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Afshordi, Niayesh ; Akçay, Sarp ; Amaro-Seoane, Pau ; Antonelli, Andrea ; Aurrekoetxea, Josu C. ; Barack, Leor ; Barausse, Enrico ; Benkel, Robert ; Bernard, Laura ; Bernuzzi, Sebastiano ; Berti, Emanuele ; Bonetti, Matteo ; Bonga, Béatrice ; Bozzola, Gabriele ; Brito, Richard ; Buonanno, Alessandra ; Cárdenas-Avendaño, Alejandro ; Casals, Marc ; Chernoff, David F. ; Chua, Alvin J. K. ; Clough, Katy ; Colleoni, Marta ; Dhesi, Mekhi ; Druart, Adrien ; Durkan, Leanne ; Faye, Guillaume ; Ferguson, Deborah ; Field, Scott E. ; Gabella, William E. ; García-Bellido, Juan ; Gracia-Linares, Miguel ; Gerosa, Davide ; Green, Stephen R. ; Haney, Maria ; Hannam, Mark ; Heffernan, Anna ; Hinderer, Tanja ; Helfer, Thomas ; Hughes, Scott A. ; Husa, Sascha ; Isoyama, Soichiro ; Katz, Michael L. ; Kavanagh, Chris ; Khanna, Gaurav ; Kidder, Larry E. ; Korol, Valeriya ; Küchler, Lorenzo ; Laguna, Pablo ; Larrouturou, François ; Le Tiec, Alexandre ; Leather, Benjamin ; Lim, Eugene A. ; Lim, Hyun ; Littenberg, Tyson B. ; Long, Oliver ; Lousto, Carlos O. ; Lovelace, Geoffrey ; Lukes-Gerakopoulos, Georgios ; Lynch, Philip ; Macedo, Rodrigo P. ; Markakis, Charalampos ; Maggio, Elisa ; Mandel, Ilya ; Maselli, Andrea ; Mathews, Josh ; Mourier, Pierre ; Neilsen, David ; Nagar, Alessandro ; Nichols, David A. ; Novák, Jan ; Okounkova, Maria ; O’Shaughnessy, Richard ; Oshita, Naritaka ; O’Toole, Conor ; Pan, Zhen ; Pani, Paolo ; Pappas, George ; Paschalidis, Vasileios ; Pfeiffer, Harald P. ; Pompili, Lorenzo ; Pound, Adam ; Pratten, Geraint ; Rüter, Hannes ; Ruiz, Milton ; Sam, Zeyd ; Sberna, Laura ; Shapiro, Stuart L. ; Shoemaker, Deirdre M. ; Sopuerta, Carlos F. ; Spiers, Andrew ; Sundar, Hari ; Tamanini, Nicola ; Thompson, Jonathan E. ; Toubiana, Alexandre ; Tsokaros, Antonios ; Upton, Samuel D. ; Meent, Maarten van de ; Vernieri, Daniele ; Wachter, Jeremy M. ; Warburton, Niels ; Wardell, Barry ; Witek, Helvi ; Witzany, Vojtěch ; Yang, Huan ; Zilhão, Miguel ; Albertini, Angelica ; Arun, K. G. ; Bezares, Miguel ; Bonilla Rivera, Alexander ; Chapman-Bird, Christian ; Cownden, Bradley ; Cunningham, Kevin ; Devitt, Chris ; Dolan, Sam ; Duque, Francisco ; Dyson, Conor ; Fryer, Chris L. ; Gair, Jonathan R. ; Giacomazzo, Bruno ; Gupta, Priti ; Han, Wen-Biao ; Haas, Roland ; Hirschmann, Eric ; Huerta, Eliu A. ; Jetzer, Philippe ; Kelly, Bernard ; Khalil, Mohammed ; Lewis, Jack ; Lloyd-Ronning, Nicole Marie ; Marsat, Sylvain ; Nardini, Germano ; Neef, Jakob ; Ottewill, Adrian ; Pantelidou, Christiana ; Piovano, Gabriel Andres ; Redondo-Yuste, Jaime ; Sagunski, Laura ; Stein, Leo C. ; Skoupý, Viktor ; Sperhake, Ulrich ; Speri, Lorenzo ; Spieksma, Thomas F. M. ; Stevens, Chris ; Trestini, David ; Vañó-Viñuales, Alex
Afshordi, Niayesh ; Akçay, Sarp ; Amaro-Seoane, Pau ; Antonelli, Andrea ; Aurrekoetxea, Josu C. ; Barack, Leor ; Barausse, Enrico ; Benkel, Robert ; Bernard, Laura ; Bernuzzi, Sebastiano ; Berti, Emanuele ; Bonetti, Matteo ; Bonga, Béatrice ; Bozzola, Gabriele ; Brito, Richard ; Buonanno, Alessandra ; Cárdenas-Avendaño, Alejandro ; Casals, Marc ; Chernoff, David F. ; Chua, Alvin J. K. ; Clough, Katy ; Colleoni, Marta ; Dhesi, Mekhi ; Druart, Adrien ; Durkan, Leanne ; Faye, Guillaume ; Ferguson, Deborah ; Field, Scott E. ; Gabella, William E. ; García-Bellido, Juan ; Gracia-Linares, Miguel ; Gerosa, Davide ; Green, Stephen R. ; Haney, Maria ; Hannam, Mark ; Heffernan, Anna ; Hinderer, Tanja ; Helfer, Thomas ; Hughes, Scott A. ; Husa, Sascha ; Isoyama, Soichiro ; Katz, Michael L. ; Kavanagh, Chris ; Khanna, Gaurav ; Kidder, Larry E. ; Korol, Valeriya ; Küchler, Lorenzo ; Laguna, Pablo ; Larrouturou, François ; Le Tiec, Alexandre ; Leather, Benjamin ; Lim, Eugene A. ; Lim, Hyun ; Littenberg, Tyson B. ; Long, Oliver ; Lousto, Carlos O. ; Lovelace, Geoffrey ; Lukes-Gerakopoulos, Georgios ; Lynch, Philip ; Macedo, Rodrigo P. ; Markakis, Charalampos ; Maggio, Elisa ; Mandel, Ilya ; Maselli, Andrea ; Mathews, Josh ; Mourier, Pierre ; Neilsen, David ; Nagar, Alessandro ; Nichols, David A. ; Novák, Jan ; Okounkova, Maria ; O’Shaughnessy, Richard ; Oshita, Naritaka ; O’Toole, Conor ; Pan, Zhen ; Pani, Paolo ; Pappas, George ; Paschalidis, Vasileios ; Pfeiffer, Harald P. ; Pompili, Lorenzo ; Pound, Adam ; Pratten, Geraint ; Rüter, Hannes ; Ruiz, Milton ; Sam, Zeyd ; Sberna, Laura ; Shapiro, Stuart L. ; Shoemaker, Deirdre M. ; Sopuerta, Carlos F. ; Spiers, Andrew ; Sundar, Hari ; Tamanini, Nicola ; Thompson, Jonathan E. ; Toubiana, Alexandre ; Tsokaros, Antonios ; Upton, Samuel D. ; Meent, Maarten van de ; Vernieri, Daniele ; Wachter, Jeremy M. ; Warburton, Niels ; Wardell, Barry ; Witek, Helvi ; Witzany, Vojtěch ; Yang, Huan ; Zilhão, Miguel ; Albertini, Angelica ; Arun, K. G. ; Bezares, Miguel ; Bonilla, Alexander Rivera ; Chapman-Bird, Christian ; Cownden, Bradley ; Cunningham, Kevin ; Devitt, Chris ; Dolan, Sam ; Duque, Francisco ; Dyson, Conor ; Fryer, Chris L. ; Gair, Jonathan R. ; Giacomazzo, Bruno ; Gupta, Priti ; Han, Wen-Biao ; Haas, Roland ; Hirschmann, Eric ; Huerta, Eliu A. ; Jetzer, Philippe ; Kelly, Bernard ; Khalil, Mohammed ; Lewis, Jack ; Lloyd-Ronning, Nicole Marie ; Marsat, Sylvain ; Nardini, Germano ; Neef, Jakob ; Ottewill, Adrian ; Pantelidou, Christiana ; Piovano, Gabriel Andres ; Redondo-Yuste, Jaime ; Sagunski, Laura ; Stein, Leo C. ; Skoupý, Viktor ; Sperhake, Ulrich ; Speri, Lorenzo ; Spieksma, Thomas F. M. ; Stevens, Chris ; Trestini, David ; Vañó-Viñuales, Alex
LISA, the Laser Interferometer Space Antenna, will usher in a new era in gravitational-wave astronomy. As the first anticipated space-based gravitational-wave detector, it will expand our view to the millihertz gravitational-wave sky, where a spectacular variety of interesting new sources abound: from millions of ultra-compact binaries in our Galaxy, to mergers of massive black holes at cosmological distances; from the beginnings of inspirals that will venture into the ground-based detectors' view to the death spiral of compact objects into massive black holes, and many sources in between. Central to realising LISA's discovery potential are waveform models, the theoretical and phenomenological predictions of the pattern of gravitational waves that these sources emit. This white paper is presented on behalf of the Waveform Working Group for the LISA Consortium. It provides a review of the current state of waveform models for LISA sources, and describes the significant challenges that must yet be overcome.
Castellani, Carlo ; Duff, Alistair J. A. ; Bell, Scott C. ; Heijerman, Harry ; Munck, Anne ; Ratjen, Felix ; Sermet-Gaudelus, Isabelle ; Southern, Kevin W. ; Barben, Jurg ; Flume, Patrick A. ; Hodková, Pavla ; Kashirskaya, Nataliya ; Kirszenbaum, Maya N. ; Madge, Sue ; Oxley, Helen ; Plant, Barry ; Schwarzenberg, Sarah ; Smyth, Alan R. ; Taccetti, Giovanni ; Wagner, Thomas O. F. ; Wolfe, Susan P. ; Drevinek, Pavel
Developments in managing CF continue to drive dramatic improvements in survival. As newborn screening rolls-out across Europe, CF centres are increasingly caring for cohorts of patients who have minimal lung disease on diagnosis. With the introduction of mutation-specific therapies and the prospect of truly personalised medicine, patients have the potential to enjoy good quality of life in adulthood with ever-increasing life expectancy. The landmark Standards of Care published in 2005 set out what high quality CF care is and how it can be delivered throughout Europe. This underwent a fundamental re-write in 2014, resulting in three documents; center framework, quality management and best practice guidelines. This document is a revision of the latter, updating standards for best practice in key aspects of CF care, in the context of a fast-moving and dynamic field.
In continuing to give a broad overview of the standards expected for newborn screening, diagnosis, preventative treatment of lung disease, nutrition, complications, transplant/end of life care and psychological support, this consensus on best practice is expected to prove useful to clinical teams both in countries where CF care is developing and those with established CF centres. The document is an ECFS product and endorsed by the CF Network in ERN LUNG and CF Europe.
Medema, Marnix H. ; Kottmann, Renzo ; Yilmaz, Pelin ; Cummings, Matthew ; Biggins, John B. ; Kai, Blin ; de Bruijn, Irene ; Chooi, Yit Heng ; Claesen, Jan ; Coates, R. Cameron ; Cruz-Morales, Pablo ; Duddela, Srikanth ; Düsterhus, Stephanie ; Edwards, Daniel J. ; Fewer, David P. ; Garg, Neha ; Geiger, Christoph ; Gomez-Escribano, Juan Pablo ; Greule, Anja ; Hadjithomas, Michalis ; Haines, Anthony S. ; Helfrich, Eric J. N. ; Hillwig, Matthew L. ; Ishida, Keishi ; Jones, Adam C. ; Jones, Carla S. ; Jungmann, Katrin ; Kegler, Carsten ; Kim, Hyun Uk ; Kötter, Peter ; Krug, Daniel ; Masschelein, Joleen ; Melnik, Alexey V. ; Mantovan, Simone M. ; Monroe, Emily A. ; Moore, Marcus ; Moss, Nathan ; Nützmann, Hans-Wilhelm ; Pan, Guohui ; Pati, Amrita ; Petras, Daniel ; Reen, F. Jerry ; Rosconi, Federico ; Rui, Zhe ; Tian, Zhenhua ; Tobias, Nicholas J. ; Tsunematsu, Yuta ; Wiemann, Philipp ; Wyckoff, Elizabeth ; Yan, Xiaohui ; Yim, Grace ; Yu, Fengan ; Xie, Yunchang ; Aigle, Bertrand ; Apel, Alexander K. ; Balibar, Carl J. ; Balskus, Emily P. ; Barona-Gómez, Francisco ; Bechthold, Andreas ; Bode, Helge Björn ; Borriss, Rainer ; Brady, Sean F. ; Brakhage, Axel A. ; Caffrey, Patrick ; Cheng, Yi-Qiang ; Clardy, Jon ; Cox, Russell J. ; De Mot, René ; Donadio, Stefano ; Donia, Mohamed S. ; van der Donk, Wilfred A. ; Dorrestein, Pieter C. ; Doyle, Sean ; Driessen, Arnold J. M. ; Ehling-Schulz, Monika ; Entian, Karl-Dieter ; Fischbach, Michael A. ; Gerwick, Lena ; Gerwick, William H. ; Gross, Harald ; Gust, Bertolt ; Hertweck, Christian ; Höfte, Monica ; Jensen, Susan E. ; Ju, Jianhua ; Katz, Leonard ; Kaysser, Leonard ; Klassen, Jonathan L. ; Keller, Nancy P. ; Kormanec, Jan ; Kuipers, Oscar P. ; Kuzuyama, Tomohisa ; Kyrpides, Nikos C. ; Kwon, Hyung-Jin ; Lautru, Sylvie ; Lavigne, Rob ; Lee, Chia Y. ; Linquan, Bai ; Liu, Xinyu ; Liu, Wen ; Luzhetskyy, Andriy ; Mahmud, Taifo ; Mast, Yvonne ; Méndez, Carmen ; Metsä-Ketelä, Mikko ; Micklefield, Jason ; Mitchell, Douglas A. ; Moore, Bradley S. ; Moreira, Leonilde M. ; Müller, Rolf ; Neilan, Brett A. ; Nett, Markus ; Nielsen, Jens ; O’Gara, Fergal ; Oikawa, Hideaki ; Osbourn, Anne ; Osburne, Marcia S. ; Ostash, Bohdan ; Payne, Shelley M. ; Pernodet, Jean-Luc ; Petricek, Miroslav ; Piel, Jörn ; Ploux, Olivier ; Raaijmakers, Jos M. ; Salas, José A. ; Schmitt, Esther K. ; Scott, Barry ; Seipke, Ryan F. ; Shen, Ben ; Sherman, David H. ; Sivonen, Kaarina ; Smanski, Michael J. ; Sosio, Margherita ; Stegmann, Evi ; Süssmuth, Roderich D. ; Tahlan, Kapil ; Thomas, Christopher M. ; Tang, Yi ; Truman, Andrew W. ; Viaud, Muriel ; Walton, Jonathan D. ; Walsh, Christopher T. ; Weber, Tilmann ; van Wezel, Gilles P. ; Wilkinson, Barrie ; Willey, Joanne M. ; Wohlleben, Wolfgang ; Wright, Gerard D. ; Ziemert, Nadine ; Zhang, Changsheng ; Zotchev, Sergey B. ; Breitling, Rainer ; Takano, Eriko ; Glöckner, Frank Oliver
A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.
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