarifeño-Saldivia, Ariel ; Tassan-Got, Laurent ; Torres-Sánchez, Pablo ; Tsinganis, Andrea ; Ulrich, Jiri ; Urlaß, Sebastian ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vlachoudis, Vasilis ; Vlastou, Rosa ; Wallner, Anton ; Woods, Philip John ; Wright, Tobias J. ; Žugec, Petar
We have measured the γ-rays following neutron capture on 240Pu and 244 Cm at the n_TOF facility at CERN with the Total Absorption Calorimeter (TAC) and with C6D6 organic scintillators. The TAC is made of 40 BaF2 crystals operating in coincidence and covering almost the entire solid angle. This allows to obtain information concerning the energy spectra and the multiplicity of the measured capture γ-ray cascades. Additional information is also obtained from the C6D6 detectors. We have analyzed the measured data in order to draw conclusions about the Photon Strength Functions (PSFs) of 241Pu and 245Cm below their neutron separation energies. The analysis has been performed by fitting the PSFs to the experimental results, using the differential evolution method, in order to find neutron capture cascades capable of reproducing at the same time a great variety of deposited energy spectra.
Lerendegui-Marco, Jorge ; Guerrero Sánchez, Carlos ; Mendoza Cembranos, Emilio ; Quesada Molina, José Manuel ; Eberhardt, Klaus ; Junghans, Arnd Rudolf ; Krtička, Milan ; Belgya, T. ; Maróti, B. ; Aberle, Oliver ; Andrzejewski, Józef ; Audouin, Laurent ; Bécares, Vicente ; Bacak, Michael ; Balibrea Correa, Javier ; Barbagallo, Massimo ; Barros, Susana C.C. ; Bečvář, František ; Beinrucker, Clemens ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brugger, Markus ; Caamaño, Manuel ; Calviño Tavares, Francisco ; Calviani, Marco ; Cano-Ott, Daniel ; Cardella, Roberto ; Casanovas Hoste, Adrià ; Castelluccio, Donato Maurizio ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Colonna, Nicola ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Cosentino, Luigi ; Damone, Lucia Anna ; Diakaki, Maria ; Domingo-Pardo, César ; Dressler, Rugard ; Dupont, Emmeric ; Durán, Ignacio ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Ferreira, Pedro G. ; Finocchiaro, Paolo ; Furman, Valter ; Göbel, Kathrin ; García Ríos, Aczel Regino ; Gawlik, Aleksandra ; Glodariu, Tudor ; Gonçalves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Goverdovski, Andrey ; Griesmayer, Erich ; Gunsing, Frank ; Harada, Hideo ; Heftrich, Tanja ; Heinitz, Stephan ; Heyse, Jan ; Jenkins, David ; Jericha, Erwin ; Käppeler, Franz ; Kadi, Yacine ; Katabuchi, Tatsuya ; Kavrigin, Pavel ; Ketlerov, Vladimir ; Khryachkov, Vitaly ; Kimura, Atsushi ; Kivel, Nikolay ; Knapová, Ingrid ; Kokkoris, Michael ; Leal Cidoncha, Esther ; Lederer, Claudia ; Leeb, Helmut ; Lo Meo, Sergio ; Lonsdale, Sarah Jane ; Losito, Roberto ; Macina, Daniela ; Marganiec, Justyna ; Martı́nez, Trinitario ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Matteucci, Francesca ; Maugeri, Emilio Andrea ; Mengoni, Alberto ; Milazzo, Paolo Maria ; Mingrone, Federica ; Mirea, Mihail ; Montesano, Simone ; Musumarra, Agatino ; Nolte, Ralf ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Porras Sánchez, José Ignacio ; Praena, Javier ; Rajeev, K. ; Rauscher, Thomas ; Reifarth, René ; Riego Pérez, Albert ; Rout, Prakash Chandra ; Rubbia, Carlo ; Ryan, James A. ; Sabaté-Gilarte, Marta ; Saxena, Alok ; Schillebeeckx, Peter ; Schmidt, Stefan ; Schumann, Dorothea ; Sedyshev, Pavel V. ; Smith, Alastair Gavin ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Tarifeño-Saldivia, Ariel ; Tassan-Got, Laurent ; Tsinganis, Andrea ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vescovi, Diego ; Vlachoudis, Vasilis ; Vlastou, Rosa ; Wallner, Anton ; Warren, Stephen J. ; Weigand, Mario ; Weiß, Christina ; Wolf, Clemens ; Woods, Philip John ; Wright, Tobias ; Žugec, Petar
The design and operation of innovative nuclear systems requires a better knowledge of the capture and fission cross sections of the Pu isotopes. For the case of capture on 242Pu, a reduction of the uncertainty in the fast region down to 8-12% is required. Moreover, aiming at improving the evaluation of the fast energy range in terms of average parameters, the OECD NEA High Priority Request List (HPRL) requests high-resolution capture measurements with improved accuracy below 2 keV. The current uncertainties also affect the thermal point, where previous experiments deviate from each other by 20%. A fruitful collaboration betwen JGU Mainz and HZ Dresden-Rossendorf within the EC CHANDA project resulted in a 242Pu sample consisting of a stack of seven fission-like targets making a total of 95(4) mg of 242Pu electrodeposited on thin (11.5 μm) aluminum backings. This contribution presents the results of a set of measurements of the 242Pu(n, γ) cross section from thermal to 500 keV combining different neutron beams and techniques. The thermal point was determined at the Budapest Research Reactor by means of Neutron Activation Analysis and Prompt Gamma Analysis, and the resolved (1 eV - 4 keV) and unresolved (1 - 500 keV) resonance regions were measured using a set of four Total Energy detectors at the CERN n_TOF-EAR1.
Chen, Yong Hao ; Tassan-Got, Laurent ; Audouin, Laurent ; Le Naour, Claire ; Durán, Ignacio ; Casarejos Ruiz, Enrique ; Aberle, Oliver ; Andrzejewski, Józef ; Bécares, Vicente ; Bacak, Michael ; Balibrea Correa, Javier ; Barbagallo, Massimo ; Barros, Susana C.C. ; Bečvář, František ; Beinrucker, Clemens ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brugger, Markus ; Caamaño, Manuel ; Calviño Tavares, Francisco ; Calviani, Marco ; Cano-Ott, Daniel ; Cardella, Roberto ; Casanovas Hoste, Adrià ; Castelluccio, Donato Maurizio ; Cerutti, Francesco ; Chiaveri, Enrico ; Colonna, Nicola ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Cosentino, Luigi ; Damone, Lucia Anna ; Diakaki, Maria ; Domingo-Pardo, César ; Dressler, Rugard ; Dupont, Emmeric ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Ferreira, Pedro G. ; Finocchiaro, Paolo ; Furman, Valter ; Göbel, Kathrin ; Gómez Hornillos, María Belén ; García Ríos, Aczel Regino ; Gawlik, Aleksandra ; Glodariu, Tudor ; Gonçalves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Goverdovski, Andrey ; Griesmayer, Erich ; Guerrero Sánchez, Carlos ; Gunsing, Frank ; Harada, Hideo ; Heftrich, Tanja ; Heinitz, Stephan ; Heyse, Jan ; Jenkins, David ; Jericha, Erwin ; Käppeler, Franz ; Kadi, Yacine ; Katabuchi, Tatsuya ; Kavrigin, Pavel ; Ketlerov, Vladimir ; Khryachkov, Vitaly ; Kimura, Atsushi ; Kivel, Nikolay ; Kokkoris, Michael ; Krtička, Milan ; Leal Cidoncha, Esther ; Lederer, Claudia ; Leeb, Helmut ; Lerendegui-Marco, Jorge ; Lo Meo, Sergio ; Lonsdale, Sarah Jane ; Losito, Roberto ; Macina, Daniela ; Marganiec, Justyna ; Martı́nez, Trinitario ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Matteucci, Francesca ; Maugeri, Emilio Andrea ; Mendoza Cembranos, Emilio ; Mengoni, Alberto ; Milazzo, Paolo Maria ; Mingrone, Federica ; Mirea, Mihail ; Montesano, Simone ; Musumarra, Agatino ; Nolte, Ralf ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Porras Sánchez, José Ignacio ; Praena, Javier ; Quesada Molina, José Manuel ; Rajeev, K. ; Rauscher, Thomas ; Reifarth, René ; Riego Pérez, Albert ; Robles Manzano, Maria Soledad ; Rout, Prakash Chandra ; Rubbia, Carlo ; Ryan, James A. ; Sabaté-Gilarte, Marta ; Saxena, Alok ; Schillebeeckx, Peter ; Schmidt, Stefan ; Schumann, Dorothea ; Sedyshev, Pavel V. ; Smith, Alastair Gavin ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Tarifeño-Saldivia, Ariel ; Tsinganis, Andrea ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vlachoudis, Vasilis ; Vlastou, Rosa ; Wallner, Anton ; Warren, Stephen J. ; Weigand, Mario ; Weiß, Christina ; Wolf, Clemens ; Woods, Philip John ; Wright, Tobias ; Žugec, Petar
The experimental area 2 (EAR-2) at CERNs neutron time-of-flight facility (n_TOF), which is operational since 2014, is designed and built as a short-distance complement to the experimental area 1 (EAR-1). The Parallel Plate Avalanche Counter (PPAC) monitor experiment was performed to characterize the beam pro↓le and the shape of the neutron 'ux at EAR-2. The prompt γ-flash which is used for calibrating the time-of-flight at EAR-1 is not seen by PPAC at EAR-2, shedding light on the physical origin of this γ-flash.
Lerendegui-Marco, Jorge ; Cortés-Giraldo, Miguel Antonio ; Guerrero Sánchez, Carlos ; Quesada Molina, José Manuel ; Lo Meo, Sergio ; Massimi, Cristian ; Barbagallo, Massimo ; Colonna, Nicola ; Mancusi, Davide ; Mingrone, Federica ; Sabaté-Gilarte, Marta ; Vannini, Gianni ; Vlachoudis, Vasilis ; Aberle, Oliver ; Andrzejewski, Józef ; Audouin, Laurent ; Bacak, Michael ; Balibrea Correa, Javier ; Bečvář, František ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brown, Adam ; Caamaño, Manuel ; Calviño Tavares, Francisco ; Calviani, Marco ; Cano-Ott, Daniel ; Cardella, Roberto ; Casanovas Hoste, Adrià ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Cortés Rossell, Guillem Pere ; Cosentino, Luigi ; Damone, Lucia Anna ; Diakaki, Maria ; Domingo-Pardo, César ; Dressler, Rugard ; Dupont, Emmeric ; Durán, Ignacio ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Ferreira, Pedro G. ; Finocchiaro, Paolo ; Göbel, Kathrin ; Gómez Hornillos, María Belén ; García Ríos, Aczel Regino ; Gawlik, Aleksandra ; Gilardoni, Simone ; Glodariu, Tudor ; Gonçalves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Griesmayer, Erich ; Gunsing, Frank ; Harada, Hideo ; Heinitz, Stephan ; Heyse, Jan ; Jenkins, David ; Jericha, Erwin ; Käppeler, Franz ; Kadi, Yacine ; Kalamara, Antigoni ; Kavrigin, Pavel ; Kimura, Atsushi ; Kivel, Nikolay ; Kokkoris, Michael ; Krtička, Milan ; Kurtulgil, Cem Deniz ; Leal Cidoncha, Esther ; Lederer, Claudia ; Leeb, Helmut ; Lonsdale, Sarah Jane ; Macina, Daniela ; Marganiec, Justyna ; Martı́nez, Trinitario ; Masi, Alessandro ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Maugeri, Emilio Andrea ; Mazzone, Annamaria ; Mendoza Cembranos, Emilio ; Mengoni, Alberto ; Milazzo, Paolo Maria ; Musumarra, Agatino ; Negret, Alexandru ; Nolte, Ralf ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Porras Sánchez, José Ignacio ; Praena, Javier ; Radeck, Désirée ; Rauscher, Thomas ; Reifarth, René ; Rout, Prakash Chandra ; Rubbia, Carlo ; Ryan, James A. ; Saxena, Alok ; Schillebeeckx, Peter ; Schumann, Dorothea ; Smith, Alastair Gavin ; Sosnin, Nikolay V. ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Tarifeño-Saldivia, Ariel ; Tassan-Got, Laurent ; Valenta, Stanislav ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vlastou, Rosa ; Wallner, Anton ; Warren, Stephen J. ; Woods, Philip John ; Wright, Tobias ; Žugec, Petar
Monte Carlo (MC) simulations are an essential tool to determine fundamental features of a neutron beam, such as the neutron flux or the γ-ray background, that sometimes can not be measured or at least not in every position or energy range. Until recently, the most widely used MC codes in this field had been MCNPX and FLUKA. However, the Geant4 toolkit has also become a competitive code for the transport of neutrons after the development of the native Geant4 format for neutron data libraries, G4NDL. In this context, we present the Geant4 simulations of the neutron spallation target of the n_TOF facility at CERN, done with version 10.1.1 of the toolkit. The first goal was the validation of the intra-nuclear cascade models implemented in the code using, as benchmark, the characteristics of the neutron beam measured at the first experimental area (EAR1), especially the neutron flux and energy distribution, and the time distribution of neutrons of equal kinetic energy, the so-called Resolution Function. The second goal was the development of a Monte Carlo tool aimed to provide useful calculations for both the analysis and planning of the upcoming measurements at the new experimental area (EAR2) of the facility.
Destruction of the cosmic γ-ray emitter 26Al in massive stars: study of the key 26Al(n,p) reaction
(2021)
Lederer-Woods, Claudia ; Woods, Philip John ; Davinson, Thomas ; Kahl, David ; Lonsdale, Sarah Jane ; Aberle, Oliver ; Amaducci, Simone ; Andrzejewski, Józef ; Audouin, Laurent ; Bacak, Michael ; Balibrea Correa, Javier ; Barbagallo, Massimo ; Bečvář, František ; Berthoumieux, Eric ; Billowes, Jonathan ; Bosnar, Damir ; Brown, Adam ; Caamaño, Manuel ; Calviño Tavares, Francisco ; Calviani, Marco ; Cano-Ott, Daniel ; Cardella, Roberto ; Casanovas Hoste, Adrià ; Cerutti, Francesco ; Chen, Yonghao ; Chiaveri, Enrico ; Colonna, Nicola ; Cortés Rossell, Guillem Pere ; Cortés-Giraldo, Miguel Antonio ; Cosentino, Luigi ; Cristallo, Sergio ; Damone, Lucia Anna ; Diakaki, Maria ; Domingo-Pardo, César ; Dressler, Rugard ; Dupont, Emmeric ; Durán, Ignacio ; Fernández Domínguez, Beatriz ; Ferrari, Alfredo ; Ferreira, Paulo ; Ferrer, Francisco Javier ; Finocchiaro, Paolo ; Furman, Valter ; Göbel, Kathrin ; García Ríos, Aczel Regino ; Gawlik, Aleksandra ; Gilardoni, Simone ; Glodariu, Tudor ; Gonçalves, Isabel Maria Ferro ; González Romero, Enrique Miguel ; Griesmayer, Erich ; Guerrero Sánchez, Carlos ; Gunsing, Frank ; Harada, Hideo ; Heinitz, Stephan ; Heyse, Jan ; Jenkins, David ; Jericha, Erwin ; Käppeler, Franz ; Kadi, Yacine ; Kalamara, Antigoni ; Kavrigin, Pavel ; Kimura, Atsushi ; Kivel, Nikolay ; Kokkoris, Michael ; Krtička, Milan ; Kurtulgil, Cem Deniz ; Leal Cidoncha, Esther ; Leeb, Helmut ; Lerendegui-Marco, Jorge ; Lo Meo, Sergio ; Macina, Daniela ; Manna, Alice ; Marganiec, Justyna ; Martínez, Trinitario ; Masi, Alessandro ; Massimi, Cristian ; Mastinu, Pierfrancesco ; Mastromarco, Mario ; Maugeri, Emilio Andrea ; Mazzone, Annamaria ; Mendoza Cembranos, Emilio ; Mengoni, Alberto ; Milazzo, Paolo Maria ; Mingrone, Federica ; Musumarra, Agatino ; Negret, Alexandru ; Nolte, Ralf ; Oprea, Andreea ; Patronis, Nikolas ; Pavlik, Andreas ; Perkowski, Jarosław ; Porras Sánchez, José Ignacio ; Praena, Javier ; Quesada Molina, José Manuel ; Radeck, Désirée ; Rauscher, Thomas ; Reifarth, René ; Rubbia, Carlo ; Ryan, James A. ; Sabaté-Gilarte, Marta ; Saxena, Alok ; Schillebeeckx, Peter ; Schumann, Dorothea ; Sedyshev, Pavel V. ; Smith, Alastair G. ; Sosnin, Nikolay V. ; Stamatopoulos, Athanasios ; Tagliente, Giuseppe ; Taı́n Enríquez, José Luis ; Tarifeño-Saldivia, Ariel ; Tassan-Got, Laurent ; Valenta, Stanislav ; Vannini, Gianni ; Variale, Vincenzo ; Vaz, Pedro ; Ventura, Alberto ; Vlachoudis, Vasilis ; Vlastou, Rosa ; Wallner, Anton ; Warren, Stuart ; Weß, Christina ; Wright, Tobias ; Žugec, Petar
The 26Al(n,p)26Mg reaction is the key reaction impacting on the abundances of the cosmic γ-ray emitter 26Al produced in massive stars and impacts on the potential pollution of the early solar system with 26Al by asymptotic giant branch stars. We performed a measurement of the 26Al(n,p)26Mg cross section at the high-flux beam line EAR-2 at the n_TOF facility (CERN). We report resonance strengths for eleven resonances, nine being measured for the first time, while there is only one previous measurement for the other two. Our resonance strengths are significantly lower than the only previous values available. Our cross-section data range to 150 keV neutron energy, which is sufficient for a reliable determination of astrophysical reactivities up to 0.5 GK stellar temperature.
Fouani, Youssef ; Kirchhof, Luisa ; Stanicek, Laura ; Luxán, Guillermo ; Heumüller, Andreas ; Knau, Andrea ; Fischer, Ariane ; Devraj, Kavi ; John, David ; Neumann, Philipp ; Bindereif, Albrecht ; Boon, Reinier ; Liebner, Stefan ; Wittig, Ilka ; Mogler, Carolin ; Karimova, Madina ; Dimmeler, Stefanie ; Jaé, Nicolas Christopher
Vascular integrity is essential for organ homeostasis to prevent edema formation and infiltration of inflammatory cells. Long non-coding RNAs (lncRNAs) are important regulators of gene expression and often expressed in a cell type-specific manner. By screening for endothelial-enriched lncRNAs, we identified the undescribed lncRNA NTRAS to control endothelial cell functions. Silencing of NTRAS induces endothelial cell dysfunction in vitro and increases vascular permeability and lethality in mice. Biochemical analysis revealed that NTRAS, through its CA-dinucleotide repeat motif, sequesters the splicing regulator hnRNPL to control alternative splicing of tight junction protein 1 (TJP1; also named zona occludens 1, ZO-1) pre-mRNA. Deletion of the hnRNPL binding motif in mice (Ntras∆CA/∆CA) significantly repressed TJP1 exon 20 usage, favoring expression of the TJP1α- isoform, which augments permeability of the endothelial monolayer. Ntras∆CA/∆CA mice further showed reduced retinal vessel growth and increased vascular permeability and myocarditis. In summary, this study demonstrates that NTRAS is an essential gatekeeper of vascular integrity.
Tetraphenyl-p-benzoquinone, according to its single crystal structure, shows some steric congestion: its quinone ring is distorted by 7° to a chair conformation, and its phenyl substituents are twisted around their CC axes between 46° and 72°. The half-wave reduction potentials of -0.57 and -1.25 V in acetonitrile confirm negligible π interaction of the phenyl substituents. Addition of alkalimetal tetraphenylborate salts lowers the second reduction potential due to contact ion formation, which can be confirmed by UV/VIS spectra recorded under aprotic conditions. Extensive ESR/ENDOR investigations prove the formation of the following species in THF solution: Tetraphenyl-p-benzosemiquinone radical anion contact ion pairs [M·⊖ Me⊕solv]' (Me⊕: Li⊕, Na⊕, Rb⊕, Cs⊕) and contact triple ion radical cations both with identical cations [M·⊖ (Me⊕solv)2]·⊕ (Me⊕: Li⊕, Na⊕, Cs⊕) and different cations [M·⊖ (Li⊕solv)(Me⊕solv)]·⊕ (Me⊕: Na⊕, Cs⊕). Addition of crown ethers can lead to external solvation of the Me⊕ counter cations, whereas cryptands form internal solvation complexes. The radical anion of 2,6-diphenyl-p-benzosemiquinone adds cations at its phenyl-free molecular half. The radical anion salt [tetraphenyl-p-benzosemiquinone·⊖ (Na⊕(tetrahydropyrane) 2)] could be crystallized and its structure determined at 200 K. In agreement with the Hirota sign rules for contact radicals in solution, the Na⊕ ion is found 62 pm above the π plane and 29° outside the axis of the CO bound, which is elongated due to one-electron reduction by 5 pm to 127 pm.
Medema, Marnix H. ; Kottmann, Renzo ; Yilmaz, Pelin ; Cummings, Matthew ; Biggins, John B. ; Kai, Blin ; de Bruijn, Irene ; Chooi, Yit Heng ; Claesen, Jan ; Coates, R. Cameron ; Cruz-Morales, Pablo ; Duddela, Srikanth ; Düsterhus, Stephanie ; Edwards, Daniel J. ; Fewer, David P. ; Garg, Neha ; Geiger, Christoph ; Gomez-Escribano, Juan Pablo ; Greule, Anja ; Hadjithomas, Michalis ; Haines, Anthony S. ; Helfrich, Eric J. N. ; Hillwig, Matthew L. ; Ishida, Keishi ; Jones, Adam C. ; Jones, Carla S. ; Jungmann, Katrin ; Kegler, Carsten ; Kim, Hyun Uk ; Kötter, Peter ; Krug, Daniel ; Masschelein, Joleen ; Melnik, Alexey V. ; Mantovan, Simone M. ; Monroe, Emily A. ; Moore, Marcus ; Moss, Nathan ; Nützmann, Hans-Wilhelm ; Pan, Guohui ; Pati, Amrita ; Petras, Daniel ; Reen, F. Jerry ; Rosconi, Federico ; Rui, Zhe ; Tian, Zhenhua ; Tobias, Nicholas J. ; Tsunematsu, Yuta ; Wiemann, Philipp ; Wyckoff, Elizabeth ; Yan, Xiaohui ; Yim, Grace ; Yu, Fengan ; Xie, Yunchang ; Aigle, Bertrand ; Apel, Alexander K. ; Balibar, Carl J. ; Balskus, Emily P. ; Barona-Gómez, Francisco ; Bechthold, Andreas ; Bode, Helge Björn ; Borriss, Rainer ; Brady, Sean F. ; Brakhage, Axel A. ; Caffrey, Patrick ; Cheng, Yi-Qiang ; Clardy, Jon ; Cox, Russell J. ; De Mot, René ; Donadio, Stefano ; Donia, Mohamed S. ; van der Donk, Wilfred A. ; Dorrestein, Pieter C. ; Doyle, Sean ; Driessen, Arnold J. M. ; Ehling-Schulz, Monika ; Entian, Karl-Dieter ; Fischbach, Michael A. ; Gerwick, Lena ; Gerwick, William H. ; Gross, Harald ; Gust, Bertolt ; Hertweck, Christian ; Höfte, Monica ; Jensen, Susan E. ; Ju, Jianhua ; Katz, Leonard ; Kaysser, Leonard ; Klassen, Jonathan L. ; Keller, Nancy P. ; Kormanec, Jan ; Kuipers, Oscar P. ; Kuzuyama, Tomohisa ; Kyrpides, Nikos C. ; Kwon, Hyung-Jin ; Lautru, Sylvie ; Lavigne, Rob ; Lee, Chia Y. ; Linquan, Bai ; Liu, Xinyu ; Liu, Wen ; Luzhetskyy, Andriy ; Mahmud, Taifo ; Mast, Yvonne ; Méndez, Carmen ; Metsä-Ketelä, Mikko ; Micklefield, Jason ; Mitchell, Douglas A. ; Moore, Bradley S. ; Moreira, Leonilde M. ; Müller, Rolf ; Neilan, Brett A. ; Nett, Markus ; Nielsen, Jens ; O’Gara, Fergal ; Oikawa, Hideaki ; Osbourn, Anne ; Osburne, Marcia S. ; Ostash, Bohdan ; Payne, Shelley M. ; Pernodet, Jean-Luc ; Petricek, Miroslav ; Piel, Jörn ; Ploux, Olivier ; Raaijmakers, Jos M. ; Salas, José A. ; Schmitt, Esther K. ; Scott, Barry ; Seipke, Ryan F. ; Shen, Ben ; Sherman, David H. ; Sivonen, Kaarina ; Smanski, Michael J. ; Sosio, Margherita ; Stegmann, Evi ; Süssmuth, Roderich D. ; Tahlan, Kapil ; Thomas, Christopher M. ; Tang, Yi ; Truman, Andrew W. ; Viaud, Muriel ; Walton, Jonathan D. ; Walsh, Christopher T. ; Weber, Tilmann ; van Wezel, Gilles P. ; Wilkinson, Barrie ; Willey, Joanne M. ; Wohlleben, Wolfgang ; Wright, Gerard D. ; Ziemert, Nadine ; Zhang, Changsheng ; Zotchev, Sergey B. ; Breitling, Rainer ; Takano, Eriko ; Glöckner, Frank Oliver
A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.
Hoffmann, Jedrzej ; Luxán, Guillermo ; Abplanalp, Wesley Tyler ; Glaser, Simone F. ; Rasper, Tina ; Fischer, Ariane ; Muhly-Reinholz, Marion ; John, David ; Aßmus, Birgit ; Zeiher, Andreas M. ; Dimmeler, Stefanie
Bone vasculature provides protection and signals necessary to control stem cell quiescence and renewal1. Specifically, type H capillaries, which highly express Endomucin, constitute the endothelial niche supporting a microenvironment of osteoprogenitors and long-term hematopoietic stem cells2–4. The age-dependent decline in type H endothelial cells was shown to be associated with bone dysregulation and accumulation of hematopoietic stem cells, which display cell-intrinsic alterations and reduced functionality3. The regulation of bone vasculature by chronic diseases, such as heart failure is unknown. Here, we describe the effects of myocardial infarction and post-infarction heart failure on the vascular bone cell composition. We demonstrate an age-independent loss of type H bone endothelium in heart failure after myocardial infarction in both mice and in humans. Using single-cell RNA sequencing, we delineate the transcriptional heterogeneity of human bone marrow endothelium showing increased expression of inflammatory genes, including IL1B and MYC, in ischemic heart failure. Inhibition of NLRP3-dependent IL-1β production partially prevents the post-myocardial infarction loss of type H vasculature in mice. These results provide a rationale for using anti-inflammatory therapies to prevent or reverse the deterioration of vascular bone function in ischemic heart disease.
Hiranuma, Naruki ; Augustin-Bauditz, Stefanie ; Bingemer, Heinz ; Budke, Carsten ; Curtius, Joachim ; Danielczok, Anja ; Diehl, Karoline ; Dreischmeier, Katharina ; Ebert, Martin ; Frank, Fabian ; Hoffmann, Nadine ; Kandler, Konrad ; Kiselev, Alexei ; Koop, Thomas ; Leisner, Thomas ; Möhler, Ottmar ; Nillius, Björn ; Peckhaus, Andreas ; Rose, Diana ; Weinbruch, Stephan ; Wex, Heike ; Boose, Yvonne ; DeMott, Paul J. ; Hader, John D. ; Hill, Thomas C. ; Kanji, Zamin A. ; Kulkarni, Gargi ; Levin, Ezra J. T. ; McCluskey, Christina S. ; Murakami, Masataka ; Murray, Benjamin J. ; Niedermeier, Dennis ; Petters, Markus D. ; O'Sullivan, Daniel ; Saito, Atsushi ; Schill, Gregory P. ; Tajiri, Takuya ; Tolbert, Margret A. ; Welti, André ; Whale, Thomas F. ; Wright, Timothy P. ; Yamashita, Katsuya
Immersion freezing is the most relevant heterogeneous ice nucleation mechanism through which ice crystals are formed in mixed-phase clouds. In recent years, an increasing number of laboratory experiments utilizing a variety of instruments have examined immersion freezing activity of atmospherically relevant ice nucleating particles (INPs). However, an inter-comparison of these laboratory results is a difficult task because investigators have used different ice nucleation (IN) measurement methods to produce these results. A remaining challenge is to explore the sensitivity and accuracy of these techniques and to understand how the IN results are potentially influenced or biased by experimental parameters associated with these techniques.
Within the framework of INUIT (Ice Nucleation research UnIT), we distributed an illite rich sample (illite NX) as a representative surrogate for atmospheric mineral dust particles to investigators to perform immersion freezing experiments using different IN measurement methods and to obtain IN data as a function of particle concentration, temperature (T), cooling rate and nucleation time. Seventeen measurement methods were involved in the data inter-comparison. Experiments with seven instruments started with the test sample pre-suspended in water before cooling, while ten other instruments employed water vapor condensation onto dry-dispersed particles followed by immersion freezing. The resulting comprehensive immersion freezing dataset was evaluated using the ice nucleation active surface-site density (ns) to develop a representative ns(T) spectrum that spans a wide temperature range (−37 °C < T < −11 °C) and covers nine orders of magnitude in ns.
Our inter-comparison results revealed a discrepancy between suspension and dry-dispersed particle measurements for this mineral dust. While the agreement was good below ~ −26 °C, the ice nucleation activity, expressed in ns, was smaller for the wet suspended samples and higher for the dry-dispersed aerosol samples between about −26 and −18 °C. Only instruments making measurement techniques with wet suspended samples were able to measure ice nucleation above −18 °C. A possible explanation for the deviation between −26 and −18 °C is discussed. In general, the seventeen immersion freezing measurement techniques deviate, within the range of about 7 °C in terms of temperature, by three orders of magnitude with respect to ns. In addition, we show evidence that the immersion freezing efficiency (i.e., ns) of illite NX particles is relatively independent on droplet size, particle mass in suspension, particle size and cooling rate during freezing. A strong temperature-dependence and weak time- and size-dependence of immersion freezing efficiency of illite-rich clay mineral particles enabled the ns parameterization solely as a function of temperature. We also characterized the ns (T) spectra, and identified a section with a steep slope between −20 and −27 °C, where a large fraction of active sites of our test dust may trigger immersion freezing. This slope was followed by a region with a gentler slope at temperatures below −27 °C. A multiple exponential distribution fit is expressed as ns(T) = exp(23.82 × exp(−exp(0.16 × (T + 17.49))) + 1.39) based on the specific surface area and ns(T) = exp(25.75 × exp(−exp(0.13 × (T + 17.17))) + 3.34) based on the geometric area (ns and T in m−2 and °C, respectively). These new fits, constrained by using an identical reference samples, will help to compare IN measurement methods that are not included in the present study and, thereby, IN data from future IN instruments.