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Postoperative complications after pancreatic surgery are still a significant problem in clinical practice. The aim of this study was to characterize and compare the microbiomes of different body compartments (bile duct, duodenal mucosa, pancreatic tumor lesion, postoperative drainage fluid, and stool samples; preoperative and postoperative) in patients undergoing pancreatic surgery for suspected pancreatic cancer, and their association with relevant clinical factors (stent placement, pancreatic fistula, and gland texture). For this, solid (duodenal mucosa, pancreatic tumor tissue, stool) and liquid (bile, drainage fluid) biopsy samples of 10 patients were analyzed using 16s rRNA gene next-generation sequencing. Our analysis revealed: (i) a distinct microbiome in the different compartments, (ii) markedly higher abundance of Enterococcus in patients undergoing preoperative stent placement in the common bile duct, (iii) significant differences in the beta diversity between patients who developed a postoperative pancreatic fistula (POPF B/C), (iv) patients with POPF B/C were more likely to have bacteria belonging to the genus Enterococcus, and (v) differences in microbiome composition with regard to the pancreatic gland texture. The structure of the microbiome is distinctive in different compartments, and can be associated with the development of a postoperative pancreatic fistula.
Das Verbundprojekt SHUFFLE (Hochschulinitiative digitale Barrierefreiheit für Alle) widmet sich der digitalen Barrierefreiheit an Hochschulen. Der Schwerpunkt des Projekts liegt dabei auf der chancengerechten Teilhabe an digitaler Lehre
für Studierende mit individuellen Bedarfen. SHUFFLE folgt dem Konzept des Universal Design for Learning und entwickelt Maßnahmen für Online- und Hybridveranstaltungen in einem studierenden- und lehrendenzentrierten Ansatz. Diese werden pilotartig skaliert, technisch und didaktisch evaluiert und in einem Reifegradmodell zusammengefasst.