Refine
Author
- Buxbaum, Joseph D. (4)
- Gill, Michael (4)
- Haines, Jonathan L. (4)
- Hakonarson, Hakon (4)
- Pericak-Vance, Margaret Ann (4)
- Schellenberg, Gerard D. (4)
- Almeida, Joana (3)
- Anney, Richard (3)
- Bacchelli, Elena (3)
- Bailey, Anthony J. (3)
- Baird, Gillian (3)
- Battaglia, Agatino (3)
- Betancur, Catalina (3)
- Bolshakova, Nadia (3)
- Bolton, Patrick F. (3)
- Bourgeron, Thomas (3)
- Brennan, Sean (3)
- Cantor, Rita M. (3)
- Cook, Edwin H. (3)
- Coon, Hilary (3)
- Correia, Catarina (3)
- Corsello, Christina (3)
- Cuccaro, Michael L. (3)
- Dawson, Geraldine (3)
- Delorme, Richard (3)
- Duketis, Eftichia (3)
- Duque, Frederico (3)
- Engeland, Herman van (3)
- Ennis, Sean (3)
- Estes, Annette (3)
- Farrar, Penny (3)
- Fernandez, Bridget A. (3)
- Folstein, Susan E. (3)
- Fombonne, Eric (3)
- Freitag, Christine M. (3)
- Gallagher, Louise (3)
- Geschwind, Daniel H. (3)
- Gilbert, John (3)
- Gillberg, Christopher (3)
- Glessner, Joseph T. (3)
- Green, Jonathan (3)
- Guter, Stephen J. (3)
- Hallmayer, Joachim (3)
- Holt, Richard (3)
- Hughes, Gillian (3)
- Hus, Vanessa (3)
- Igliozzi, Roberta (3)
- Jonge, Maretha de (3)
- Kim, Cecilia (3)
- Klauck, Sabine M. (3)
- Kolevzon, Alexander (3)
- Lamb, Janine A. (3)
- Le Couteur, Ann (3)
- Leboyer, Marion (3)
- Leventhal, Bennett L. (3)
- Lord, Catherine (3)
- Lund, Sabata C. (3)
- Maestrini, Elena (3)
- Magalhães, Tiago R. (3)
- Mantoulan, Carine (3)
- McDougle, Christopher J. (3)
- McMahon, William M. (3)
- Merikangas, Alison (3)
- Miller, Judith (3)
- Mirza, Ghazala K. (3)
- Monaco, Anthony P. (3)
- Munson, Jeff (3)
- Nelson, Stanley F. (3)
- Nurnberger, John I. (3)
- Nygren, Gudrun (3)
- Nöthen, Markus Maria (3)
- Oliveira, Guiomar (3)
- Pagnamenta, Alistair T. (3)
- Papanikolaou, Katerina (3)
- Parr, Jeremy R. (3)
- Parrini, Barbara (3)
- Pickles, Andrew (3)
- Pinto, Dalila (3)
- Piven, Joseph (3)
- Posey, David J. (3)
- Poustka, Fritz (3)
- Ragoussis, Jiannis (3)
- Regan, Regina (3)
- Roge, Bernadette (3)
- Rutter, Michael L. (3)
- Scherer, Stephen W. (3)
- Shah, Naisha (3)
- Soorya, Latha (3)
- Sousa, Inês (3)
- Stoppioni, Vera (3)
- Sutcliffe, James S. (3)
- Sykes, Nuala (3)
- Szatmari, Peter (3)
- Tancredi, Raffaella (3)
- Thompson, Ann P. (3)
- Thomson, Susanne (3)
- Tsiantis, John (3)
- Vicente, Astrid M. (3)
- Vieland, Veronica J. (3)
- Vincent, John B. (3)
- Volkmar, Fred (3)
- Wallace, Simon (3)
- Wassink, Thomas H. (3)
- Wijsman, Ellen M. (3)
- Wing, Kirsty (3)
- Wittemeyer, Kerstin (3)
- Zwaigenbaum, Lonnie (3)
- Abrahams, Brett S. (2)
- Agnoletti, Vanni (2)
- Amin, Najaf (2)
- Andreassen, Ole A. (2)
- Ansaloni, Luca (2)
- Arvieux, Catherine (2)
- Bala, Miklosh (2)
- Baune, Bernhard T. (2)
- Berney, Tom (2)
- Biffl, Walter (2)
- Bing, Camilla (2)
- Brian, Jessica (2)
- Bölte, Sven (2)
- Casey, Jillian (2)
- Catena, Fausto (2)
- Ceresoli, Marco (2)
- Chiara, Osvaldo (2)
- Cimbanassi, Stefania (2)
- Coccolini, Federico (2)
- Coimbra, Raul (2)
- Conroy, Judith (2)
- Crawford, Emily L. (2)
- De Angelis, Nicola (2)
- De Moya, Marc (2)
- Del Zompo, Maria (2)
- Devlin, Bernie (2)
- Di Saverio, Salomone (2)
- Duijn, Cornelia M. van (2)
- Ferrada, Paula (2)
- Fraga, Gustavo Pereira (2)
- Fugazzola, Paola (2)
- Gamberini, Emiliano (2)
- Gomes, Carlos Augusto (2)
- Green, Andrew (2)
- Handolin, Lauri (2)
- Harris, Tamara B. (2)
- Heron, Elizabeth A. (2)
- Hofman, Albert (2)
- Horer, Tal (2)
- Howe, Jennifer L. (2)
- Inaba, Kenji (2)
- Ivatury, Rao (2)
- Khokha, Vladimir (2)
- Klei, Lambertus (2)
- Kluger, Yoram (2)
- Kustanovich, Vlad (2)
- Lajonchere, Clara M. (2)
- Landén, Mikael (2)
- Latifi, Rifat (2)
- Leppaniemi, Ari (2)
- Liu, Xiao-Qing (2)
- Lotspeich, Linda (2)
- Marshall, Christian R. (2)
- Masiakos, Peter T. (2)
- McConachie, Helen (2)
- McGrath, Jane (2)
- Mefire, Alain Chichom (2)
- Melhem, Nadine M. (2)
- Minshew, Nancy J. (2)
- Moebus, Susanne (2)
- Montori, Giulia (2)
- Moore, Ernest E. (2)
- Naidoo, Noel (2)
- Napolitano, Lena (2)
- Noakes, Carolyn (2)
- Parry, Neil (2)
- Paterson, Andrew D. (2)
- Paton, Tara (2)
- Peitzman, Andrew B. (2)
- Pereira, Bruno M. (2)
- Poustka, Annemarie (2)
- Reif, Andreas (2)
- Reva, Viktor (2)
- Rizoli, Sandro (2)
- Roberts, Wendy (2)
- Roeder, Kathryn (2)
- Sakakushev, Boris (2)
- Salvetti, Francesco (2)
- Sartelli, Massimo (2)
- Sheffield, Val C. (2)
- Soreide, Kjetil (2)
- Stein, Dan J. (2)
- Tomasoni, Matteo (2)
- Tryfon, Ana (2)
- Velmahos, George C. (2)
- Völzke, Henry (2)
- Wang, Kai (2)
- Weber, Dieter (2)
- Wood, Shawn (2)
- Yaspan, Brian L. (2)
- Zurawiecki, Danielle (2)
- Abecasis, Gonçalo R. (1)
- Absher, Devin (1)
- Abu-Zidan, Fikri (1)
- Abu-Zidan, Fikri M. (1)
- Abé, Christoph (1)
- Achtyes, Eric D. (1)
- Agaoglu, Esen (1)
- Agartz, Ingrid (1)
- Akudjedu, Theophilus N. (1)
- Al-Gazali, Lihadh (1)
- Albrecht, Eva (1)
- Allen, Nicholas B. (1)
- Altınbaş, Kürşat (1)
- Alvarez, Victoria (1)
- Ames, David (1)
- Amouyel, Philippe (1)
- Anderson, Denise (1)
- Andlauer, Till (1)
- Andre, Aleman (1)
- Angelopoulos, Elias (1)
- Ardau, Raffaella (1)
- Arias Vásquez, Alejandro (1)
- Armstrong, Nicola J. (1)
- Arrua Vares, Edgar (1)
- Arveiler, Dominique (1)
- Assimes, Themistocles L. (1)
- Atalay, Mustafa (1)
- Attwood, Antony Paul (1)
- Auburger, Georg (1)
- Aydin, Memduha (1)
- Ayhan, Yavuz (1)
- Baethge, Christopher Jan (1)
- Bahouth, Hany (1)
- Bakker, Stephan J. L. (1)
- Balaban, Ceylan (1)
- Baldwin, Clinton (1)
- Balogh, Zsolt J. (1)
- Barberger-Gateau, Pascale (1)
- Bardakjian, Tanya M. (1)
- Barlassina, Cristina (1)
- Barroso, Inês (1)
- Basart, Hanneke (1)
- Bastin, Mark E. (1)
- Batalla, Albert (1)
- Bauer, Jochen (1)
- Bauer, Michael (1)
- Bauer, Rita (1)
- Bauer, Sabrina (1)
- Baur, Ramona (1)
- Bayer, Anthony (1)
- Becerra-Palars, Claudia (1)
- Becker, Tim (1)
- Beckmann, Jacques S. (1)
- Beecham, Gary W. (1)
- Beekly, Duane (1)
- Behere, Aniruddh P. (1)
- Behere, Prakash B. (1)
- Beilby, John P. (1)
- Belete, Habte (1)
- Belete, Tilahun (1)
- Belizario, Gabriel Okawa (1)
- Bellenguez, Céline (1)
- Bellivier, Frank (1)
- Belmaker, Robert H. (1)
- Benatti, Simone Vasilij (1)
- Benedetti, Francesco (1)
- Bennett, David A. (1)
- Bergo, Felipe (1)
- Berk, Michael (1)
- Berr, Claudine (1)
- Bersudsky, Yuly (1)
- Bettens, Karolien (1)
- Beusekom, Ellen van (1)
- Bicakci, Şule (1)
- Bicknell, Louise (1)
- Biederman, Joseph (1)
- Bierut, Laura Jean (1)
- Bihoreau, Marie-Thérèse (1)
- Birabwa-Oketcho, Harriet (1)
- Bis, Joshua C. (1)
- Bjella, Thomas D. (1)
- Blacker, Deborah (1)
- Blaine, Sara K. (1)
- Boada, Mercè (1)
- Boedhoe, Premika (1)
- Boehnke, Michael (1)
- Boerwinkle, Eric (1)
- Boffard, Ken (1)
- Bokhoven, Hans van (1)
- Bolton, Jennifer L. (1)
- Bonnefond, Amélie (1)
- Bonnycastle, Lori L. (1)
- Bonuccelli, Ubaldo (1)
- Boomsma, Dorret I. (1)
- Borecki, Ingrid B. (1)
- Bornstein, Stefan R. (1)
- Bosco, Paolo (1)
- Bose, Anushree (1)
- Bossù, Paola (1)
- Boucher, Gabrielle (1)
- Brady, Conan (1)
- Bralten, Janita (1)
- Brandeis, Daniel (1)
- Branney, Peter (1)
- Brayne, Carol (1)
- Brem, Silvia (1)
- Brice, Alexis (1)
- Brodaty, Henry (1)
- Broeckhoven, Christine Van (1)
- Broek, Richard P. G. ten (1)
- Brooks, Samantha J. (1)
- Brown, Kristelle (1)
- Bruijn, Renee F. A. G. de (1)
- Brunner, Han G. (1)
- Bröhl, Henrieke (1)
- Buechler, Christa (1)
- Buitelaar, Jan K. (1)
- Busatto Filho, Geraldo (1)
- Böhm, Bernhard O. (1)
- Bøen, Erlend (1)
- Bülow, Robin (1)
- Bürger, Christian (1)
- Cabrera, Jorge (1)
- Caffarra, Paolo (1)
- Calhoun, Vince D. (1)
- Cali, Phil (1)
- Calvo, Anna (1)
- Campbell, Harry (1)
- Campion, Dominique (1)
- Canales-Rodrı́guez, Erick Jorge (1)
- Canive, Jose M. (1)
- Cannon, Dara M. (1)
- Cantwell, Laura B. (1)
- Caparelli, Elisabeth C. (1)
- Cappucciati, Marco (1)
- Carmenate-Naranjo, Deinys (1)
- Carrasquillo, Minerva M. (1)
- Carson, Andrew R. (1)
- Casallo, Guillermo (1)
- Casey, Jillian P. (1)
- Castellanos, Francisco X. (1)
- Castro, Angela Marianne Paredes (1)
- Caulfield, Mark J. (1)
- Cavalleri, Gianpiero L. (1)
- Celotti, Andrea (1)
- Cendes, Fernando (1)
- Cervenka, Simon (1)
- Cesana, Giancarlo (1)
- Chaim-Avancini, Tiffany Moukbel (1)
- Chanock, Stephen J. (1)
- Chantiluke, Kaylita (1)
- Chasman, Daniel I. (1)
- Chen, Qun-lin (1)
- Chen, Wei-Ling (1)
- Chen, Xiayu (1)
- Chen, Yii-Der Ida (1)
- Cheng, Yuqi (1)
- Cheung, Eric Y. Wo (1)
- Chiesa, Silvia (1)
- Chines, Peter S. (1)
- Chirica, Mircea (1)
- Choi, Seung-Hoan (1)
- Chouraki, Vincent (1)
- Christakou, Anastasia (1)
- Chu, Su H. (1)
- Cichon, Sven (1)
- Clarimon, Jordi (1)
- Clark, Vincent P. (1)
- Clarke, Robert (1)
- Clegg, Deborah J. (1)
- Cochrane, Lynne (1)
- Coghill, David (1)
- Collinge, John (1)
- Collins, Francis S. (1)
- Collste, Karin (1)
- Combarros, Onofre (1)
- Connolly, Colm G. (1)
- Conroy, Judith M. (1)
- Conzelmann, Annette (1)
- Costanzo, Antonio (1)
- Coto, Eliecer (1)
- Cousijn, Janna (1)
- Coutanche, Marc (1)
- Craig, David (1)
- Crane, Paul K. (1)
- Crivello, Fabrice (1)
- Crossett, Andrew (1)
- Croteau-Chonka, Damien C. (1)
- Crow, Tim (1)
- Crowe, Marie (1)
- Cruchaga, Carlos (1)
- Cubillo, Ana (1)
- Cuomo, Alessandro (1)
- Cupples, L. Adrienne (1)
- Cόrdova-Palomera, Aldo (1)
- Dallaspezia, Sara (1)
- Dannlowski, Udo (1)
- Dartigues, Jean-François (1)
- Davis, Kimberly A. (1)
- Day, Felix R. (1)
- De Zubicaray, Greig (1)
- DeStefano, Anita L. (1)
- Deary, Ian J. (1)
- Dedoussis, George (1)
- Degenhardt, Franziska (1)
- Delanty, Norman (1)
- Deloukas, Panos (1)
- Demeter, Damion V. (1)
- Demetrashvili, Zaza (1)
- Deniz Naranjo, Maria Candida (1)
- Denning, Nicola (1)
- Deramecourt, Vincent (1)
- Dermitzakis, Emmanouil T. (1)
- Desai, Pratikkumar (1)
- Di Martino, Adriana (1)
- Dickie, Erin W (1)
- Dietsche, Bruno (1)
- Dimas, Antigone S. (1)
- Dimitriou, Maria (1)
- Doan, N. Trung (1)
- Dodd, Seetal (1)
- Doherty, Colin P. (1)
- Donix, Markus (1)
- Doyle, Alysa (1)
- Drmic, Irene (1)
- Dufouil, Carole (1)
- Dunstan, Melanie L. (1)
- Durston, Sarah (1)
- Earl, Eric (1)
- Edkins, Sarah (1)
- Ehrlich, Stefan (1)
- Eijk, Liza van (1)
- Eiriksdottir, Gudny (1)
- Eisinger, Kristina (1)
- Eklund, Niina (1)
- Ekman, Carl Johan (1)
- Elcioglu, Nursel (1)
- Elvsåshagen, Torbjørn (1)
- Engberg, Goran (1)
- Epstein, Jeffery N. (1)
- Erbel, Raimund (1)
- Erdmann, Jeanette (1)
- Erhardt, Sophie (1)
- Eriksson, Johan G. (1)
- Escott-Price, Valentina (1)
- Esko, Tõnu (1)
- Estrada, Karol (1)
- Etain, Bruno (1)
- Evans, Denis (1)
- Faber, Kelley M. (1)
- Fagiolini, Andrea (1)
- Fair, Damien A. (1)
- Faire, Ulf de (1)
- Fall, Tove (1)
- Faraone, Stephen V. (1)
- Farde, Lars (1)
- Farrall, Martin (1)
- Farrer, Lindsay A. (1)
- Fatouros-Bergman, Helena (1)
- Feitosa, Mary F. (1)
- Fellendorf, Frederike Tabea (1)
- Ferensztajn-Rochowiak, Ewa (1)
- Fernndez, Guillen (1)
- Ferreira, Teresa (1)
- Fiedorowicz, Jess G. (1)
- Fier, Heide (1)
- Fischer, Krista (1)
- Fischer, Sascha B. (1)
- Fisher, Malcolm (1)
- Fisher, Simon E. (1)
- FitzPatrick, David R. (1)
- Fitzpatrick, Annette L. (1)
- Fiévet, Nathalie (1)
- Flyckt, Lena (1)
- Foley, Suzanne (1)
- Foroud, Tatiana M. (1)
- Forster, Katharina (1)
- Forstner, Andreas Josef (1)
- Fountoulakis, Kostas N. (1)
- Fowkes, Gerry (1)
- Fox, Caroline S. (1)
- Fox, Nick C. (1)
- Foxe, John J. (1)
- Francks, Clyde (1)
- Frank-García, Ana (1)
- Franke, Barbara (1)
- Franks, Paul W. (1)
- Fraser, Ross M. (1)
- Fratiglioni, Laura (1)
- Frayling, Timothy (1)
- Froguel, Philippe (1)
- Frye, Mark A. (1)
- Fuentes-Claramonte, Paola (1)
- Fullerton, Janice M. (1)
- Furga, Andrea Superti (1)
- Galante, Joseph (1)
- Galante, Joseph M. (1)
- Galimberti, Daniela (1)
- Gallacher, John (1)
- Ganna, Andrea (1)
- Garavan, Hugh (1)
- Garavelli, Livia (1)
- Garcia, Danielle do Santos (1)
- Gautier, Philippe (1)
- Gejman, Pablo V. (1)
- Geoffroy, Pierre A. (1)
- Gerrish, Amy (1)
- Gieger, Christian (1)
- Gigante, Bruna (1)
- Gillessen-Kaesbach, Gabriele Gertrud (1)
- Glahn, David C. (1)
- Glenn, Tasha (1)
- Goate, Alison M. (1)
- Goel, Anuj (1)
- Goldberg, Jeremy (1)
- Gonzalez-Pinto, Ana (1)
- Gotlib, Ian H. (1)
- Gottlieb, John F. (1)
- Goudriaan, Anna E. (1)
- Grabe, Hans Jörgen (1)
- Graff, Caroline (1)
- Grallert, Harald (1)
- Grenier-Boley, Benjamin (1)
- Groenewold, Nynke A. (1)
- Grof, Paul (1)
- Groop, Leif C. (1)
- Grotegerd, Dominik (1)
- Gruber, Oliver (1)
- Grönberg, Henrik (1)
- Gu, Wei (1)
- Guadalupe, Tulio (1)
- Gudnason, Vilmundur (1)
- Gurholt, Tiril (1)
- Gustafsson, Stefan (1)
- Gyllensten, Ulf (1)
- Haarman, Bartholomeus C. M. (1)
- Haavik, Jan (1)
- Hahn, Tim (1)
- Hall, Alistair S. (1)
- Hall, Per (1)
- Hallmans, Göran (1)
- Hamilton-Nelson, Kara L. (1)
- Hampel, Harald (1)
- Hamsten, Anders (1)
- Hannequin, Didier (1)
- Hanon, Olivier (1)
- Hansell, Narelle K. (1)
- Hardy, John (1)
- Harima, Hirohiko (1)
- Haritunians, Talin (1)
- Harold, Denise (1)
- Harris, Mathew A. (1)
- Harst, Pim van der (1)
- Hartikainen, Anna-Liisa (1)
- Hartman, Catharina (1)
- Hasse-Sousa, Mathias (1)
- Hayward, Caroline (1)
- Heard-Costa, Nancy L. (1)
- Hecker, Andreas (1)
- Hecker, Julian (1)
- Hedberg, Mikael (1)
- Heid, Iris M. (1)
- Heijer, Martin den (1)
- Heilmann-Heimbach, Stefanie (1)
- Hengstenberg, Christian (1)
- Hennekam, Raoul C. (1)
- Henry, Chantal (1)
- Herms, Stefan (1)
- Hernandez, Maria del Carmen Valdes (1)
- Hernández, Isabel (1)
- Heslenfeld, Dirk (1)
- Hester, Robert (1)
- Hibar, Derrek Paul (1)
- Hicks, Andrew A. (1)
- Hill, Matthew (1)
- Hiltunen, Mikko (1)
- Hingorani, Aroon (1)
- Hirschhorn, Joel N. (1)
- Ho, Beng-Choon (1)
- Ho, Tiffany C. (1)
- Hoekstra, Pieter J. (1)
- Hoffmann, Per (1)
- Hollingworth, Paul (1)
- Holmans, Peter (1)
- Holmes, Clive (1)
- Hoogman, Martine (1)
- Hottenga, Jouke-Jan (1)
- Houenou, Josselin (1)
- Hovik, Marie F. (1)
- Hovingh, Kees G. (1)
- Howells, Fleur M. (1)
- Huentelman, Matthew J. (1)
- Hugdahl, Kenneth (1)
- Hui, Jennie (1)
- Huikuri, Heikki (1)
- Humphries, Steve E. (1)
- Hung, Joseph (1)
- Hunter, David (1)
- Huyser, Chaim (1)
- Hveem, Kristian (1)
- Hyppönen, Elina (1)
- Høffding, Lone (1)
- I. Berndt, Sonja (1)
- Ibrahim-Verbaas, Carla A. (1)
- Ikram, M. Arfan (1)
- Illig, Thomas (1)
- Imbesi, Massimiliano (1)
- Ingelsson, Erik (1)
- Ingelsson, Martin (1)
- Ingvar, Martind (1)
- Iribarren, Carlos (1)
- Irwin, Lourdes (1)
- Ishikawa, Akari (1)
- Isometsä, Erkki T. (1)
- Ivkovic, Maja (1)
- Jackson, Anne U. (1)
- Jackson, Ian J. (1)
- Jacob, Suma (1)
- Jacobs, Kevin B. (1)
- Jager, Philip L. De (1)
- Jahanshad, Neda (1)
- James, Anthony (1)
- Janno, Sven (1)
- Jarvelin, Marjo-Riitta (1)
- Jean-Paul, Fouche (1)
- Jernigan, Terry L. (1)
- Johansson, Åsa (1)
- Johnsen, Simon (1)
- Johnson, Andrew D. (1)
- Johnson, Toby (1)
- Johnston, Janet A. (1)
- Jolley, Jennifer (1)
- Jones, Lesley (1)
- Jonsson, Palmi V. (1)
- Jula, Antti (1)
- Jun, Gyungah (1)
- Jönsson, Erik G. (1)
- Kahler, Claas (1)
- Kaleda, Vasily (1)
- Kamatani, Yoichiro (1)
- Kamboh, M. Ilyas (1)
- Kanoni, Stavroula (1)
- Kapczinski, Flávio (1)
- Kaplan, Robert (1)
- Kaprio, Jaakko (1)
- Karakatsoulis, Gregory N. (1)
- Kardell, Mathias (1)
- Karpe, Fredrik (1)
- Kashuk, Jeffry L. (1)
- Kashuk, Joseph (1)
- Kathiresan, Sekar (1)
- Kauwe, John S. K. (1)
- Keinanen-Kiukaanniemi, Sirkka M. (1)
- Keller, Lina (1)
- Kelly, Clare (1)
- Kenny, Graham P. (1)
- Kerich, Michael (1)
- Keshavan, Matcheri S (1)
- Kessing, Lars Vedel (1)
- Khadka, Sabin (1)
- Khan, Ayesha (1)
- Khaw, Kay-Tee (1)
- Kiemeney, Lambertus Adrianus (1)
- Kike, Kaoru (1)
- Kilpeläinen, Tuomas O. (1)
- Kim, Seong Jae (1)
- Kircher, Tilo (1)
- Kirkpatrick, Andrew (1)
- Kirkpatrick, Andrew Wallace (1)
- Kivimaki, Mika (1)
- Klauw, Melanie M. van der (1)
- Kleber, Marcus E. (1)
- Koenig, Rainer (1)
- Koenig, Wolfgang (1)
- Kohls, Gregor (1)
- Koller, Anna C. (1)
- Kolovou, Genovefa (1)
- Kong, Xiang-Zhen (1)
- Konrad, Kerstin (1)
- Korucuoglu, Ozlem (1)
- Korvatska, Olena (1)
- Kot, Timur L. (1)
- Kovacs, Peter (1)
- Koval, Michael (1)
- Kraja, Aldi T. (1)
- Kristiansson, Kati (1)
- Krjutškov, Kaarel (1)
- Krohn, Jon P. (1)
- Krug, Axel (1)
- Krämer, Bernd (1)
- Kuh, Diana (1)
- Kukull, Walter A. (1)
- Kumari, Meena (1)
- Kunkle, Brian (1)
- Kunz, Mauricio (1)
- Kutalik, Zoltán (1)
- Kuulasmaa, Kari (1)
- Kuusisto, Johanna (1)
- Kwon, Jun Soo (1)
- König, Barbara (1)
- Laakso, Markku (1)
- Lafer, Beny (1)
- Lakka, Timo A. (1)
- Lambert, Jean-Charles (1)
- Lambregts-Rommelse, Nanda (1)
- Lamina, Claudia (1)
- Langenberg, Claudia (1)
- Lannfelt, Lars (1)
- Larrea, Martha (1)
- Larsen, Erik R. (1)
- Larson, Eric B. (1)
- Laskawiec, Magdalena (1)
- Lathrop, Mark (1)
- Launer, Lenore J. (1)
- Law-Smith, Miriam (1)
- Lebedeva, Irina (1)
- Lehtimäki, Terho (1)
- Lenger, Melanie (1)
- Lenroot, Rhoshel (1)
- Lesch, Klaus-Peter J. (1)
- Letenneur, Luc (1)
- Lewitzka, Ute (1)
- Li, Guo (1)
- Li, Qinqin (1)
- Li, Shengxu (1)
- Liang, Liming (1)
- Licht, Rasmus W. (1)
- Lim, Kelvin O. (1)
- Lin, Chiao-Feng (1)
- Lin, Heng-Fu (1)
- Lind, Lars (1)
- Lindgren, Cecilia M. (1)
- Lindström, Jaana (1)
- Lionel, Anath C. (1)
- Liu, Jia (1)
- Lleo, Alberto (1)
- Lochner, Christine (1)
- Locke, Adam E. (1)
- Lokki, Marja-Liisa (1)
- Loley, Christina (1)
- Lombard, Frances (1)
- London, Edythe D. (1)
- Lonning, Vera (1)
- Loos, Ruth J. F. (1)
- Lopez, Oscar L. (1)
- Lopez-Jaramillo, Carlos (1)
- Lorentzon, Mattias (1)
- Lorenzetti, Valentina (1)
- Love, Seth (1)
- Lovestone, Simon (1)
- Luan, Jian'an (1)
- Luciano, Michelle (1)
- Ludwig, Kerstin (1)
- Luijten, Maartje (1)
- Lundervold, Astri J. (1)
- Lunetta, Kathryn L. (1)
- Lázaro, Luisa (1)
- Maaser, Anna (1)
- MacKenzie, Alan (1)
- MacMaster, Frank P. (1)
- Maccatrozzo, Stefano (1)
- Mackey, Scott (1)
- Madsen, Helle Østergaard (1)
- Madsen, Simone Alberte Kongstad A. (1)
- Magnone, Stefano (1)
- Magnusson, Patrik K. E. (1)
- Mahadevan, Jayant (1)
- Mahardika, Agustine (1)
- Mahoney, William (1)
- Maier, Ron (1)
- Maier, Ronald V. (1)
- Maier, Wolfgang (1)
- Maingault, Sophie (1)
- Malbrain, Manu (1)
- Malmqvist, Anna (1)
- Malpas, Charles B. (1)
- Malt, Ulrik F. (1)
- Manchia, Mirko (1)
- Mancuso, Michelangelo (1)
- Mangino, Massimo (1)
- Maniega, Susana Munoz (1)
- Marcheco-Teruel, Beatriz (1)
- Marsh, Wendy (1)
- Martin, Eden R. (1)
- Martin, Nicholas Gordon (1)
- Martin-Santos, Rocio (1)
- Martinez Hernandez, Juan Alberto (1)
- Martinez-Cengotitabengoa, Monica (1)
- Martiny, Klaus (1)
- Martzi, Ingo (1)
- Marzi, Ingo (1)
- Maschio, Andrea (1)
- Mashima, Yuki (1)
- Mataix-Cols, David (1)
- Mateo Leach, Irene (1)
- Mateo, Ignacio (1)
- Mathias, Samuel R. (1)
- Mathieson, Iain (1)
- Mayer, Andrew R. (1)
- Mayeux, Richard (1)
- Mayhaus, Manuel (1)
- Mazoyer, Bernard (1)
- McArdle, Wendy L. (1)
- McCarthy, Hazel (1)
- McCarthy, Mark I. (1)
- McDonald, Colm (1)
- McGuinness, Bernadette (1)
- McKie, Lisa (1)
- McLellan, Quinn (1)
- McLoughlin, Declan M. (1)
- McMahon, Katie L. (1)
- McPhilemy, Genevieve (1)
- Mead, Simon (1)
- Mecocci, Patrizia (1)
- Medina-Gomez, Carolina (1)
- Medland, Sarah E. (1)
- Meesters, Ybe (1)
- Melle, Ingrid (1)
- Melotti, Rita Maria (1)
- Metspalu, Andres (1)
- Meza-Urzúa, Fátima (1)
- Migita, Ohsuke (1)
- Mihailov, Evelin (1)
- Min, Josine L. (1)
- Ming, Mok Yee (1)
- Minopoli, Fiorella (1)
- Mitchell, Philip B. (1)
- Mohlke, Karen L. (1)
- Momenan, Reza (1)
- Monda, Keri L. (1)
- Monteith, Scott (1)
- Montgomery, Grant W. (1)
- Montine, Thomas J. (1)
- Montravers, Philippe (1)
- Moore, Frederick (1)
- Moorthy, Muthukumaran (1)
- Morales, Angelica M. (1)
- Moreira, José Carlos Vasques (1)
- Morgan, Kevin (1)
- Morken, Gunnar (1)
- Morris, Andrew David (1)
- Morrison, Harris (1)
- Mors, Ole (1)
- Mosca, Enrica (1)
- Mosley, Thomas H. (1)
- Mozzhegorov, Anton A. (1)
- Mueller, Bryon A. (1)
- Munoz, Rodrigo (1)
- Munroe, Patricia B. (1)
- Myers, Amanda J. (1)
- Mylonas, Konstantinos (1)
- Mythri, Starlin V. (1)
- Mägi, Reedik (1)
- März, Winfried (1)
- Mégarbané, Andre (1)
- Müller-Nurasyid, Martina (1)
- Nacef, Fethi (1)
- Nacmias, Benedetta (1)
- Nadella, Ravi K. (1)
- Naj, Adam C. (1)
- Nakanotani, Takako (1)
- Nalls, Michael A. (1)
- Narayanaswamy, Janardhanan C. (1)
- Narisu, Narisu (1)
- Navarro, David Costa (1)
- Navis, Gerjan (1)
- Nerland, Stener (1)
- Nestor, Liam (1)
- Nicholson, George (1)
- Nielsen, René Ernst (1)
- Nigg, Joel T. (1)
- Njølstad, Inger (1)
- Nolte, Ilja M. (1)
- Noor, Abdul (1)
- Nordvik, Jan-Egil (1)
- North, Kari E. (1)
- Novotny, Stephanie (1)
- Nürnberg, Peter (1)
- O'Connell, Jeffrey R. (1)
- O'Donovan, Claire (1)
- O'Donovan, Michael C. (1)
- Oberwelland, Eileen (1)
- Ohlsson, Claes (1)
- Omrani, Adel (1)
- Ong, Ken K. (1)
- Oosterlaan, Jaap (1)
- Oostra, Ben A. (1)
- Oranje, Bob (1)
- Ordoñez, Carlos A. (1)
- Orhan, Funda (1)
- Orozco-Díaz, Guillermo (1)
- Orr, Catherine (1)
- Osher, Yamima (1)
- Otomo, Yashuiro (1)
- Ouali, Uta (1)
- Overs, Bronwyn (1)
- Owen, Michael J. (1)
- Ozkinay, Ferda (1)
- O’Gorman, Ruth L. (1)
- Pallotta, Rosanna (1)
- Palmer, Colin N. A. (1)
- Palmer, Lyle J. (1)
- Pantovic-Stefanovic, Maja (1)
- Panza, Francesco (1)
- Pariwatcharakul, Pornjira (1)
- Pasquier, Florence (1)
- Passmore, Peter (1)
- Pastor, Pau (1)
- Pauli, Paul (1)
- Paulus, Martin (1)
- Pechlivanis, Sonali (1)
- Pedersen, Nancy L. (1)
- Penninx, Brenda W. J. H. (1)
- Perola, Markus (1)
- Perry, Paul (1)
- Perry, William (1)
- Person, Thomas (1)
- Peters, Annette (1)
- Petite, Joanne (1)
- Pfennig, Andrea (1)
- Pica Ruiz, Yolanda (1)
- Pichler, Sabrina (1)
- Piehl, Fredrik (1)
- Pilhatsch, Maximilian (1)
- Pilotto, Alberto (1)
- Pinna, Marco (1)
- Pisano, Michele (1)
- Plessen, Kerstin (1)
- Polier, Georg von (1)
- Pomarol-Clotet, Edith (1)
- Pompili, Maurizio (1)
- Porter, Richard (1)
- Powell, John F. (1)
- Power, Chris (1)
- Pramstaller, Peter P. (1)
- Prasad, Aparna (1)
- Price, Jackie F. (1)
- Proenza-Barzaga, Niurka (1)
- Proitsi, Petra (1)
- Prokopenko, Inga (1)
- Province, Michael A. (1)
- Psaty, Bruce M. (1)
- Qi, Lu (1)
- Qiu, Jiang (1)
- Quiroz, Danilo (1)
- Rabelo-da-Ponte, Francisco Diego (1)
- Radua, Joaquim (1)
- Raff, Ruth (1)
- Rainger, Joe (1)
- Raitakari, Olli (1)
- Ramesar, Raj (1)
- Ramirez, Alfredo (1)
- Ramos, Lina (1)
- Ramos-Quiroga, J. Antoni (1)
- Ramsay, Jacqueline K. (1)
- Randall, Joshua C. (1)
- Rasgon, Natalie (1)
- Ratta-apha, Woraphat (1)
- Ratzenhofer, Michaela (1)
- Rauramaa, Rainer (1)
- Razek, Tarek (1)
- Razquin, Cristina (1)
- Redahan, Maria (1)
- Reddy, M. S. (1)
- Reddy, Y.C. Janardhan (1)
- Rehnberg, Emil (1)
- Reinbold, Céline S. (1)
- Reininghaus, Eva Z. (1)
- Reitz, Christiane (1)
- Renshaw, Katy (1)
- Rice, John P. (1)
- Richards, Alexander (1)
- Richards, Jenny Gringer (1)
- Rickaby, Jessica (1)
- Ridker, Paul M. (1)
- Riemenschneider, Matthias (1)
- Rietschel, Marcella (1)
- Ripatti, Samuli (1)
- Ritchie, Karen (1)
- Ritter, Philipp (1)
- Rivadeneira, Fernando (1)
- Rivolta, Carlo (1)
- Roberts, Derek (1)
- Roberts, Gloria (1)
- Rogaeva, Ekaterina (1)
- Rosa, Pedro (1)
- Rose, Lynda M. (1)
- Rotter, Jerome I. (1)
- Rubia, Katya (1)
- Rubinsztein, David C. (1)
- Rudan, Igor (1)
- Ruiz, Agustin (1)
- Rujescu, Dan (1)
- Russo, Giancarlo (1)
- Rybakowski, Janusz K. (1)
- Saaristo, Timo E. (1)
- Sacchet, Matthew D. (1)
- Sachdev, Perminder S. (1)
- Sager, Hendrik (1)
- Salomaa, Veikko (1)
- Salt, Jeff (1)
- Salvador, Raymond (1)
- Samani, Nilesh J. (1)
- Sambrook, Jennifer G. (1)
- Sanchez Garcia, Florentino (1)
- Sansom, Katherine (1)
- Saponari, Anita (1)
- Saramies, Jouko (1)
- Sathyaputri, Leela (1)
- Sato, Daisuke (1)
- Saud, Alhusaini (1)
- Scalea, Thomas (1)
- Scarpini, Elio (1)
- Scherag, André (1)
- Schlessinger, David (1)
- Schlitt, Sabine (1)
- Schmaal, Lianne (1)
- Schmidt, Helena (1)
- Schmidt, Reinhold (1)
- Schneider, Adele S. (1)
- Schunkert, Heribert (1)
- Schwarz, Peter E. H. (1)
- Schweren, Lisanne (1)
- Schwieler, Lilly (1)
- Scippa, Ângela M. (1)
- Segurado, Ricardo (1)
- Seidman, Larry J. (1)
- Seitz, Jochen (1)
- Semerci, C. Nur (1)
- Senman, Lili (1)
- Sequeira, Ana F. (1)
- Serpa, Mauricio Henriques (1)
- Seshadri, Sudha (1)
- Severus, Emanuel (1)
- Sexton, David (1)
- Shaw, Philip (1)
- Shi, Jianxin (1)
- Shields, Denis C. (1)
- Shuldiner, Alan R. (1)
- Shumskaya, Elena (1)
- Shungin, Dmitry (1)
- Siciliano, Gabriele (1)
- Silk, Timothy J. (1)
- Simhandl, Christian (1)
- Simmons, Alan N. (1)
- Simone, Belinda De (1)
- Sims, Rebecca (1)
- Simulionyte, Egle (1)
- Sinha, Rajita (1)
- Sinisalo, Juha (1)
- Sivalingam, Sugirthan (1)
- Sjoerds, Zsuzsika (1)
- Sleegers, Kristel (1)
- Smelror, Runar Elle (1)
- Smith, Albert V. (1)
- Smith, Albert Vernon (1)
- Smith, Daniel (1)
- Smith, José (1)
- Snieder, Harold (1)
- Soininen, Hilkka (1)
- Sokhi, Kishan (1)
- Solaini, Leonardo (1)
- Solfrizzi, Vincenzo (1)
- Soliva, Joan Carlos (1)
- Solowij, Nadia (1)
- Sorbi, Sandro (1)
- Sousa, Sérgio B. (1)
- Spain, David A. (1)
- Spalletta, Gianfranco (1)
- Spector, Tim D. (1)
- Speliotes, Elizabeth K. (1)
- Sponheim, Scott R. (1)
- St George-Hyslop, Peter (1)
- Stackhouse Jr., Paul W. (1)
- Stefansson, Kari (1)
- Stein, Elliot A. (1)
- Steinthorsdottir, Valgerdur (1)
- Stevens, Michael (1)
- Stilwell, Kellen (1)
- Stirrups, Kathleen (1)
- Strachan, David P. (1)
- Strawbridge, Christina (1)
- Strawbridge, Rona J. (1)
- Streit, Fabian (1)
- Strejilevich, Sergio (1)
- Strike, Lachlan T. (1)
- Strohmaier, Jana (1)
- Su, Kuan-Pin (1)
- Subramaniam, Mythily (1)
- Sudre, Gustavo (1)
- Sugrue, Michael (1)
- Sui, Jing (1)
- Sulaiman, Ahmad Hatim (1)
- Suominen, Kirsi (1)
- Surakka, Ida (1)
- Swift, Amy J. (1)
- Tamm, Leanne (1)
- Tanra, Andi J. (1)
- Tansey, Katherine (1)
- Tatebayashi, Yoshitaka (1)
- Tauber, Maïté (1)
- Teder-Laving, Maris (1)
- Teh, Wen Lin (1)
- Temmingh, Hendrik S. (1)
- Teumer, Alexander (1)
- Thiele, Holger (1)
- Thiruvahindrapduram, Bhooma (1)
- Thoma, Robert J. (1)
- Thomas, Charlene (1)
- Thompson, Paul M. (1)
- Thorand, Barbara (1)
- Thorleifsson, Gudmar (1)
- Thornton-Wells, Tricia A. (1)
- Thorsteinsdottir, Unnur (1)
- Todd, Stephen (1)
- Tolonen, Matti (1)
- Tomyshev, Alexander S. (1)
- Tondo, Leonardo (1)
- Torrent, Carla (1)
- Tremoli, Elena (1)
- Tronchin, Giulia (1)
- Tsolaki, Magda (1)
- Tsuang, Debby W. (1)
- Tuinstra, Daniel (1)
- Tuomilehto, Jaakko (1)
- Turner, Jessica A. (1)
- Tyrer, Jonathan (1)
- Tzourio, Christophe (1)
- Tzourio-Mazoyer, Nathalie (1)
- Tönjes, Anke (1)
- Uchida, Takahito (1)
- Uhlmann, Anne (1)
- Uitterlinden, André G. (1)
- Uusitupa, Matti (1)
- Vaaler, Arne E. (1)
- Valetti, Tino M. (1)
- Valladares, Otto (1)
- Vance, Alasdair (1)
- Vardarajan, Badri N. (1)
- Vedantam, Sailaja (1)
- Vedernikov, Alexey (1)
- Veeh, Julia (1)
- Veer, Ilya M. (1)
- Veltman, Dick J. (1)
- Venkatasubramanian, Ganesan (1)
- Victorsson, Pauliina (1)
- Vieta, Eduard (1)
- Vilarroya, Oscar (1)
- Virtamo, Jarmo (1)
- Viswanath, Biju (1)
- Vives-Gilabert, Yolanda (1)
- Vliet-Ostaptchouk, Jana V. van (1)
- Voineskos, Aristotle N. (1)
- Vorstman, JAS (1)
- Vorstman, Jacob A. S. (1)
- Vronskaya, Maria (1)
- Vuletic, Daniella (1)
- Waite, Lindsay L. (1)
- Walitza, Susanne (1)
- Wallon, David (1)
- Walter, Henrik (1)
- Walton, Esther (1)
- Wang, Li-San (1)
- Wang, Zhaoming (1)
- Wang, Zhouzhi (1)
- Wani, Imtiaz (1)
- Wardlaw, Joanna M. (1)
- Wareham, Nicholas J. (1)
- Wehlie, Liban (1)
- Wen, Wei (1)
- Westlye, Lars T. (1)
- Whelan, Christopher D. (1)
- White, Kathy (1)
- White, Tonya (1)
- Whybrow, Peter C. (1)
- Wichmann, Heinz Erich (1)
- Wieczorek, Dagmar (1)
- Wiers, Reinout W. (1)
- Williams, Julie (1)
- Wilsgaard, Tom (1)
- Wilson, James F. (1)
- Winkelmann, Bernhard R. (1)
- Winkler, Thomas W. (1)
- Wischmeijer, Anita (1)
- Witt, Stephanie (1)
- Wittfeld, Katharina (1)
- Wong, Andrew (1)
- Wood, Andrew R. (1)
- Workalemahu, Tsegaselassie (1)
- Wright, Margaret J. (1)
- Yalcinkaya, Oguz Kaan (1)
- Yang, Jian (1)
- Yang, Tony T. (1)
- Yarnell, John W. G. (1)
- Yasuda, Clarissa L. (1)
- Yoldi-Negrete, Maria (1)
- Yoncheva, Yuliya (1)
- Young, Allan H. (1)
- Younkin, Steven G. (1)
- Yu, Lei (1)
- Yuan, Kuo-Ching (1)
- Yucel, Murat (1)
- Yun, Je-Yeon (1)
- Zafar, Saemah (1)
- Zanetti, Marcus Vinicius (1)
- Zeeuw, Patrick de (1)
- Zelenika, Diana (1)
- Zgueb, Yosra (1)
- Zhao, Jing Hua (1)
- Zhen, Zonglei (1)
- Zhu, Xing-xing (1)
- Ziegler, Georg Christoph (1)
- Zierhut, Kathrin (1)
- Zillikens, M. Carola (1)
- Zou, Fanggeng (1)
- Zwiers, Marcel P. (1)
- de Bruttopilo, Sara Ambrosino (1)
- van Erp, Theo G.M. (1)
- van Holst, Ruth J. (1)
- van den Heuvel, Odile (1)
- van der Meer, Dennis (1)
Language
- English (11)
Has Fulltext
- yes (11)
Is part of the Bibliography
- no (11)
Keywords
- Bipolar disorder (2)
- Guidelines (2)
- Trauma (2)
- Adult (1)
- Alleles (1)
- Biological (1)
- Circadian (1)
- Classification (1)
- Closure (1)
- Conservative (1)
Institute
- Medizin (11) (remove)
Randall, Joshua C. ; Winkler, Thomas W. ; Kutalik, Zoltán ; I. Berndt, Sonja ; Jackson, Anne U. ; Monda, Keri L. ; Kilpeläinen, Tuomas O. ; Esko, Tõnu ; Mägi, Reedik ; Li, Shengxu ; Workalemahu, Tsegaselassie ; Feitosa, Mary F. ; Croteau-Chonka, Damien C. ; Day, Felix R. ; Fall, Tove ; Ferreira, Teresa ; Gustafsson, Stefan ; Locke, Adam E. ; Mathieson, Iain ; Scherag, André ; Vedantam, Sailaja ; Wood, Andrew R. ; Liang, Liming ; Steinthorsdottir, Valgerdur ; Thorleifsson, Gudmar ; Dermitzakis, Emmanouil T. ; Dimas, Antigone S. ; Karpe, Fredrik ; Min, Josine L. ; Nicholson, George ; Clegg, Deborah J. ; Person, Thomas ; Krohn, Jon P. ; Bauer, Sabrina ; Buechler, Christa ; Eisinger, Kristina ; Bonnefond, Amélie ; Froguel, Philippe ; Hottenga, Jouke-Jan ; Prokopenko, Inga ; Waite, Lindsay L. ; Harris, Tamara B. ; Smith, Albert Vernon ; Shuldiner, Alan R. ; McArdle, Wendy L. ; Caulfield, Mark J. ; Munroe, Patricia B. ; Grönberg, Henrik ; Chen, Yii-Der Ida ; Li, Guo ; Beckmann, Jacques S. ; Johnson, Toby ; Thorsteinsdottir, Unnur ; Teder-Laving, Maris ; Khaw, Kay-Tee ; Wareham, Nicholas J. ; Zhao, Jing Hua ; Amin, Najaf ; Oostra, Ben A. ; Kraja, Aldi T. ; Province, Michael A. ; Cupples, L. Adrienne ; Heard-Costa, Nancy L. ; Kaprio, Jaakko ; Ripatti, Samuli ; Surakka, Ida ; Collins, Francis S. ; Saramies, Jouko ; Tuomilehto, Jaakko ; Jula, Antti ; Salomaa, Veikko ; Erdmann, Jeanette ; Hengstenberg, Christian ; Loley, Christina ; Schunkert, Heribert ; Lamina, Claudia ; Wichmann, Heinz Erich ; Albrecht, Eva ; Gieger, Christian ; Hicks, Andrew A. ; Johansson, Åsa ; Pramstaller, Peter P. ; Kathiresan, Sekar ; Speliotes, Elizabeth K. ; Penninx, Brenda W. J. H. ; Hartikainen, Anna-Liisa ; Jarvelin, Marjo-Riitta ; Gyllensten, Ulf ; Boomsma, Dorret I. ; Campbell, Harry ; Wilson, James F. ; Chanock, Stephen J. ; Farrall, Martin ; Goel, Anuj ; Medina-Gomez, Carolina ; Rivadeneira, Fernando ; Estrada, Karol ; Uitterlinden, André G. ; Hofman, Albert ; Zillikens, M. Carola ; Heijer, Martin den ; Kiemeney, Lambertus Adrianus ; Maschio, Andrea ; Hall, Per ; Tyrer, Jonathan ; Teumer, Alexander ; Völzke, Henry ; Kovacs, Peter ; Tönjes, Anke ; Mangino, Massimo ; Spector, Tim D. ; Hayward, Caroline ; Rudan, Igor ; Hall, Alistair S. ; Samani, Nilesh J. ; Attwood, Antony Paul ; Sambrook, Jennifer G. ; Hung, Joseph ; Palmer, Lyle J. ; Lokki, Marja-Liisa ; Sinisalo, Juha ; Boucher, Gabrielle ; Huikuri, Heikki ; Lorentzon, Mattias ; Ohlsson, Claes ; Eklund, Niina ; Eriksson, Johan G. ; Barlassina, Cristina ; Rivolta, Carlo ; Nolte, Ilja M. ; Snieder, Harold ; Klauw, Melanie M. van der ; Vliet-Ostaptchouk, Jana V. van ; Gejman, Pablo V. ; Shi, Jianxin ; Jacobs, Kevin B. ; Wang, Zhaoming ; Bakker, Stephan J. L. ; Mateo Leach, Irene ; Navis, Gerjan ; Harst, Pim van der ; Martin, Nicholas Gordon ; Medland, Sarah E. ; Montgomery, Grant W. ; Yang, Jian ; Chasman, Daniel I. ; Ridker, Paul M. ; Rose, Lynda M. ; Lehtimäki, Terho ; Raitakari, Olli ; Absher, Devin ; Iribarren, Carlos ; Basart, Hanneke ; Hovingh, Kees G. ; Hyppönen, Elina ; Power, Chris ; Power, Chris ; Anderson, Denise ; Beilby, John P. ; Hui, Jennie ; Jolley, Jennifer ; Sager, Hendrik ; Bornstein, Stefan R. ; Schwarz, Peter E. H. ; Kristiansson, Kati ; Perola, Markus ; Lindström, Jaana ; Swift, Amy J. ; Uusitupa, Matti ; Atalay, Mustafa ; Lakka, Timo A. ; Rauramaa, Rainer ; Bolton, Jennifer L. ; Fowkes, Gerry ; Fraser, Ross M. ; Price, Jackie F. ; Fischer, Krista ; KrjutÅ¡kov, Kaarel ; Metspalu, Andres ; Mihailov, Evelin ; Langenberg, Claudia ; Luan, Jian'an ; Ong, Ken K. ; Chines, Peter S. ; Keinanen-Kiukaanniemi, Sirkka M. ; Saaristo, Timo E. ; Edkins, Sarah ; Franks, Paul W. ; Hallmans, Göran ; Shungin, Dmitry ; Morris, Andrew David ; Palmer, Colin N. A. ; Erbel, Raimund ; Moebus, Susanne ; Nöthen, Markus Maria ; Pechlivanis, Sonali ; Hveem, Kristian ; Narisu, Narisu ; Hamsten, Anders ; Humphries, Steve E. ; Strawbridge, Rona J. ; Tremoli, Elena ; Grallert, Harald ; Thorand, Barbara ; Illig, Thomas ; Koenig, Wolfgang ; Müller-Nurasyid, Martina ; Peters, Annette ; Böhm, Bernhard O. ; Kleber, Marcus E. ; März, Winfried ; Winkelmann, Bernhard R. ; Kuusisto, Johanna ; Laakso, Markku ; Arveiler, Dominique ; Cesana, Giancarlo ; Kuulasmaa, Kari ; Virtamo, Jarmo ; Yarnell, John W. G. ; Kuh, Diana ; Wong, Andrew ; Lind, Lars ; Faire, Ulf de ; Gigante, Bruna ; Magnusson, Patrik K. E. ; Pedersen, Nancy L. ; Dedoussis, George ; Dimitriou, Maria ; Kolovou, Genovefa ; Kanoni, Stavroula ; Stirrups, Kathleen ; Bonnycastle, Lori L. ; Njølstad, Inger ; Wilsgaard, Tom ; Ganna, Andrea ; Rehnberg, Emil ; Hingorani, Aroon ; Kivimaki, Mika ; Kumari, Meena ; Assimes, Themistocles L. ; Barroso, Inês ; Boehnke, Michael ; Borecki, Ingrid B. ; Deloukas, Panos ; Fox, Caroline S. ; Frayling, Timothy ; Groop, Leif C. ; Haritunians, Talin ; Hunter, David ; Ingelsson, Erik ; Kaplan, Robert ; Mohlke, Karen L. ; North, Kari E. ; Lindgren, Cecilia M. ; Qi, Lu ; Loos, Ruth J. F. ; Heid, Iris M. ; Hirschhorn, Joel N. ; McCarthy, Mark I. ; Abecasis, Gonçalo R. ; Stefansson, Kari ; Strachan, David P. ; Schlessinger, David ; O'Connell, Jeffrey R. ; Duijn, Cornelia M. van
Men and women differ substantially regarding height, weight, and body fat. Interestingly, previous work detecting genetic effects for waist-to-hip ratio, to assess body fat distribution, has found that many of these showed sex-differences. However, systematic searches for sex-differences in genetic effects have not yet been conducted. Therefore, we undertook a genome-wide search for sexually dimorphic genetic effects for anthropometric traits including 133,723 individuals in a large meta-analysis and followed promising variants in further 137,052 individuals, including a total of 94 studies. We identified seven loci with significant sex-difference including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were significant in women, but not in men. Of interest is that sex-difference was only observed for waist phenotypes, but not for height or body-mass-index. We found no evidence for sex-differences with opposite effect direction for men and women. The PPARG locus is of specific interest due to its link to diabetes genetics and therapy. Our findings demonstrate the importance of investigating sex differences, which may lead to a better understanding of disease mechanisms with a potential relevance to treatment options.
Escott-Price, Valentina ; Bellenguez, Céline ; Wang, Li-San ; Choi, Seung-Hoan ; Harold, Denise ; Jones, Lesley ; Holmans, Peter ; Gerrish, Amy ; Vedernikov, Alexey ; Richards, Alexander ; DeStefano, Anita L. ; Lambert, Jean-Charles ; Ibrahim-Verbaas, Carla A. ; Naj, Adam C. ; Sims, Rebecca ; Jun, Gyungah ; Bis, Joshua C. ; Beecham, Gary W. ; Grenier-Boley, Benjamin ; Russo, Giancarlo ; Thornton-Wells, Tricia A. ; Denning, Nicola ; Smith, Albert V. ; Chouraki, Vincent ; Thomas, Charlene ; Ikram, M. Arfan ; Zelenika, Diana ; Vardarajan, Badri N. ; Kamatani, Yoichiro ; Lin, Chiao-Feng ; Schmidt, Helena ; Kunkle, Brian ; Dunstan, Melanie L. ; Vronskaya, Maria ; Johnson, Andrew D. ; Ruiz, Agustin ; Bihoreau, Marie-Thérèse ; Reitz, Christiane ; Pasquier, Florence ; Hollingworth, Paul ; Hanon, Olivier ; Fitzpatrick, Annette L. ; Buxbaum, Joseph D. ; Campion, Dominique ; Crane, Paul K. ; Baldwin, Clinton ; Becker, Tim ; Gudnason, Vilmundur ; Cruchaga, Carlos ; Craig, David ; Amin, Najaf ; Berr, Claudine ; Lopez, Oscar L. ; Jager, Philip L. De ; Deramecourt, Vincent ; Johnston, Janet A. ; Evans, Denis ; Lovestone, Simon ; Letenneur, Luc ; Hernández, Isabel ; Rubinsztein, David C. ; Eiriksdottir, Gudny ; Sleegers, Kristel ; Goate, Alison M. ; Fiévet, Nathalie ; Huentelman, Matthew J. ; Gill, Michael ; Brown, Kristelle ; Kamboh, M. Ilyas ; Keller, Lina ; Barberger-Gateau, Pascale ; McGuinness, Bernadette ; Larson, Eric B. ; Myers, Amanda J. ; Dufouil, Carole ; Todd, Stephen ; Wallon, David ; Love, Seth ; Rogaeva, Ekaterina ; Gallacher, John ; St George-Hyslop, Peter ; Clarimon, Jordi ; Lleo, Alberto ; Bayer, Anthony ; Tsuang, Debby W. ; Yu, Lei ; Tsolaki, Magda ; Bossù, Paola ; Spalletta, Gianfranco ; Proitsi, Petra ; Collinge, John ; Sorbi, Sandro ; Sanchez Garcia, Florentino ; Fox, Nick C. ; Hardy, John ; Deniz Naranjo, Maria Candida ; Bosco, Paolo ; Clarke, Robert ; Brayne, Carol ; Galimberti, Daniela ; Scarpini, Elio ; Bonuccelli, Ubaldo ; Mancuso, Michelangelo ; Siciliano, Gabriele ; Moebus, Susanne ; Mecocci, Patrizia ; Del Zompo, Maria ; Maier, Wolfgang ; Hampel, Harald ; Pilotto, Alberto ; Frank-García, Ana ; Panza, Francesco ; Solfrizzi, Vincenzo ; Caffarra, Paolo ; Nacmias, Benedetta ; Perry, William ; Mayhaus, Manuel ; Lannfelt, Lars ; Hakonarson, Hakon ; Pichler, Sabrina ; Carrasquillo, Minerva M. ; Ingelsson, Martin ; Beekly, Duane ; Alvarez, Victoria ; Zou, Fanggeng ; Valladares, Otto ; Younkin, Steven G. ; Coto, Eliecer ; Hamilton-Nelson, Kara L. ; Gu, Wei ; Razquin, Cristina ; Pastor, Pau ; Mateo, Ignacio ; Owen, Michael J. ; Faber, Kelley M. ; Jonsson, Palmi V. ; Combarros, Onofre ; O'Donovan, Michael C. ; Cantwell, Laura B. ; Soininen, Hilkka ; Blacker, Deborah ; Mead, Simon ; Mosley, Thomas H. ; Bennett, David A. ; Harris, Tamara B. ; Fratiglioni, Laura ; Holmes, Clive ; Bruijn, Renee F. A. G. de ; Passmore, Peter ; Montine, Thomas J. ; Bettens, Karolien ; Rotter, Jerome I. ; Brice, Alexis ; Morgan, Kevin ; Foroud, Tatiana M. ; Kukull, Walter A. ; Hannequin, Didier ; Powell, John F. ; Nalls, Michael A. ; Ritchie, Karen ; Lunetta, Kathryn L. ; Kauwe, John S. K. ; Boerwinkle, Eric ; Riemenschneider, Matthias ; Boada, Mercè ; Hiltunen, Mikko ; Martin, Eden R. ; Schmidt, Reinhold ; Rujescu, Dan ; Dartigues, Jean-François ; Mayeux, Richard ; Tzourio, Christophe ; Hofman, Albert ; Nöthen, Markus Maria ; Graff, Caroline ; Psaty, Bruce M. ; Haines, Jonathan L. ; Lathrop, Mark ; Pericak-Vance, Margaret Ann ; Launer, Lenore J. ; Broeckhoven, Christine Van ; Farrer, Lindsay A. ; Duijn, Cornelia M. van ; Ramirez, Alfredo ; Seshadri, Sudha ; Schellenberg, Gerard D. ; Amouyel, Philippe ; Williams, Julie
Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.
Principal findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10−6) and 14 (IGHV1-67 p = 7.9×10−8) which indexed novel susceptibility loci.
Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
(2017)
Kong, Xiang-Zhen ; Mathias, Samuel R. ; Guadalupe, Tulio ; Abé, Christoph ; Agartz, Ingrid ; Akudjedu, Theophilus N. ; Andre, Aleman ; Saud, Alhusaini ; Allen, Nicholas B. ; Ames, David ; Andreassen, Ole A. ; Arias Vásquez, Alejandro ; Armstrong, Nicola J. ; Bergo, Felipe ; Bastin, Mark E. ; Batalla, Albert ; Bauer, Jochen ; Baune, Bernhard T. ; Baur, Ramona ; Biederman, Joseph ; Blaine, Sara K. ; Boedhoe, Premika ; Bøen, Erlend ; Bose, Anushree ; Bralten, Janita ; Brandeis, Daniel ; Brem, Silvia ; Brodaty, Henry ; Bröhl, Henrieke ; Brooks, Samantha J. ; Buitelaar, Jan K. ; Bürger, Christian ; Bülow, Robin ; Calhoun, Vince D. ; Calvo, Anna ; Canales-Rodrı́guez, Erick Jorge ; Canive, Jose M. ; Cannon, Dara M. ; Caparelli, Elisabeth C. ; Castellanos, Francisco X. ; Cavalleri, Gianpiero L. ; Cendes, Fernando ; Chaim-Avancini, Tiffany Moukbel ; Chantiluke, Kaylita ; Chen, Qun-lin ; Chen, Xiayu ; Cheng, Yuqi ; Christakou, Anastasia ; Clark, Vincent P. ; Coghill, David ; Connolly, Colm G. ; Conzelmann, Annette ; Cόrdova-Palomera, Aldo ; Cousijn, Janna ; Crow, Tim ; Cubillo, Ana ; Dannlowski, Udo ; de Bruttopilo, Sara Ambrosino ; Zeeuw, Patrick de ; Deary, Ian J. ; Delanty, Norman ; Demeter, Damion V. ; Di Martino, Adriana ; Dickie, Erin W ; Dietsche, Bruno ; Doan, N. Trung ; Doherty, Colin P. ; Doyle, Alysa ; Durston, Sarah ; Earl, Eric ; Ehrlich, Stefan ; Ekman, Carl Johan ; Elvsåshagen, Torbjørn ; Epstein, Jeffery N. ; Fair, Damien A. ; Faraone, Stephen V. ; Fatouros-Bergman, Helena ; Fernndez, Guillen ; Busatto Filho, Geraldo ; Flyckt, Lena ; Forster, Katharina ; Jean-Paul, Fouche ; Foxe, John J. ; Fuentes-Claramonte, Paola ; Fullerton, Janice M. ; Garavan, Hugh ; Garcia, Danielle do Santos ; Gotlib, Ian H. ; Goudriaan, Anna E. ; Grabe, Hans Jörgen ; Groenewold, Nynke A. ; Grotegerd, Dominik ; Gruber, Oliver ; Gurholt, Tiril ; Haavik, Jan ; Hahn, Tim ; Hansell, Narelle K. ; Harris, Mathew A. ; Hartman, Catharina ; Hernandez, Maria del Carmen Valdes ; Heslenfeld, Dirk ; Hester, Robert ; Hibar, Derrek Paul ; Ho, Beng-Choon ; Ho, Tiffany C. ; Hoekstra, Pieter J. ; van Holst, Ruth J. ; Hoogman, Martine ; Hovik, Marie F. ; Howells, Fleur M. ; Hugdahl, Kenneth ; Huyser, Chaim ; Ingvar, Martind ; Irwin, Lourdes ; Ishikawa, Akari ; James, Anthony ; Jahanshad, Neda ; Jernigan, Terry L. ; Jönsson, Erik G. ; Kahler, Claas ; Kaleda, Vasily ; Kelly, Clare ; Kerich, Michael ; Keshavan, Matcheri S ; Khadka, Sabin ; Kircher, Tilo ; Kohls, Gregor ; Konrad, Kerstin ; Korucuoglu, Ozlem ; Krämer, Bernd ; Krug, Axel ; Kwon, Jun Soo ; Lambregts-Rommelse, Nanda ; Landén, Mikael ; Lázaro, Luisa ; Lebedeva, Irina ; Lenroot, Rhoshel ; Lesch, Klaus-Peter J. ; Li, Qinqin ; Lim, Kelvin O. ; Liu, Jia ; Lochner, Christine ; London, Edythe D. ; Lonning, Vera ; Lorenzetti, Valentina ; Luciano, Michelle ; Luijten, Maartje ; Lundervold, Astri J. ; Mackey, Scott ; MacMaster, Frank P. ; Maingault, Sophie ; Malpas, Charles B. ; Malt, Ulrik F. ; Mataix-Cols, David ; Martin-Santos, Rocio ; Mayer, Andrew R. ; McCarthy, Hazel ; Mitchell, Philip B. ; Mueller, Bryon A. ; Maniega, Susana Munoz ; Mazoyer, Bernard ; McDonald, Colm ; McLellan, Quinn ; McMahon, Katie L. ; McPhilemy, Genevieve ; Momenan, Reza ; Morales, Angelica M. ; Narayanaswamy, Janardhanan C. ; Moreira, José Carlos Vasques ; Nerland, Stener ; Nestor, Liam ; Nigg, Joel T. ; Nordvik, Jan-Egil ; Novotny, Stephanie ; Oberwelland, Eileen ; O’Gorman, Ruth L. ; Oosterlaan, Jaap ; Oranje, Bob ; Orr, Catherine ; Overs, Bronwyn ; Pauli, Paul ; Paulus, Martin ; Plessen, Kerstin ; Polier, Georg von ; Pomarol-Clotet, Edith ; Qiu, Jiang ; Radua, Joaquim ; Ramos-Quiroga, J. Antoni ; Reddy, Y.C. Janardhan ; Reif, Andreas ; Roberts, Gloria ; Rosa, Pedro ; Rubia, Katya ; Sacchet, Matthew D. ; Sachdev, Perminder S. ; Salvador, Raymond ; Schmaal, Lianne ; Schweren, Lisanne ; Seidman, Larry J. ; Seitz, Jochen ; Serpa, Mauricio Henriques ; Shaw, Philip ; Shumskaya, Elena ; Silk, Timothy J. ; Simmons, Alan N. ; Simulionyte, Egle ; Sinha, Rajita ; Sjoerds, Zsuzsika ; Smelror, Runar Elle ; Soliva, Joan Carlos ; Solowij, Nadia ; Sponheim, Scott R. ; Stein, Dan J. ; Stein, Elliot A. ; Stevens, Michael ; Strike, Lachlan T. ; Sudre, Gustavo ; Sui, Jing ; Tamm, Leanne ; Temmingh, Hendrik S. ; Thoma, Robert J. ; Tomyshev, Alexander S. ; Tronchin, Giulia ; Turner, Jessica A. ; Uhlmann, Anne ; van Erp, Theo G.M. ; van den Heuvel, Odile ; van der Meer, Dennis ; Eijk, Liza van ; Vance, Alasdair ; Veer, Ilya M. ; Veltman, Dick J. ; Venkatasubramanian, Ganesan ; Vilarroya, Oscar ; Vives-Gilabert, Yolanda ; Voineskos, Aristotle N. ; Völzke, Henry ; Vuletic, Daniella ; Walitza, Susanne ; Walter, Henrik ; Walton, Esther ; Wardlaw, Joanna M. ; Wen, Wei ; Westlye, Lars T. ; Whelan, Christopher D. ; White, Tonya ; Wiers, Reinout W. ; Wright, Margaret J. ; Wittfeld, Katharina ; Yang, Tony T. ; Yasuda, Clarissa L. ; Yoncheva, Yuliya ; Yucel, Murat ; Yun, Je-Yeon ; Zanetti, Marcus Vinicius ; Zhen, Zonglei ; Zhu, Xing-xing ; Ziegler, Georg Christoph ; Zierhut, Kathrin ; De Zubicaray, Greig ; Zwiers, Marcel P. ; Glahn, David C. ; Franke, Barbara ; Crivello, Fabrice ; Tzourio-Mazoyer, Nathalie ; Fisher, Simon E. ; Thompson, Paul M. ; Francks, Clyde ; Farde, Lars ; Engberg, Goran ; Erhardt, Sophie ; Cervenka, Simon ; Schwieler, Lilly ; Piehl, Fredrik ; Collste, Karin ; Victorsson, Pauliina ; Malmqvist, Anna ; Hedberg, Mikael ; Orhan, Funda
Anney, Richard ; Klei, Lambertus ; Pinto, Dalila ; Regan, Regina ; Conroy, Judith ; Magalhães, Tiago R. ; Correia, Catarina ; Abrahams, Brett S. ; Sykes, Nuala ; Pagnamenta, Alistair T. ; Almeida, Joana ; Bacchelli, Elena ; Bailey, Anthony J. ; Baird, Gillian ; Battaglia, Agatino ; Berney, Tom ; Bolshakova, Nadia ; Bölte, Sven ; Bolton, Patrick F. ; Bourgeron, Thomas ; Brennan, Sean ; Brian, Jessica ; Carson, Andrew R. ; Casallo, Guillermo ; Casey, Jillian ; Chu, Su H. ; Cochrane, Lynne ; Corsello, Christina ; Crawford, Emily L. ; Crossett, Andrew ; Dawson, Geraldine ; Jonge, Maretha de ; Delorme, Richard ; Drmic, Irene ; Duketis, Eftichia ; Duque, Frederico ; Estes, Annette ; Farrar, Penny ; Fernandez, Bridget A. ; Folstein, Susan E. ; Fombonne, Eric ; Freitag, Christine M. ; Gilbert, John ; Gillberg, Christopher ; Glessner, Joseph T. ; Goldberg, Jeremy ; Green, Jonathan ; Guter, Stephen J. ; Hakonarson, Hakon ; Heron, Elizabeth A. ; Hill, Matthew ; Holt, Richard ; Howe, Jennifer L. ; Hughes, Gillian ; Hus, Vanessa ; Igliozzi, Roberta ; Kim, Cecilia ; Klauck, Sabine M. ; Kolevzon, Alexander ; Korvatska, Olena ; Kustanovich, Vlad ; Lajonchere, Clara M. ; Lamb, Janine A. ; Laskawiec, Magdalena ; Leboyer, Marion ; Le Couteur, Ann ; Leventhal, Bennett L. ; Lionel, Anath C. ; Liu, Xiao-Qing ; Lord, Catherine ; Lotspeich, Linda ; Lund, Sabata C. ; Maestrini, Elena ; Mahoney, William ; Mantoulan, Carine ; Marshall, Christian R. ; McConachie, Helen ; McDougle, Christopher J. ; McGrath, Jane ; McMahon, William M. ; Melhem, Nadine M. ; Merikangas, Alison ; Migita, Ohsuke ; Minshew, Nancy J. ; Mirza, Ghazala K. ; Munson, Jeff ; Nelson, Stanley F. ; Noakes, Carolyn ; Noor, Abdul ; Nygren, Gudrun ; Oliveira, Guiomar ; Papanikolaou, Katerina ; Parr, Jeremy R. ; Parrini, Barbara ; Paton, Tara ; Pickles, Andrew ; Piven, Joseph ; Posey, David J. ; Poustka, Annemarie ; Poustka, Fritz ; Prasad, Aparna ; Ragoussis, Jiannis ; Renshaw, Katy ; Rickaby, Jessica ; Roberts, Wendy ; Roeder, Kathryn ; Roge, Bernadette ; Rutter, Michael L. ; Bierut, Laura Jean ; Rice, John P. ; Salt, Jeff ; Sansom, Katherine ; Sato, Daisuke ; Segurado, Ricardo ; Senman, Lili ; Shah, Naisha ; Sheffield, Val C. ; Soorya, Latha ; Sousa, Inês ; Stoppioni, Vera ; Strawbridge, Christina ; Tancredi, Raffaella ; Tansey, Katherine ; Thiruvahindrapduram, Bhooma ; Thompson, Ann P. ; Thomson, Susanne ; Tryfon, Ana ; Tsiantis, John ; Engeland, Herman van ; Vincent, John B. ; Volkmar, Fred ; Wallace, Simon ; Wang, Kai ; Wang, Zhouzhi ; Wassink, Thomas H. ; Wing, Kirsty ; Wittemeyer, Kerstin ; Wood, Shawn ; Yaspan, Brian L. ; Zurawiecki, Danielle ; Zwaigenbaum, Lonnie ; Betancur, Catalina ; Buxbaum, Joseph D. ; Cantor, Rita M. ; Cook, Edwin H. ; Coon, Hilary ; Cuccaro, Michael L. ; Gallagher, Louise ; Geschwind, Daniel H. ; Gill, Michael ; Haines, Jonathan L. ; Miller, Judith ; Monaco, Anthony P. ; Nurnberger, John I. ; Paterson, Andrew D. ; Pericak-Vance, Margaret Ann ; Schellenberg, Gerard D. ; Scherer, Stephen W. ; Sutcliffe, James S. ; Szatmari, Peter ; Vicente, Astrid M. ; Vieland, Veronica J. ; Wijsman, Ellen M. ; Devlin, Bernie ; Ennis, Sean ; Hallmayer, Joachim
Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ASD. In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P < 5 × 10−8. When a smaller replication sample was analyzed, the risk allele at rs4141463 was again over-transmitted; yet, consistent with the winner's curse, its effect size in the replication sample was much smaller; and, for the combined samples, the association signal barely fell below the P < 5 × 10−8 threshold. Exploratory analyses of phenotypic subtypes yielded no significant associations after correction for multiple testing. They did, however, yield strong signals within several genes, KIAA0564, PLD5, POU6F2, ST8SIA2 and TAF1C.
Rainger, Joe ; Beusekom, Ellen van ; Ramsay, Jacqueline K. ; McKie, Lisa ; Al-Gazali, Lihadh ; Pallotta, Rosanna ; Saponari, Anita ; Branney, Peter ; Fisher, Malcolm ; Morrison, Harris ; Bicknell, Louise ; Gautier, Philippe ; Perry, Paul ; Sokhi, Kishan ; Sexton, David ; Bardakjian, Tanya M. ; Schneider, Adele S. ; Elcioglu, Nursel ; Ozkinay, Ferda ; Koenig, Rainer ; Mégarbané, Andre ; Semerci, C. Nur ; Khan, Ayesha ; Zafar, Saemah ; Hennekam, Raoul C. ; Sousa, Sérgio B. ; Ramos, Lina ; Garavelli, Livia ; Furga, Andrea Superti ; Wischmeijer, Anita ; Jackson, Ian J. ; Gillessen-Kaesbach, Gabriele Gertrud ; Brunner, Han G. ; Wieczorek, Dagmar ; Bokhoven, Hans van ; FitzPatrick, David R.
Ophthalmo-acromelic syndrome (OAS), also known as Waardenburg Anophthalmia syndrome, is defined by the combination of eye malformations, most commonly bilateral anophthalmia, with post-axial oligosyndactyly. Homozygosity mapping and subsequent targeted mutation analysis of a locus on 14q24.2 identified homozygous mutations in SMOC1 (SPARC-related modular calcium binding 1) in eight unrelated families. Four of these mutations are nonsense, two frame-shift, and two missense. The missense mutations are both in the second Thyroglobulin Type-1 (Tg1) domain of the protein. The orthologous gene in the mouse, Smoc1, shows site- and stage-specific expression during eye, limb, craniofacial, and somite development. We also report a targeted pre-conditional gene-trap mutation of Smoc1 (Smoc1tm1a) that reduces mRNA to ~10% of wild-type levels. This gene-trap results in highly penetrant hindlimb post-axial oligosyndactyly in homozygous mutant animals (Smoc1tm1a/tm1a). Eye malformations, most commonly coloboma, and cleft palate occur in a significant proportion of Smoc1tm1a/tm1a embryos and pups. Thus partial loss of Smoc-1 results in a convincing phenocopy of the human disease. SMOC-1 is one of the two mammalian paralogs of Drosophila Pentagone, an inhibitor of decapentaplegic. The orthologous gene in Xenopus laevis, Smoc-1, also functions as a Bone Morphogenic Protein (BMP) antagonist in early embryogenesis. Loss of BMP antagonism during mammalian development provides a plausible explanation for both the limb and eye phenotype in humans and mice.
Anney, Richard ; Klei, Lambertus ; Pinto, Dalila ; Almeida, Joana ; Bacchelli, Elena ; Baird, Gillian ; Bolshakova, Nadia ; Bölte, Sven ; Bolton, Patrick F. ; Bourgeron, Thomas ; Brennan, Sean ; Brian, Jessica ; Casey, Jillian ; Conroy, Judith ; Correia, Catarina ; Corsello, Christina ; Crawford, Emily L. ; Jonge, Maretha de ; Delorme, Richard ; Duketis, Eftichia ; Duque, Frederico ; Estes, Annette ; Farrar, Penny ; Fernandez, Bridget A. ; Folstein, Susan E. ; Fombonne, Eric ; Gilbert, John ; Gillberg, Christopher ; Glessner, Joseph T. ; Green, Andrew ; Green, Jonathan ; Guter, Stephen J. ; Heron, Elizabeth A. ; Holt, Richard ; Howe, Jennifer L. ; Hughes, Gillian ; Hus, Vanessa ; Igliozzi, Roberta ; Jacob, Suma ; Kenny, Graham P. ; Kim, Cecilia ; Kolevzon, Alexander ; Kustanovich, Vlad ; Lajonchere, Clara M. ; Lamb, Janine A. ; Law-Smith, Miriam ; Leboyer, Marion ; Le Couteur, Ann ; Leventhal, Bennett L. ; Liu, Xiao-Qing ; Lombard, Frances ; Lord, Catherine ; Lotspeich, Linda ; Lotspeich, Linda ; Lund, Sabata C. ; Magalhães, Tiago R. ; Mantoulan, Carine ; McDougle, Christopher J. ; Melhem, Nadine M. ; Merikangas, Alison ; Minshew, Nancy J. ; Mirza, Ghazala K. ; Munson, Jeff ; Noakes, Carolyn ; Nygren, Gudrun ; Papanikolaou, Katerina ; Pagnamenta, Alistair T. ; Parrini, Barbara ; Paton, Tara ; Paton, Tara ; Pickles, Andrew ; Posey, David J. ; Poustka, Fritz ; Ragoussis, Jiannis ; Regan, Regina ; Roberts, Wendy ; Roeder, Kathryn ; Roge, Bernadette ; Rutter, Michael L. ; Schlitt, Sabine ; Shah, Naisha ; Sheffield, Val C. ; Soorya, Latha ; Sousa, Inês ; Stoppioni, Vera ; Sykes, Nuala ; Tancredi, Raffaella ; Thompson, Ann P. ; Thomson, Susanne ; Tryfon, Ana ; Tsiantis, John ; Engeland, Herman van ; Vincent, John B. ; Volkmar, Fred ; Vorstman, JAS ; Wallace, Simon ; Wing, Kirsty ; Wittemeyer, Kerstin ; Wood, Shawn ; Zurawiecki, Danielle ; Zwaigenbaum, Lonnie ; Bailey, Anthony J. ; Battaglia, Agatino ; Cantor, Rita M. ; Coon, Hilary ; Cuccaro, Michael L. ; Dawson, Geraldine ; Ennis, Sean ; Freitag, Christine M. ; Geschwind, Daniel H. ; Haines, Jonathan L. ; Klauck, Sabine M. ; McMahon, William M. ; Maestrini, Elena ; Miller, Judith ; Monaco, Anthony P. ; Nelson, Stanley F. ; Nurnberger, John I. ; Oliveira, Guiomar ; Parr, Jeremy R. ; Pericak-Vance, Margaret Ann ; Piven, Joseph ; Schellenberg, Gerard D. ; Scherer, Stephen W. ; Vicente, Astrid M. ; Wassink, Thomas H. ; Wijsman, Ellen M. ; Betancur, Catalina ; Buxbaum, Joseph D. ; Cook, Edwin H. ; Gallagher, Louise ; Gill, Michael ; Hallmayer, Joachim ; Paterson, Andrew D. ; Sutcliffe, James S. ; Szatmari, Peter ; Vieland, Veronica J. ; Hakonarson, Hakon ; Devlin, Bernie
While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stages 1 and 2). In addition to evaluating the association of individual single nucleotide polymorphisms (SNPs), we also sought evidence that common variants, en masse, might affect the risk. Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level. The SNP that achieves the smallest P-value from secondary analyses is rs1718101. It falls in CNTNAP2, a gene previously implicated in susceptibility for ASD. This SNP also shows modest association with age of word/phrase acquisition in ASD subjects, of interest because features of language development are also associated with other variation in CNTNAP2. In contrast, allele scores derived from the transmission of common alleles to Stage 1 cases significantly predict case status in the independent Stage 2 sample. Despite being significant, the variance explained by these allele scores was small (Vm< 1%). Based on results from individual SNPs and their en masse effect on risk, as inferred from the allele score results, it is reasonable to conclude that common variants affect the risk for ASD but their individual effects are modest.
Casey, Jillian P. ; Magalhães, Tiago R. ; Conroy, Judith M. ; Regan, Regina ; Shah, Naisha ; Anney, Richard ; Shields, Denis C. ; Abrahams, Brett S. ; Almeida, Joana ; Bacchelli, Elena ; Bailey, Anthony J. ; Baird, Gillian ; Battaglia, Agatino ; Berney, Tom ; Bolshakova, Nadia ; Bolton, Patrick F. ; Bourgeron, Thomas ; Brennan, Sean ; Cali, Phil ; Correia, Catarina ; Corsello, Christina ; Coutanche, Marc ; Dawson, Geraldine ; Jonge, Maretha de ; Delorme, Richard ; Duketis, Eftichia ; Duque, Frederico ; Estes, Annette ; Farrar, Penny ; Fernandez, Bridget A. ; Folstein, Susan E. ; Foley, Suzanne ; Fombonne, Eric ; Freitag, Christine M. ; Gilbert, John ; Gillberg, Christopher ; Glessner, Joseph T. ; Green, Jonathan ; Guter, Stephen J. ; Hakonarson, Hakon ; Holt, Richard ; Hughes, Gillian ; Hus, Vanessa ; Igliozzi, Roberta ; Kim, Cecilia ; Klauck, Sabine M. ; Kolevzon, Alexander ; Lamb, Janine A. ; Leboyer, Marion ; Le Couteur, Ann ; Leventhal, Bennett L. ; Lord, Catherine ; Lund, Sabata C. ; Maestrini, Elena ; Mantoulan, Carine ; Marshall, Christian R. ; McConachie, Helen ; McDougle, Christopher J. ; McGrath, Jane ; McMahon, William M. ; Merikangas, Alison ; Miller, Judith ; Minopoli, Fiorella ; Mirza, Ghazala K. ; Munson, Jeff ; Nelson, Stanley F. ; Nygren, Gudrun ; Oliveira, Guiomar ; Pagnamenta, Alistair T. ; Papanikolaou, Katerina ; Parr, Jeremy R. ; Parrini, Barbara ; Pickles, Andrew ; Pinto, Dalila ; Piven, Joseph ; Posey, David J. ; Poustka, Annemarie ; Poustka, Fritz ; Ragoussis, Jiannis ; Roge, Bernadette ; Rutter, Michael L. ; Sequeira, Ana F. ; Soorya, Latha ; Sousa, Inês ; Sykes, Nuala ; Stoppioni, Vera ; Tancredi, Raffaella ; Tauber, Maïté ; Thompson, Ann P. ; Thomson, Susanne ; Tsiantis, John ; Engeland, Herman van ; Vincent, John B. ; Volkmar, Fred ; Vorstman, Jacob A. S. ; Wallace, Simon ; Wang, Kai ; Wassink, Thomas H. ; White, Kathy ; Wing, Kirsty ; Wittemeyer, Kerstin ; Yaspan, Brian L. ; Zwaigenbaum, Lonnie ; Betancur, Catalina ; Buxbaum, Joseph D. ; Cantor, Rita M. ; Cook, Edwin H. ; Coon, Hilary ; Cuccaro, Michael L. ; Geschwind, Daniel H. ; Haines, Jonathan L. ; Hallmayer, Joachim ; Monaco, Anthony P. ; Nurnberger, John I. ; Pericak-Vance, Margaret Ann ; Schellenberg, Gerard D. ; Scherer, Stephen W. ; Sutcliffe, James S. ; Szatmari, Peter ; Vieland, Veronica J. ; Wijsman, Ellen M. ; Green, Andrew ; Gill, Michael ; Gallagher, Louise ; Vicente, Astrid M. ; Ennis, Sean
Autism spectrum disorder (ASD) is a highly heritable disorder of complex and heterogeneous aetiology. It is primarily characterized by altered cognitive ability including impaired language and communication skills and fundamental deficits in social reciprocity. Despite some notable successes in neuropsychiatric genetics, overall, the high heritability of ASD (~90%) remains poorly explained by common genetic risk variants. However, recent studies suggest that rare genomic variation, in particular copy number variation, may account for a significant proportion of the genetic basis of ASD. We present a large scale analysis to identify candidate genes which may contain low-frequency recessive variation contributing to ASD while taking into account the potential contribution of population differences to the genetic heterogeneity of ASD. Our strategy, homozygous haplotype (HH) mapping, aims to detect homozygous segments of identical haplotype structure that are shared at a higher frequency amongst ASD patients compared to parental controls. The analysis was performed on 1,402 Autism Genome Project trios genotyped for 1 million single nucleotide polymorphisms (SNPs). We identified 25 known and 1,218 novel ASD candidate genes in the discovery analysis including CADM2, ABHD14A, CHRFAM7A, GRIK2, GRM3, EPHA3, FGF10, KCND2, PDZK1, IMMP2L and FOXP2. Furthermore, 10 of the previously reported ASD genes and 300 of the novel candidates identified in the discovery analysis were replicated in an independent sample of 1,182 trios. Our results demonstrate that regions of HH are significantly enriched for previously reported ASD candidate genes and the observed association is independent of gene size (odds ratio 2.10). Our findings highlight the applicability of HH mapping in complex disorders such as ASD and offer an alternative approach to the analysis of genome-wide association data.
Bauer, Michael ; Glenn, Tasha ; Achtyes, Eric D. ; Agaoglu, Esen ; Altınbaş, Kürşat ; Andreassen, Ole A. ; Angelopoulos, Elias ; Ardau, Raffaella ; Arrua Vares, Edgar ; Aydin, Memduha ; Ayhan, Yavuz ; Baethge, Christopher Jan ; Bauer, Rita ; Baune, Bernhard T. ; Balaban, Ceylan ; Becerra-Palars, Claudia ; Behere, Aniruddh P. ; Behere, Prakash B. ; Belete, Habte ; Belete, Tilahun ; Belizario, Gabriel Okawa ; Bellivier, Frank ; Belmaker, Robert H. ; Benedetti, Francesco ; Berk, Michael ; Bersudsky, Yuly ; Bicakci, Şule ; Birabwa-Oketcho, Harriet ; Bjella, Thomas D. ; Brady, Conan ; Cabrera, Jorge ; Cappucciati, Marco ; Castro, Angela Marianne Paredes ; Chen, Wei-Ling ; Cheung, Eric Y. Wo ; Chiesa, Silvia ; Crowe, Marie ; Cuomo, Alessandro ; Dallaspezia, Sara ; Del Zompo, Maria ; Desai, Pratikkumar ; Dodd, Seetal ; Donix, Markus ; Etain, Bruno ; Fagiolini, Andrea ; Fellendorf, Frederike Tabea ; Ferensztajn-Rochowiak, Ewa ; Fiedorowicz, Jess G. ; Fountoulakis, Kostas N. ; Frye, Mark A. ; Geoffroy, Pierre A. ; Gonzalez-Pinto, Ana ; Gottlieb, John F. ; Grof, Paul ; Haarman, Bartholomeus C. M. ; Harima, Hirohiko ; Hasse-Sousa, Mathias ; Henry, Chantal ; Høffding, Lone ; Houenou, Josselin ; Imbesi, Massimiliano ; Isometsä, Erkki T. ; Ivkovic, Maja ; Janno, Sven ; Johnsen, Simon ; Kapczinski, Flávio ; Karakatsoulis, Gregory N. ; Kardell, Mathias ; Kessing, Lars Vedel ; Kim, Seong Jae ; König, Barbara ; Kot, Timur L. ; Koval, Michael ; Kunz, Mauricio ; Lafer, Beny ; Landén, Mikael ; Larsen, Erik R. ; Lenger, Melanie ; Lewitzka, Ute ; Licht, Rasmus W. ; Lopez-Jaramillo, Carlos ; MacKenzie, Alan ; Madsen, Helle Østergaard ; Madsen, Simone Alberte Kongstad A. ; Mahadevan, Jayant ; Mahardika, Agustine ; Manchia, Mirko ; Marsh, Wendy ; Martinez-Cengotitabengoa, Monica ; Martiny, Klaus ; Mashima, Yuki ; McLoughlin, Declan M. ; Meesters, Ybe ; Melle, Ingrid ; Meza-Urzúa, Fátima ; Ming, Mok Yee ; Monteith, Scott ; Moorthy, Muthukumaran ; Morken, Gunnar ; Mosca, Enrica ; Mozzhegorov, Anton A. ; Munoz, Rodrigo ; Mythri, Starlin V. ; Nacef, Fethi ; Nadella, Ravi K. ; Nakanotani, Takako ; Nielsen, René Ernst ; O'Donovan, Claire ; Omrani, Adel ; Osher, Yamima ; Ouali, Uta ; Pantovic-Stefanovic, Maja ; Pariwatcharakul, Pornjira ; Petite, Joanne ; Pfennig, Andrea ; Pica Ruiz, Yolanda ; Pilhatsch, Maximilian ; Pinna, Marco ; Pompili, Maurizio ; Porter, Richard ; Quiroz, Danilo ; Rabelo-da-Ponte, Francisco Diego ; Ramesar, Raj ; Rasgon, Natalie ; Ratta-apha, Woraphat ; Ratzenhofer, Michaela ; Redahan, Maria ; Reddy, M. S. ; Reif, Andreas ; Reininghaus, Eva Z. ; Richards, Jenny Gringer ; Ritter, Philipp ; Rybakowski, Janusz K. ; Sathyaputri, Leela ; Scippa, Ângela M. ; Simhandl, Christian ; Severus, Emanuel ; Smith, Daniel ; Smith, José ; Stackhouse Jr., Paul W. ; Stein, Dan J. ; Stilwell, Kellen ; Strejilevich, Sergio ; Su, Kuan-Pin ; Subramaniam, Mythily ; Sulaiman, Ahmad Hatim ; Suominen, Kirsi ; Tanra, Andi J. ; Tatebayashi, Yoshitaka ; Teh, Wen Lin ; Tondo, Leonardo ; Torrent, Carla ; Tuinstra, Daniel ; Uchida, Takahito ; Vaaler, Arne E. ; Veeh, Julia ; Vieta, Eduard ; Viswanath, Biju ; Yoldi-Negrete, Maria ; Yalcinkaya, Oguz Kaan ; Young, Allan H. ; Zgueb, Yosra ; Whybrow, Peter C.
Background: Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods: Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun’s electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results: This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p < 0.01. Conclusion: A large change in solar insolation, both between winter and summer and between the minimum and maximum monthly values, may increase the risk of suicide attempts in bipolar I disorder. With frequent circadian rhythm dysfunction and suicidal behavior in bipolar disorder, greater understanding of the optimal roles of daylight and electric lighting in circadian entrainment is needed.
Coccolini, Federico ; Montori, Giulia ; Catena, Fausto ; Kluger, Yoram ; Biffl, Walter ; Moore, Ernest E. ; Reva, Viktor ; Bing, Camilla ; Bala, Miklosh ; Fugazzola, Paola ; Bahouth, Hany ; Marzi, Ingo ; Velmahos, George C. ; Ivatury, Rao ; Soreide, Kjetil ; Horer, Tal ; Broek, Richard P. G. ten ; Pereira, Bruno M. ; Fraga, Gustavo Pereira ; Inaba, Kenji ; Kashuk, Joseph ; Parry, Neil ; Masiakos, Peter T. ; Mylonas, Konstantinos ; Kirkpatrick, Andrew ; Abu-Zidan, Fikri ; Gomes, Carlos Augusto ; Benatti, Simone Vasilij ; Naidoo, Noel ; Salvetti, Francesco ; Maccatrozzo, Stefano ; Agnoletti, Vanni ; Gamberini, Emiliano ; Solaini, Leonardo ; Costanzo, Antonio ; Celotti, Andrea ; Tomasoni, Matteo ; Khokha, Vladimir ; Arvieux, Catherine ; Napolitano, Lena ; Handolin, Lauri ; Pisano, Michele ; Magnone, Stefano ; Spain, David A. ; De Moya, Marc ; Davis, Kimberly A. ; De Angelis, Nicola ; Leppaniemi, Ari ; Ferrada, Paula ; Latifi, Rifat ; Navarro, David Costa ; Otomo, Yashuiro ; Coimbra, Raul ; Maier, Ronald V. ; Moore, Frederick ; Rizoli, Sandro ; Sakakushev, Boris ; Galante, Joseph M. ; Chiara, Osvaldo ; Cimbanassi, Stefania ; Mefire, Alain Chichom ; Weber, Dieter ; Ceresoli, Marco ; Peitzman, Andrew B. ; Wehlie, Liban ; Sartelli, Massimo ; Di Saverio, Salomone ; Ansaloni, Luca
Spleen injuries are among the most frequent trauma-related injuries. At present, they are classified according to the anatomy of the injury. The optimal treatment strategy, however, should keep into consideration the hemodynamic status, the anatomic derangement, and the associated injuries. The management of splenic trauma patients aims to restore the homeostasis and the normal physiopathology especially considering the modern tools for bleeding management. Thus, the management of splenic trauma should be ultimately multidisciplinary and based on the physiology of the patient, the anatomy of the injury, and the associated lesions. Lastly, as the management of adults and children must be different, children should always be treated in dedicated pediatric trauma centers. In fact, the vast majority of pediatric patients with blunt splenic trauma can be managed non-operatively. This paper presents the World Society of Emergency Surgery (WSES) classification of splenic trauma and the management guidelines.
Coccolini, Federico ; Roberts, Derek ; Ansaloni, Luca ; Ivatury, Rao ; Gamberini, Emiliano ; Kluger, Yoram ; Moore, Ernest E. ; Coimbra, Raul ; Kirkpatrick, Andrew Wallace ; Pereira, Bruno M. ; Montori, Giulia ; Ceresoli, Marco ; Abu-Zidan, Fikri M. ; Sartelli, Massimo ; Velmahos, George C. ; Fraga, Gustavo Pereira ; Leppaniemi, Ari ; Tolonen, Matti ; Galante, Joseph ; Razek, Tarek ; Maier, Ron ; Bala, Miklosh ; Sakakushev, Boris ; Khokha, Vladimir ; Malbrain, Manu ; Agnoletti, Vanni ; Peitzman, Andrew B. ; Demetrashvili, Zaza ; Sugrue, Michael ; Di Saverio, Salomone ; Martzi, Ingo ; Soreide, Kjetil ; Biffl, Walter ; Ferrada, Paula ; Parry, Neil ; Montravers, Philippe ; Melotti, Rita Maria ; Salvetti, Francesco ; Valetti, Tino M. ; Scalea, Thomas ; Chiara, Osvaldo ; Cimbanassi, Stefania ; Kashuk, Jeffry L. ; Larrea, Martha ; Martinez Hernandez, Juan Alberto ; Lin, Heng-Fu ; Chirica, Mircea ; Arvieux, Catherine ; Bing, Camilla ; Horer, Tal ; Simone, Belinda De ; Masiakos, Peter T. ; Reva, Viktor ; De Angelis, Nicola ; Kike, Kaoru ; Balogh, Zsolt J. ; Fugazzola, Paola ; Tomasoni, Matteo ; Latifi, Rifat ; Naidoo, Noel ; Weber, Dieter ; Handolin, Lauri ; Inaba, Kenji ; Hecker, Andreas ; Yuan, Kuo-Ching ; Ordoñez, Carlos A. ; Rizoli, Sandro ; Gomes, Carlos Augusto ; De Moya, Marc ; Wani, Imtiaz ; Mefire, Alain Chichom ; Boffard, Ken ; Napolitano, Lena ; Catena, Fausto
Damage control resuscitation may lead to postoperative intra-abdominal hypertension or abdominal compartment syndrome. These conditions may result in a vicious, self-perpetuating cycle leading to severe physiologic derangements and multiorgan failure unless interrupted by abdominal (surgical or other) decompression. Further, in some clinical situations, the abdomen cannot be closed due to the visceral edema, the inability to control the compelling source of infection or the necessity to re-explore (as a “planned second-look” laparotomy) or complete previously initiated damage control procedures or in cases of abdominal wall disruption. The open abdomen in trauma and non-trauma patients has been proposed to be effective in preventing or treating deranged physiology in patients with severe injuries or critical illness when no other perceived options exist. Its use, however, remains controversial as it is resource consuming and represents a non-anatomic situation with the potential for severe adverse effects. Its use, therefore, should only be considered in patients who would most benefit from it. Abdominal fascia-to-fascia closure should be done as soon as the patient can physiologically tolerate it. All precautions to minimize complications should be implemented.