Refine
Author
- Boomsma, Dorret I. (2)
- Duijn, Cornelia M. van (2)
- Jarvelin, Marjo-Riitta (2)
- Kaprio, Jaakko (2)
- Lehtimäki, Terho (2)
- Medland, Sarah E. (2)
- Pedersen, Nancy L. (2)
- Raitakari, Olli (2)
- Snieder, Harold (2)
- Uitterlinden, André G. (2)
- Abecasis, Gonçalo R. (1)
- Absher, Devin (1)
- Adams, Mark J. (1)
- Albrecht, Eva (1)
- Alemany, Silvia (1)
- Amin, Najaf (1)
- Anderson, Denise (1)
- Andreassen, Ole A. (1)
- Arindrarto, Wibowo (1)
- Arseneault, Louise (1)
- Arveiler, Dominique (1)
- Assimes, Themistocles L. (1)
- Atalay, Mustafa (1)
- Attwood, Antony Paul (1)
- Bakermans-Kranenburg, Marian J. (1)
- Bakker, Stephan J. L. (1)
- Barlassina, Cristina (1)
- Barroso, Inês (1)
- Bartels, Meike (1)
- Basart, Hanneke (1)
- Baselmans, Bart M. L. (1)
- Bauer, Sabrina (1)
- Beckmann, Jacques S. (1)
- Beekman, Marian (1)
- Beilby, John P. (1)
- Berg, Leonard H. van den (1)
- Beijsterveldt, Catharina Eugenie Maria van (1)
- Binder, Elisabeth (1)
- Boehnke, Michael (1)
- Bolton, Jennifer L. (1)
- Bonder, Marc Jan (1)
- Bonnefond, Amélie (1)
- Bonnycastle, Lori L. (1)
- Boomsma, Dorret (1)
- Borecki, Ingrid B. (1)
- Bornstein, Stefan R. (1)
- Bot, Jan (1)
- Boucher, Gabrielle (1)
- Breggen, Ruud van der (1)
- Buechler, Christa (1)
- Burwell, Scott J. (1)
- Böhm, Bernhard O. (1)
- Campbell, Archie (1)
- Campbell, Harry (1)
- Caspi, Avshalom (1)
- Caulfield, Mark J. (1)
- Cesana, Giancarlo (1)
- Chanock, Stephen J. (1)
- Chasman, Daniel I. (1)
- Chen, Yii-Der Ida (1)
- Chines, Peter S. (1)
- Chorlian, David B. (1)
- Clegg, Deborah J. (1)
- Colins, Olivier F. (1)
- Collins, Francis S. (1)
- Corcoran, David L. (1)
- Corpeleijn, Eva (1)
- Croteau-Chonka, Damien C. (1)
- Cupples, L. Adrienne (1)
- Czamara, Darina (1)
- Davies, Gareth E. (1)
- Day, Felix R. (1)
- Dedoussis, George (1)
- Deelen, Joris (1)
- Deelen, Patrick (1)
- Dellen, Edwin van (1)
- Deloukas, Panos (1)
- Dermitzakis, Emmanouil T. (1)
- Deuschle, Michael (1)
- Dijk, Freerk van (1)
- Dimas, Antigone S. (1)
- Dimitriou, Maria (1)
- Dongen, Jenny van (1)
- Edkins, Sarah (1)
- Eisinger, Kristina (1)
- Eklund, Niina (1)
- Elvsåshagen, Torbjørn (1)
- Erbel, Raimund (1)
- Erdmann, Jeanette (1)
- Eriksson, Johan G. (1)
- Escaramis, Georgia (1)
- Esko, Tõnu (1)
- Estrada, Karol (1)
- Evandt, Jorunn (1)
- Evans, Kathryn L. (1)
- Faire, Ulf de (1)
- Fall, Tove (1)
- Farrall, Martin (1)
- Feitosa, Mary F. (1)
- Felix, Janine F. (1)
- Fernández-Rivas, Aranzazu (1)
- Ferreira, Teresa (1)
- Fischer, Krista (1)
- Fowkes, Gerry (1)
- Fox, Caroline S. (1)
- Frank, Josef (1)
- Franke, Barbara (1)
- Franke, Lude (1)
- Franks, Paul W. (1)
- Fraser, Ross M. (1)
- Frayling, Timothy (1)
- Freitag, Christine M. (1)
- Froguel, Philippe (1)
- Galen, Michiel van (1)
- Ganna, Andrea (1)
- Geburtig-Chiocchetti, Andreas (1)
- Gejman, Pablo V. (1)
- Geus, Eco J. C. de (1)
- Gieger, Christian (1)
- Gigante, Bruna (1)
- Goel, Anuj (1)
- González Ruiz, Juan Ramon (1)
- Gordon, Reyna L. (1)
- Grallert, Harald (1)
- Grazuleviciene, Regina (1)
- Greevenbroek, Marleen M. J. van (1)
- Groop, Leif C. (1)
- Grönberg, Henrik (1)
- Gustafsson, Stefan (1)
- Gutzkow, Kristine B. (1)
- Gyllensten, Ulf (1)
- Hafferty, Jonathan D. (1)
- Hagenbeek, Fiona A. (1)
- Hakulinen, Christian (1)
- Hall, Alistair S. (1)
- Hall, Per (1)
- Hallmans, Göran (1)
- Hamsten, Anders (1)
- Hannon, Eilis (1)
- Haritunians, Talin (1)
- Harper, Jeremy (1)
- Harris, Tamara B. (1)
- Harst, Pim van der (1)
- Hartikainen, Anna-Liisa (1)
- Hayward, Caroline (1)
- Heard-Costa, Nancy L. (1)
- Heemst, Diana van (1)
- Hegerl, Ulrich (1)
- Heid, Iris M. (1)
- Heijer, Martin den (1)
- Heijmans, Bastiaan Theodoor (1)
- Hengstenberg, Christian (1)
- Hensch, Tilman (1)
- Hervás, Amaia (1)
- Hicks, Andrew A. (1)
- Hingorani, Aroon (1)
- Hirschhorn, Joel N. (1)
- Hoen, Peter A. C. 't (1)
- Hoen, Peter-Bram ’t (1)
- Hof, Peter van ’t (1)
- Hofman, Albert (1)
- Hofman, Bert A. (1)
- Hottenga, Jouke J. (1)
- Hottenga, Jouke-Jan (1)
- Hovingh, Kees G. (1)
- Hui, Jennie (1)
- Huikuri, Heikki (1)
- Humphries, Steve E. (1)
- Hung, Joseph (1)
- Hunter, David (1)
- Hveem, Kristian (1)
- Hyppönen, Elina (1)
- Hägg, Sara (1)
- I. Berndt, Sonja (1)
- IJzendoorn, Marinus H. van (1)
- Iacono, William G. (1)
- Illig, Thomas (1)
- Ingelsson, Erik (1)
- Ip, Hill F. (1)
- Iribarren, Carlos (1)
- Isaacs, Aaron (1)
- Ismail, Khadeeja (1)
- Iterson, Maarten van (1)
- Jackson, Anne U. (1)
- Jacobs, Kevin B. (1)
- Jansen, Rick (1)
- Jawinski, Philippe (1)
- Jhamai, P. Mila (1)
- Johansson, Åsa (1)
- Johnson, Toby (1)
- Jolley, Jennifer (1)
- Jula, Antti (1)
- Jylhävä, Juulia (1)
- Jönsson, Erik G. (1)
- Kallen, Carla J. H. van der (1)
- Kanoni, Stavroula (1)
- Kaplan, Robert (1)
- Karpe, Fredrik (1)
- Kathiresan, Sekar (1)
- Keinanen-Kiukaanniemi, Sirkka M. (1)
- Keltikangas-Järvinen, Liisa (1)
- Khaw, Kay-Tee (1)
- Kielbasa, Szymon M. (1)
- Kiemeney, Lambertus Adrianus (1)
- Kilpeläinen, Tuomas O. (1)
- Kivimaki, Mika (1)
- Klauw, Melanie M. van der (1)
- Kleber, Marcus E. (1)
- Klein, Marieke (1)
- Kluft, Cornelis (1)
- Koenig, Wolfgang (1)
- Kolovou, Genovefa (1)
- Konrad, Kerstin (1)
- Korhonen, Tellervo (1)
- Kovacs, Peter (1)
- Kraja, Aldi T. (1)
- Kristiansson, Kati (1)
- Krjutškov, Kaarel (1)
- Krohn, Jon P. (1)
- Kuh, Diana (1)
- Kumari, Meena (1)
- Kutalik, Zoltán (1)
- Kuulasmaa, Kari (1)
- Kuusisto, Johanna (1)
- Küpers, Leanne K. (1)
- Laakso, Markku (1)
- Lahti, Jari (1)
- Lakenberg, Nico (1)
- Lakka, Timo A. (1)
- Lamina, Claudia (1)
- Langenberg, Claudia (1)
- Li, Guo (1)
- Li, Shengxu (1)
- Liang, Liming (1)
- Ligthart, Lannie (1)
- Lind, Lars (1)
- Lindgren, Cecilia M. (1)
- Lindström, Jaana (1)
- Locke, Adam E. (1)
- Lokki, Marja-Liisa (1)
- Loley, Christina (1)
- Loos, Ruth J. F. (1)
- Lorentzon, Mattias (1)
- Lowry, Estelle (1)
- Luan, Jian'an (1)
- Luijk, René (1)
- Luykx, Jurjen J. (1)
- Magne, Cyrille L. (1)
- Magnusson, Patrik K. E. (1)
- Malone, Stephen M. (1)
- Mangino, Massimo (1)
- Martin, Nicholas Gordon (1)
- Maschio, Andrea (1)
- Mateo Leach, Irene (1)
- Mathieson, Iain (1)
- McArdle, Wendy L. (1)
- McCarthy, Mark I. (1)
- McIntosh, Andrew M. (1)
- Medina-Gomez, Carolina (1)
- Meer, Dennis van der (1)
- Mei, Hailiang (1)
- Meijer, Mandy (1)
- Metspalu, Andres (1)
- Meurs, Joyce Berdina Josepha van (1)
- Meyers, Jacquelyn L. (1)
- Mihailov, Evelin (1)
- Mill, Jonathan (1)
- Min, Josine L. (1)
- Mishra, Pashupati Prasad (1)
- Moberget, Torgeir (1)
- Moebus, Susanne (1)
- Moed, Matthijs (1)
- Moffitt, Terrie E. (1)
- Mohlke, Karen L. (1)
- Monda, Keri L. (1)
- Montgomery, Grant W. (1)
- Morris, Andrew David (1)
- Morris, Stewart W. (1)
- Mulder, Rosa H. (1)
- Munroe, Patricia B. (1)
- Mägi, Reedik (1)
- März, Winfried (1)
- Müller-Nurasyid, Martina (1)
- Narisu, Narisu (1)
- Navis, Gerjan (1)
- Nicholson, George (1)
- Njølstad, Inger (1)
- Nolte, Ilja M. (1)
- Nooren, Irene (1)
- North, Kari E. (1)
- Nöthen, Markus Maria (1)
- O'Connell, Jeffrey R. (1)
- Ohlsson, Claes (1)
- Ollikainen, Miina (1)
- Ong, Ken K. (1)
- Oostra, Ben A. (1)
- Palmer, Colin N. A. (1)
- Palmer, Lyle J. (1)
- Parmar, Priyanka (1)
- Pechlivanis, Sonali (1)
- Penninx, Brenda W. J. H. (1)
- Perola, Markus (1)
- Person, Thomas (1)
- Peters, Annette (1)
- Pool, René (1)
- Porjesz, Bernice (1)
- Poulton, Richie (1)
- Power, Chris (1)
- Pramstaller, Peter P. (1)
- Price, Jackie F. (1)
- Prokopenko, Inga (1)
- Province, Michael A. (1)
- Qi, Lu (1)
- Randall, Joshua C. (1)
- Rauramaa, Rainer (1)
- Rehnberg, Emil (1)
- Relton, Caroline (1)
- Ridker, Paul M. (1)
- Ripatti, Samuli (1)
- Rivadeneira, Fernando (1)
- Rivolta, Carlo (1)
- Roetman, Peter J. (1)
- Rooij, Jeroen van (1)
- Rose, Lynda M. (1)
- Rudan, Igor (1)
- Räikkönen, Katri (1)
- Saaristo, Timo E. (1)
- Sager, Hendrik (1)
- Salomaa, Veikko (1)
- Samani, Nilesh J. (1)
- Sambrook, Jennifer G. (1)
- Sander, Christian (1)
- Saramies, Jouko (1)
- Schalkwijk, Casper G. (1)
- Scherag, André (1)
- Schlessinger, David (1)
- Schunkert, Heribert (1)
- Schwarz, Peter E. H. (1)
- Sebert, Sylvain (1)
- Send, Tabea S. (1)
- Shi, Jianxin (1)
- Shuldiner, Alan R. (1)
- Shungin, Dmitry (1)
- Sinisalo, Juha (1)
- Sirignano, Lea (1)
- Sisodiya, Sanjay M. (1)
- Slagboom, P. Eline (1)
- Smit, Dirk J. A. (1)
- Smith, Albert Vernon (1)
- Spector, Tim D. (1)
- Speliotes, Elizabeth K. (1)
- Stefansson, Kari (1)
- Stehouwer, Coen D. A. (1)
- Steinthorsdottir, Valgerdur (1)
- Stirrups, Kathleen (1)
- Strachan, David P. (1)
- Strandberg, Timo (1)
- Strawbridge, Rona J. (1)
- Streit, Fabian (1)
- Suchiman, H. Eka D. (1)
- Suderman, Matthew (1)
- Sugden, Karen (1)
- Sunyer, Jordi (1)
- Surakka, Ida (1)
- Swertz, Morris A. (1)
- Swift, Amy J. (1)
- Teder-Laving, Maris (1)
- Teumer, Alexander (1)
- Thompson, Paul M. (1)
- Thorand, Barbara (1)
- Thorleifsson, Gudmar (1)
- Thorsteinsdottir, Unnur (1)
- Tiemeier, Henning (1)
- Tigchelaar, Ettje F. (1)
- Tremoli, Elena (1)
- Tuomilehto, Jaakko (1)
- Tyrer, Jonathan (1)
- Tönjes, Anke (1)
- Uusitupa, Matti (1)
- Vafeiadi, Marina (1)
- Vedantam, Sailaja (1)
- Veldink, Jan H. (1)
- Verbiest, Michael (1)
- Verkerk, Marijn (1)
- Vermaat, Martijn (1)
- Vermeiren, Robert (1)
- Vetro, Agnes (1)
- Via, Marc (1)
- Virtamo, Jarmo (1)
- Vliet-Ostaptchouk, Jana V. van (1)
- Vrijheid, Martine (1)
- Vuoksimaa, Eero (1)
- Völzke, Henry (1)
- Waite, Lindsay L. (1)
- Walker, Rosie M. (1)
- Wang, Yunzhang (1)
- Wang, Zhaoming (1)
- Wareham, Nicholas J. (1)
- Wichmann, Heinz Erich (1)
- Wijmenga, Cisca (1)
- Wilsgaard, Tom (1)
- Wilson, James F. (1)
- Winkelmann, Bernhard R. (1)
- Winkler, Thomas W. (1)
- Witt, Stephanie H. (1)
- Wong, Andrew (1)
- Wood, Andrew R. (1)
- Workalemahu, Tsegaselassie (1)
- Wright, Margaret J. (1)
- Yang, Jian (1)
- Yarnell, John W. G. (1)
- Zhao, Jing Hua (1)
- Zhernakova, Dasha V. (1)
- Zhernakova, Sasha (1)
- Zillikens, M. Carola (1)
- Zwet, Erik. W. van (1)
Document Type
- Article (3)
Language
- English (3)
Has Fulltext
- yes (3)
Is part of the Bibliography
- no (3)
Keywords
- ENIGMA (1)
- Genetics (1)
- Molecular biology (1)
- brain disorders (1)
- electroencephalography (1)
- harmonization (1)
- imaging genetics (1)
- open science (1)
Institute
- Medizin (3)
Smit, Dirk J. A. ; Andreassen, Ole A. ; Boomsma, Dorret ; Burwell, Scott J. ; Chorlian, David B. ; Geus, Eco J. C. de ; Elvsåshagen, Torbjørn ; Gordon, Reyna L. ; Harper, Jeremy ; Hegerl, Ulrich ; Hensch, Tilman ; Iacono, William G. ; Jawinski, Philippe ; Jönsson, Erik G. ; Luykx, Jurjen J. ; Magne, Cyrille L. ; Malone, Stephen M. ; Medland, Sarah E. ; Meyers, Jacquelyn L. ; Moberget, Torgeir ; Porjesz, Bernice ; Sander, Christian ; Sisodiya, Sanjay M. ; Thompson, Paul M. ; Beijsterveldt, Catharina Eugenie Maria van ; Dellen, Edwin van ; Via, Marc ; Wright, Margaret J.
Background and purpose: The ENIGMA-EEG working group was established to enable large-scale international collaborations among cohorts that investigate the genetics of brain function measured with electroencephalography (EEG). In this perspective, we will discuss why analyzing the genetics of functional brain activity may be crucial for understanding how neurological and psychiatric liability genes affect the brain. Methods: We summarize how we have performed our currently largest genome-wide association study of oscillatory brain activity in EEG recordings by meta-analyzing the results across five participating cohorts, resulting in the first genome-wide significant hits for oscillatory brain function located in/near genes that were previously associated with psychiatric disorders. We describe how we have tackled methodological issues surrounding genetic meta-analysis of EEG features. We discuss the importance of harmonizing EEG signal processing, cleaning, and feature extraction. Finally, we explain our selection of EEG features currently being investigated, including the temporal dynamics of oscillations and the connectivity network based on synchronization of oscillations. Results: We present data that show how to perform systematic quality control and evaluate how choices in reference electrode and montage affect individual differences in EEG parameters. Conclusion: The long list of potential challenges to our large-scale meta-analytic approach requires extensive effort and organization between participating cohorts; however, our perspective shows that these challenges are surmountable. Our perspective argues that elucidating the genetic of EEG oscillatory activity is a worthwhile effort in order to elucidate the pathway from gene to disease liability.
Randall, Joshua C. ; Winkler, Thomas W. ; Kutalik, Zoltán ; I. Berndt, Sonja ; Jackson, Anne U. ; Monda, Keri L. ; Kilpeläinen, Tuomas O. ; Esko, Tõnu ; Mägi, Reedik ; Li, Shengxu ; Workalemahu, Tsegaselassie ; Feitosa, Mary F. ; Croteau-Chonka, Damien C. ; Day, Felix R. ; Fall, Tove ; Ferreira, Teresa ; Gustafsson, Stefan ; Locke, Adam E. ; Mathieson, Iain ; Scherag, André ; Vedantam, Sailaja ; Wood, Andrew R. ; Liang, Liming ; Steinthorsdottir, Valgerdur ; Thorleifsson, Gudmar ; Dermitzakis, Emmanouil T. ; Dimas, Antigone S. ; Karpe, Fredrik ; Min, Josine L. ; Nicholson, George ; Clegg, Deborah J. ; Person, Thomas ; Krohn, Jon P. ; Bauer, Sabrina ; Buechler, Christa ; Eisinger, Kristina ; Bonnefond, Amélie ; Froguel, Philippe ; Hottenga, Jouke-Jan ; Prokopenko, Inga ; Waite, Lindsay L. ; Harris, Tamara B. ; Smith, Albert Vernon ; Shuldiner, Alan R. ; McArdle, Wendy L. ; Caulfield, Mark J. ; Munroe, Patricia B. ; Grönberg, Henrik ; Chen, Yii-Der Ida ; Li, Guo ; Beckmann, Jacques S. ; Johnson, Toby ; Thorsteinsdottir, Unnur ; Teder-Laving, Maris ; Khaw, Kay-Tee ; Wareham, Nicholas J. ; Zhao, Jing Hua ; Amin, Najaf ; Oostra, Ben A. ; Kraja, Aldi T. ; Province, Michael A. ; Cupples, L. Adrienne ; Heard-Costa, Nancy L. ; Kaprio, Jaakko ; Ripatti, Samuli ; Surakka, Ida ; Collins, Francis S. ; Saramies, Jouko ; Tuomilehto, Jaakko ; Jula, Antti ; Salomaa, Veikko ; Erdmann, Jeanette ; Hengstenberg, Christian ; Loley, Christina ; Schunkert, Heribert ; Lamina, Claudia ; Wichmann, Heinz Erich ; Albrecht, Eva ; Gieger, Christian ; Hicks, Andrew A. ; Johansson, Åsa ; Pramstaller, Peter P. ; Kathiresan, Sekar ; Speliotes, Elizabeth K. ; Penninx, Brenda W. J. H. ; Hartikainen, Anna-Liisa ; Jarvelin, Marjo-Riitta ; Gyllensten, Ulf ; Boomsma, Dorret I. ; Campbell, Harry ; Wilson, James F. ; Chanock, Stephen J. ; Farrall, Martin ; Goel, Anuj ; Medina-Gomez, Carolina ; Rivadeneira, Fernando ; Estrada, Karol ; Uitterlinden, André G. ; Hofman, Albert ; Zillikens, M. Carola ; Heijer, Martin den ; Kiemeney, Lambertus Adrianus ; Maschio, Andrea ; Hall, Per ; Tyrer, Jonathan ; Teumer, Alexander ; Völzke, Henry ; Kovacs, Peter ; Tönjes, Anke ; Mangino, Massimo ; Spector, Tim D. ; Hayward, Caroline ; Rudan, Igor ; Hall, Alistair S. ; Samani, Nilesh J. ; Attwood, Antony Paul ; Sambrook, Jennifer G. ; Hung, Joseph ; Palmer, Lyle J. ; Lokki, Marja-Liisa ; Sinisalo, Juha ; Boucher, Gabrielle ; Huikuri, Heikki ; Lorentzon, Mattias ; Ohlsson, Claes ; Eklund, Niina ; Eriksson, Johan G. ; Barlassina, Cristina ; Rivolta, Carlo ; Nolte, Ilja M. ; Snieder, Harold ; Klauw, Melanie M. van der ; Vliet-Ostaptchouk, Jana V. van ; Gejman, Pablo V. ; Shi, Jianxin ; Jacobs, Kevin B. ; Wang, Zhaoming ; Bakker, Stephan J. L. ; Mateo Leach, Irene ; Navis, Gerjan ; Harst, Pim van der ; Martin, Nicholas Gordon ; Medland, Sarah E. ; Montgomery, Grant W. ; Yang, Jian ; Chasman, Daniel I. ; Ridker, Paul M. ; Rose, Lynda M. ; Lehtimäki, Terho ; Raitakari, Olli ; Absher, Devin ; Iribarren, Carlos ; Basart, Hanneke ; Hovingh, Kees G. ; Hyppönen, Elina ; Power, Chris ; Power, Chris ; Anderson, Denise ; Beilby, John P. ; Hui, Jennie ; Jolley, Jennifer ; Sager, Hendrik ; Bornstein, Stefan R. ; Schwarz, Peter E. H. ; Kristiansson, Kati ; Perola, Markus ; Lindström, Jaana ; Swift, Amy J. ; Uusitupa, Matti ; Atalay, Mustafa ; Lakka, Timo A. ; Rauramaa, Rainer ; Bolton, Jennifer L. ; Fowkes, Gerry ; Fraser, Ross M. ; Price, Jackie F. ; Fischer, Krista ; KrjutÅ¡kov, Kaarel ; Metspalu, Andres ; Mihailov, Evelin ; Langenberg, Claudia ; Luan, Jian'an ; Ong, Ken K. ; Chines, Peter S. ; Keinanen-Kiukaanniemi, Sirkka M. ; Saaristo, Timo E. ; Edkins, Sarah ; Franks, Paul W. ; Hallmans, Göran ; Shungin, Dmitry ; Morris, Andrew David ; Palmer, Colin N. A. ; Erbel, Raimund ; Moebus, Susanne ; Nöthen, Markus Maria ; Pechlivanis, Sonali ; Hveem, Kristian ; Narisu, Narisu ; Hamsten, Anders ; Humphries, Steve E. ; Strawbridge, Rona J. ; Tremoli, Elena ; Grallert, Harald ; Thorand, Barbara ; Illig, Thomas ; Koenig, Wolfgang ; Müller-Nurasyid, Martina ; Peters, Annette ; Böhm, Bernhard O. ; Kleber, Marcus E. ; März, Winfried ; Winkelmann, Bernhard R. ; Kuusisto, Johanna ; Laakso, Markku ; Arveiler, Dominique ; Cesana, Giancarlo ; Kuulasmaa, Kari ; Virtamo, Jarmo ; Yarnell, John W. G. ; Kuh, Diana ; Wong, Andrew ; Lind, Lars ; Faire, Ulf de ; Gigante, Bruna ; Magnusson, Patrik K. E. ; Pedersen, Nancy L. ; Dedoussis, George ; Dimitriou, Maria ; Kolovou, Genovefa ; Kanoni, Stavroula ; Stirrups, Kathleen ; Bonnycastle, Lori L. ; Njølstad, Inger ; Wilsgaard, Tom ; Ganna, Andrea ; Rehnberg, Emil ; Hingorani, Aroon ; Kivimaki, Mika ; Kumari, Meena ; Assimes, Themistocles L. ; Barroso, Inês ; Boehnke, Michael ; Borecki, Ingrid B. ; Deloukas, Panos ; Fox, Caroline S. ; Frayling, Timothy ; Groop, Leif C. ; Haritunians, Talin ; Hunter, David ; Ingelsson, Erik ; Kaplan, Robert ; Mohlke, Karen L. ; North, Kari E. ; Lindgren, Cecilia M. ; Qi, Lu ; Loos, Ruth J. F. ; Heid, Iris M. ; Hirschhorn, Joel N. ; McCarthy, Mark I. ; Abecasis, Gonçalo R. ; Stefansson, Kari ; Strachan, David P. ; Schlessinger, David ; O'Connell, Jeffrey R. ; Duijn, Cornelia M. van
Men and women differ substantially regarding height, weight, and body fat. Interestingly, previous work detecting genetic effects for waist-to-hip ratio, to assess body fat distribution, has found that many of these showed sex-differences. However, systematic searches for sex-differences in genetic effects have not yet been conducted. Therefore, we undertook a genome-wide search for sexually dimorphic genetic effects for anthropometric traits including 133,723 individuals in a large meta-analysis and followed promising variants in further 137,052 individuals, including a total of 94 studies. We identified seven loci with significant sex-difference including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were significant in women, but not in men. Of interest is that sex-difference was only observed for waist phenotypes, but not for height or body-mass-index. We found no evidence for sex-differences with opposite effect direction for men and women. The PPARG locus is of specific interest due to its link to diabetes genetics and therapy. Our findings demonstrate the importance of investigating sex differences, which may lead to a better understanding of disease mechanisms with a potential relevance to treatment options.
Dongen, Jenny van ; Hagenbeek, Fiona A. ; Suderman, Matthew ; Roetman, Peter J. ; Sugden, Karen ; Geburtig-Chiocchetti, Andreas ; Ismail, Khadeeja ; Mulder, Rosa H. ; Hafferty, Jonathan D. ; Adams, Mark J. ; Walker, Rosie M. ; Morris, Stewart W. ; Lahti, Jari ; Küpers, Leanne K. ; Escaramis, Georgia ; Alemany, Silvia ; Bonder, Marc Jan ; Meijer, Mandy ; Ip, Hill F. ; Jansen, Rick ; Baselmans, Bart M. L. ; Parmar, Priyanka ; Lowry, Estelle ; Streit, Fabian ; Sirignano, Lea ; Send, Tabea S. ; Frank, Josef ; Jylhävä, Juulia ; Wang, Yunzhang ; Mishra, Pashupati Prasad ; Colins, Olivier F. ; Corcoran, David L. ; Poulton, Richie ; Mill, Jonathan ; Hannon, Eilis ; Arseneault, Louise ; Korhonen, Tellervo ; Vuoksimaa, Eero ; Felix, Janine F. ; Bakermans-Kranenburg, Marian J. ; Campbell, Archie ; Czamara, Darina ; Binder, Elisabeth ; Corpeleijn, Eva ; González Ruiz, Juan Ramon ; Grazuleviciene, Regina ; Gutzkow, Kristine B. ; Evandt, Jorunn ; Vafeiadi, Marina ; Klein, Marieke ; Meer, Dennis van der ; Ligthart, Lannie ; Heijmans, Bastiaan Theodoor ; Hoen, Peter A. C. 't ; Meurs, Joyce Berdina Josepha van ; Franke, Lude ; Boomsma, Dorret I. ; Pool, René ; Hottenga, Jouke J. ; Greevenbroek, Marleen M. J. van ; Stehouwer, Coen D. A. ; Kallen, Carla J. H. van der ; Schalkwijk, Casper G. ; Wijmenga, Cisca ; Zhernakova, Sasha ; Tigchelaar, Ettje F. ; Slagboom, P. Eline ; Beekman, Marian ; Deelen, Joris ; Heemst, Diana van ; Veldink, Jan H. ; Berg, Leonard H. van den ; Duijn, Cornelia M. van ; Hofman, Bert A. ; Isaacs, Aaron ; Uitterlinden, André G. ; Jhamai, P. Mila ; Verbiest, Michael ; Suchiman, H. Eka D. ; Verkerk, Marijn ; Breggen, Ruud van der ; Rooij, Jeroen van ; Lakenberg, Nico ; Mei, Hailiang ; Iterson, Maarten van ; Galen, Michiel van ; Bot, Jan ; Zhernakova, Dasha V. ; Hof, Peter van ’t ; Deelen, Patrick ; Nooren, Irene ; Moed, Matthijs ; Vermaat, Martijn ; Luijk, René ; Dijk, Freerk van ; Arindrarto, Wibowo ; Kielbasa, Szymon M. ; Swertz, Morris A. ; Zwet, Erik. W. van ; Hoen, Peter-Bram ’t ; Kluft, Cornelis ; Davies, Gareth E. ; Hakulinen, Christian ; Keltikangas-Järvinen, Liisa ; Franke, Barbara ; Freitag, Christine M. ; Konrad, Kerstin ; Hervás, Amaia ; Fernández-Rivas, Aranzazu ; Vetro, Agnes ; Raitakari, Olli ; Lehtimäki, Terho ; Vermeiren, Robert ; Strandberg, Timo ; Räikkönen, Katri ; Snieder, Harold ; Witt, Stephanie H. ; Deuschle, Michael ; Pedersen, Nancy L. ; Hägg, Sara ; Sunyer, Jordi ; Kaprio, Jaakko ; Ollikainen, Miina ; Moffitt, Terrie E. ; Tiemeier, Henning ; IJzendoorn, Marinus H. van ; Relton, Caroline ; Vrijheid, Martine ; Sebert, Sylvain ; Jarvelin, Marjo-Riitta ; Caspi, Avshalom ; Evans, Kathryn L. ; McIntosh, Andrew M. ; Bartels, Meike
DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of epigenome-wide association studies (EWAS) of aggressive behavior (N = 15,324 participants). In peripheral blood samples of 14,434 participants from 18 cohorts with mean ages ranging from 7 to 68 years, 13 methylation sites were significantly associated with aggression (alpha = 1.2 × 10−7; Bonferroni correction). In cord blood samples of 2425 children from five cohorts with aggression assessed at mean ages ranging from 4 to 7 years, 83% of these sites showed the same direction of association with childhood aggression (r = 0.74, p = 0.006) but no epigenome-wide significant sites were found. Top-sites (48 at a false discovery rate of 5% in the peripheral blood meta-analysis or in a combined meta-analysis of peripheral blood and cord blood) have been associated with chemical exposures, smoking, cognition, metabolic traits, and genetic variation (mQTLs). Three genes whose expression levels were associated with top-sites were previously linked to schizophrenia and general risk tolerance. At six CpGs, DNA methylation variation in blood mirrors variation in the brain. On average 44% (range = 3–82%) of the aggression–methylation association was explained by current and former smoking and BMI. These findings point at loci that are sensitive to chemical exposures with potential implications for neuronal functions. We hope these results to be a starting point for studies leading to applications as peripheral biomarkers and to reveal causal relationships with aggression and related traits.
- 1 to 3