Refine
Year of publication
Document Type
- Article (86)
- Conference Proceeding (10)
- Preprint (5)
Has Fulltext
- yes (101)
Is part of the Bibliography
- no (101)
Keywords
- ADHD (16)
- Depression (8)
- Bipolar disorder (7)
- Genetics (6)
- bipolar disorder (5)
- Human behaviour (4)
- Psychiatric disorders (4)
- Suicide (4)
- Dopamine (3)
- Neuroscience (3)
- Physical activity (3)
- Treatment (3)
- fMRI (3)
- schizophrenia (3)
- Attention-deficit/hyperactivity disorder (2)
- Biomarker (2)
- Brain (2)
- COVID-19 (2)
- Clinical genetics (2)
- Comorbidity (2)
- Diagnostic markers (2)
- Emotion regulation (2)
- Exercise (2)
- Inflammation (2)
- L-DOPA (2)
- Major depressive disorder (2)
- PARK2 (2)
- Pandemic (2)
- Predominant polarity (2)
- Primary care (2)
- attention (2)
- biomarker (2)
- continuous performance test (2)
- hyperactivity (2)
- impulsivity (2)
- machine learning (2)
- polygenic risk score (2)
- 14-3-3 gene family (1)
- A2BP1 (1)
- ADHD differential diagnosis (1)
- AKI (1)
- Accidents (1)
- Acidification (1)
- Adjuvant procedure (1)
- Adjuvantes Verfahren (1)
- Adult-onset ADHD (1)
- Affect (1)
- Affective disorders (1)
- Agoraphobia (1)
- Ambulatory Assessment (1)
- Amino acids (1)
- Amisulpride (1)
- Amphetamine (1)
- Amygdala (1)
- Animal models (1)
- Antidepressant (1)
- Anxiolytic pharmacological therapy (1)
- Atomoxetine (1)
- Attention (1)
- Attention Deficit Hyperactivity Disorder (ADHD) (1)
- Attention deficit (1)
- Attention-deficit / hyperactivity disorder (1)
- Attentional bias (1)
- Batten disease (1)
- Behavioral tests (1)
- Big Five (1)
- Brain DNA methylation (1)
- Bright light therapy (1)
- Brms (1)
- Brodalumab (1)
- CAPON (1)
- CDH13 (1)
- CNVs (1)
- COMT (1)
- Cardiac surgery (1)
- Central Europe (1)
- Circadian (1)
- Cln3 (1)
- Co-morbidity (1)
- Cognitive (1)
- Cognitive dysfunction (1)
- Cognitive enhancers of exposure therapy (1)
- Cognitive impairment (1)
- Comorbidities (1)
- Completed suicide (1)
- Consensus (1)
- Copy number (1)
- Course (1)
- DTI (1)
- DYT1 (1)
- Developmental programming (1)
- Developmental trajectory (1)
- Diagnosis (1)
- Diagnostic medicine (1)
- Diagnostic test (1)
- Dietary intake (1)
- Differential diagnosis (1)
- Dot-probe task (1)
- EBM (1)
- Early (prenatal and postnatal) life experiences (1)
- Ecological Momentary Assessment (EMA) (1)
- Ecological momentary assessment (1)
- Energy (1)
- Environmental enrichment (1)
- Epigenetics (1)
- Euthymic phase (1)
- Evidence-based (1)
- Evidence-based drug discovery (1)
- Evidenzbasierung (1)
- Explicit (1)
- Fruit fly (1)
- GHQ-28 (1)
- GWAS (1)
- Gaba (1)
- Gene (1)
- Genetic syndromes (1)
- Guidelines (1)
- Healthy Living Index (HLI) (1)
- Hippocampus (1)
- Hyperactivity (1)
- IL-17 (1)
- Imaging genetics (1)
- Immunity (1)
- Immunogenetics (1)
- Immunology (1)
- Implicit (1)
- Injuries (1)
- Intervention (1)
- KDIGO (1)
- Konsens (1)
- LFP (1)
- Lafora disease (1)
- Langzeiteffekt (1)
- Learning and memory (1)
- Leitlinien (1)
- Lithium (1)
- Long-term effect (1)
- Longitudinal (1)
- MDD (1)
- MVPA (1)
- Maintenance treatment (1)
- Mania (1)
- Maternal separation (1)
- Mechanism of action (1)
- Memory (1)
- Mental disorder (1)
- Mental health and psychiatry (1)
- Mental health disorders (1)
- Metabolic diseases (1)
- Methylphenidate (1)
- Mitochondrial dysfunction (1)
- Molecular neuroscience (1)
- Monetary incentive delay (1)
- Monitoring (1)
- Mood (1)
- Mouse (1)
- Multilevel two-part modelling (1)
- Multiplex immunoassay (1)
- NOS-I (1)
- NOS1AP (1)
- NPSR1 (1)
- Nesplora Aquarium (1)
- Neurodevelopmental disorder (1)
- Neuromodulatorisches Netzwerk (1)
- Neuromodulatory network (1)
- Neurostimulation (1)
- Norepinephrine (1)
- Obesity (1)
- Outcome (1)
- Panic disorder (1)
- Patients (1)
- Personalized medicine (1)
- Phenylketonuria (PKU) (1)
- Physical fitness (1)
- Physical self-perception (1)
- Physicians (1)
- Polarity index (1)
- Polygenic risk score (1)
- Postvention (1)
- Prediction (1)
- Predictive markers (1)
- Psychedelics (1)
- Psychiatric traits (1)
- Psychiatry (1)
- Qb-Test (1)
- QbTest® (1)
- Quality of life (1)
- R (1)
- RBFOX1 (1)
- RDoC (1)
- RNAi (1)
- Randomized controlled trial (1)
- Research article (1)
- Reward (1)
- Rodents (1)
- SARS-CoV2 (1)
- Schizophrenia (1)
- Scientific community (1)
- Seasonal variation (1)
- Self-efficacy (1)
- Self-esteem (1)
- Semicontinuous (1)
- Solar insolation (1)
- Stimulant (1)
- Stress resilience (1)
- Stress vulnerability/resilience genes (1)
- Striatum (1)
- Suicidal behavior (1)
- Suicidal thoughts (1)
- Suicidality (1)
- Suicide attempt (1)
- Suizidalität (1)
- Sunlight (1)
- Synaptic dysfunction (1)
- TBSS (1)
- TOR1A (1)
- Trajectories (1)
- Two-hit hypothesis (1)
- Tyrosinemia (1)
- UPPS (1)
- Westphal-Paradigm (1)
- Wirkmechanismus (1)
- Working memory capacity (1)
- YWHAE (1)
- YWHAZ (1)
- Yoga (1)
- Zebrafish (1)
- accidents (1)
- adaptation (1)
- adeno-associated virus (1)
- adult attention deficit/hyperactivity disorder (adult ADHD) (1)
- adversity (1)
- affective disorder (1)
- affective disorders (1)
- aggressiveness (1)
- aging (1)
- agreeableness (1)
- alcohol use disorder (1)
- allostasis (1)
- amisulpride (1)
- associative memory (1)
- attention deficit hyperactivity disorder (1)
- attention-deficit/hyperactivity disorder (1)
- autism (1)
- bipolar disorders (1)
- blood (1)
- body mass index (1)
- ceramides (1)
- children (1)
- cognition (1)
- common variant (1)
- common variants (1)
- coping (1)
- cross-sectional study (1)
- data science (1)
- dementia (1)
- depression (1)
- development (1)
- diabetes mellitus (1)
- diet (1)
- dietary assessment (1)
- disease modelling (1)
- disease prevalence (1)
- dopamine (1)
- dynamic system (1)
- early recognition (1)
- ecological momentary assessment (1)
- endocannabinoids (1)
- epigenetics (1)
- epilepsy (1)
- euthymic (1)
- eutrophication (1)
- ex-Gaussian analysis (1)
- executive functions (1)
- expression studies (1)
- extraversion (1)
- face-name association task (1)
- fear conditioning (1)
- fear generalization (1)
- feasibility (1)
- forest ecology (1)
- functional connectivity (1)
- gender (1)
- genetic phenotypes (1)
- genetic variants (1)
- genetics (1)
- gene×environment interactions (1)
- glucose metabolism (1)
- graph theory (1)
- hiPSC (1)
- homeostasis (1)
- inflammation (1)
- insula (1)
- insulin resistance (1)
- juvenile myoclonic epilepsy (1)
- lifestyle (1)
- lipids (1)
- mHealth (1)
- major depression (1)
- major depression (MD) (1)
- major depressive disorder (1)
- major depressive disorder (MDD) (1)
- maturation (1)
- mental health (1)
- metabolic syndrome (1)
- microtemporal processes (1)
- mitochondria (1)
- mobile phone (1)
- nNOS (1)
- naturalistic sample (1)
- neurodevelopment (1)
- neurodevelopmental disorders (1)
- neuropsychology (1)
- neuroticism (1)
- nitric oxide (1)
- obesity (1)
- pharmaco-fMRI (1)
- pharmacogenetics (1)
- pharmacoresistance (1)
- physical activity (1)
- prediabetes (1)
- progressive myoclonus epilepsy (1)
- proteome (1)
- psychiatric disorders (1)
- psychosocial stress (1)
- rare mendelian disorders (1)
- rare variant (1)
- rare variants (1)
- resting-state fMRI (1)
- resting‐state (1)
- risk genes (1)
- schizophrenia spectrum (1)
- single subject classification (1)
- skin conductance (1)
- smartphone-app (1)
- stress (1)
- substance abuse disorder (1)
- tandem mass spectrometry (1)
- temporal classification (1)
- transcriptomics (1)
- usability (1)
- validity (1)
- ventral tegmental area (1)
- venturesomeness (1)
- viral gene transfer (1)
- white-matter (1)
- within-person factors (1)
- working memory (1)
Institute
- Medizin (97)
- Psychologie (6)
- Psychologie und Sportwissenschaften (3)
- Biowissenschaften (2)
- Präsidium (1)
Background: Nitric oxide synthase 1 adaptor protein (NOS1AP; previously named CAPON) is linked to the glutamatergic postsynaptic density through interaction with neuronal nitric oxide synthase (nNOS). NOS1AP and its interaction with nNOS have been associated with several mental disorders. Despite the high levels of NOS1AP expression in the hippocampus and the relevance of this brain region in glutamatergic signalling as well as mental disorders, a potential role of hippocampal NOS1AP in the pathophysiology of these disorders has not been investigated yet.
Methods: To uncover the function of NOS1AP in hippocampus, we made use of recombinant adeno-associated viruses to overexpress murine full-length NOS1AP or the NOS1AP carboxyterminus in the hippocampus of mice. We investigated these mice for changes in gene expression, neuronal morphology, and relevant behavioural phenotypes.
Findings: We found that hippocampal overexpression of NOS1AP markedly increased the interaction of nNOS with PSD-95, reduced dendritic spine density, and changed dendritic spine morphology at CA1 synapses. At the behavioural level, we observed an impairment in social memory and decreased spatial working memory capacity.
Interpretation: Our data provide a mechanistic explanation for a highly selective and specific contribution of hippocampal NOS1AP and its interaction with the glutamatergic postsynaptic density to cross-disorder pathophysiology. Our findings allude to therapeutic relevance due to the druggability of this molecule.