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The Coulomb Dissociation (CD) cross sections of the stable isotopes 92,94,100Mo and of the unstable isotope 93Mo were measured at the LAND/R3B setup at GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. Experimental data on these isotopes may help to explain the problem of the underproduction of 92,94Mo and 96,98Ru in the models of p-process nucleosynthesis. The CD cross sections obtained for the stable Mo isotopes are in good agreement with experiments performed with real photons, thus validating the method of Coulomb Dissociation. The result for the reaction 93Mo(γ,n) is especially important since the corresponding cross section has not been measured before. A preliminary integral Coulomb Dissociation cross section of the 94Mo(γ,n) reaction is presented. Further analysis will complete the experimental database for the (γ,n) production chain of the p-isotopes of molybdenum.
Einleitung
(2010)
Die hier vorgelegte Anthologie verdankt ihre Entstehung einer in 2008/09 am Deutschen Forum für Kunstgeschichte in Paris geführten Diskussion. Das Forum stellt sein Stipendienprogramm und dessen begleitende Veranstaltungen stets unter ein Jahresthema, das dieses Mal, unter gemeinsamer Federführung von Danièle Cohn und dem, der hier schreibt, der Frage nach dem Verhältnis von Kunstgeschichte und Kunstphilosophie nachging und das deren Abgrenzungen und Synergien in historischer Perspektive wie zeitgenössischer Praxis gleichermaßen untersuchte. In regelmäßigen, von der wissenschaftlichen Koordinatorin des Jahresthemas, Tanja Vladova, geleiteten "Ateliers de lecture" haben die Jahresstipendiaten, die sich aus beiden Fächern ebenso wie aus beiden Sprachen rekrutierten, Texte gelesen und erörtert, die das Generalthema zentral verhandeln und so in die gemeinsame Diskussion gefunden. Es war die überaus reiche und anregende Erfahrung dieses Lesezirkels, aus der die Idee geboren wurde, kapitale, in einer entscheidenden Phase der Debatte entstandene Aufsätze zu dieser Themenstellung, die die deutschsprachige nicht weniger als die französische Wissenschaft vital und nachhaltig beschäftigt hat, zusammenzustellen und in der jeweils anderen Sprache zu edieren. ...
Neutron total cross sections are an important source of experimental data in the evaluation of neutron-induced cross sections. The sum of all neutron-induced reaction cross sections can be determined with a precision of a few per cent in a relative measurement. The neutron spectrum of the photoneutron source nELBE extends in the fast region from about 100 keV to 10 MeV and has favourable conditions for transmission measurements due to the low instantaneous flux of neutrons and low gamma-flash background. Several materials of interest (in part included in the CIELO evaluation or on the HPRL of OECD/NEA) have been investigated: 197Au [1, 2], natFe [2], natW [2], 238U, natPt, 4He, natO, natNe, natXe. For gaseous targets high pressure gas cells with flat end-caps have been built that hold up to 200 bar pressure. The experimental setup will be presented including results from several transmission experiments and the data analysis leading to the total cross sections will be discussed.
Sigrid Weigel ist 2016 mit dem Aby Warburg-Preis der Stadt Hamburg ausgezeichnet worden. Die Reden von Andreas Beyer und Sigrid Weigel wurden am 21. November 2016 im Rahmen der Preisverleihung im Großen Festsaal des Hamburger Rathauses gehalten. Peter Geimer hielt seinen Vortrag zu Ehren von Sigrid Weigel am 13. Dezember 2016 im ZfL in Berlin.
Natural products (NPs) from microorganisms have been important sources for discovering new therapeutic and chemical entities. While their corresponding biosynthetic gene clusters (BGCs) can be easily identified by gene-sequence-similarity-based bioinformatics strategies, the actual access to these NPs for structure elucidation and bioactivity testing remains difficult. Deletion of the gene encoding the RNA chaperone, Hfq, results in strains losing the production of most NPs. By exchanging the native promoter of a desired BGC against an inducible promoter in Δhfq mutants, almost exclusive production of the corresponding NP from the targeted BGC in Photorhabdus, Xenorhabdus and Pseudomonas was observed including the production of several new NPs derived from previously uncharacterized non-ribosomal peptide synthetases (NRPS). This easyPACId approach (easy Promoter Activated Compound Identification) facilitates NP identification due to low interference from other NPs. Moreover, it allows direct bioactivity testing of supernatants containing secreted NPs, without laborious purification.
Introduction
(2010)
La présente anthologie est née d’une discussion qui a été soulevée en 2008/2009 au Centre Allemand d’Histoire de l’Art à Paris. Le Centre établit son programme de bourses, ainsi que celui des conférences et colloques qui ont lieu parallèlement, en fonction d’un thème annuel. Mené par Danièle Cohn et moi-même, le projet de cette année visait à étudier les rapports entre histoire de l’art et histoire de la philosophie, tout en interrogeant, autant d’un point de vue historique que de celui de la pratique contemporaine, les lignes de démarcations ainsi que les synergies qui s’opèrent entre ces deux champs disciplinaires. Lors des « ateliers de lecture » dirigés par la coordinatrice scientifique du thème annuel, Tania Vladova, les étudiants boursiers, francophones et germanophones issus des deux disciplines, ont procédé à la lecture et à l’interprétation de textes qui ont trait à cette thématique centrale. Ils ont ainsi pu élaborer les bases d’une discussion commune, la richesse des expériences qu’ils ont faites dans ce cercle de lecture ayant stimulé la réflexion. C’est ainsi qu’a germé l’idée d’une publication rassemblant des essais écrits durant une phase de discussions décisive et respectivement traduits dans « l’autre langue ». Ces essais revêtent une importance majeure au vu de la problématique traitée, d’autant que celle-ci a durablement marqué la recherche scientifique allemande, aussi bien que la recherche française. ...
Der Name Aby Warburgs steht für eine kulturwissenschaftlich ausgerichtete Kunstgeschichte, mehr noch aber für eine heute weltweit operierende Denkschule, die sich vielen Fachrichtungen öffnet und die in wechselwirksamer Begegnung und Teilhabe ein Instrumentarium entwickelt, das die Herausforderungen unserer Zeit in Kunst, Kultur und Gesellschaft besonders wirksam zu bewältigen verspricht. Denn Kulturwissenschaft, das muss man der so sehr von den Life Sciences beseelten Politik immer wieder in Erinnerung rufen, Kulturwissenschaft ist die eigentliche Lebenswissenschaft.
In this paper we develop empirical measures for the strength of spillover effects. Modifying and extending the framework by Diebold and Yilmaz (2011), we quantify spillovers between sovereign credit markets and banks in the euro area. Spillovers are estimated recursively from a vector autoregressive model of daily CDS spread changes, with exogenous common factors. We account for interdependencies between sovereign and bank CDS spreads and we derive generalised impulse response functions. Specifically, we assess the systemic effect of an unexpected shock to the creditworthiness of a particular sovereign or country-specific bank index to other sovereign or bank CDSs between October 2009 and July 2012. Channels of transmission from or to sovereigns and banks are aggregated as a Contagion index (CI). This index is disentangled into four components, the average potential spillover: i) amongst sovereigns, ii) amongst banks, iii) from sovereigns to banks, and iv) vice-versa. We highlight the impact of policy-related events along the different components of the contagion index. The systemic contribution of each sovereign or banking group is quantified as the net spillover weight in the total net-spillover measure. Finally, the captured time-varying interdependence between banks and sovereigns emphasises the evolution of their strong nexus.
Opting out of the great inflation: German monetary policy after the break down of Bretton Woods
(2009)
During the turbulent 1970s and 1980s the Bundesbank established an outstanding reputation in the world of central banking. Germany achieved a high degree of domestic stability and provided safe haven for investors in times of turmoil in the international financial system. Eventually the Bundesbank provided the role model for the European Central Bank. Hence, we examine an episode of lasting importance in European monetary history. The purpose of this paper is to highlight how the Bundesbank monetary policy strategy contributed to this success. We analyze the strategy as it was conceived, communicated and refined by the Bundesbank itself. We propose a theoretical framework (following Söderström, 2005) where monetary targeting is interpreted, first and foremost, as a commitment device. In our setting, a monetary target helps anchoring inflation and inflation expectations. We derive an interest rate rule and show empirically that it approximates the way the Bundesbank conducted monetary policy over the period 1975-1998. We compare the Bundesbank´s monetary policy rule with those of the FED and of the Bank of England. We find that the Bundesbank´s policy reaction function was characterized by strong persistence of policy rates as well as a strong response to deviations of inflation from target and to the activity growth gap. In contrast, the response to the level of the output gap was not significant. In our empirical analysis we use real-time data, as available to policy-makers at the time. JEL Classification: E31, E32, E41, E52, E58
Extending the data set used in Beyer (2009) to 2017, we estimate I(1) and I(2) money demand models for euro area M3. After including two broken trends and a few dummies to account for shifts in the variables following the global financial crisis and the ECB's non-standard monetary policy measures, we find that the money demand and the real wealth relations identified in Beyer (2009) have remained remarkably stable throughout the extended sample period. Testing for price homogeneity in the I(2) model we find that the nominal-to-real transformation is not rejected for the money relation whereas the wealth relation cannot be expressed in real terms.
Therapy of acute myeloid leukemia (AML) is unsatisfactory. Histone deacetylase inhibitors (HDACi) are active against leukemic cells in vitro and in vivo. Clinical data suggest further testing of such epigenetic drugs and to identify mechanisms and markers for their efficacy. Primary and permanent AML cells were screened for viability, replication stress/DNA damage, and regrowth capacities after single exposures to the clinically used pan-HDACi panobinostat (LBH589), the class I HDACi entinostat/romidepsin (MS-275/FK228), the HDAC3 inhibitor RGFP966, the HDAC6 inhibitor marbostat-100, the non-steroidal anti-inflammatory drug (NSAID) indomethacin, and the replication stress inducer hydroxyurea (HU). Immunoblotting was used to test if HDACi modulate the leukemia-associated transcription factors β-catenin, Wilms tumor (WT1), and myelocytomatosis oncogene (MYC). RNAi was used to delineate how these factors interact. We show that LBH589, MS-275, FK228, RGFP966, and HU induce apoptosis, replication stress/DNA damage, and apoptotic fragmentation of β-catenin. Indomethacin destabilizes β-catenin and potentiates anti-proliferative effects of HDACi. HDACi attenuate WT1 and MYC caspase-dependently and -independently. Genetic experiments reveal a cross-regulation between MYC and WT1 and a regulation of β-catenin by WT1. In conclusion, reduced levels of β-catenin, MYC, and WT1 are molecular markers for the efficacy of HDACi. HDAC3 inhibition induces apoptosis and disrupts tumor-associated protein expression.